{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:09:08Z","timestamp":1790428148647,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.pnpbp.2019.109774","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T12:39:28Z","timestamp":1571834368000},"page":"109774","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Developmental stage and genotype dependent behavioral effects of embryonic alcohol exposure in zebrafish larvae"],"prefix":"10.1016","volume":"97","author":[{"given":"Amira","family":"Abozaid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Trzuskot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelaikha","family":"Najmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishti","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gerlai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2019.109774_bb0005","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.neuron.2017.10.032","article-title":"Alcohol and the brain: neuronal molecular targets, synapses, and circuits","volume":"96","author":"Abrahao","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2019.109774_bb0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbr.2010.07.028","article-title":"An automated predator avoidance task in zebrafish","volume":"216","author":"Ahmed","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0015","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ntt.2006.02.001","article-title":"Teratogenic effects of ethanol exposure on zebrafish visual system development","volume":"28","author":"Arenzana","year":"2006","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0020","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1093\/jxb\/ers291","article-title":"Heterosis: emerging ideas about hybrid vigour","volume":"63","author":"Baranwal","year":"2012","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0025","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ntt.2004.06.011","article-title":"Ethanol exposure alters zebrafish development: a novel model of fetal alcohol syndrome","volume":"26","author":"Bilotta","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0030","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3758\/BF03192800","article-title":"Behavioral phenotyping in zebrafish: comparison of three behavioral quantification methods","volume":"38","author":"Blaser","year":"2006","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.pnpbp.2019.109774_bb0035","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijdevneu.2014.08.007","article-title":"Attention, locomotor activity and developmental milestones in rats prenatally exposed to ethanol","volume":"38","author":"Brys","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0040","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.ntt.2011.05.009","article-title":"Early embryonic ethanol exposure impairs shoaling and the dopaminergic and serotoninergic systems in adult zebrafish","volume":"33","author":"Buske","year":"2011","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0045","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.pnpbp.2010.09.003","article-title":"Shoaling develops with age in zebrafish (Danio rerio)","volume":"35","author":"Buske","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2019.109774_bb0050","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00726-013-1658-y","article-title":"Chronic and acute alcohol administration induced neurochemical changes in the brain: comparison of distinct zebrafish populations","volume":"46","author":"Chatterjee","year":"2014","journal-title":"Amino Acids"},{"key":"10.1016\/j.pnpbp.2019.109774_bb0055","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s10646-008-0267-0","article-title":"Genetic variation in strains of zebrafish (Danio rerio) and the implications for ecotoxicology studies","volume":"18","author":"Coe","year":"2009","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.pnpbp.2019.109774_bb0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1023\/B:MICS.0000006851.84998.e0","article-title":"Identifying axon guidance defects in the embryonic zebrafish brain","volume":"25","author":"Devine","year":"2003","journal-title":"Methods Cell Sci."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0065","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/acer.13066","article-title":"The genetics of fetal alcohol spectrum disorders","volume":"40","author":"Eberhart","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0070","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neubiorev.2019.01.012","article-title":"Alcohol exposure during embryonic development: an opportunity to conduct systematic developmental time course analyses in zebrafish","volume":"98","author":"Facciol","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0075","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1530-0277.2008.00874.x","article-title":"Long-term behavioral changes in response to early developmental exposure to ethanol in zebrafish","volume":"33","author":"Fernandes","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0080","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbr.2014.02.035","article-title":"Embryonic alcohol exposure impairs associative learning performance in adult zebrafish","volume":"265","author":"Fernandes","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ijnp\/pyu089","article-title":"Embryonic alcohol exposure impairs the dopaminergic system and social behavioural responses in adult zebrafish","volume":"18","author":"Fernandes","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0090","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/dev.21318","article-title":"Embryonic alcohol exposure: towards the development of a zebrafish model of fetal alcohol spectrum disorders","volume":"57","author":"Gerlai","year":"2015","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0095","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0091-3057(00)00422-6","article-title":"Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects","volume":"67","author":"Gerlai","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0100","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1601-183X.2009.00488.x","article-title":"Acute and chronic alcohol dose: population differences in behavior and neurochemistry of zebrafish","volume":"8","author":"Gerlai","year":"2009","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0105","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0091-679X(08)61910-X","article-title":"Genetic backgrounds and some standard stocks and strains used in zebrafish developmental biology and genetics","volume":"60","author":"Johnson","year":"1999","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0110","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tips.2013.12.002","article-title":"Zebrafish as an emerging model for studying complex brain disorders","volume":"35","author":"Kalueff","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0115","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ddrr.69","article-title":"Animal models of fetal alcohol spectrum disorders: impact of the social environment","volume":"15","author":"Kelly","year":"2009","journal-title":"Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0120","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s11064-012-0960-5","article-title":"Effects of ethanol exposure during early pregnancy in hyperactive, inattentive and impulsive behaviors and MeCP2 expression in rodent offspring","volume":"38","author":"Kim","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0125","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0130","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1530-0277.2011.01661.x","article-title":"A review of social skills deficits in individuals with fetal alcohol spectrum disorders and prenatal alcohol exposure: profiles, mechanisms, and interventions","volume":"36","author":"Kully-Martens","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0135","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1001\/jamapediatrics.2017.1919","article-title":"Global prevalence of fetal alcohol spectrum disorder among children and youth: a systematic review and meta-analysis","volume":"171","author":"Lange","year":"2017","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0140","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ntt.2004.06.015","article-title":"Zebrafish as a neurotoxicological model","volume":"26","author":"Linney","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0145","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ntt.2004.06.017","article-title":"Strain-dependent effects of developmental ethanol exposure in zebrafish","volume":"26","author":"Loucks","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ntt.2013.11.001","article-title":"Strain dependent neurochemical changes induced by embryonic alcohol exposure in zebrafish","volume":"41","author":"Mahabir","year":"2014","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0155","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/ejn.13975","article-title":"Lasting changes induced by mild alcohol exposure during embryonic development in brain derived neurotrophic factor, neuronal cell adhesion molecule and synaptophysin positive neurons quantified in adult zebrafish","volume":"47","author":"Mahabir","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0160","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.physbeh.2012.01.017","article-title":"Strain dependent gene expression and neurochemical levels in the brain of zebrafish: focus on a few alcohol related targets","volume":"107","author":"Pan","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0165","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbr.2013.11.006","article-title":"Acute ethanol exposure induces behavioural differences in two zebrafish (Danio rerio) strains: a time course analysis","volume":"25","author":"Pannia","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2014.00093","article-title":"A comparison of the different animal models of fetal alcohol Spectrum disorders and their use in studying complex behaviors","volume":"2","author":"Patten","year":"2014","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0175","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-pharmtox-010611-134751","article-title":"Systematic approaches to toxicology in the zebrafish","volume":"52","author":"Peterson","year":"2012","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0180","series-title":"World Health Organization International Study on the Prevalence of Fetal Alcohol Spectrum Disorder (FASD): Canadian Component","first-page":"83","author":"Popova","year":"2018"},{"key":"10.1016\/j.pnpbp.2019.109774_bb0185","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1363\/3509403","article-title":"The measurement and meaning of unintended pregnancy","volume":"35","author":"Santelli","year":"2003","journal-title":"Perspect. Sex. Reprod. Health"},{"key":"10.1016\/j.pnpbp.2019.109774_bb0190","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbr.2017.10.005","article-title":"Fetal alcohol spectrum disorders: zebrafish in the analysis of the milder and more prevalent form of the disease","volume":"352","author":"Seguin","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0195","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1111\/acer.13249","article-title":"Behavioural responses to novelty or to a predator stimulus are not altered in adult zebrafish by early embryonic alcohol exposure","volume":"40","author":"Seguin","year":"2016","journal-title":"Alcoholism"},{"key":"10.1016\/j.pnpbp.2019.109774_bb0200","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0166-4328(94)90008-6","article-title":"Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions","volume":"61","author":"Simon","year":"1994","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0205","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1017\/S1355617714001088","article-title":"Social perspective taking and empathy in children with fetal alcohol Spectrum disorders","volume":"21","author":"Stevens","year":"2015","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.pnpbp.2019.109774_bb1005","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbr.2013.05.065","article-title":"Time-course of behavioural changes induced by ethanol in zebrafish (Danio rerio)","volume":"252","author":"Tran","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0210","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0091-679X(04)77032-6","article-title":"Genetic backgrounds, standard lines, and husbandry of zebrafish zebrafish: 2nd edition genetics genomics and informatics","volume":"77","author":"Trevarrow","year":"2004","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0215","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1034\/j.1601-183X.2003.00038.x","article-title":"Can zebrafish be used as a model to study the neurodevelopmental causes of autism?","volume":"2","author":"Tropepe","year":"2003","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0220","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1017\/S0140525X00077797","article-title":"Insensitivity of the analysis of variance to heredity-environment interaction","volume":"13","author":"Wahlsten","year":"1990","journal-title":"Behav. Brain Sci."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0225","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10597-017-0104-0","article-title":"Fetal alcohol Spectrum disorders: characteristics, complications, and treatment","volume":"53","author":"Wilhoit","year":"2017","journal-title":"Community Ment. Health J."},{"key":"10.1016\/j.pnpbp.2019.109774_bb0230","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ntt.2014.06.001","article-title":"Molecular and morphological changes in zebrafish following transient ethanol exposure during defined developmental stages","volume":"44","author":"Zhang","year":"2014","journal-title":"Neurotoxicol. Teratol."}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027858461930541X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027858461930541X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T19:47:54Z","timestamp":1759520874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027858461930541X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":47,"alternative-id":["S027858461930541X"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2019.109774","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developmental stage and genotype dependent behavioral effects of embryonic alcohol exposure in zebrafish larvae","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2019.109774","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109774"}}