{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:44:52Z","timestamp":1786995892590,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.pnpbp.2024.111178","type":"journal-article","created":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T10:11:52Z","timestamp":1729419112000},"page":"111178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Cannabidiol exerts antipyretic effects by downmodulating inflammatory mediators in LPS-induced fever"],"prefix":"10.1016","volume":"136","author":[{"given":"Emilly S.S.","family":"Andres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Passaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanderson S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis P.","family":"Trajano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Nery","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Miranda","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauce C.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Del-Bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz G.S.","family":"Branco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2024.111178_bb0005","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12974-019-1512-6","article-title":"Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation","volume":"16","author":"Amorim","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.pnpbp.2024.111178_bb0010","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1038\/s41598-020-63949-x","article-title":"Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation","volume":"10","author":"Amorim","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0015","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1113\/JP280321","article-title":"Increased lipopolysaccharide-induced hypothermia in neurogenic hypertension is caused by reduced hypothalamic PGE 2 production and increased heat loss","volume":"598","author":"Amorim","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1165\/ajrcmb.17.1.f132","article-title":"The role of nuclear factor- \u03ba B in cytokine gene regulation","volume":"17","author":"Blackwell","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0025","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1038\/s41598-020-60193-1","article-title":"Comparison of fever-reducing effects in self-reported data from the Mobile app: antipyretic drugs in pediatric patients","volume":"10","author":"Choi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0030","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.bcp.2006.07.016","article-title":"Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure\u2013activity relationship","volume":"72","author":"Comalada","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0035","article-title":"Cannflavin a inhibits TLR4-induced chemokine and cytokine expression in human macrophages","volume":"1\u20137","author":"Fitzpatrick","year":"2024","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/bph.16383","article-title":"Single nucleotide polymorphisms in the cannabinoid CB 2 receptor: molecular pharmacology and disease associations","author":"Foyzun","year":"2024","journal-title":"British Aust. J. Pharm."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0045","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0050","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.3390\/ijms25074050","article-title":"Potential therapeutic targets to modulate the endocannabinoid system in Alzheimer\u2019s disease","volume":"25","author":"Kanwal","year":"2024","journal-title":"IJMS"},{"key":"10.1016\/j.pnpbp.2024.111178_bb0055","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3390\/ijms20030668","article-title":"Cannabinoids reduce inflammation but inhibit lymphocyte recovery in murine models of bone marrow transplantation","volume":"20","author":"Khuja","year":"2019","journal-title":"IJMS"},{"key":"10.1016\/j.pnpbp.2024.111178_bb0060","first-page":"R81","article-title":"An antipyretic role for interleukin-10 in LPS fever in mice","volume":"276","author":"Leon","year":"1999","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0065","article-title":"Cannabidiol in the dorsal hippocampus attenuates emotional and cognitive impairments related to neuropathic pain: role of prelimbic neocortex-hippocampal connections","volume":"111039","author":"Medeiros","year":"2024","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2024.111178_bb0070","first-page":"R375","article-title":"Neural control of the spleen as an effector of immune responses to inflammation: mechanisms and treatments","volume":"323","author":"Mota","year":"2022","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0075","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.bbi.2017.07.010","article-title":"Central serotonin attenuates LPS-induced systemic inflammation","volume":"66","author":"Mota","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0080","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.brainresbull.2018.05.024","article-title":"Central fractalkine stimulates central prostaglandin E2 production and induces systemic inflammatory responses","volume":"140","author":"Mota","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0085","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbi.2019.03.017","article-title":"Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation","volume":"80","author":"Mota","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0090","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4155\/fmc.09.93","article-title":"Cannabinoids as novel anti-inflammatory drugs","volume":"1","author":"Nagarkatti","year":"2009","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2019.102411","article-title":"Splenic anti-inflammatory reflex in immune tolerance","volume":"85","author":"Nogueira","year":"2019","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0100","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbi.2024.03.037","article-title":"Diminazene aceturate attenuates systemic inflammation via microbiota gut-5-HT brain-spleen sympathetic axis in male mice","volume":"119","author":"Passaglia","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0105","first-page":"C1097","article-title":"Corticosterone inhibits vagal afferent glutamate release in the nucleus of the solitary tract via retrograde endocannabinoid signaling","volume":"319","author":"Ragozzino","year":"2020","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0110","first-page":"R223","article-title":"Sex differences and the role of ovarian hormones in site-specific nociception of SHR","volume":"317","author":"Santos","year":"2019","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0115","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13373","article-title":"Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down-modulating PGE 2 production","volume":"228","author":"Santos","year":"2020","journal-title":"Acta Physiol."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2023.105734","article-title":"Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats","volume":"152","author":"Santos","year":"2023","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0125","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nn.3159","article-title":"Neural circuitry engaged by prostaglandins during the sickness syndrome","volume":"15","author":"Saper","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110701","article-title":"The sex-dependent and enduring impact of pubertal stress on health and disease","volume":"200","author":"Smith","year":"2023","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0135","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jneuroim.2010.04.018","article-title":"Reduced stress fever is accompanied by increased glucocorticoids and reduced PGE2 in adult rats exposed to endotoxin as neonates","volume":"225","author":"Soriano","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114504","article-title":"Cannabidiol attenuates the expression of conditioned place aversion induced by naloxone-precipitated morphine withdrawal through the activation of 5-HT1A receptors","volume":"450","author":"Souza","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0145","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1124\/dmd.108.020909","article-title":"Cannabidiolic acid as a selective Cyclooxygenase-2 inhibitory component in Cannabis","volume":"36","author":"Takeda","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0150","doi-asserted-by":"crossref","first-page":"834","DOI":"10.3390\/cells13100834","article-title":"Sex differences in visceral pain and comorbidities: clinical outcomes, preclinical models, and cellular and molecular mechanisms","volume":"13","author":"Tiwari","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.pnpbp.2024.111178_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.926696","article-title":"Cannabidiol modulates expression of type I IFN response genes and HIV infection in macrophages","volume":"13","author":"Tomer","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.pnpbp.2024.111178_bb0160","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2024.111178_bb0165","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/08916930500356674","article-title":"Cannabidiol lowers incidence of diabetes in non-obese diabetic mice","volume":"39","author":"Weiss","year":"2006","journal-title":"Autoimmunity"},{"key":"10.1016\/j.pnpbp.2024.111178_bb0170","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1111\/epi.12426","article-title":"Hippocampal volume loss following childhood convulsive status epilepticus is not limited to prolonged febrile seizures","volume":"54","author":"Yoong","year":"2013","journal-title":"Epilepsia"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027858462400246X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027858462400246X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T11:05:27Z","timestamp":1745838327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027858462400246X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":34,"alternative-id":["S027858462400246X"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2024.111178","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabidiol exerts antipyretic effects by downmodulating inflammatory mediators in LPS-induced fever","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2024.111178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111178"}}