{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:34:26Z","timestamp":1792852466738,"version":"4.5.0"},"reference-count":9,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Protein & Peptide Letters"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ppl.2026.07.003","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:22:53Z","timestamp":1786033373000},"page":"1-4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ubiquitination in hepatocellular carcinoma: mechanisms and therapeutic opportunities"],"prefix":"10.1016","volume":"34","author":[{"given":"Xiaonan","family":"Geng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ppl.2026.07.003_bib1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41392-025-02392-8","article-title":"Targeting ubiquitination in disease and therapy","volume":"10","author":"Yang","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ppl.2026.07.003_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1581398","article-title":"PSMD12 promotes hepatocellular carcinoma progression by stabilizing CDK1","volume":"16","author":"Peng","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ppl.2026.07.003_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13046-025-03606-1","article-title":"LL22NC03-N14H11.1 regulates the m6A modification of MYC and promotes glycolytic activity in hepatocellular carcinoma cells by inhibiting IGF2BP3 ubiquitination degradation","volume":"45","author":"Yi","year":"2025","journal-title":"J. Exp. Clin. Cancer Res. : CR"},{"key":"10.1016\/j.ppl.2026.07.003_bib4","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1038\/s41467-023-42170-0","article-title":"Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma","volume":"14","author":"Jeong","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ppl.2026.07.003_bib5","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.7150\/ijbs.125201","article-title":"NPLOC4 inhibition remodels tumor microenvironment via M2-to-M1 macrophage reprogramming and boosts Anti-PD-1 response in liver cancer","volume":"22","author":"Gao","year":"2026","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ppl.2026.07.003_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41389-025-00592-z","article-title":"Dual roles of USP1 in HELLS deubiquitination and SUMOylation drive EMT and FOLFOX-based chemoresistance","volume":"14","author":"Gao","year":"2025","journal-title":"Oncogenesis"},{"key":"10.1016\/j.ppl.2026.07.003_bib7","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41419-024-07089-4","article-title":"Hypoxia-induced DTL promotes the proliferation, metastasis, and sorafenib resistance of hepatocellular carcinoma through ubiquitin-mediated degradation of SLTM and subsequent Notch pathway activation","volume":"15","author":"Chen","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ppl.2026.07.003_bib8","first-page":"16","article-title":"Carbon nanotube-mediated platinum-based drug delivery for the treatment of cancer: advancements and future perspectives","volume":"206","author":"Khan","year":"2024","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.ppl.2026.07.003_bib9","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41418-024-01436-w","article-title":"ABCF1-K430-Lactylation promotes HCC malignant progression via transcriptional activation of HIF1 signaling pathway","volume":"32","author":"Hong","year":"2025","journal-title":"Cell Death Differ."}],"container-title":["Protein & Peptide Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929866526000032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929866526000032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:04:55Z","timestamp":1788282295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929866526000032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0929866526000032"],"URL":"https:\/\/doi.org\/10.1016\/j.ppl.2026.07.003","relation":{},"ISSN":["0929-8665"],"issn-type":[{"value":"0929-8665","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ubiquitination in hepatocellular carcinoma: mechanisms and therapeutic opportunities","name":"articletitle","label":"Article Title"},{"value":"Protein & Peptide Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ppl.2026.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}