{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:19:31Z","timestamp":1777511971476,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Parkinsonism &amp; Related Disorders"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.prdoa.2022.100138","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T12:43:58Z","timestamp":1644842638000},"page":"100138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Radiation of parotid or submandibular glands is effective for drooling in patients with parkinsonism; a randomised double-blind placebo-controlled trial"],"prefix":"10.1016","volume":"6","author":[{"given":"R.J.H.M.","family":"Steenbakkers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.P.","family":"van Doornik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vissink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Kerdijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"van Laar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.prdoa.2022.100138_b0005","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00415-009-5098-2","article-title":"Prevalence and definition of drooling in Parkinson's disease: a systematic review","volume":"256","author":"Kalf","year":"2009","journal-title":"J. Neurol."},{"issue":"9","key":"10.1016\/j.prdoa.2022.100138_b0010","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00415-007-0508-9","article-title":"Impact of drooling in Parkinson's disease","volume":"254","author":"Kalf","year":"2007","journal-title":"J. Neurol."},{"issue":"7","key":"10.1016\/j.prdoa.2022.100138_b0015","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.parkreldis.2009.12.003","article-title":"The impact of and the factors associated with drooling in Parkinson's disease","volume":"16","author":"Leibner","year":"2010","journal-title":"Parkinsonism Relat. Disord."},{"issue":"4","key":"10.1016\/j.prdoa.2022.100138_b0020","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/01.wco.0000280411.57836.aa","article-title":"Treatment of sialorrhoea in patients with Parkinson's disease: best current evidence","volume":"20","author":"Molloy","year":"2007","journal-title":"Curr. Opin. Neurol."},{"issue":"11","key":"10.1016\/j.prdoa.2022.100138_b0025","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.parkreldis.2014.08.013","article-title":"Drooling in Parkinson's disease: a review","volume":"20","author":"Srivanitchapoom","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"issue":"4","key":"10.1016\/j.prdoa.2022.100138_b0030","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1176\/appi.neuropsych.11100315","article-title":"Motor and non-motor symptoms in Turkish patients with Parkinson's disease affecting family caregiver burden and quality of life","volume":"24","author":"Ozdilek","year":"2012","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.prdoa.2022.100138_b0035","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/MOO.0b013e32835328ec","article-title":"The management of drooling in adults with neurological conditions","volume":"20","author":"Squires","year":"2012","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"issue":"1","key":"10.1016\/j.prdoa.2022.100138_b0040","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tripleo.2005.08.018","article-title":"Drooling of saliva: a review of the etiology and management options","volume":"101","author":"Meningaud","year":"2006","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"issue":"16","key":"10.1016\/j.prdoa.2022.100138_b0045","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1002\/mds.21646","article-title":"Sialorrhea in Parkinson's disease: a review","volume":"22","author":"Chou","year":"2007","journal-title":"Mov. Disord."},{"issue":"9","key":"10.1016\/j.prdoa.2022.100138_b0050","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/mds.23720","article-title":"Pathophysiology of diurnal drooling in Parkinson's disease","volume":"26","author":"Kalf","year":"2011","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.prdoa.2022.100138_b0055","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1590\/S0004-28032013000100009","article-title":"Dysphagia and sialorrhea: the relationship to Parkinson's disease","volume":"50","author":"Nicaretta","year":"2013","journal-title":"Arq. Gastroenterol."},{"issue":"1","key":"10.1016\/j.prdoa.2022.100138_b0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0722.2010.00802.x","article-title":"Orofacial function and oral health in patients with Parkinson\u2019s disease","volume":"119","author":"Bakke","year":"2011","journal-title":"Eur. J. Oral Sci."},{"issue":"8","key":"10.1016\/j.prdoa.2022.100138_b0065","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.parkreldis.2007.12.007","article-title":"Is silent aspiration a risk factor for respiratory infection in Parkinson\u2019s disease patients?","volume":"14","author":"Nobrega","year":"2008","journal-title":"Parkinsonism Relat. Disord."},{"issue":"9","key":"10.1016\/j.prdoa.2022.100138_b0070","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/archoto.2009.110","article-title":"Surgical management of drooling: a meta-analysis","volume":"135","author":"Reed","year":"2009","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"issue":"6","key":"10.1016\/j.prdoa.2022.100138_b0075","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/bja\/aef268","article-title":"Parkinson's disease and anaesthesia","volume":"89","author":"Nicholson","year":"2002","journal-title":"Br. J. Anaesth."},{"issue":"2","key":"10.1016\/j.prdoa.2022.100138_b0080","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1001\/archneur.1967.00470260014002","article-title":"Cholinergic-anticholinergic antagonism in parkinsonism","volume":"17","author":"Duvoisin","year":"1967","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.prdoa.2022.100138_b0085","first-page":"325","article-title":"Mental impairment in Parkinson's disease. The role of anticholinergic drugs","volume":"84","author":"Meco","year":"1984","journal-title":"Acta Psychiatr. Belg."},{"issue":"2","key":"10.1016\/j.prdoa.2022.100138_b0090","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0010-9452(84)80051-9","article-title":"Disturbance of recent memory function in parkinsonian patients on anticholinergic therapy","volume":"20","author":"Koller","year":"1984","journal-title":"Cortex"},{"issue":"6","key":"10.1016\/j.prdoa.2022.100138_b0095","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.parkreldis.2006.06.002","article-title":"Botulinum toxin: clinical use","volume":"12","author":"Truong","year":"2006","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.prdoa.2022.100138_b0100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.parkreldis.2016.07.001","article-title":"Drooling in Parkinson's disease: a randomized controlled trial of incobotulinum toxin A and meta-analysis of Botulinum toxins","volume":"30","author":"Narayanaswami","year":"2016","journal-title":"Parkinsonism Relat. Disord."},{"issue":"1-2","key":"10.1016\/j.prdoa.2022.100138_b0105","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-510X(01)00565-2","article-title":"Recurrent jaw dislocation after botulinum toxin treatment for sialorrhoea in amyotrophic lateral sclerosis","volume":"190","author":"Tan","year":"2001","journal-title":"J. Neurol. Sci."},{"issue":"s1","key":"10.1016\/j.prdoa.2022.100138_b0110","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3109\/13682820109177898","article-title":"Drooling in Parkinson's disease: a novel speech and language therapy intervention","volume":"36","author":"Marks","year":"2001","journal-title":"Int. J. Lang. Commun. Disord."},{"issue":"1","key":"10.1016\/j.prdoa.2022.100138_b0115","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/lary.25444","article-title":"The role of radiation therapy in the management of Sialorrhea: a systematic review","volume":"126","author":"Hawkey","year":"2016","journal-title":"Laryngoscope"},{"issue":"9","key":"10.1016\/j.prdoa.2022.100138_b0120","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1517\/14656566.6.9.1551","article-title":"Controlling sialorrhoea: a review of available treatment options","volume":"6","author":"Potulska","year":"2005","journal-title":"Expert Opin. Pharmacother."},{"issue":"3","key":"10.1016\/j.prdoa.2022.100138_b0125","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0167-8140(02)00129-9","article-title":"Comparison of radiosensitivity of rat parotid and submandibular glands after different radiation schedules","volume":"63","author":"Coppes","year":"2002","journal-title":"Radiother. Oncol."},{"issue":"4","key":"10.1016\/j.prdoa.2022.100138_b0130","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.ijrobp.2004.12.051","article-title":"On the mechanism of salivary gland radiosensitivity","volume":"62","author":"Konings","year":"2005","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"2","key":"10.1016\/j.prdoa.2022.100138_b0135","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1067\/mpr.2001.113778","article-title":"A review of saliva: normal composition, flow, and function","volume":"85","author":"Humphrey","year":"2001","journal-title":"J. Prosthet. Dent."},{"issue":"1","key":"10.1016\/j.prdoa.2022.100138_b0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/mds.21198","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): process, format, and clinimetric testing plan","volume":"22","author":"Goetz","year":"2007","journal-title":"Mov. Disord."},{"issue":"5","key":"10.1016\/j.prdoa.2022.100138_b0145","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1212\/WNL.17.5.427","article-title":"Parkinsonism: onset, progression and mortality","volume":"17","author":"Hoehn","year":"1967","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.prdoa.2022.100138_b0150","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1754-4505.1995.tb00504.x","article-title":"A pilot study comparing three salivary collection methods in an adult population with salivary gland hypofunction","volume":"15","author":"Mulligan","year":"1995","journal-title":"Spec. Care Dentist."},{"key":"10.1016\/j.prdoa.2022.100138_b0155","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1749-6632.1993.tb18343.x","article-title":"Methods for collecting saliva","volume":"694","author":"Navazesh","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"12","key":"10.1016\/j.prdoa.2022.100138_b0160","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1001\/archpedi.154.12.1214","article-title":"Treatment of sialorrhea with glycopyrrolate: a double-blind, dose-ranging study","volume":"154","author":"Mier","year":"2000","journal-title":"Arch. Pediatr. Adolesc. Med."},{"issue":"7","key":"10.1016\/j.prdoa.2022.100138_b0165","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00702-019-02000-4","article-title":"Hypersalivation: update of the German S2k guideline (AWMF) in short form","volume":"126","author":"Steffen","year":"2019","journal-title":"J. Neural Transm."},{"issue":"1","key":"10.1016\/j.prdoa.2022.100138_b0170","first-page":"69","article-title":"Efficacy and safety of botulinum toxin for treating sialorrhea: A systematic review and meta\u2010analysis","volume":"29","author":"Yu","year":"2022","journal-title":"J. Neurol."},{"key":"10.1016\/j.prdoa.2022.100138_b0175","series-title":"Saliva diagnostics","first-page":"37","article-title":"Saliva collectors","author":"Vissink","year":"2008"},{"issue":"16","key":"10.1016\/j.prdoa.2022.100138_b0180","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/mds.21752","article-title":"van Laar T (2007) Radiotherapy to the salivary glands as treatment of sialorrhea in patients with parkinsonism","volume":"22","author":"Postma","year":"2007","journal-title":"Mov. Disord."},{"issue":"3","key":"10.1016\/j.prdoa.2022.100138_b0185","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ijrobp.2013.11.230","article-title":"Pradat PF (2014) Radiation therapy for hypersalivation: a prospective study in 50 amyotrophic lateral sclerosis patients","volume":"88","author":"Assouline","year":"2014","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"3","key":"10.1016\/j.prdoa.2022.100138_b0190","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/ane.12559","article-title":"Botulinum toxin-A injections vs radiotherapy for drooling in ALS","volume":"134","author":"Weikamp","year":"2016","journal-title":"Acta Neurol. Scand."}],"container-title":["Clinical Parkinsonism &amp; Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112522000093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112522000093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T01:46:22Z","timestamp":1762911982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590112522000093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":38,"alternative-id":["S2590112522000093"],"URL":"https:\/\/doi.org\/10.1016\/j.prdoa.2022.100138","relation":{},"ISSN":["2590-1125"],"issn-type":[{"value":"2590-1125","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiation of parotid or submandibular glands is effective for drooling in patients with parkinsonism; a randomised double-blind placebo-controlled trial","name":"articletitle","label":"Article Title"},{"value":"Clinical Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prdoa.2022.100138","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100138"}}