{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:15:40Z","timestamp":1790518540137,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["HPF\/2010\/17"],"award-info":[{"award-number":["HPF\/2010\/17"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["TRA\/2007\/5"],"award-info":[{"award-number":["TRA\/2007\/5"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.pnpbp.2022.110656","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T02:11:53Z","timestamp":1665108713000},"page":"110656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Whole blood mitochondrial DNA copy number in depression and response to electroconvulsive therapy"],"prefix":"10.1016","volume":"121","author":[{"given":"Karen M.","family":"Ryan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eimear","family":"Doody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan M.","family":"McLoughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2022.110656_bb0005","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fnins.2018.00386","article-title":"Mitochondria and mood: mitochondrial dysfunction as a key player in the manifestation of depression","volume":"12","author":"Allen","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.pnpbp.2022.110656_bb0010","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bbi.2021.09.003","article-title":"Low peripheral mitochondrial DNA copy number during manic episodes of bipolar disorders is associated with disease severity and inflammation","volume":"98","author":"Angrand","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.pnpbp.2022.110656_bb0015","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3390\/cells8040328","article-title":"Circulating cell-free mtDNA contributes to AIM2 inflammasome-mediated chronic inflammation in patients with type 2 diabetes","volume":"8","author":"Bae","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0020","series-title":"Hamilton Rating Scale for Depression","author":"Beckham","year":"1985"},{"issue":"8","key":"10.1016\/j.pnpbp.2022.110656_bb0025","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1177\/0706743716648290","article-title":"Mitochondrial oxidative phosphorylation system (OXPHOS) deficits in schizophrenia: possible interactions with cellular processes","volume":"61","author":"Bergman","year":"2016","journal-title":"Can. J. Psychiatr."},{"issue":"9","key":"10.1016\/j.pnpbp.2022.110656_bb0030","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cub.2015.03.008","article-title":"Molecular signatures of major depression","volume":"25","author":"Cai","year":"2015","journal-title":"Curr. Biol."},{"issue":"24","key":"10.1016\/j.pnpbp.2022.110656_bb0035","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/j.cub.2015.10.065","article-title":"Genetic control over mtDNA and its relationship to major depressive disorder","volume":"25","author":"Cai","year":"2015","journal-title":"Curr. Biol."},{"issue":"5","key":"10.1016\/j.pnpbp.2022.110656_bb0040","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1084\/jem.20151876","article-title":"Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus","volume":"213","author":"Caielli","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pnpbp.2022.110656_bb0045","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.mito.2020.06.004","article-title":"Thinking outside the nucleus: mitochondrial DNA copy number in health and disease","volume":"53","author":"Castellani","year":"2020","journal-title":"Mitochondrion"},{"issue":"5","key":"10.1016\/j.pnpbp.2022.110656_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125855","article-title":"Mitochondria DNA change and oxidative damage in clinically stable patients with major depressive disorder","volume":"10","author":"Chang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2019.112616","article-title":"Investigation of mitochondrial DNA copy number in patients with major depressive disorder","volume":"282","author":"Chung","year":"2019","journal-title":"Psychiatry Res."},{"issue":"2","key":"10.1016\/j.pnpbp.2022.110656_bb0060","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/15622975.2019.1588993","article-title":"Mitochondrial DNA copy number, damage, repair and degradation in depressive disorder","volume":"21","author":"Czarny","year":"2020","journal-title":"World J. Biol. Psychiatry"},{"issue":"11","key":"10.1016\/j.pnpbp.2022.110656_bb0065","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.3390\/cells10112898","article-title":"Molecular Mechanisms of mtDNA-mediated inflammation","volume":"10","author":"De Gaetano","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.pnpbp.2022.110656_bb0070","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"de Kloet","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pnpbp.2022.110656_bb0075","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.toxlet.2016.07.001","article-title":"Fluoxetine and the mitochondria: a review of the toxicological aspects","volume":"258","author":"de Oliveira","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.pnpbp.2022.110656_bb0080","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pnpbp.2013.09.002","article-title":"Leukocyte mitochondrial DNA copy number in bipolar disorder","volume":"48","author":"de Sousa","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fimmu.2017.00081","article-title":"Neutrophil extracellular traps and its implications in inflammation: an overview","volume":"8","author":"Delgado-Rizo","year":"2017","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110656_bb0090","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0960-0760(95)00159-W","article-title":"The mitochondrion as a primary site of action of glucocorticoids: the interaction of the glucocorticoid receptor with mitochondrial DNA sequences showing partial similarity to the nuclear glucocorticoid responsive elements","volume":"55","author":"Demonacos","year":"1995","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"11","key":"10.1016\/j.pnpbp.2022.110656_bb0095","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/da.22517","article-title":"Chronicity of depression and molecular markers in a large sample of Han Chinese women","volume":"33","author":"Edwards","year":"2016","journal-title":"Depress. Anxiety"},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110656_bb0100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41398-021-01723-x","article-title":"Blood-based mitochondrial respiratory chain function in major depression","volume":"11","author":"Fernstrom","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"11","key":"10.1016\/j.pnpbp.2022.110656_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259591","article-title":"Plasma circulating cell-free mitochondrial DNA in depressive disorders","volume":"16","author":"Fernstrom","year":"2021","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.pnpbp.2022.110656_bb0110","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.tins.2019.07.002","article-title":"Anxiety and brain mitochondria: a bidirectional crosstalk","volume":"42","author":"Filiou","year":"2019","journal-title":"Trends Neurosci."},{"issue":"8","key":"10.1016\/j.pnpbp.2022.110656_bb0115","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/1873-3468.14021","article-title":"Mitochondrial DNA copy number in human disease: the more the better?","volume":"595","author":"Filograna","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pnpbp.2022.110656_bb0120","series-title":"Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV)","author":"First","year":"1996"},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110656_bb0125","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/npp.2016.125","article-title":"Danger signals and inflammasomes: stress-evoked sterile inflammation in mood disorders","volume":"42","author":"Fleshner","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"11","key":"10.1016\/j.pnpbp.2022.110656_bb0130","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1001\/jamapsychiatry.2021.2099","article-title":"The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study","volume":"78","author":"Giannakopoulou","year":"2021","journal-title":"JAMA Psychiatry"},{"issue":"11","key":"10.1016\/j.pnpbp.2022.110656_bb0135","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.1073\/pnas.77.11.6715","article-title":"Maternal inheritance of human mitochondrial DNA","volume":"77","author":"Giles","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pnpbp.2022.110656_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.546801","article-title":"The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment","volume":"12","author":"Gimenez-Palomo","year":"2021","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0145","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3389\/fimmu.2018.00832","article-title":"Mitochondrial damage-associated molecular patterns: from inflammatory signaling to human diseases","volume":"9","author":"Grazioli","year":"2018","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.pnpbp.2022.110656_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096869","article-title":"Leukocyte mitochondrial DNA copy number in blood is not associated with major depressive disorder in young adults","volume":"9","author":"He","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.pnpbp.2022.110656_bb0160","doi-asserted-by":"crossref","first-page":"E478","DOI":"10.1073\/pnas.1711950115","article-title":"Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C","volume":"115","author":"Ingelsson","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.pnpbp.2022.110656_bb0165","first-page":"1405","article-title":"Presence of glucocorticoid responsive elements in the mitochondrial genome","volume":"8","author":"Ioannou","year":"1988","journal-title":"Anticancer Res."},{"issue":"2","key":"10.1016\/j.pnpbp.2022.110656_bb0170","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1016\/j.archger.2010.11.019","article-title":"Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women","volume":"53","author":"Kim","year":"2011","journal-title":"Arch. Gerontol. Geriatr."},{"issue":"5","key":"10.1016\/j.pnpbp.2022.110656_bb0175","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1192\/bjp.2021.37","article-title":"Electroconvulsive therapy for depression: 80 years of progress","volume":"219","author":"Kirov","year":"2021","journal-title":"Brit. J. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0180","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neubiorev.2021.02.004","article-title":"Cognitive functioning and mental health in mitochondrial disease: a systematic scoping review","volume":"125","author":"Klein","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1\u20132","key":"10.1016\/j.pnpbp.2022.110656_bb0185","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10863-014-9584-6","article-title":"A mitochondrial bioenergetic basis of depression","volume":"47","author":"Klinedinst","year":"2015","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.pnpbp.2022.110656_bb0190","doi-asserted-by":"crossref","first-page":"18553","DOI":"10.1038\/srep18553","article-title":"Association of telomere length and mitochondrial DNA copy number with risperidone treatment response in first-episode antipsychotic-naive schizophrenia","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.pnpbp.2022.110656_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.236","article-title":"Increased plasma levels of circulating cell-free mitochondrial DNA in suicide attempters: associations with HPA-axis hyperactivity","volume":"6","author":"Lindqvist","year":"2016","journal-title":"Transl. Psychiatry"},{"issue":"7","key":"10.1016\/j.pnpbp.2022.110656_bb0200","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1038\/s41386-017-0001-9","article-title":"Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder","volume":"43","author":"Lindqvist","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0205","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fcell.2020.00467","article-title":"Mitophagy, mitochondrial homeostasis, and cell fate","volume":"8","author":"Ma","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"issue":"5","key":"10.1016\/j.pnpbp.2022.110656_bb0210","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.mito.2012.10.011","article-title":"Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?","volume":"13","author":"Malik","year":"2013","journal-title":"Mitochondrion"},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110656_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2011.06.067","article-title":"Mitochondrial DNA as a non-invasive biomarker: accurate quantification using real time quantitative PCR without co-amplification of pseudogenes and dilution bias","volume":"412","author":"Malik","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.pnpbp.2022.110656_bb0220","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3389\/fpsyt.2019.00974","article-title":"Cortisol and major depressive disorder-translating findings from humans to animal models and back","volume":"10","author":"Nandam","year":"2019","journal-title":"Front. Psychiatry"},{"issue":"7","key":"10.1016\/j.pnpbp.2022.110656_bb0225","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/mnfr.200700075","article-title":"Medication-induced mitochondrial damage and disease","volume":"52","author":"Neustadt","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"issue":"7397","key":"10.1016\/j.pnpbp.2022.110656_bb0230","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature10992","article-title":"Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure","volume":"485","author":"Oka","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0235","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neubiorev.2018.08.007","article-title":"Low on energy? An energy supply-demand perspective on stress and depression","volume":"94","author":"Ostergaard","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110656_bb0240","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1038\/s41598-017-03599-8","article-title":"Aberrant telomere length and mitochondrial DNA copy number in suicide completers","volume":"7","author":"Otsuka","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.pnpbp.2022.110656_bb0245","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.biopsych.2017.11.018","article-title":"Mitochondrial etiology of neuropsychiatric disorders","volume":"83","author":"Pei","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2021.06.010","article-title":"Blood mitochondrial DNA copy number: what are we counting?","volume":"60","author":"Picard","year":"2021","journal-title":"Mitochondrion"},{"issue":"2","key":"10.1016\/j.pnpbp.2022.110656_bb0255","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/PSY.0000000000000545","article-title":"Psychological stress and mitochondria: a systematic review","volume":"80","author":"Picard","year":"2018","journal-title":"Psychosom. Med."},{"issue":"3","key":"10.1016\/j.pnpbp.2022.110656_bb0260","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/cells10030537","article-title":"Cell death and inflammation: the role of mitochondria in health and disease","volume":"10","author":"Picca","year":"2021","journal-title":"Cells"},{"issue":"17","key":"10.1016\/j.pnpbp.2022.110656_bb0265","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899238","article-title":"Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis","volume":"37","author":"Riley","year":"2018","journal-title":"EMBO J."},{"issue":"12","key":"10.1016\/j.pnpbp.2022.110656_bb0270","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1017\/S0033291719002228","article-title":"Telomere length in depression and association with therapeutic response to electroconvulsive therapy and cognitive side-effects","volume":"50","author":"Ryan","year":"2020","journal-title":"Psychol. Med."},{"key":"10.1016\/j.pnpbp.2022.110656_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2022.114725","article-title":"Peripheral blood inflammatory markers in depression: response to electroconvulsive therapy and relationship with cognitive performance","volume":"315","author":"Ryan","year":"2022","journal-title":"Psychiatry Res."},{"issue":"5","key":"10.1016\/j.pnpbp.2022.110656_bb0280","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.brs.2018.05.011","article-title":"BDNF plasma levels and genotype in depression and the response to electroconvulsive therapy","volume":"11","author":"Ryan","year":"2018","journal-title":"Brain Stimul."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110656_bb0285","doi-asserted-by":"crossref","first-page":"11257","DOI":"10.1038\/s41598-017-10843-8","article-title":"Live imaging reveals the dynamics and regulation of mitochondrial nucleoids during the cell cycle in Fucci2-HeLa cells","volume":"7","author":"Sasaki","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.pnpbp.2022.110656_bb0290","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1176\/appi.ajp.2015.15030372","article-title":"Bitemporal versus high-dose unilateral twice-weekly electroconvulsive therapy for depression (EFFECT-Dep): a pragmatic, randomized, non-inferiority trial","volume":"173","author":"Semkovska","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0295","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jbiotec.2019.04.018","article-title":"Quantification of peripheral whole blood, cell-free plasma and exosome encapsulated mitochondrial DNA copy numbers in patients with atrial fibrillation","volume":"299","author":"Soltesz","year":"2019","journal-title":"J. Biotechnol."},{"issue":"11","key":"10.1016\/j.pnpbp.2022.110656_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113662","article-title":"Transcriptional evidence for the role of chronic venlafaxine treatment in neurotrophic signaling and neuroplasticity including also glutamatergic - and insulin-mediated neuronal processes","volume":"9","author":"Tamasi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0305","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3389\/fpsyt.2019.00312","article-title":"Mitochondrial DNA copy number raises the potential of left frontopolar hemodynamic response as a diagnostic marker for distinguishing bipolar disorder from major depressive disorder","volume":"10","author":"Tsujii","year":"2019","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0310","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.exger.2015.04.002","article-title":"Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults","volume":"66","author":"Tyrka","year":"2015","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.pnpbp.2022.110656_bb0315","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biopsych.2014.12.025","article-title":"Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology","volume":"79","author":"Tyrka","year":"2016","journal-title":"Biol. Psychiatry"},{"issue":"9360","key":"10.1016\/j.pnpbp.2022.110656_bb0320","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0140-6736(03)12705-5","article-title":"Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis","volume":"361","author":"UK ECT Review Group","year":"2003","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.pnpbp.2022.110656_bb0325","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/mp.2017.48","article-title":"Depression, telomeres and mitochondrial DNA: between- and within-person associations from a 10-year longitudinal study","volume":"23","author":"Verhoeven","year":"2018","journal-title":"Mol. Psychiatry"},{"issue":"8","key":"10.1016\/j.pnpbp.2022.110656_bb0330","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.euroneuro.2017.06.001","article-title":"Association of mitochondrial DNA in peripheral blood with depression, anxiety and stress- and adjustment disorders in primary health care patients","volume":"27","author":"Wang","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.pnpbp.2022.110656_bb0335","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12888-018-1717-8","article-title":"Differential mitochondrial DNA copy number in three mood states of bipolar disorder","volume":"18","author":"Wang","year":"2018","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0340","article-title":"Circulating brain-derived neurotrophic factor, antioxidant enzymes activities, and mitochondrial DNA in bipolar disorder: an exploratory report","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Psychiatry"},{"issue":"20","key":"10.1016\/j.pnpbp.2022.110656_bb0345","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.pnpbp.2022.110656_bb0350","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.psychres.2018.08.014","article-title":"Mitochondrial DNA copy number of peripheral blood in bipolar disorder: the present study and a meta-analysis","volume":"269","author":"Yamaki","year":"2018","journal-title":"Psychiatry Res."},{"issue":"9","key":"10.1016\/j.pnpbp.2022.110656_bb0355","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nm.1855","article-title":"Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense","volume":"14","author":"Yousefi","year":"2008","journal-title":"Nat. Med."}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584622001488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584622001488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:00:19Z","timestamp":1759521619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584622001488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":70,"alternative-id":["S0278584622001488"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2022.110656","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole blood mitochondrial DNA copy number in depression and response to electroconvulsive therapy","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2022.110656","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110656"}}