{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:05:52Z","timestamp":1783933552241,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":98,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.prdoa.2026.100442","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T08:39:08Z","timestamp":1775896748000},"page":"100442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Patterns of weariness-related symptoms in Parkinson\u2019s disease: impact of disease progression and levodopa treatment"],"prefix":"10.1016","volume":"14","author":[{"given":"Danielle","family":"Hersonsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Benesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Ben-Ami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Raveh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prdoa.2026.100442_b0005","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1056\/NEJMra2401857","article-title":"Parkinson\u2019s disease","volume":"391","author":"Tanner","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.prdoa.2026.100442_b0010","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.prdoa.2026.100442_b0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41583-021-00542-9","article-title":"Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?","volume":"23","author":"Blesa","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.prdoa.2026.100442_b0020","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jns.2013.07.005","article-title":"Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson\u2019s disease","volume":"332","author":"Santos-Garc\u00eda","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.prdoa.2026.100442_b0025","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3233\/JPD-140446","article-title":"A survey of Parkinson\u2019s disease patients: most bothersome symptoms and coping preferences","volume":"4","author":"Uebelacker","year":"2014","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.prdoa.2026.100442_b0030","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.prdoa.2026.100442_b0035","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1002\/mds.27461","article-title":"Fatigue in Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"33","author":"Siciliano","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100442_b0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.14412\/2074-2711-2017-4-88-84","article-title":"Sleep disorders in Parkinson\u2019s disease: approaches to treatment and prevention","volume":"9","author":"Nodel","year":"2017","journal-title":"RJTAO"},{"key":"10.1016\/j.prdoa.2026.100442_b0045","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/mdc3.12343","article-title":"The pathophysiology of fatigue in Parkinson\u2019s disease and its pragmatic management","volume":"3","author":"Kosti\u0107","year":"2016","journal-title":"Mov. Disord. Clin. Pract."},{"key":"10.1016\/j.prdoa.2026.100442_b0050","first-page":"381","article-title":"Sleep and Parkinson disease","volume":"114","author":"Bollu","year":"2017","journal-title":"Mo. Med."},{"key":"10.1016\/j.prdoa.2026.100442_b0055","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41531-024-00642-0","article-title":"Sleep disorders in Parkinson\u2019s disease, an early and multiple problem","volume":"10","author":"Dodet","year":"2024","journal-title":"Npj Parkinsons Dis."},{"key":"10.1016\/j.prdoa.2026.100442_b0060","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s11325-019-01921-4","article-title":"Excessive daytime sleepiness and fatigue in neurological disorders","volume":"24","author":"Maestri","year":"2020","journal-title":"Sleep Breath."},{"key":"10.1016\/j.prdoa.2026.100442_b0065","series-title":"Encyclopedia of Gerontology and Population Aging","first-page":"1","article-title":"Global deterioration scale","author":"Hardcastle","year":"2019"},{"key":"10.1016\/j.prdoa.2026.100442_b0070","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4103\/aomd.aomd_99_24","article-title":"Fatigue in Parkinson\u2019s disease\u2014A narrative review","volume":"7","author":"Panigrahi","year":"2024","journal-title":"Ann. Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100442_b0075","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/mds.26511","article-title":"Parkinson\u2019s disease\u2010related fatigue: a case definition and recommendations for clinical research","volume":"31","author":"Kluger","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100442_b0080","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/ene.14520","article-title":"Progression of fatigue in Parkinson\u2019s disease - a 9-year follow-up","volume":"28","author":"Ongre","year":"2021","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.prdoa.2026.100442_b0085","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00415-020-10140-x","article-title":"Progression of sleep disturbances in Parkinson\u2019s disease: a 5-year longitudinal study","volume":"268","author":"Xu","year":"2021","journal-title":"J. Neurol."},{"key":"10.1016\/j.prdoa.2026.100442_b0090","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1007\/s00415-021-10419-7","article-title":"Effects of Levodopa on quality of sleep and nocturnal movements in Parkinson\u2019s Disease","volume":"268","author":"Schaeffer","year":"2021","journal-title":"J. Neurol."},{"key":"10.1016\/j.prdoa.2026.100442_b0095","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1212\/01.WNL.0000144277.06917.CC","article-title":"Is fatigue an independent and persistent symptom in patients with Parkinson disease?","volume":"63","author":"Alves","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.prdoa.2026.100442_b0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/mds.21240","article-title":"Working group on fatigue in Parkinson\u2019s disease, fatigue in parkinson\u2019s disease: a review","volume":"22","author":"Friedman","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100442_b0105","doi-asserted-by":"crossref","first-page":"974","DOI":"10.4103\/0366-6999.229889","article-title":"Excessive daytime sleepiness in Parkinson\u2019s disease: clinical implications and management","volume":"131","author":"Shen","year":"2018","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.prdoa.2026.100442_b0110","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.pneurobio.2011.09.005","article-title":"The Parkinson progression marker initiative (PPMI)","volume":"95","author":"Initiative","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.prdoa.2026.100442_b0115","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/acn3.644","article-title":"Parkinson\u2019s progression markers initiative, the Parkinson\u2019s progression markers initiative (PPMI) - establishing a PD biomarker cohort","volume":"5","author":"Marek","year":"2018","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.prdoa.2026.100442_b0120","unstructured":"M.M. Hoehn, Parkinsonism: onset, progression, and mortality, (n.d.)."},{"key":"10.1016\/j.prdoa.2026.100442_b0125","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement disorder society-sponsored revision of the Unified Parkinson\u2019s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results: MDS-UPDRS: clinimetric assessment","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100442_b0130","unstructured":"R. Gon\u00e7alves, S.M.G. Togeiro, Sonol\u00eancia e ins\u00f4nia causadas por drogas: artigo de atualiza\u00e7\u00e3o, (n.d.)."},{"key":"10.1016\/j.prdoa.2026.100442_b0135","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/mds.29410","article-title":"International Parkinson and movement disorders society non-motor parkinson disease study group, levodopa dose equivalency in parkinson\u2019s disease: updated systematic review and proposals","volume":"38","author":"Jost","year":"2023","journal-title":"Mov. Disord."},{"issue":"Suppl 17","key":"10.1016\/j.prdoa.2026.100442_b0140","doi-asserted-by":"crossref","first-page":"S367","DOI":"10.1002\/mds.21682","article-title":"Sleep disorders in Parkinson\u2019s disease: an overview","volume":"22","author":"Comella","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100442_b0145","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.pmrj.2010.04.018","article-title":"Mechanisms by which pharmacologic agents may contribute to fatigue","volume":"2","author":"Zlott","year":"2010","journal-title":"PM R"},{"key":"10.1016\/j.prdoa.2026.100442_b0150","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s00415-013-7207-5","article-title":"Association between fatigue and other motor and non-motor symptoms in Parkinson\u2019s disease patients","volume":"261","author":"Solla","year":"2014","journal-title":"J. Neurol."},{"key":"10.1016\/j.prdoa.2026.100442_b0155","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.exger.2015.07.011","article-title":"Fatigue: relevance and implications in the aging population","volume":"70","author":"Zengarini","year":"2015","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.prdoa.2026.100442_b0160","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.parkreldis.2007.07.017","article-title":"Clinical and psychosocial factors associated with fatigue in patients with Parkinson\u2019s disease","volume":"14","author":"Havlikova","year":"2008","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.prdoa.2026.100442_b0165","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1002\/mds.23372","article-title":"Fatigue in Parkinson\u2019s disease: prevalence and associated factors","volume":"25","author":"Beiske","year":"2010","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100442_b0170","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000067022","article-title":"Dopamine agonists induce episodes of irresistible daytime sleepiness","volume":"49","author":"Schlesinger","year":"2003","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.prdoa.2026.100442_b0175","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.smrv.2005.01.001","article-title":"Excessive daytime sleepiness in parkinsonism","volume":"9","author":"Arnulf","year":"2005","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.prdoa.2026.100442_b0180","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1212\/01.wnl.0000233980.25978.9d","article-title":"Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease?","volume":"67","author":"Gjerstad","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.prdoa.2026.100442_b0185","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41531-024-00734-x","article-title":"Clinical symptoms and neuroanatomical substrates of daytime sleepiness in Parkinson\u2019s disease","volume":"10","author":"Rosinvil","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.prdoa.2026.100442_b0190","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.smrv.2006.08.003","article-title":"The involvement of dopamine in the modulation of sleep and waking","volume":"11","author":"Monti","year":"2007","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.prdoa.2026.100442_b0195","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/jnnp-2016-315023","article-title":"Parkinson\u2019s Progression Markers Initiative, Longitudinal assessment of excessive daytime sleepiness in early Parkinson\u2019s disease","volume":"88","author":"Amara","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.prdoa.2026.100442_b0200","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.5664\/jcsm.10450","article-title":"An overview of the effects of levodopa and dopaminergic agonists on sleep disorders in Parkinson\u2019s disease","volume":"19","author":"Scanga","year":"2023","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.prdoa.2026.100442_b0205","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/14737175.2025.2450789","article-title":"Managing sleep issues in Parkinson\u2019s disease: an up-to-date review","volume":"25","author":"Suzuki","year":"2025","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.prdoa.2026.100442_b0210","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1007\/s00415-012-6557-8","article-title":"The progression of non-motor symptoms in Parkinson\u2019s disease and their contribution to motor disability and quality of life","volume":"259","author":"Antonini","year":"2012","journal-title":"J. Neurol."},{"key":"10.1016\/j.prdoa.2026.100442_b0215","article-title":"Exploring the layers of fatigue in Parkinson\u2019s Disease: a comprehensive analysis of its prevalence and contributing factors","volume":"11","author":"Sarmento","year":"2024","journal-title":"Clin. Park. Relat. Disord."},{"key":"10.1016\/j.prdoa.2026.100442_b0220","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1212\/01.wnl.0000324862.29733.69","article-title":"The Parkinson study Group ELLDOPA investigators, fatigue in levodopa-na\u00efve subjects with Parkinson disease","volume":"71","author":"Schifitto","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.prdoa.2026.100442_b0225","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0140-6736(00)02119-X","article-title":"Sleep attacks and Parkinson\u2019s disease treatment","volume":"355","author":"Ferreira","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.prdoa.2026.100442_b0230","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/00002826-200105000-00013","article-title":"Sleep attacks and antiparkinsonian drugs: a pilot prospective pharmacoepidemiologic study","volume":"24","author":"Montastruc","year":"2001","journal-title":"Clin. Neuropharmacol."}],"container-title":["Clinical Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112526000228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112526000228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:16:25Z","timestamp":1783930585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590112526000228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":46,"alternative-id":["S2590112526000228"],"URL":"https:\/\/doi.org\/10.1016\/j.prdoa.2026.100442","relation":{},"ISSN":["2590-1125"],"issn-type":[{"value":"2590-1125","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patterns of weariness-related symptoms in Parkinson\u2019s disease: impact of disease progression and levodopa treatment","name":"articletitle","label":"Article Title"},{"value":"Clinical Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prdoa.2026.100442","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100442"}}