{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:16:46Z","timestamp":1789186606489,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","theclinics.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Primary Care: Clinics in Office Practice"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.pop.2024.02.004","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T03:20:14Z","timestamp":1711941614000},"page":"283-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Stroke and Transient Ischemic Attack"],"prefix":"10.1016","volume":"51","author":[{"given":"Paige","family":"Banyas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Jadhav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pop.2024.02.004_bib1","doi-asserted-by":"crossref","first-page":"180411","DOI":"10.5888\/pcd16.180411","article-title":"The Burden of Cerebrovascular Disease in the United States","volume":"16","author":"Tong","year":"2019","journal-title":"Prev Chronic Dis"},{"key":"10.1016\/j.pop.2024.02.004_bib3","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1161\/STR.0000000000000375","article-title":"2021 Guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the american heart association\/american stroke association","volume":"52","author":"Kleindorfer","year":"2021","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.pop.2024.02.004_bib4","first-page":"260","article-title":"Epidemiology and primary prevention of stroke","volume":"26","author":"Furie","year":"2020","journal-title":"Continuum"},{"issue":"8","key":"10.1016\/j.pop.2024.02.004_bib6","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart Disease and Stroke Statistics\u20142022\u00a0Update: A Report From the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.pop.2024.02.004_bib7","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1161\/STR.0b013e318296aeca","article-title":"An updated Definition of Stroke for the 21st Century","volume":"44","author":"Sacco","year":"2013","journal-title":"Stroke"},{"issue":"10244","key":"10.1016\/j.pop.2024.02.004_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0140-6736(20)31179-X","article-title":"Stroke","volume":"396","author":"Campbell","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.pop.2024.02.004_bib9","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1161\/STROKEAHA.108.192218","article-title":"Definition and Evaluation of Transient Ischemic Attack","volume":"40","author":"Easton","year":"2009","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.pop.2024.02.004_bib10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/STROKEAHA.108.515817","article-title":"DWI Lesions and TIA Etiology Improve the Prediction of Stroke After TIA","volume":"40","author":"Calvet","year":"2009","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.pop.2024.02.004_bib11","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1080\/07853890.2021.1890205","article-title":"Stroke mimics: incidence, aetiology, clinical features and treatment","volume":"53","author":"Buck","year":"2021","journal-title":"Ann Med"},{"key":"10.1016\/j.pop.2024.02.004_bib12","doi-asserted-by":"crossref","first-page":"e013098","DOI":"10.1161\/JAHA.119.013098","article-title":"Effect of Baseline Kidney Function on the Risk of Recurrent Stroke and on Effects of Intensive Blood Pressure Control in Patients With Previous Lacunar Stroke: A Post Hoc Analysis of the SPS3 Trial (Secondary Prevention of Small Subcortical Strokes)","volume":"8","author":"Agarwal","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.pop.2024.02.004_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa1910355","article-title":"A\u00a0Comparison of Two LDL Cholesterol Targets after Ischemic Stroke","volume":"382","author":"Amerenco","year":"2020","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.pop.2024.02.004_bib14","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019\u00a0Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association","volume":"50","author":"Powers","year":"2019","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.pop.2024.02.004_bib15","first-page":"462","article-title":"Diagnosis and Management of Cardioembolic Stroke","volume":"29","author":"Yaghi","year":"2023","journal-title":"Continuum"},{"issue":"20","key":"10.1016\/j.pop.2024.02.004_bib16","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.3390\/ijms21207609","article-title":"Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives","volume":"21","author":"Kuriakose","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.pop.2024.02.004_bib17","series-title":"Caplan\u2019s stroke: a clinical approach","first-page":"22","article-title":"Basic Pathology, Anatomy and Pathophysiology of Stroke","author":"Caplan","year":"2009"},{"key":"10.1016\/j.pop.2024.02.004_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.pop.2024.02.004_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1161\/01.STR.0000048148.09143.6C","article-title":"Admitting Acute Ischemic Stroke Patients to a Stroke Care Monitoring Unit Versus a Conventional Stroke Unit: A Randomized Pilot Study","volume":"34","author":"Sulter","year":"2003","journal-title":"Stroke"},{"issue":"7088","key":"10.1016\/j.pop.2024.02.004_bib20","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1136\/bmj.314.7088.1151","article-title":"Collaborative systematic review of the randomised trials of organised inpatient (stroke unit) care after stroke. Stroke Unit Trialists' Collaboration","volume":"314","year":"1997","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.pop.2024.02.004_bib21","first-page":"CD000197","article-title":"Stroke Unit Trialists' Collaboration. Organised inpatient (stroke unit) care for stroke: network meta-analysis","volume":"4","author":"Langhorne","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.pop.2024.02.004_bib22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/01.STR.0000196957.55928.ab","article-title":"Time is Brain\u2013Quantified","volume":"37","author":"Saver","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.pop.2024.02.004_bib23","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM199512143332401","article-title":"Tissue Plasminogen Activator for Acute Ischemic Stroke","volume":"333","year":"1995","journal-title":"N\u00a0Eng J Med"},{"key":"10.1016\/j.pop.2024.02.004_bib24","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","article-title":"Thrombolysis with Alteplase 3 to 4.5 hours after Acute Ischemic Stroke","volume":"359","author":"Hacke","year":"2008","journal-title":"N\u00a0Eng J Med"},{"key":"10.1016\/j.pop.2024.02.004_bib25","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1056\/NEJMoa1813046","article-title":"Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke","volume":"380","author":"Ma","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pop.2024.02.004_bib26","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJMoa1804355","article-title":"MRI-guided thrombolysis for stroke with unknown time of onset","volume":"379","author":"Thomalla","year":"2018","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.pop.2024.02.004_bib27","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1161\/STROKEAHA.108.540708","article-title":"Treatment time-specific number needed to treat estimates for tissue plasminogen activator therapy in acute stroke based on shifts over the entire range of the modified Rankin Scale","volume":"40","author":"Lansberg","year":"2009","journal-title":"Stroke"},{"issue":"9180","key":"10.1016\/j.pop.2024.02.004_bib28","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0140-6736(99)07403-6","article-title":"Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomised trial","volume":"354","author":"Van De Werf","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.pop.2024.02.004_bib29","doi-asserted-by":"crossref","first-page":"1102463","DOI":"10.3389\/fneur.2023.1102463","article-title":"Tenecteplase vs. alteplase for treatment of acute ischemic stroke: A systematic review and meta-analysis of randomized trials","volume":"14","author":"Kobeissi","year":"2023","journal-title":"Front Neurol"},{"key":"10.1016\/j.pop.2024.02.004_bib30","series-title":"StatPearls","article-title":"Thrombectomy","author":"Mathews","year":"2023"},{"key":"10.1016\/j.pop.2024.02.004_bib31","first-page":"e000168","article-title":"Therapeutic advancements in the endovascular management of acute ischemic stroke","volume":"1","author":"Mohammaden","year":"2021","journal-title":"Stroke: Vascular and Interventional Neurology"},{"key":"10.1016\/j.pop.2024.02.004_bib32","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1056\/NEJMoa1813959","article-title":"Dabigatran for prevention of stroke after embolic stroke of undetermined source","volume":"380","author":"Diener","year":"2019","journal-title":"N\u00a0Eng J Med"},{"key":"10.1016\/j.pop.2024.02.004_bib33","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1161\/STROKEAHA.119.028669","article-title":"Potential embolic sources and outcomes in embolic stroke of undetermined source in the NAVIGATE-ESUS trial","volume":"51","author":"Ntaios","year":"2020","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.pop.2024.02.004_bib34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1215340","article-title":"Clopidogrel with aspirin in acute minor stroke or transient ischemic attack","volume":"369","author":"Wang","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.pop.2024.02.004_bib35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1056\/NEJMoa1800410","article-title":"Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA","volume":"379","author":"Johnston","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pop.2024.02.004_bib36","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1105335","article-title":"Stenting versus Aggressive medical therapy for intracranial arterial stenosis","volume":"365","author":"Chimowitz","year":"2011","journal-title":"N\u00a0Eng J Med"},{"key":"10.1016\/j.pop.2024.02.004_bib37","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1056\/NEJMoa2111749","article-title":"Ticagrelor versus Clopidogrel in CYP2C19 Loss-of-Function Carriers with Stroke or TIA","volume":"385","author":"Wang","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.pop.2024.02.004_bib38","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jacc.2022.05.007","article-title":"Carotid artery stenting","volume":"80","author":"White","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.pop.2024.02.004_bib39","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.15420\/icr.2019.27","article-title":"Patent foramen ovale closure: state of the art","volume":"15","author":"Giblett","year":"2020","journal-title":"Interv Cardiol"},{"issue":"3","key":"10.1016\/j.pop.2024.02.004_bib40","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nrcardio.2010.224","article-title":"Patent foramen ovale: anatomy, outcomes, and closure","volume":"8","author":"Calvert","year":"2011","journal-title":"Nat Rev Cardiol"},{"issue":"2","key":"10.1016\/j.pop.2024.02.004_bib41","first-page":"353","article-title":"The evolving concept of cryptogenic stroke","volume":"26","author":"Kamel","year":"2020","journal-title":"Continuum"},{"issue":"2","key":"10.1016\/j.pop.2024.02.004_bib42","first-page":"540","article-title":"Cervical artery dissection","volume":"29","author":"Omran","year":"2023","journal-title":"Continuum"},{"issue":"6","key":"10.1016\/j.pop.2024.02.004_bib43","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1001\/jamaneurol.2019.0072","article-title":"Antiplatelet therapy vs anticoagulation therapy in cervical artery dissection","volume":"76","author":"Markus","year":"2019","journal-title":"JAMA Neurol"},{"issue":"2","key":"10.1016\/j.pop.2024.02.004_bib44","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1212\/WNL.0b013e3181c9188b","article-title":"Early clinical worsening in patients with TIA or minor stroke: the Austrian Stroke Unit Registry","volume":"74","author":"Ferrari","year":"2010","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.pop.2024.02.004_bib45","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1212\/WNL.0000000000001780","article-title":"ABCD2 score and secondary stroke prevention: meta-analysis and effect per 1,000 patients triaged","volume":"85","author":"Wardlaw","year":"2015","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.pop.2024.02.004_bib46","first-page":"49","article-title":"Inpatient versus Outpatient Management of TIA or Minor Stroke: Clinical Outcome","volume":"9","author":"Majidi","year":"2017","journal-title":"J\u00a0Vasc Interv Neurol"},{"issue":"2","key":"10.1016\/j.pop.2024.02.004_bib47","first-page":"443","article-title":"Mechanical thrombectomy for acute ischemic stroke","volume":"29","author":"Sheth","year":"2023","journal-title":"Continuum"},{"key":"10.1016\/j.pop.2024.02.004_bib48","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1161\/STROKEAHA.121.037376","article-title":"Mobile stroke units: evidence, gaps, and next steps","volume":"53","author":"Navi","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.pop.2024.02.004_bib49","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1161\/STROKEAHA.117.017283","article-title":"Reconsidering neuroprotection in the reperfusion era","volume":"48","author":"Savitz","year":"2017","journal-title":"Stroke"}],"container-title":["Primary Care: Clinics in Office Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009545432400006X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009545432400006X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T19:49:12Z","timestamp":1714420152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009545432400006X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S009545432400006X"],"URL":"https:\/\/doi.org\/10.1016\/j.pop.2024.02.004","relation":{},"ISSN":["0095-4543"],"issn-type":[{"value":"0095-4543","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stroke and Transient Ischemic Attack","name":"articletitle","label":"Article Title"},{"value":"Primary Care: Clinics in Office Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pop.2024.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}