{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:18:27Z","timestamp":1791101907844,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Primary Care: Clinics in Office Practice"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.pop.2005.09.002","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T09:28:46Z","timestamp":1168421326000},"page":"1027-1055","source":"Crossref","is-referenced-by-count":44,"title":["Hyperlipidemia"],"prefix":"10.1016","volume":"32","author":[{"given":"Charles B.","family":"Eaton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pop.2005.09.002_bib1","series-title":"Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Final report. NIH Publication No. 02\u20135125","year":"2002"},{"key":"10.1016\/j.pop.2005.09.002_bib2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.0000133317.49796.0E","article-title":"Implications of recent clinical trials for the National Cholesterol Program Adult Treatment Panel III guidelines","volume":"110","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.pop.2005.09.002_bib3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1046\/j.1525-1497.2003.20207.x","article-title":"Comparison of current guidelines for primary prevention of coronary heart disease: risk assessment and lipid-lowering therapy","volume":"18","author":"Broedl","year":"2003","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.pop.2005.09.002_bib4","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/01.CIR.97.10.946","article-title":"Cholesterol reduction yields clinical benefit: impact of statin trials","volume":"97","author":"Gould","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.pop.2005.09.002_bib5","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1056\/NEJMp048023","article-title":"Increasing HDL cholesterol levels","volume":"350","author":"Brewer","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pop.2005.09.002_bib6","series-title":"Primer in preventive cardiology","first-page":"17","article-title":"Biology of atherosclerosis","author":"St. Clair","year":"1994"},{"key":"10.1016\/j.pop.2005.09.002_bib7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.atherosclerosis.2005.01.003","article-title":"High-density lipoprotein cholesterol in the cardiovascular equation: does the \u201cgood\u201d still count?","volume":"180","author":"Alsheikh-Ali","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pop.2005.09.002_bib8","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1161\/01.CIR.0000146339.57154.9B","article-title":"Multivariate assessment of lipid parameters as predictors of coronary heart disease among postmenopausal women: implications for clinical guidelines","volume":"110","author":"Shai","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.pop.2005.09.002_bib9","series-title":"Beyond cholesterol. The Johns Hopkins complete guide for avoiding heart disease","author":"Kwiterovich","year":"1989"},{"key":"10.1016\/j.pop.2005.09.002_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0002-9149(93)90155-6","article-title":"Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics","volume":"72","author":"Williams","year":"1993","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pop.2005.09.002_bib11","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/0002-9149(94)90461-8","article-title":"Indications for low-density lipoprotein apheresis","volume":"74","author":"Gordon","year":"1994","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pop.2005.09.002_bib12","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/0735-1097(92)90520-W","article-title":"Lipoprotein cholesterol, apolipoprotein A-I and B and lipoprotein (a) abnormalities in men with premature coronary artery disease","volume":"19","author":"Genest","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pop.2005.09.002_bib13","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1161\/01.ATV.0000111245.75752.C6","article-title":"Definition of metabolic syndrome: report of the National Heart Lung Blood Institute\/American Heart Association conference on scientific issues related to definition","volume":"24","author":"Grundy","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pop.2005.09.002_bib14","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1161\/01.str.0000034125.94759.41","article-title":"ACC\/AHA\/NHLBI clinical advisory on the use and safety of statins","volume":"33","author":"Pasternak","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.pop.2005.09.002_bib15","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0002-9149(97)00430-X","article-title":"Safety and efficiacy of long-term statin-fibrate combinations in patients with refractory familial combined hyperlipidemia","volume":"80","author":"Athyros","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pop.2005.09.002_bib16","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1001\/archinte.1994.00420140051007","article-title":"Comparative effects of lovastatin and niacin in primary hypercholesterolemia, a prospective trial","volume":"154","author":"Illingworth","year":"1994","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.pop.2005.09.002_bib17","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1001\/jama.1990.03450060069031","article-title":"Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus","volume":"264","author":"Garg","year":"1990","journal-title":"JAMA"},{"key":"10.1016\/j.pop.2005.09.002_bib18","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1056\/NEJMoa031766","article-title":"Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol","volume":"350","author":"Brousseau","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pop.2005.09.002_bib19","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1056\/NEJMoa011090","article-title":"Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease","volume":"345","author":"Brown","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pop.2005.09.002_bib20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0140-6736(99)07072-5","article-title":"GISSI-Prevenzione investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial","volume":"354","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.pop.2005.09.002_bib21","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/nm1195-1148","article-title":"A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolemia","volume":"1","author":"Grossman","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.pop.2005.09.002_bib22","doi-asserted-by":"crossref","first-page":"10A","DOI":"10.1016\/S0002-9149(99)00933-9","article-title":"Rationale and design of the Cardiac Hospitalization Atherosclerosis Management Program at the University of California Los Angeles","volume":"85","author":"Fonarow","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pop.2005.09.002_bib23","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/01.CIR.0000134791.68010.FA","article-title":"AHA\/ACC guidelines for the management of patients with ST-elevation myocardial infarction","volume":"110","author":"Antman","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.pop.2005.09.002_bib24","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/S0140-6736(03)13636-7","article-title":"MRC\/BHF Heart Protection Study of cholesterol lowering with simvastatin in 5963 people with diabetes: a randomized placebo-controlled trial","volume":"361","author":"Collins","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.pop.2005.09.002_bib25","first-page":"1383","article-title":"Randomized trial of cholesterol lowering in 444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)","volume":"344","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.pop.2005.09.002_bib26","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1056\/NEJM199610033351401","article-title":"The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels","volume":"335","author":"Sacks","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pop.2005.09.002_bib27","doi-asserted-by":"crossref","first-page":"931","DOI":"10.7326\/0003-4819-134-10-200105150-00007","article-title":"Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: results from the LIPID trial","volume":"134","author":"Hunt","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.pop.2005.09.002_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0140-6736(02)09327-3","article-title":"MRC\/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals. A randomized placebo-controlled trial","volume":"360","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.pop.2005.09.002_bib29","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/S0140-6736(02)11600-X","article-title":"PROSPER study group. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomized controlled trial. Prospective Study of Pravastatin in the Elderly at Risk","volume":"360","author":"Shepard","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.pop.2005.09.002_bib30","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1001\/archinte.162.12.1395","article-title":"Therapy with hydroxymethylglutaryl coenzyme a reductase inhibitors (statins) and associated risk of incident cardiovascular events in older adults: evidence from the cardiovascular health study","volume":"162","author":"Lamaitre","year":"2002","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.pop.2005.09.002_bib31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.amjmed.2003.12.041","article-title":"Adherence to evidence-based therapies after discharge from acute coronary syndromes: an ongoing prospective, observational study","volume":"117","author":"Eagle","year":"2004","journal-title":"Am J Med"},{"key":"10.1016\/j.pop.2005.09.002_bib32","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1525-1497.2004.30516.x","article-title":"Suboptimal statin adherence and discontinuation in primary and secondary populations","volume":"19","author":"Ellis","year":"2004","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.pop.2005.09.002_bib33","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1001\/archinte.164.21.2343","article-title":"Impact of concurrent medication use on statin adherence and refill persistence","volume":"164","author":"Grant","year":"2004","journal-title":"Arch Intern Med"}],"container-title":["Primary Care: Clinics in Office Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095454305000771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095454305000771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T23:20:04Z","timestamp":1547076004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0095454305000771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0095454305000771"],"URL":"https:\/\/doi.org\/10.1016\/j.pop.2005.09.002","relation":{},"ISSN":["0095-4543"],"issn-type":[{"value":"0095-4543","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}