{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:08:24Z","timestamp":1785186504275,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","primarycare.theclinics.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Primary Care: Clinics in Office Practice"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.pop.2017.10.002","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T22:27:56Z","timestamp":1514413676000},"page":"81-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Valvular Heart Disease"],"prefix":"10.1016","volume":"45","author":[{"given":"Zorana","family":"Mrsic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott P.","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared L.","family":"Antevil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Mullenix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pop.2017.10.002_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/heart.83.1.81","article-title":"Clinical significance of the bicuspid aortic valve","volume":"83","author":"Ward","year":"2000","journal-title":"Heart"},{"issue":"1","key":"10.1016\/j.pop.2017.10.002_bib2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jacc.2004.03.050","article-title":"Bicuspid aortic valve is heritable","volume":"44","author":"Cripe","year":"2004","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.pop.2017.10.002_bib3","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.CIR.0000027905.26586.E8","article-title":"Clinical and pathophysiological implications of a bicuspid aortic valve","volume":"106","author":"Fedak","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.pop.2017.10.002_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/CLEP.S12977","article-title":"The worldwide epidemiology of acute rheumatic fever and rheumatic heart disease","volume":"3","author":"Seckeler","year":"2011","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.pop.2017.10.002_bib5","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1161\/CIRCULATIONAHA.104.495903","article-title":"Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged followup","volume":"111","author":"Pellikka","year":"2005","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.pop.2017.10.002_bib6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1001\/archinte.1974.00320220149021","article-title":"Gallavardin phenomenon in aortic stenosis: a possible mechanism","volume":"134","author":"Giles","year":"1974","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.pop.2017.10.002_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/CIR.0000000000000029","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease","volume":"129","author":"Nishimura","year":"2014","journal-title":"Circulation"},{"issue":"36","key":"10.1016\/j.pop.2017.10.002_bib8","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"38","author":"Baurmgartner","year":"2017","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.pop.2017.10.002_bib9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cjca.2012.11.006","article-title":"Imaging of valvular heart disease","volume":"29","author":"Pibarot","year":"2013","journal-title":"Can J Cardiol"},{"issue":"2","key":"10.1016\/j.pop.2017.10.002_bib10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jacc.2017.03.011","article-title":"2017 AHA\/ACC focused update of the 2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"70","author":"Nishimura","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.pop.2017.10.002_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/01.HYP.28.1.47","article-title":"Effect of hypertension on aortic root size and prevalence of aortic regurgitation","volume":"28","author":"Kim","year":"1996","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.pop.2017.10.002_bib12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00007611-198104000-00022","article-title":"Quincke, de Musset, Duroziez, and Hill: some aortic regurgitation signs","volume":"74","author":"Sapira","year":"1981","journal-title":"South Med J"},{"issue":"3","key":"10.1016\/j.pop.2017.10.002_bib13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/10976640600604856","article-title":"Severity of mitral and aortic regurgitation as assessed by cardiovascular magnetic resonance: optimizing correlation with Doppler echocardiography","volume":"8","author":"Gelfand","year":"2006","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"issue":"5","key":"10.1016\/j.pop.2017.10.002_bib14","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0735-1097(96)00326-9","article-title":"Measurement of mitral valve area in mitral stenosis: four echocardiographic methods compared with direct measurement of anatomic orifices","volume":"28","author":"Faletra","year":"1996","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.pop.2017.10.002_bib15","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/eurheartj\/ehm001","article-title":"What are the characteristics of patients with severe, symptomatic mitral regurgitation who are denied surgery?","volume":"28","author":"Mirabel","year":"2007","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1016\/j.pop.2017.10.002_bib16","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jacc.2008.05.008","volume":"52","author":"Nishimura","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.pop.2017.10.002_bib17","first-page":"18","article-title":"Mitral regurgitation","volume":"9672","author":"Enriquez-Sarano","year":"2009","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.pop.2017.10.002_bib18","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/S0735-1097(02)02161-7","article-title":"Mitral valve prolapse in the general population: the benign nature of echocardiographic features in the Framingham heart study","volume":"40","author":"Freed","year":"2002","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.pop.2017.10.002_bib19","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/j.jacc.2006.02.048","article-title":"Left atrial size: physiologic determinants and clinical applications","volume":"47","author":"Abhayaratna","year":"2006","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.pop.2017.10.002_bib20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1399-6576.1995.tb04051.x","article-title":"Comparison of cardiac output measurement techniques: thermodilution, Doppler, CO2-rebreathing and the direct Fick method","volume":"39","author":"Espersen","year":"1995","journal-title":"Acta Anaesthesiol Scand"},{"issue":"Supp B","key":"10.1016\/j.pop.2017.10.002_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/eurheartj\/12.suppl_B.5","article-title":"Natural history of severe mitral regurgitation","volume":"12","author":"Delahaye","year":"1991","journal-title":"Eur Heart J"},{"issue":"13","key":"10.1016\/j.pop.2017.10.002_bib22","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2008.05.007","volume":"52","author":"Bonow","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.pop.2017.10.002_bib23","doi-asserted-by":"crossref","first-page":"g2116","DOI":"10.1136\/bmj.g2116","article-title":"Anticoagulation in atrial fibrillation","volume":"348","author":"Steinberg","year":"2014","journal-title":"BMJ"}],"container-title":["Primary Care: Clinics in Office Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009545431730129X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009545431730129X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T19:31:27Z","timestamp":1570563087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009545431730129X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S009545431730129X"],"URL":"https:\/\/doi.org\/10.1016\/j.pop.2017.10.002","relation":{},"ISSN":["0095-4543"],"issn-type":[{"value":"0095-4543","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valvular Heart Disease","name":"articletitle","label":"Article Title"},{"value":"Primary Care: Clinics in Office Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pop.2017.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}