{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:21:07Z","timestamp":1783646467118,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2405605"],"award-info":[{"award-number":["2022YFC2405605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M721681"],"award-info":[{"award-number":["2022M721681"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20231126"],"award-info":[{"award-number":["BK20231126"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20701"],"award-info":[{"award-number":["U24A20701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20700"],"award-info":[{"award-number":["U24A20700"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"publisher","award":["STG1\/M-501\/23-N"],"award-info":[{"award-number":["STG1\/M-501\/23-N"]}],"id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["ZD2021026"],"award-info":[{"award-number":["ZD2021026"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.pnpbp.2025.111460","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T22:36:30Z","timestamp":1753569390000},"page":"111460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Uric acid metabolism and brain dysfunction linking childhood maltreatment to self-harm in adolescents with mood disorders"],"prefix":"10.1016","volume":"141","author":[{"given":"Yufei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshuai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuenan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.pnpbp.2025.111460_bb0005","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1073\/pnas.78.11.6858","article-title":"Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer: a hypothesis","volume":"78","author":"Ames","year":"1981","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0010","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.genhosppsych.2017.09.002","article-title":"Testing the role of the antioxidant uric acid as a biomarker of suicidal ideation in subjects with major affective disorders: an exploratory study","volume":"51","author":"Bartoli","year":"2018","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.pnpbp.2025.111460_bb0015","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00406-017-0817-7","article-title":"Antioxidant uric acid in treated and untreated subjects with major depressive disorder: a meta-analysis and meta-regression","volume":"268","author":"Bartoli","year":"2018","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.pnpbp.2025.111460_bb0020","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3390\/brainsci10030160","article-title":"Purinergic signaling and related biomarkers in depression","volume":"10","author":"Bartoli","year":"2020","journal-title":"Brain Sci."},{"issue":"2","key":"10.1016\/j.pnpbp.2025.111460_bb0025","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0145-2134(02)00541-0","article-title":"Development and validation of a brief screening version of the childhood trauma questionnaire","volume":"27","author":"Bernstein","year":"2003","journal-title":"Child Abuse Negl."},{"issue":"4","key":"10.1016\/j.pnpbp.2025.111460_bb0030","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.3233\/JAD-2010-1330","article-title":"Uric acid as a CNS antioxidant","volume":"19","author":"Bowman","year":"2010","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"11","key":"10.1016\/j.pnpbp.2025.111460_bb0035","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/s41386-023-01596-2","article-title":"Genetic, environmental, and behavioral correlates of lifetime suicide attempt: analysis of additive and interactive effects in two cohorts of US Army soldiers","volume":"48","author":"Campbell-Sills","year":"2023","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.pnpbp.2025.111460_bb0040","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.yebeh.2010.04.018","article-title":"Suicidality and brain volumes in pediatric epilepsy","volume":"18","author":"Caplan","year":"2010","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0045","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00787-018-01270-9","article-title":"Psychosocial risk factors for suicidality in children and adolescents","volume":"29","author":"Carballo","year":"2020","journal-title":"Eur. Child Adolesc. Psychiatry"},{"issue":"2","key":"10.1016\/j.pnpbp.2025.111460_bb0050","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1503\/jpn.170226","article-title":"Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands","volume":"44","author":"Chang","year":"2019","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12888-020-02891-8","article-title":"Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study","volume":"20","author":"Chen","year":"2020","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.pnpbp.2025.111460_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2024.115795","article-title":"Abnormal energy metabolism, oxidative stress, and polyunsaturated fatty acid metabolism in depressed adolescents associated with childhood maltreatment: a targeted metabolite analysis","volume":"335","author":"Chen","year":"2024","journal-title":"Psychiatry Res."},{"issue":"9","key":"10.1016\/j.pnpbp.2025.111460_bb0065","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jaac.2018.06.008","article-title":"Spontaneous thoughts and brain connectivity: possible links between early maltreatment and later depression","volume":"57","author":"Cullen","year":"2018","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"issue":"1","key":"10.1016\/j.pnpbp.2025.111460_bb0070","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0010-9452(80)80026-8","article-title":"Memory function in focal epilepsy: a comparison of non-surgical, unilateral temporal lobe and frontal lobe samples","volume":"16","author":"Delaney","year":"1980","journal-title":"Cortex"},{"issue":"1","key":"10.1016\/j.pnpbp.2025.111460_bb0075","doi-asserted-by":"crossref","first-page":"25338","DOI":"10.1038\/srep25338","article-title":"Early life stress affects limited regional brain activity in depression","volume":"6","author":"Du","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0080","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biopsycho.2015.09.003","article-title":"Childhood trauma and parental style: relationship with markers of inflammation, oxidative stress, and aggression in healthy and personality disordered subjects","volume":"112","author":"Fanning","year":"2015","journal-title":"Biol. Psychol."},{"issue":"10","key":"10.1016\/j.pnpbp.2025.111460_bb0085","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1007\/s00787-023-02264-y","article-title":"The prevalence of self-injury in adolescence: a systematic review and meta-analysis","volume":"33","author":"Farkas","year":"2024","journal-title":"Eur. Child Adolesc. Psychiatry"},{"issue":"8","key":"10.1016\/j.pnpbp.2025.111460_bb0090","first-page":"782","article-title":"Burden of mental disorders and suicide attributable to childhood maltreatment","volume":"81","author":"Grummitt","year":"2024","journal-title":"J. Am. Med. Assoc. Psychiatr."},{"issue":"1","key":"10.1016\/j.pnpbp.2025.111460_bb0095","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br. J. Med. Psychol."},{"issue":"12","key":"10.1016\/j.pnpbp.2025.111460_bb0100","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/j.1469-7610.2012.02559.x","article-title":"Repetition of self-harm and suicide following self-harm in children and adolescents: findings from the multicentre study of self-harm in England","volume":"53","author":"Hawton","year":"2012","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2025.111460_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2025.111949","article-title":"Neural indices of cognitive reappraisal impact the association between childhood trauma and suicide risk in adulthood","volume":"348","author":"Jenkins","year":"2025","journal-title":"Psychiatry Res. Neuroimaging"},{"issue":"10","key":"10.1016\/j.pnpbp.2025.111460_bb0110","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41386-020-0753-5","article-title":"Structural\u2013functional decoupling predicts suicide attempts in bipolar disorder patients with a current major depressive episode","volume":"45","author":"Jiang","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.pnpbp.2025.111460_bb0115","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41386-020-0753-5","article-title":"Structural-functional decoupling predicts suicide attempts in bipolar disorder patients with a current major depressive episode","volume":"45","author":"Jiang","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"7","key":"10.1016\/j.pnpbp.2025.111460_bb0120","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/00004583-199707000-00021","article-title":"Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data","volume":"36","author":"Kaufman","year":"1997","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.pnpbp.2025.111460_bb0125","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jad.2024.06.012","article-title":"Childhood maltreatment and suicide attempts in major depression and bipolar disorders in South Korea: a prospective nationwide cohort study","volume":"361","author":"Kim","year":"2024","journal-title":"J. Affect. Disord."},{"issue":"3","key":"10.1016\/j.pnpbp.2025.111460_bb0130","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.neuroimage.2009.05.087","article-title":"An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatment","volume":"47","author":"Kong","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.pnpbp.2025.111460_bb0135","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.2147\/NDT.S368471","article-title":"Association between serum uric acid levels and suicide attempts in adolescents and young adults with major depressive disorder: a retrospective study","author":"Kong","year":"2022","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0140","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.2147\/NDT.S368471","article-title":"Association between serum uric acid levels and suicide attempts in adolescents and young adults with major depressive disorder: a retrospective study","volume":"18","author":"Kong","year":"2022","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"9","key":"10.1016\/j.pnpbp.2025.111460_bb0145","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3390\/brainsci12091121","article-title":"Altered regional homogeneity and amplitude of low-frequency fluctuations induced by electroconvulsive therapy for adolescents with depression and suicidal ideation","volume":"12","author":"Li","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0150","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.biochi.2015.06.025","article-title":"Uric acid as a modulator of glucose and lipid metabolism","volume":"116","author":"Lima","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.pnpbp.2025.111460_bb0155","doi-asserted-by":"crossref","first-page":"5151168","DOI":"10.1155\/2021\/5151168","article-title":"Protective effect of uric acid on ox-LDL-induced HUVECs injury via Keap1-Nrf2-ARE pathway","volume":"2021","author":"Lin","year":"2021","journal-title":"J Immunol Res"},{"issue":"8","key":"10.1016\/j.pnpbp.2025.111460_bb0160","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1176\/appi.ajp.19010020","article-title":"The devastating clinical consequences of child abuse and neglect: increased disease vulnerability and poor treatment response in mood disorders","volume":"180","author":"Lippard","year":"2023","journal-title":"Am. J. Psychiatry"},{"issue":"2\u20133","key":"10.1016\/j.pnpbp.2025.111460_bb0165","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jad.2005.01.016","article-title":"Life events, psychopathology, and suicidal behavior in Chinese adolescents","volume":"86","author":"Liu","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0170","doi-asserted-by":"crossref","first-page":"1470380","DOI":"10.1155\/2021\/1470380","article-title":"The role of oxidative stress in hyperuricemia and xanthine oxidoreductase (XOR) inhibitors","volume":"2021","author":"Liu","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.pnpbp.2025.111460_bb0175","article-title":"Phosphatidylserine decarboxylase downregulation in uric acid-induced hepatic mitochondrial dysfunction and apoptosis","volume":"4","author":"Liu","year":"2023","journal-title":"MedComm (2020)"},{"key":"10.1016\/j.pnpbp.2025.111460_bb0180","article-title":"Aberrant static and dynamic functional connectivity of amygdala subregions in patients with major depressive disorder and childhood maltreatment","volume":"36","author":"Luo","year":"2022","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.pnpbp.2025.111460_bb0185","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s12916-024-03479-9","article-title":"Associations of serum uric acid variability with neuroimaging metrics and cognitive decline: a population-based cohort study","volume":"22","author":"Lv","year":"2024","journal-title":"BMC Med."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2377-10-61","article-title":"Association of childhood trauma with cognitive function in healthy adults: a pilot study","volume":"10","author":"Majer","year":"2010","journal-title":"BMC Neurol."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0195","first-page":"48","article-title":"The impact of childhood maltreatment: a review of neurobiological and genetic factors","volume":"2","author":"McCrory","year":"2011","journal-title":"Front. Psychol."},{"issue":"11","key":"10.1016\/j.pnpbp.2025.111460_bb0200","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.3390\/nu14112268","article-title":"Ganoderma lucidum triterpenoids improve maternal separation-induced anxiety-and depression-like behaviors in mice by mitigating inflammation in the periphery and brain","volume":"14","author":"Mi","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.pnpbp.2025.111460_bb0205","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s11011-018-0209-3","article-title":"In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life","volume":"33","author":"Moraes","year":"2018","journal-title":"Metab. Brain Dis."},{"issue":"3","key":"10.1016\/j.pnpbp.2025.111460_bb0210","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0165-0327(02)00120-9","article-title":"Differentiating moderate and severe depression using the Montgomery\u2013\u00c5sberg depression rating scale (MADRS)","volume":"77","author":"M\u00fcller","year":"2003","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0215","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuroimage.2017.05.024","article-title":"Unreliability of putative fMRI biomarkers during emotional face processing","volume":"156","author":"Nord","year":"2017","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.pnpbp.2025.111460_bb0220","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/cercor\/bhac104","article-title":"The effect of early trauma on suicidal vulnerability depends on fronto-insular sulcation","volume":"33","author":"Oli\u00e9","year":"2023","journal-title":"Cereb. Cortex"},{"issue":"5","key":"10.1016\/j.pnpbp.2025.111460_bb0230","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.3886","article-title":"Trends in suicide among youth aged 10 to 19 years in the United States, 1975 to 2016","volume":"2","author":"Ruch","year":"2019","journal-title":"JAMA Netw. Open"},{"issue":"5","key":"10.1016\/j.pnpbp.2025.111460_bb0235","doi-asserted-by":"crossref","first-page":"e813","DOI":"10.1038\/tp.2016.76","article-title":"The NADPH oxidase NOX2 as a novel biomarker for suicidality: evidence from human post mortem brain samples","volume":"6","author":"Schiavone","year":"2016","journal-title":"Transl. Psychiatry"},{"issue":"2","key":"10.1016\/j.pnpbp.2025.111460_bb0240","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41380-019-0587-x","article-title":"Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies","volume":"25","author":"Schmaal","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.pnpbp.2025.111460_bb0245","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s10072-021-05558-8","article-title":"Low serum uric acid levels are associated with the nonmotor symptoms and brain gray matter volume in Parkinson's disease","volume":"43","author":"Shi","year":"2022","journal-title":"Neurol. Sci."},{"issue":"5026","key":"10.1016\/j.pnpbp.2025.111460_bb0250","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1126\/science.1896849","article-title":"The medial temporal lobe memory system","volume":"253","author":"Squire","year":"1991","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.pnpbp.2025.111460_bb0255","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.metabol.2008.01.030","article-title":"Uric acid and the development of metabolic syndrome in women and men","volume":"57","author":"Sui","year":"2008","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.pnpbp.2025.111460_bb0260","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s41593-023-01282-y","article-title":"Intrinsic activity development unfolds along a sensorimotor\u2013association cortical axis in youth","volume":"26","author":"Sydnor","year":"2023","journal-title":"Nat. Neurosci."},{"issue":"10","key":"10.1016\/j.pnpbp.2025.111460_bb0265","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nrn.2016.111","article-title":"The effects of childhood maltreatment on brain structure, function and connectivity","volume":"17","author":"Teicher","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"issue":"10024","key":"10.1016\/j.pnpbp.2025.111460_bb0270","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0140-6736(15)00234-2","article-title":"Suicide and suicidal behaviour","volume":"387","author":"Turecki","year":"2016","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.pnpbp.2025.111460_bb0275","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jad.2013.05.016","article-title":"Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts","volume":"150","author":"Vargas","year":"2013","journal-title":"J. Affect. Disord."},{"issue":"3","key":"10.1016\/j.pnpbp.2025.111460_bb0280","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/s41380-021-01407-4","article-title":"Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis","volume":"27","author":"Vasupanrajit","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.pnpbp.2025.111460_bb0285","first-page":"7088856","article-title":"The interaction effects of suicidal ideation and childhood abuse on brain structure and function in major depressive disorder patients","volume":"2021","author":"Wang","year":"2021","journal-title":"Neural Plast."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0290","author":"World Health Organization"},{"issue":"1","key":"10.1016\/j.pnpbp.2025.111460_bb0295","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1038\/s41467-023-40079-2","article-title":"Association between vmPFC gray matter volume and smoking initiation in adolescents","volume":"14","author":"Xiang","year":"2023","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.pnpbp.2025.111460_bb0300","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.pnpbp.2025.111460_bb0305","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jad.2023.11.074","article-title":"The role of the thalamic subregions in major depressive disorder with childhood maltreatment: evidences from dynamic and static functional connectivity","volume":"347","author":"Yu","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0310","first-page":"1","article-title":"Individual and combined association analysis of famine exposure and serum uric acid with hypertension in the mid-aged and older adult: a population-based cross-sectional study","volume":"21","author":"Zhang","year":"2021","journal-title":"BioMed Cent. Cardiovasc.Disord."},{"key":"10.1016\/j.pnpbp.2025.111460_bb0315","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.2147\/NDT.S452643","article-title":"Gender differences of antioxidant system and thyroid function in depressed adolescents with non-suicidal self-injury","volume":"20","author":"Zhang","year":"2024","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"5","key":"10.1016\/j.pnpbp.2025.111460_bb0320","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s44220-024-00226-0","article-title":"Associations of dietary patterns with brain health from behavioral, neuroimaging, biochemical and genetic analyses","volume":"2","author":"Zhang","year":"2024","journal-title":"Nat. Mental Health"},{"issue":"4","key":"10.1016\/j.pnpbp.2025.111460_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101166","article-title":"Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid","volume":"297","author":"Zhao","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.pnpbp.2025.111460_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040608","article-title":"Low serum urate levels are associated to female gender in multiple sclerosis patients","volume":"7","author":"Zoccolella","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.pnpbp.2025.111460_bb0335","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jneumeth.2008.04.012","article-title":"An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: fractional ALFF","volume":"172","author":"Zou","year":"2008","journal-title":"J. Neurosci. Methods"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584625002143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584625002143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T19:32:05Z","timestamp":1765913525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584625002143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":66,"alternative-id":["S0278584625002143"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2025.111460","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uric acid metabolism and brain dysfunction linking childhood maltreatment to self-harm in adolescents with mood disorders","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2025.111460","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111460"}}