{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:10:03Z","timestamp":1793985003143,"version":"4.8.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"am","delay-in-days":272,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJOP1831"],"award-info":[{"award-number":["JPMJOP1831"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H00184"],"award-info":[{"award-number":["21H00184"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H05612"],"award-info":[{"award-number":["21H05612"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004169","name":"Meiji Seika Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004169","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008529","name":"Chiba University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008529","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001695","name":"Japan Science and Technology Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.pnpbp.2022.110652","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T12:59:54Z","timestamp":1664542794000},"page":"110652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["A role of gut\u2013microbiota\u2013brain axis via subdiaphragmatic vagus nerve in depression-like phenotypes in Chrna7 knock-out mice"],"prefix":"10.1016","volume":"120","author":[{"given":"Yong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youge","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2022.110652_bb0005","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev-immunol-020711-075015","article-title":"Reflex principles of immunological homeostasis","volume":"30","author":"Andersson","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0010","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.2147\/JIR.S324922","article-title":"Gut microbiota-derived inflammation-related serum metabolites as potential biomarkers for major depressive disorder","volume":"14","author":"Bai","year":"2021","journal-title":"J. Inflamm. Res."},{"issue":"7","key":"10.1016\/j.pnpbp.2022.110652_bb0015","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1038\/s41380-020-00913-1","article-title":"The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites","volume":"26","author":"Bartoli","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110652_bb0020","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fnins.2018.00049","article-title":"The vagus nerve at the interface of the microbiota-gut-brain axis","volume":"12","author":"Bonaz","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0025","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbi.2022.02.003","article-title":"Metabolomic and inflammatory signatures of symptom dimensions in major depression","volume":"102","author":"Brydges","year":"2022","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0030","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41398-021-01755-3","article-title":"Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder","volume":"11","author":"Caso","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110652_bb0035","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.brainres.2018.01.012","article-title":"Gut bacteria interaction with vagal afferents","volume":"1693","author":"Cawthon","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0040","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainresbull.2022.02.004","article-title":"Brain-gut-microbiota axis in depression: a historical overview and future directions","volume":"182","author":"Chang","year":"2022","journal-title":"Brain Res. Bull."},{"issue":"4","key":"10.1016\/j.pnpbp.2022.110652_bb0045","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/bs.irn.2015.07.001","article-title":"Neuronal nicotinic acetylcholine receptor structure and function and response to nicotine","volume":"124","author":"Dani","year":"2015","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0055","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1146\/annurev.pharmtox.47.120505.105214","article-title":"Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system","volume":"47","author":"Dani","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0060","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-4939-0897-4_5","article-title":"Vagal pathways for microbiome-brain-gut axis communication","volume":"817","author":"Forsythe","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0065","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/npp.2011.205","article-title":"Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior","volume":"37","author":"Haroon","year":"2012","journal-title":"Neuropsychopharmacology."},{"issue":"2","key":"10.1016\/j.pnpbp.2022.110652_bb0070","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.brainresrev.2009.05.005","article-title":"Emerging role of glutamate in the pathophysiology of major depressive disorder","volume":"61","author":"Hashimoto","year":"2009","journal-title":"Brain Res. Rev."},{"issue":"4","key":"10.1016\/j.pnpbp.2022.110652_bb0075","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.3390\/ijms16047796","article-title":"Inflammatory biomarkers as differential predictors of antidepressant response","volume":"16","author":"Hashimoto","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113935","article-title":"Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine","volume":"177","author":"Hashimoto","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.pnpbp.2022.110652_bb0085","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/pcn.13370","article-title":"Gut\u2013microbiota\u2013brain by bile acids in depression","volume":"76","author":"Hashimoto","year":"2022","journal-title":"Psychiatry Clin. Neurosci."},{"issue":"21","key":"10.1016\/j.pnpbp.2022.110652_bb0090","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1007\/s00213-017-4712-8","article-title":"Decreased serum L-arginine and L-citrulline levels in major depression","volume":"234","author":"Hess","year":"2017","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2022.110652_bb0095","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.pbb.2018.12.001","article-title":"Role of Actinobacteria and Coriobacteriia in the antidepressant effects of ketamine in an inflammation model of depression","volume":"176","author":"Huang","year":"2019","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0100","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered fecal microbiota composition in patients with major depressive disorder","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jpsychires.2016.07.019","article-title":"Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat","volume":"82","author":"Kelly","year":"2016","journal-title":"J. Psychiatr. Res."},{"issue":"2","key":"10.1016\/j.pnpbp.2022.110652_bb0110","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000504474","article-title":"Advances in the treatment of cholinergic anti-inflammatory pathways in gastrointestinal diseases by electrical stimulation of vagus nerve","volume":"102","author":"Lei","year":"2021","journal-title":"Digestion"},{"key":"10.1016\/j.pnpbp.2022.110652_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-022-01569-9","article-title":"Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression","author":"Li","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.pnpbp.2022.110652_bb0120","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41380-019-0474-5","article-title":"Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis","volume":"25","author":"Liu","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110652_bb0125","first-page":"1","article-title":"Nitric oxide synthase activity in major depressive episodes before and after antidepressant treatment: results of a large case-control treatment study","author":"Loeb","year":"2020","journal-title":"Psychol. Med."},{"issue":"3","key":"10.1016\/j.pnpbp.2022.110652_bb0130","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1124\/pharmrev.120.000043","article-title":"Aiding and abetting anhedonia: impact of inflammation on the brain and pharmacological implications","volume":"73","author":"Lucido","year":"2021","journal-title":"Pharmacol. Rev."},{"issue":"7","key":"10.1016\/j.pnpbp.2022.110652_bb0135","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1038\/s41380-020-00867-4","article-title":"The longitudinal associations of inflammatory biomarkers and depression revisited: systematic review, meta-analysis, and meta-regression","volume":"26","author":"Mac Giollabhui","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110652_bb0140","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.autneu.2013.12.007","article-title":"The cholinergic anti-inflammatory pathway: a critical review","volume":"182","author":"Martelli","year":"2014","journal-title":"Auton. Neurosci."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0145","doi-asserted-by":"crossref","first-page":"14290","DOI":"10.1038\/s41598-019-50807-8","article-title":"Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut-brain signalling","volume":"9","author":"McVey Neufeld","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.pnpbp.2022.110652_bb0155","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1001\/jamapsychiatry.2021.2573","article-title":"Perturbations in gut microbiota composition in psychiatric disorders: a review and meta-analysis","volume":"78","author":"Nikolova","year":"2021","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0160","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1600-065X.2012.01138.x","article-title":"Rethinking inflammation: neural circuits in the regulation of immunity","volume":"248","author":"Olofsson","year":"2012","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.pnpbp.2022.110652_bb0165","doi-asserted-by":"crossref","first-page":"R1118","DOI":"10.1152\/ajpregu.90904.2008","article-title":"Loss of vagal anti-inflammatory effect: in vivo visualization and adoptive transfer","volume":"297","author":"O\u2019Mahony","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"9","key":"10.1016\/j.pnpbp.2022.110652_bb0170","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/nmo.12153","article-title":"Altered colonic function and microbiota profile in a mouse model of chronic depression","volume":"25","author":"Park","year":"2013","journal-title":"Neurogastroenterol. Motil."},{"issue":"9","key":"10.1016\/j.pnpbp.2022.110652_bb0175","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.3390\/ijms22094912","article-title":"Cholinergic modulation of neuroinflammation: focus on \u03b17 nicotinic receptor","volume":"22","author":"Piovesana","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.pnpbp.2022.110652_bb0180","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1038\/s41380-020-0645-4","article-title":"An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder","volume":"26","author":"Pu","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110652_bb0185","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbi.2020.12.032","article-title":"A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes","volume":"94","author":"Pu","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0190","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41398-022-01993-z","article-title":"Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation","volume":"12","author":"Pu","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0195","doi-asserted-by":"crossref","first-page":"15725","DOI":"10.1038\/s41598-017-16060-7","article-title":"Comparison of (R)-ketamine and lanicemine on depression-like phenotype and abnormal composition of gut microbiota in a social defeat stress model","volume":"7","author":"Qu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2020.01.102","article-title":"Gut microbiota and major depressive disorder: a systematic review and meta-analysis","volume":"266","author":"Sanada","year":"2020","journal-title":"J. Affect. Disord."},{"issue":"4","key":"10.1016\/j.pnpbp.2022.110652_bb0205","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1021\/es5002105","article-title":"Identifying small molecules via high resolution mass spectrometry: communicating confidence","volume":"48","author":"Schymanski","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.pnpbp.2022.110652_bb0210","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"issue":"9","key":"10.1016\/j.pnpbp.2022.110652_bb0215","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.3390\/ijms23094951","article-title":"Soluble epoxide hydrolase as a therapeutic target for neuropsychiatric disorders","volume":"23","author":"Shan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0220","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41380-021-01306-8","article-title":"Inflammation and depression in young people: a systematic review and proposed inflammatory pathways","volume":"27","author":"Toenders","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.pnpbp.2022.110652_bb0225","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3390\/nu13030732","article-title":"The role of gut bacterial metabolites in brain development, aging and disease","volume":"13","author":"Tran","year":"2021","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.pnpbp.2022.110652_bb0230","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: data-independent MS\/MS deconvolution for comprehensive metabolome analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat. Methods"},{"issue":"8","key":"10.1016\/j.pnpbp.2022.110652_bb0235","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1797","article-title":"The vagus nerve and the nicotinic anti-inflammatory pathway","volume":"4","author":"Ulloa","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109139","article-title":"Effects of (R)-ketamine on reduced bone mineral density in ovariectomized mice: a role of gut microbiota","volume":"213","author":"Wan","year":"2022","journal-title":"Neuropharmacol."},{"issue":"7","key":"10.1016\/j.pnpbp.2022.110652_bb0245","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00406-022-01437-1","article-title":"Gut\u2013microbiota\u2013brain axis in the vulnerability to psychosis in adulthood after repeated cannabis exposure during adolescence","volume":"272","author":"Wan","year":"2022","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"6921","key":"10.1016\/j.pnpbp.2022.110652_bb0250","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor \u03b17 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0255","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12974-020-01916-z","article-title":"Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.pnpbp.2022.110652_bb0260","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jad.2019.09.064","article-title":"Antibiotic-induced microbiome depletion is associated with resilience in mice after chronic social defeat stress","volume":"260","author":"Wang","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0265","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jad.2021.06.006","article-title":"Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: a role of brain-gut-microbiota axis via the subdiaphragmatic vagus nerve","volume":"292","author":"Wang","year":"2021","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0270","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41380-021-01121-1","article-title":"Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor","volume":"27","author":"Wei","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110652_bb0275","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainresbull.2022.02.008","article-title":"Brain-spleen axis in health and diseases: a review and future perspective","volume":"182","author":"Wei","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0280","author":"WHO"},{"issue":"6","key":"10.1016\/j.pnpbp.2022.110652_bb0285","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/mp.2016.46","article-title":"Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition","volume":"21","author":"Wong","year":"2016","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.pnpbp.2022.110652_bb0290","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s10753-020-01396-6","article-title":"The role of \u03b17 nAChR-mediated cholinergic anti-inflammatory pathway in immune cells","volume":"44","author":"Wu","year":"2021","journal-title":"Inflammation."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0295","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13098-022-00795-z","article-title":"Plasma 1,5-anhydro-D-glucitol is associated with peripheral nerve function and diabetic peripheral neuropathy in patients with type 2 diabetes and mild-to-moderate hyperglycemia","volume":"14","author":"Xu","year":"2022","journal-title":"Diabetol. Metab. Syndr."},{"issue":"9","key":"10.1016\/j.pnpbp.2022.110652_bb0300","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.136","article-title":"R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects","volume":"5","author":"Yang","year":"2015","journal-title":"Transl. Psychiatry"},{"issue":"12","key":"10.1016\/j.pnpbp.2022.110652_bb0305","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/s41398-017-0031-4","article-title":"Possible role of the gut microbiota-brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model","volume":"7","author":"Yang","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0310","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41398-019-0379-8","article-title":"Key role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain","volume":"9","author":"Yang","year":"2019","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0315","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s10020-022-00483-8","article-title":"Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm","volume":"28","author":"Yang","year":"2022","journal-title":"Mol. Med."},{"issue":"3","key":"10.1016\/j.pnpbp.2022.110652_bb0320","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00406-021-01325-0","article-title":"Microglial depletion and abnormalities in gut microbiota composition and short-chain fatty acids in mice after repeated administration of colony stimulating factor 1 receptor inhibitor PLX5622","volume":"272","author":"Yang","year":"2022","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"4","key":"10.1016\/j.pnpbp.2022.110652_bb0325","first-page":"pyu077","article-title":"Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation","volume":"18","author":"Zhang","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"7","key":"10.1016\/j.pnpbp.2022.110652_bb0330","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2174\/1570159X14666160119094646","article-title":"Brain-derived neurotrophic factor (BDNF)-TrkB signaling in inflammation-related depression and potential therapeutic targets","volume":"14","author":"Zhang","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.pnpbp.2022.110652_bb0335","doi-asserted-by":"crossref","first-page":"36705","DOI":"10.1038\/srep36705","article-title":"Depression-like phenotype by deletion of \u03b17 nicotinic acetylcholine receptor: role of BDNF-TrkB in nucleus accumbens","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.pnpbp.2022.110652_bb0340","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.112","article-title":"Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut-microbiota-brain axis","volume":"7","author":"Zhang","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0345","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s41398-019-0571-x","article-title":"Abnormal composition of gut microbiota is associated with resilience versus susceptibility to inescapable electric stress","volume":"9","author":"Zhang","year":"2019","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110652_bb0350","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41398-020-00878-3","article-title":"A key role of the subdiaphragmatic vagus nerve in the depression-like phenotype and abnormal composition of gut microbiota in mice after lipopolysaccharide administration","volume":"10","author":"Zhang","year":"2020","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"10.1016\/j.pnpbp.2022.110652_bb0355","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/mp.2016.44","article-title":"Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host\u2019s metabolism","volume":"21","author":"Zheng","year":"2016","journal-title":"Mol. Psychiatry"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584622001440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584622001440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:24:11Z","timestamp":1778682251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584622001440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":71,"alternative-id":["S0278584622001440"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2022.110652","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A role of gut\u2013microbiota\u2013brain axis via subdiaphragmatic vagus nerve in depression-like phenotypes in Chrna7 knock-out mice","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2022.110652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110652"}}