{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:44:26Z","timestamp":1786995866003,"version":"build-2736575974"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"MICINN","doi-asserted-by":"publisher","award":["PID-2020- 112672RB-100"],"award-info":[{"award-number":["PID-2020- 112672RB-100"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011597","name":"Generalitat Valenciana Conselleria de Sanitat","doi-asserted-by":"publisher","award":["CIPROM\/2021\/080"],"award-info":[{"award-number":["CIPROM\/2021\/080"]}],"id":[{"id":"10.13039\/501100011597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII","doi-asserted-by":"publisher","award":["RD21 \/0009\/0005"],"award-info":[{"award-number":["RD21 \/0009\/0005"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.pnpbp.2023.110722","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T09:51:08Z","timestamp":1674985868000},"page":"110722","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Oleoylethanolamide attenuates the stress-mediated potentiation of rewarding properties of cocaine associated with an increased TLR4 proinflammatory response"],"prefix":"10.1016","volume":"124","author":[{"given":"Macarena","family":"Gonz\u00e1lez-Portilla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Moya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Montagud-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Rodr\u00edguez","family":"de Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Orio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rodr\u00edguez-Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2023.110722_bb0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuroscience.2009.03.023","article-title":"Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats","volume":"161","author":"Anstrom","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0010","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/adb.12365","article-title":"Oleoylethanolamide prevents neuroimmune HMGB1\/TLR4\/NF-kB danger signaling in rat frontal cortex and depressive-like behavior induced by ethanol binge administration: OEA blocks ethanol TLR4 signaling","volume":"22","author":"Ant\u00f3n","year":"2017","journal-title":"Addict. Biol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0015","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1111\/bph.14501","article-title":"Alcohol binge disrupts the rat intestinal barrier: the partial protective role of oleoylethanolamide: OEA in ethanol-induced gut dysfunction","volume":"175","author":"Ant\u00f3n","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0020","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.drugalcdep.2017.08.003","article-title":"Glial and neuroinflammatory targets for treating substance use disorders","volume":"180","author":"Bachtell","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0025","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36401","article-title":"Normal cognitive and social development require posterior cerebellar activity","volume":"7","author":"Badura","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0030","first-page":"R1180","article-title":"Repeated social defeat increases the bactericidal activity of splenic macrophages through a toll-like receptor-dependent pathway","volume":"293","author":"Bailey","year":"2007","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110123","article-title":"Neuroinflammatory and behavioral susceptibility profile of mice exposed to social stress towards cocaine effects","volume":"105","author":"Ballest\u00edn","year":"2021","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0040","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/adb.12006","article-title":"Oleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPAR\u03b1 receptor-independent mechanism: OEA-PPAR\u03b1 and cocaine","volume":"18","author":"Bilbao","year":"2013","journal-title":"Addict. Biol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0045","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/adb.12276","article-title":"Role of the satiety factor oleoylethanolamide in alcoholism: Oleoylethanolamide and alcohol","volume":"21","author":"Bilbao","year":"2016","journal-title":"Addict. Biol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0050","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1007\/s00213-019-05256-6","article-title":"Pharmacological modulation of the behavioral effects of social defeat in memory and learning in male mice","volume":"236","author":"Blanco-Gandia","year":"2019","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0055","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.biopsych.2006.12.001","article-title":"Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress","volume":"62","author":"Bortolato","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0060","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1089\/can.2019.0041","article-title":"Chronic psychosocial stress causes increased anxiety-like behavior and alters endocannabinoid levels in the brain of C57B l \/6J mice","volume":"5","author":"Bouter","year":"2020","journal-title":"Cannabis and Cannabinoid Research"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0065","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0070","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/add.15242","article-title":"Pharmacotherapeutic strategies for treating cocaine use disorder\u2014what do we have to offer?","volume":"116","author":"Brandt","year":"2021","journal-title":"Addiction"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnpbp.2013.12.002","article-title":"Changes in endocannabinoid and N-acylethanolamine levels in rat brain structures following cocaine self-administration and extinction training","volume":"50","author":"Bystrowska","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0080","doi-asserted-by":"crossref","first-page":"eaav0581","DOI":"10.1126\/science.aav0581","article-title":"Cerebellar modulation of the reward circuitry and social behavior","volume":"363","author":"Carta","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0085","doi-asserted-by":"crossref","DOI":"10.1515\/RNS.2011.044","article-title":"Structural and synaptic plasticity in stress-related disorders","volume":"22","author":"Christoffel","year":"2011","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neubiorev.2020.01.001","article-title":"Can cocaine-induced neuroinflammation explain maladaptive cocaine-associated memories?","volume":"111","author":"Correia","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0095","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s002130100858","article-title":"Repeated social-defeat stress, cocaine or morphine","volume":"158","author":"Covington","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0100","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.neuron.2011.06.007","article-title":"A role for repressive histone methylation in cocaine-induced vulnerability to stress","volume":"71","author":"Covington","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2023.110722_bib399","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neuropharm.2018.11.011","article-title":"Oxytocin prevents the increase of cocaine-related responses produced by social defeat","volume":"146","author":"Ferrer-P\u00e9rez","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209291","article-title":"Indomethacin blocks the increased conditioned rewarding effects of cocaine induced by repeated social defeat","volume":"13","author":"Ferrer-P\u00e9rez","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0110","series-title":"The Mouse Brain in Stereotaxic Coordinates, Compact","author":"Franklin","year":"2008"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0115","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pnpbp.2015.06.006","article-title":"Long-term effects of repeated social stress on the conditioned place preference induced by MDMA in mice","volume":"63","author":"Garc\u00eda-Pardo","year":"2015","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108753","article-title":"Decreased kynurenine pathway potentiate resilience to social defeat effect on cocaine reward","volume":"197","author":"Gim\u00e9nez-G\u00f3mez","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0125","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.nbd.2013.10.008","article-title":"Oleoylethanolamide reduces L-DOPA-induced dyskinesia via TRPV1 receptor in a mouse model of Parkinson\u2019s disease","volume":"62","author":"Gonz\u00e1lez-Aparicio","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0130","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.3390\/ijms22105279","article-title":"Pairing binge drinking and a high-fat diet in adolescence modulates the inflammatory effects of subsequent alcohol consumption in mice","volume":"22","author":"Gonz\u00e1lez-Portilla","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0135","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ijdevneu.2018.11.006","article-title":"Impact of neuroimmune activation induced by alcohol or drug abuse on adolescent brain development","volume":"77","author":"Guerri","year":"2019","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0140","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/npp.2011.205","article-title":"Psychoneuroimmunology meets Neuropsychopharmacology: translational implications of the impact of inflammation on behavior","volume":"37","author":"Haroon","year":"2012","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0145","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2217\/epi.12.34","article-title":"The lasting legacy of social stress on the epigenome of the hypothalamic\u2013pituitary\u2013adrenal axis","volume":"4","author":"Hoffmann","year":"2012","journal-title":"Epigenomics"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0150","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.pbb.2015.04.001","article-title":"Antidepressant-like effects of oleoylethanolamide in a mouse model of chronic unpredictable mild stress","volume":"133","author":"Jin","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0155","doi-asserted-by":"crossref","first-page":"12921","DOI":"10.1038\/s41598-018-31242-7","article-title":"Oleoylethanolamide treatment reduces neurobehavioral deficits and brain pathology in a mouse model of gulf war illness","volume":"8","author":"Joshi","year":"2018","journal-title":"Sci. Rep."},{"issue":"33","key":"10.1016\/j.pnpbp.2023.110722_bb0160","doi-asserted-by":"crossref","first-page":"8865","DOI":"10.1073\/pnas.1705974114","article-title":"Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior","volume":"114","author":"Kashima","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0170","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pbb.2019.01.007","article-title":"Neuroinflammation in addiction: a review of neuroimaging studies and potential immunotherapies","volume":"179","author":"Kohno","year":"2019","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2012.00121","article-title":"The effects of psychostimulant drugs on blood brain barrier function and neuroinflammation","volume":"3","author":"Kousik","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0180","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3389\/fncel.2015.00279","article-title":"Cocaine promotes oxidative stress and microglial-macrophage activation in rat cerebellum","volume":"9","author":"L\u00f3pez-Pedrajas","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.pnpbp.2023.110722_bb0185","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/01.fbp.0000190685.84984.ec","article-title":"Gamma-hydroxybutyric acid affects the acquisition and reinstatement of cocaine-induced conditioned place preference in mice","volume":"17","author":"Maldonado","year":"2006","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0190","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.biopsych.2010.07.009","article-title":"Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors","volume":"69","author":"Mascia","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0195","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/sj.npp.1300872","article-title":"Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system","volume":"31","author":"McLaughlin","year":"2006","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0200","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.pharmthera.2008.07.006","article-title":"Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake","volume":"120","author":"Miczek","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0205","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s002130050829","article-title":"Behavioral sensitization to cocaine after a brief social defeat stress: c-fos expression in the PAG","volume":"141","author":"Miczek","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0210","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.molmed.2017.12.010","article-title":"Central and peripheral biomarkers of stress response for addiction risk and relapse vulnerability","volume":"24","author":"Milivojevic","year":"2018","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2020.586574","article-title":"The cerebellum on cocaine","volume":"14","author":"Miquel","year":"2020","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0220","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pnpbp.2016.07.008","article-title":"Role of dopamine neurotransmission in the long-term effects of repeated social defeat on the conditioned rewarding effects of cocaine","volume":"71","author":"Montagud-Romero","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0225","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1111\/ejn.14127","article-title":"Social defeat stress: mechanisms underlying the increase in rewarding effects of drugs of abuse","volume":"48","author":"Montagud-Romero","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2019.109753","article-title":"Social defeat-induced increase in the conditioned rewarding effects of cocaine: role of CX3CL1","volume":"96","author":"Montagud-Romero","year":"2020","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2023.110722_bib396","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1007\/s00213-017-4612-y","article-title":"Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB receptor in the mesolimbic system","volume":"234","author":"Montagud-Romero","year":"2017","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108368","article-title":"Critical role of TLR4 in uncovering the increased rewarding effects of cocaine and ethanol induced by social defeat in male mice","volume":"182","author":"Montagud-Romero","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0240","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbi.2015.12.006","article-title":"Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence","volume":"53","author":"Montesinos","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110190","article-title":"Cerebellar and cortical TLR4 activation and behavioral impairments in Wernicke-Korsakoff syndrome: pharmacological effects of oleoylethanolamide","volume":"108","author":"Moya","year":"2021","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0250","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.coph.2006.01.010","article-title":"Understanding and exploiting the endogenous interleukin-10\/STAT3-mediated anti-inflammatory response","volume":"6","author":"Murray","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0255","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.650785","article-title":"Neuroimmune mechanisms as novel treatment targets for substance use disorders and associated comorbidities","volume":"15","author":"Namba","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0260","author":"National Institute on Drug Abuse (NIDA)"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0265","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00213-012-2853-3","article-title":"Emotional valence and context of social influences on drug abuse-related behavior in animal models of social stress and prosocial interaction","volume":"224","author":"Neisewander","year":"2012","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0270","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.neuron.2018.06.035","article-title":"The innate immune receptors TLR2\/4 mediate repeated social defeat stress-induced social avoidance through prefrontal microglial activation","volume":"99","author":"Nie","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0275","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1038\/mp.2014.177","article-title":"DAT isn\u2019t all that: cocaine reward and reinforcement require toll-like receptor 4 signaling","volume":"20","author":"Northcutt","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0280","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/1673-5374.264457","article-title":"The multifaceted potential of the lipid transmitter oleoylethanolamide to treat alcohol-induced neuroinflammation and alcohol use disorders","volume":"15","author":"Orio","year":"2020","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0285","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3389\/fnmol.2018.00490","article-title":"Oleoylethanolamide, Neuroinflammation, and alcohol abuse","volume":"11","author":"Orio","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0290","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/syn.20733","article-title":"Effects of the endogenous PPAR-\u00ce\u00b1 agonist, oleoylethanolamide on MDMA-induced cognitive deficits in mice","volume":"64","author":"Plaza-Zabala","year":"2010","journal-title":"Synapse"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0295","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/10409238.2015.1092944","article-title":"Macrophage-derived lipid agonists of PPAR- \u03b1 as intrinsic controllers of inflammation","volume":"51","author":"Pontis","year":"2016","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2021.100317","article-title":"Brain histamine and oleoylethanolamide restore behavioral deficits induced by chronic social defeat stress in mice","volume":"14","author":"Rani","year":"2021","journal-title":"Neurobiology of Stress"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0305","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2017.01.039","article-title":"Dopamine D2 receptors mediate the increase in reinstatement of the conditioned rewarding effects of cocaine induced by acute social defeat","volume":"799","author":"Reguil\u00f3n","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2020.108004","article-title":"Voluntary wheel running protects against the increase in ethanol consumption induced by social stress in mice","volume":"212","author":"Reguil\u00f3n","year":"2020","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2020.104875","article-title":"Oxytocin reverses ethanol consumption and neuroinflammation induced by social defeat in male mice","volume":"127","author":"Reguil\u00f3n","year":"2021","journal-title":"Horm. Behav."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0320","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/35102582","article-title":"An anorexic lipid mediator regulated by feeding","volume":"414","author":"Rodr\u00edguez de Fonseca","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0325","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.731910","article-title":"Effects of alcohol binge drinking and Oleoylethanolamide pretreatment in the gut microbiota","volume":"11","author":"Rodr\u00edguez-Gonz\u00e1lez","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0330","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyu111","article-title":"Systemic administration of oleoylethanolamide protects from neuroinflammation and anhedonia induced by LPS in rats","volume":"18","author":"Sayd","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0335","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1038\/sj.npp.1301346","article-title":"Cerebellar gray matter volume correlates with duration of cocaine use in cocaine-dependent subjects","volume":"32","author":"Sim","year":"2007","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0345","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fnbeh.2017.00207","article-title":"Microglial over-activation by social defeat stress contributes to anxiety- and depressive-like behaviors","volume":"11","author":"Stein","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0350","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.15448","article-title":"Repeated social defeat stress enhances glutamatergic synaptic plasticity in the VTA and cocaine place conditioning","volume":"5","author":"Stelly","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0355","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s11745-008-3217-y","article-title":"Biological functions and metabolism of Oleoylethanolamide","volume":"43","author":"Thabuis","year":"2008","journal-title":"Lipids"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0360","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1007\/s00213-015-4072-1","article-title":"Cocaine-induced plasticity in the cerebellum of sensitised mice","volume":"232","author":"Vazquez-Sanroman","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0365","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/ijnp\/pyab070","article-title":"Alterations of stress-related glucocorticoids and endocannabinoids in hair of chronic cocaine users","volume":"25","author":"Voegel","year":"2022","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0370","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/npp.2016.102","article-title":"Repeated social defeat, Neuroinflammation, and behavior: monocytes carry the signal","volume":"42","author":"Weber","year":"2017","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0375","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1523\/JNEUROSCI.0450-11.2011","article-title":"Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat","volume":"31","author":"Wohleb","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0380","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.psyneuen.2012.02.003","article-title":"Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice","volume":"37","author":"Wohleb","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0385","doi-asserted-by":"crossref","first-page":"34611","DOI":"10.1038\/srep34611","article-title":"Oleoylethanolamide exerts anti-inflammatory effects on LPS-induced THP-1 cells by enhancing PPAR\u03b1 signaling and inhibiting the NF-\u03baB and ERK1\/2\/AP-1\/STAT3 pathways","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pnpbp.2023.110722_bb0390","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1525","article-title":"Effect of toll-like receptor 4 on depressive-like behaviors induced by chronic social defeat stress","volume":"10","author":"Zhang","year":"2020","journal-title":"Brain Behav"},{"key":"10.1016\/j.pnpbp.2023.110722_bb0395","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00210-016-1309-4","article-title":"Oleoylethanolamide attenuates apoptosis by inhibiting the TLR4\/NF-\u03baB and ERK1\/2 signaling pathways in mice with acute ischemic stroke","volume":"390","author":"Zhou","year":"2017","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"10","key":"10.1016\/j.pnpbp.2023.110722_bib398","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206421","article-title":"Social stress during adolescence activates long-term microglia inflammation insult in reward processing nuclei","volume":"13","author":"Rodr\u00edguez-Arias","year":"2018","journal-title":"PLoS One"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584623000088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584623000088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:41:52Z","timestamp":1777545712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584623000088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":81,"alternative-id":["S0278584623000088"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2023.110722","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oleoylethanolamide attenuates the stress-mediated potentiation of rewarding properties of cocaine associated with an increased TLR4 proinflammatory response","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2023.110722","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110722"}}