{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:00:56Z","timestamp":1785272456114,"version":"3.55.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Primary Care: Clinics in Office Practice"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.pop.2026.03.006","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:59:12Z","timestamp":1779911952000},"page":"441-448","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Understanding Benzodiazepines"],"prefix":"10.1016","volume":"53","author":[{"given":"Stephanie","family":"Widmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Prokopiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Lipman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.pop.2026.03.006_bib1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4140\/TCP.n.2013.538","article-title":"The history of benzodiazepines","volume":"28","author":"Wick","year":"2013","journal-title":"Consult Pharm"},{"issue":"2","key":"10.1016\/j.pop.2026.03.006_bib2","first-page":"181","article-title":"Chemical and biological properties of benzodiazepines\u2014An overview","volume":"5","author":"Mahadik","year":"2012","journal-title":"Res J Pharm Technol"},{"issue":"3","key":"10.1016\/j.pop.2026.03.006_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/01.yco.0000165594.60434.84","article-title":"The diagnosis and management of benzodiazepine dependence","volume":"18","author":"Ashton","year":"2005","journal-title":"Curr Opin Psychiatr"},{"issue":"2","key":"10.1016\/j.pop.2026.03.006_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.31887\/DCNS.2017.19.2\/bbandelow","article-title":"Treatment of anxiety disorders","volume":"19","author":"Bandelow","year":"2017","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1016\/j.pop.2026.03.006_bib7","article-title":"Mechanisms underlying tolerance after long-term benzodiazepine use: a future for subtype-selective GABA(A) receptor modulators?","volume":"2012","author":"Vinkers","year":"2012","journal-title":"Adv Pharmacol Sci"},{"issue":"12","key":"10.1016\/j.pop.2026.03.006_bib8","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1111\/j.1360-0443.2011.03563.x","article-title":"Benzodiazepines revisited\u2014will we ever learn?","volume":"106","author":"Lader","year":"2011","journal-title":"Addiction"},{"key":"10.1016\/j.pop.2026.03.006_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-3-540-74806-9_16","article-title":"Midazolam and other benzodiazepines","volume":"182","author":"Olkkola","year":"2008","journal-title":"Handb Exp Pharmacol"},{"issue":"11","key":"10.1016\/j.pop.2026.03.006_bib10","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1111\/jgs.13702","article-title":"American Geriatrics Society 2015 updated Beers Criteria for potentially inappropriate medication use in older adults","volume":"63","year":"2015","journal-title":"J Am Geriatr Soc"},{"issue":"10","key":"10.1016\/j.pop.2026.03.006_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11920-016-0727-9","article-title":"Benzodiazepine misuse in the elderly: risk factors, consequences, and management","volume":"18","author":"Airagnes","year":"2016","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.pop.2026.03.006_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.addbeh.2015.10.002","article-title":"Risk factors associated with benzodiazepine use among people who inject drugs in an urban Canadian setting","volume":"52","author":"Tucker","year":"2016","journal-title":"Addict Behav"},{"issue":"4","key":"10.1016\/j.pop.2026.03.006_bib13","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3109\/02813432.2015.1117282","article-title":"Risk factors for excessive benzodiazepine use in a working age population: a nationwide 5-year survey in Norway","volume":"33","author":"Fride Tvete","year":"2015","journal-title":"Scand J Prim Health Care"},{"key":"10.1016\/j.pop.2026.03.006_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.drugalcdep.2014.01.026","article-title":"The misuse of benzodiazepines among adolescents: psychosocial risk factors in a national sample","volume":"137","author":"Rigg","year":"2014","journal-title":"Drug Alcohol Depend"},{"issue":"10","key":"10.1016\/j.pop.2026.03.006_bib15","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.pop.2026.03.006_bib16","doi-asserted-by":"crossref","first-page":"i90","DOI":"10.1136\/bmj.i90","article-title":"Benzodiazepine use and risk of incident dementia or cognitive decline: prospective population based study","volume":"352","author":"Gray","year":"2016","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.pop.2026.03.006_bib17","first-page":"515","article-title":"The role of pharmacists in deprescribing benzodiazepines: a narrative review","volume":"9","author":"Campbell","year":"2018","journal-title":"Therapeutic Advances in Drug Safety"}],"container-title":["Primary Care: Clinics in Office Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095454326000199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095454326000199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:39:19Z","timestamp":1785271159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0095454326000199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0095454326000199"],"URL":"https:\/\/doi.org\/10.1016\/j.pop.2026.03.006","relation":{},"ISSN":["0095-4543"],"issn-type":[{"value":"0095-4543","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding Benzodiazepines","name":"articletitle","label":"Article Title"},{"value":"Primary Care: Clinics in Office Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pop.2026.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}