{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:06:19Z","timestamp":1783933579627,"version":"3.55.0"},"reference-count":147,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":131,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DBT-BT\/PR25787\/GET\/119\/96\/2017"],"award-info":[{"award-number":["DBT-BT\/PR25787\/GET\/119\/96\/2017"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["UoH-IoE- RC2-21-016"],"award-info":[{"award-number":["UoH-IoE- RC2-21-016"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000964","name":"Arthritis National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.prdoa.2026.100453","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:44:29Z","timestamp":1779583469000},"page":"100453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification of genes associated with smell dysfunction in Parkinson\u2019s disease"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8001-8339","authenticated-orcid":false,"given":"Md Zainul","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari","family":"Kiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8615-9861","authenticated-orcid":false,"given":"Pankaj Singh","family":"Dholaniya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prdoa.2026.100453_b0005","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/ana.21995","article-title":"Clinical progression in Parkinson disease and the neurobiology of axons","volume":"67","author":"Cheng","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.prdoa.2026.100453_b0010","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/jnnp-2015-311890","article-title":"The prediagnostic phase of Parkinson\u2019s disease","volume":"87","author":"Noyce","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.prdoa.2026.100453_b0015","doi-asserted-by":"crossref","first-page":"974","DOI":"10.5692\/clinicalneurol.53.974","article-title":"Non-motor symptoms in premotor phase of Parkinson disease","volume":"53","author":"Takahashi","year":"2013","journal-title":"Rinsho Shinkeigaku"},{"key":"10.1016\/j.prdoa.2026.100453_b0020","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.prdoa.2026.100453_b0025","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrneurol.2012.80","article-title":"Olfactory dysfunction in Parkinson disease","volume":"8","author":"Doty","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.prdoa.2026.100453_b0030","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fneur.2020.00447","article-title":"Olfactory dysfunction in familial and sporadic Parkinson\u2019s disease","volume":"11","author":"Chase","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.prdoa.2026.100453_b0035","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.parkreldis.2014.09.026","article-title":"Risk of Parkinson\u2019s disease following severe constipation: a nationwide population-based cohort study","volume":"20","author":"Lin","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.prdoa.2026.100453_b0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000527513","article-title":"Constipation in Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"86","author":"Yao","year":"2023","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.prdoa.2026.100453_b0045","first-page":"381","article-title":"Sleep and Parkinson disease","volume":"114","author":"Bollu","year":"2017","journal-title":"Mo. Med."},{"key":"10.1016\/j.prdoa.2026.100453_b0050","doi-asserted-by":"crossref","DOI":"10.1038\/npjparkd.2015.25","article-title":"Fatigue in Parkinson\u2019s disease: report from a mutidisciplinary symposium","volume":"2","author":"Friedman","year":"2016","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.prdoa.2026.100453_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106115","article-title":"Mood disturbances in Parkinson\u2019s disease: from prodromal origins to application of animal models","volume":"181","author":"Hayley","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.prdoa.2026.100453_b0060","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1474-4422(18)30127-3","article-title":"Risk factors for non-motor symptoms in Parkinson\u2019s disease","volume":"17","author":"Marinus","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.prdoa.2026.100453_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2017.00225","article-title":"Implications of DNA methylation in Parkinson\u2019s disease","volume":"10","author":"Miranda-Morales","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.prdoa.2026.100453_b0070","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/15592294.2019.1588682","article-title":"DNA methylation changes associated with Parkinson\u2019s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood","volume":"14","author":"Henderson-Smith","year":"2019","journal-title":"Epigenetics"},{"key":"10.1016\/j.prdoa.2026.100453_b0075","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jns.2013.11.033","article-title":"Hypomethylation of SNCA in blood of patients with sporadic Parkinson\u2019s disease","volume":"337","author":"Ai","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.prdoa.2026.100453_b0080","unstructured":"E. by Sujata Dash, S. Kumar Pani, J.J. P C Rodrigues, B. Majhi, Deep learning, machine learning and IoT in biomedical and health informatics; techniques and applications, n.d. https:\/\/www.routledge.com\/Biomedical-Engineering\/book-series\/CRCBIOMEDENG."},{"key":"10.1016\/j.prdoa.2026.100453_b0085","doi-asserted-by":"crossref","unstructured":"M.B. Makarious, H.L. Leonard, D. Vitale, H. Iwaki, L. Sargent, A. Dadu, I. Violich, E. Hutchins, D. Saffo, S. Bandres-Ciga, J.J. Kim, Y. Song, M. Maleknia, M. Bookman, W. Nojopranoto, R.H. Campbell, S.H. Hashemi, J.A. Botia, J.F. Carter, D.W. Craig, K. Van Keuren-Jensen, H.R. Morris, J.A. Hardy, C. Blauwendraat, A.B. Singleton, F. Faghri, M.A. Nalls, Multi-modality machine learning predicting Parkinson\u2019s disease, Npj Parkinson\u2019s Disease 2022 8:1 8 (2022) 1\u201313. https:\/\/doi.org\/10.1038\/s41531-022-00288-w.","DOI":"10.1038\/s41531-022-00288-w"},{"key":"10.1016\/j.prdoa.2026.100453_b0090","doi-asserted-by":"crossref","unstructured":"F. Rodriguez-Sanchez, C. Rodriguez-Blazquez, C. Bielza, P. Larra\u00f1aga, D. Weintraub, P. Martinez-Martin, A. Rizos, A. Schrag, K.R. Chaudhuri, Identifying Parkinson\u2019s disease subtypes with motor and non-motor symptoms via model-based multi-partition clustering, Scientific Reports 2021 11:1 11 (2021) 1\u201310. https:\/\/doi.org\/10.1038\/s41598-021-03118-w.","DOI":"10.1038\/s41598-021-03118-w"},{"key":"10.1016\/j.prdoa.2026.100453_b0095","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1007\/s00521-022-07256-8","article-title":"Diagnostic classification of Parkinson\u2019s disease based on non-motor manifestations and machine learning strategies","volume":"35","author":"Martinez-Eguiluz","year":"2023","journal-title":"Neural Comput. Appl."},{"key":"10.1016\/j.prdoa.2026.100453_b0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41531-022-00439-z","article-title":"Identification and prediction of Parkinson\u2019s disease subtypes and progression using machine learning in two cohorts","volume":"8","author":"Dadu","year":"2022","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.prdoa.2026.100453_b0105","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.pneurobio.2011.09.005","article-title":"The Parkinson progression marker initiative (PPMI)","volume":"95","author":"Marek","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.prdoa.2026.100453_b0110","unstructured":"University of Pennsylvania Smell Identification Test, (n.d.). https:\/\/psycnet.apa.org\/doiLanding?doi=10.1037%2Ft21403-000 (accessed March 7, 2024)."},{"key":"10.1016\/j.prdoa.2026.100453_b0115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/nips.1507.2003","article-title":"Olfaction: from odorant molecules to the olfactory cortex","volume":"19","author":"Menini","year":"2004","journal-title":"Physiology"},{"key":"10.1016\/j.prdoa.2026.100453_b0120","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12915-021-01116-y","article-title":"The role of the odorant receptors in the formation of the sensory map","volume":"19","author":"Francia","year":"2021","journal-title":"BMC Biol."},{"key":"10.1016\/j.prdoa.2026.100453_b0125","first-page":"263","article-title":"Decision tree","author":"F\u00fcrnkranz","year":"2011","journal-title":"Encyclopedia Mach. Learn."},{"key":"10.1016\/j.prdoa.2026.100453_b0130","first-page":"157","article-title":"Random forests","author":"Cutler","year":"2012","journal-title":"Ensemble Mach. Learn."},{"key":"10.1016\/j.prdoa.2026.100453_b0135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"Breiman","year":"2001","journal-title":"Mach. Learn."},{"key":"10.1016\/j.prdoa.2026.100453_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i11","article-title":"Feature selection with the Boruta package","volume":"36","author":"Kursa","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.prdoa.2026.100453_b0145","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.4249\/scholarpedia.1658","article-title":"Mutual information","volume":"4","author":"Latham","year":"2009","journal-title":"Scholarpedia"},{"key":"10.1016\/j.prdoa.2026.100453_b0150","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/978-0-387-30162-4_415","article-title":"Support vector machines","author":"Cristianini","year":"2008","journal-title":"Encyclopedia of Algorithms"},{"key":"10.1016\/j.prdoa.2026.100453_b0155","first-page":"83","author":"Mucherino","year":"2009","journal-title":"k-Nearest Neighbor Classification"},{"key":"10.1016\/j.prdoa.2026.100453_b0160","first-page":"713","article-title":"Na\u00efve bayes","author":"Webb","year":"2011","journal-title":"Encyclopedia Mach. Learn."},{"key":"10.1016\/j.prdoa.2026.100453_b0165","unstructured":"B. Ghojogh, B. Ca, M. Crowley, M. Ca, Linear and quadratic discriminant analysis: tutorial, (2019). https:\/\/arxiv.org\/abs\/1906.02590v1 (accessed March 8, 2024)."},{"key":"10.1016\/j.prdoa.2026.100453_b0170","first-page":"109","article-title":"Neural networks for data classification","author":"Kumaraswamy","year":"2021","journal-title":"Artificial Intelligence in Data Mining: Theories and Applications"},{"key":"10.1016\/j.prdoa.2026.100453_b0175","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/978-3-642-21551-3_33","article-title":"Bagging, boosting and ensemble methods","author":"B\u00fchlmann","year":"2012","journal-title":"Handbook of Computational Statistics"},{"key":"10.1016\/j.prdoa.2026.100453_b0180","unstructured":"Python Classification with Lasso: How to Predict Classes | Saturn Cloud Blog, (n.d.). https:\/\/saturncloud.io\/blog\/python-classification-with-lasso-how-to-predict-classes\/ (accessed March 8, 2024)."},{"key":"10.1016\/j.prdoa.2026.100453_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/frai.2024.1287875","article-title":"A distance-based kernel for classification via support vector machines","volume":"7","author":"Amaya-Tejera","year":"2024","journal-title":"Front. Artif. Intell."},{"key":"10.1016\/j.prdoa.2026.100453_b0190","unstructured":"What Is Support Vector Machine? | IBM, (n.d.). https:\/\/www.ibm.com\/think\/topics\/support-vector-machine (accessed July 5, 2025)."},{"key":"10.1016\/j.prdoa.2026.100453_b0195","doi-asserted-by":"crossref","DOI":"10.1111\/cts.70056","article-title":"Practical guide to SHAP analysis: explaining supervised machine learning model predictions in drug development","volume":"17","author":"Ponce-Bobadilla","year":"2024","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.prdoa.2026.100453_b0200","unstructured":"S.M. Lundberg, P.G. Allen, S.-I. Lee, A Unified Approach to Interpreting Model Predictions, (n.d.). https:\/\/doi.org\/10.5555\/3295222.3295230."},{"key":"10.1016\/j.prdoa.2026.100453_b0205","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2307\/3001968","article-title":"Individual comparisons by ranking methods","volume":"1","author":"Wilcoxon","year":"1945","journal-title":"Biometrics"},{"key":"10.1016\/j.prdoa.2026.100453_b0210","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjaminit","year":"1995","journal-title":"J. R. Stat. Soc. Series B Stat. Methodol."},{"key":"10.1016\/j.prdoa.2026.100453_b0215","doi-asserted-by":"crossref","unstructured":"P. Langfelder, S. Horvath, WGCNA: an R package for weighted correlation network analysis., BMC Bioinformatics 9 (2008) 559. https:\/\/doi.org\/10.1186\/1471-2105-9-559.","DOI":"10.1186\/1471-2105-9-559"},{"key":"10.1016\/j.prdoa.2026.100453_b0220","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1128","article-title":"A general framework for weighted gene co-expression network analysis","volume":"4","author":"Zhang","year":"2005","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.prdoa.2026.100453_b0225","doi-asserted-by":"crossref","DOI":"10.1038\/s41531-024-00790-3","article-title":"Single-cell RNA sequencing reveals peripheral immunological features in Parkinson\u2019s Disease","volume":"10","author":"Xiong","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.prdoa.2026.100453_b0230","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/mds.21413","article-title":"Olfactory loss may be a first sign of idiopathic Parkinson\u2019s disease","volume":"22","author":"Haehner","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100453_b0235","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.00043","article-title":"\u201cSmelling and tasting\u201d Parkinson\u2019s disease: using senses to improve the knowledge of the disease","volume":"12","author":"Oppo","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.prdoa.2026.100453_b0240","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3233\/JPD-130278","article-title":"A clinical approach towards smell loss in Parkinson\u2019s disease","volume":"4","author":"Haehner","year":"2014","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.prdoa.2026.100453_b0245","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2500\/ajr.2007.21.3043","article-title":"Office procedures for quantitative assessment of olfactory function","volume":"21","author":"Doty","year":"2007","journal-title":"Am. J. Rhinol."},{"key":"10.1016\/j.prdoa.2026.100453_b0250","doi-asserted-by":"crossref","unstructured":"H.R. Lee, K.S. Kim, H.J. Min, Development of a Digital olfactory function test: a preliminary study, 14 (2024) 75. https:\/\/doi.org\/10.3390\/LIFE14010075\/S1.","DOI":"10.3390\/life14010075"},{"key":"10.1016\/j.prdoa.2026.100453_b0255","doi-asserted-by":"crossref","unstructured":"M. Nakanishi, M.A. Fornazieri, P. Lan\u00e7a Gomes, L.A. de M. Dias, G.S.M. Freire, L.G. do A. Vinha, L.C. Barbosa de Sa, R.L. Voegels, C. Galv\u00e3o, W.T.A. Lima, The digital scent device as a new concept for olfactory assessment, Int. Forum Allergy Rhinol. 12 (2022) 1263\u20131272. https:\/\/doi.org\/10.1002\/ALR.22992.","DOI":"10.1002\/alr.22992"},{"key":"10.1016\/j.prdoa.2026.100453_b0260","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1002\/alr.23100","article-title":"High prevalence of persistent smell loss and qualitative smell dysfunction during the COVID-19 pandemic in the United States: urgent need for clinical trials","volume":"13","author":"Lechner","year":"2022","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.prdoa.2026.100453_b0265","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.add0484","article-title":"Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium","volume":"14","author":"Finlay","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.prdoa.2026.100453_b0270","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/wjo2.163","article-title":"Recovery rates and long\u2010term olfactory dysfunction following COVID\u201019 infection","volume":"10","author":"Dias","year":"2024","journal-title":"World J. Otorhinolaryngol. Head Neck Surg."},{"key":"10.1016\/j.prdoa.2026.100453_b0275","doi-asserted-by":"crossref","first-page":"308","DOI":"10.21053\/ceo.2023.00185","article-title":"The olfactory system: basic anatomy and physiology for general otorhinolaryngologists","volume":"16","author":"Han","year":"2023","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"10.1016\/j.prdoa.2026.100453_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106514","article-title":"RNA sequencing of olfactory bulb in Parkinson\u2019s disease reveals gene alterations associated with olfactory dysfunction","volume":"196","author":"Tremblay","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.prdoa.2026.100453_b0285","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4103\/1673-5374.380875","article-title":"Olfactory dysfunction and its related molecular mechanisms in Parkinson s disease","volume":"19","author":"Gu","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.prdoa.2026.100453_b0290","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/0976500X221085802","article-title":"The role of olfactory system in the etiogenesis of Parkinson\u2019s diseases: an overview","volume":"13","author":"Avanipully","year":"2022","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.prdoa.2026.100453_b0295","first-page":"1","article-title":"Epigenetic biomarkers for Parkinson\u2019s disease: from diagnostics to therapeutics","volume":"7","author":"Jakubowski","year":"2017","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.prdoa.2026.100453_b0300","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.98250","article-title":"Single-cell transcriptomics of vomeronasal neuroepithelium reveals a differential endoplasmic reticulum environment amongst neuronal subtypes","volume":"13","author":"Devakinandan","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.prdoa.2026.100453_b0305","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24097829","article-title":"Identification and characterization of proteins that are involved in RTP1S-dependent transport of olfactory receptors","volume":"24","author":"Inoue","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.prdoa.2026.100453_b0310","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1523\/JNEUROSCI.4955-04.2005","article-title":"Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration","volume":"25","author":"Yoshizawa","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.prdoa.2026.100453_b0315","doi-asserted-by":"crossref","first-page":"11507","DOI":"10.1096\/fj.201900914RR","article-title":"Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration","volume":"33","author":"Preising","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.prdoa.2026.100453_b0320","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1113\/jphysiol.2009.176131","article-title":"Calcium-activated chloride currents in olfactory sensory neurons from mice lacking bestrophin-2","volume":"587","author":"Pifferi","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.prdoa.2026.100453_b0325","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10519-005-9031-x","article-title":"The Inositol 1,4,5-triphosphate kinase1 gene affects olfactory reception in Drosophila melanogaster","volume":"36","author":"Gomez-Diaz","year":"2006","journal-title":"Behav. Genet."},{"key":"10.1016\/j.prdoa.2026.100453_b0330","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1074\/jbc.M006703200","article-title":"Odorants stimulate the ERK\/mitogen-activated protein kinase pathway and activate cAMP-response element-mediated transcription in olfactory sensory neurons","volume":"276","author":"Watt","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prdoa.2026.100453_b0335","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/chemse\/bjq020","article-title":"PI3Kgamma-dependent signaling in mouse olfactory receptor neurons","volume":"35","author":"Brunert","year":"2010","journal-title":"Chem. Senses"},{"key":"10.1016\/j.prdoa.2026.100453_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.ibmb.2024.104164","article-title":"JAK and STAT5B mediate olfactory response of migratory locusts to their own volatiles","volume":"173","author":"Ma","year":"2024","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.prdoa.2026.100453_b0345","doi-asserted-by":"crossref","first-page":"6314","DOI":"10.1523\/JNEUROSCI.15-10-06314.1995","article-title":"Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis","volume":"15","author":"Thinakaran","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.prdoa.2026.100453_b0350","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fncel.2020.00029","article-title":"DIP2B interacts with \u03b1-tubulin to regulate axon outgrowth","volume":"14","author":"Xing","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.prdoa.2026.100453_b0355","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/dvdy.20159","article-title":"Crk-associated substrate (Cas) family member, NEDD9, is regulated in human neuroblastoma cells and in the embryonic hindbrain by all-trans retinoic acid","volume":"231","author":"Merrill","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.prdoa.2026.100453_b0360","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1242\/dev.01935","article-title":"Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function","volume":"132","author":"Grobe","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.prdoa.2026.100453_b0365","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2003.11.009","article-title":"Reticulon3 expression in rat optic and olfactory systems","volume":"356","author":"Kumamaru","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.prdoa.2026.100453_b0370","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.biochi.2011.11.006","article-title":"Identification of HSP90 as a new GABARAPL1 (GEC1)-interacting protein","volume":"94","author":"Seguin-Py","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.prdoa.2026.100453_b0375","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.neuron.2010.09.027","article-title":"Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration","volume":"68","author":"Hippenmeyer","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.prdoa.2026.100453_b0380","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuroscience.2014.04.031","article-title":"The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system","volume":"271","author":"Pei","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.prdoa.2026.100453_b0385","doi-asserted-by":"crossref","first-page":"33","DOI":"10.29245\/2572.942X\/2018\/5.1223","article-title":"Sema7A signaling is essential for activity-dependent synapse formation in the mouse olfactory bulb","volume":"3","author":"Sakano","year":"2018","journal-title":"J. Neurol. Neuromedicine"},{"key":"10.1016\/j.prdoa.2026.100453_b0390","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1128\/MCB.25.12.5253-5269.2005","article-title":"Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption","volume":"25","author":"Pavlos","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.prdoa.2026.100453_b0395","doi-asserted-by":"crossref","first-page":"C662","DOI":"10.1152\/ajpcell.00623.2006","article-title":"Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells","volume":"294","author":"Evans","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.prdoa.2026.100453_b0400","doi-asserted-by":"crossref","first-page":"13366","DOI":"10.1073\/pnas.0910488107","article-title":"Maturation of the olfactory sensory neurons by Apaf-1\/caspase-9-mediated caspase activity","volume":"107","author":"Ohsawa","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.prdoa.2026.100453_b0405","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ebiom.2019.06.035","article-title":"A subunit of V-ATPases, ATP6V1B2, underlies the pathology of intellectual disability","volume":"45","author":"Zhao","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.prdoa.2026.100453_b0410","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neures.2005.06.018","article-title":"The proto-oncogene BCL-6 is expressed in olfactory sensory neurons","volume":"53","author":"Otaki","year":"2005","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.prdoa.2026.100453_b0415","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1091\/mbc.e04-01-0048","article-title":"Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells","volume":"15","author":"Bertling","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.prdoa.2026.100453_b0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41531-021-00272-w","article-title":"Cofilin 1 promotes the pathogenicity and transmission of pathological \u03b1-synuclein in mouse models of Parkinson\u2019s disease","volume":"8","author":"Yan","year":"2022","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.prdoa.2026.100453_b0425","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s00018-022-04593-8","article-title":"Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology","volume":"79","author":"Heinze","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.prdoa.2026.100453_b0430","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mcn.2018.06.004","article-title":"Semaphorin 3A as an inhibitive factor for migration of olfactory ensheathing cells through cofilin activation is involved in formation of olfactory nerve layer","volume":"92","author":"Wang","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.prdoa.2026.100453_b0435","doi-asserted-by":"crossref","DOI":"10.3390\/biom13121762","article-title":"Antiviral functions of type I and type III interferons in the olfactory epithelium","volume":"13","author":"Zedan","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.prdoa.2026.100453_b0440","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1007\/s12035-016-9849-7","article-title":"Insulin-like growth factor-II\/cation-independent mannose 6-phosphate receptor in neurodegenerative diseases","volume":"54","author":"Wang","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.prdoa.2026.100453_b0445","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1177\/1945892420930945","article-title":"Differences in mechanisms of steroid therapy and olfactory training for olfactory loss in mice","volume":"34","author":"Kim","year":"2020","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.prdoa.2026.100453_b0450","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00405-021-06868-5","article-title":"Correlations between IL-6 serum level and olfactory dysfunction severity in COVID-19 patients: a preliminary study","volume":"279","author":"Vaira","year":"2022","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.prdoa.2026.100453_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.virol.2024.110386","article-title":"Role of interferon regulatory factor 1 in acute and chronic virus infections","volume":"603","author":"Rahlf","year":"2025","journal-title":"Virology"},{"key":"10.1016\/j.prdoa.2026.100453_b0460","doi-asserted-by":"crossref","first-page":"6190","DOI":"10.1158\/0008-5472.CAN-17-1388","article-title":"Histone acetyltransferase KAT6A upregulates PI3K\/AKT signaling through TRIM24 binding","volume":"77","author":"Lv","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.prdoa.2026.100453_b0465","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13023-020-1317-9","article-title":"Five new cases of syndromic intellectual disability due to KAT6A mutations: widening the molecular and clinical spectrum","volume":"15","author":"Urreizti","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.prdoa.2026.100453_b0470","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1210\/endo.140.4.6782","article-title":"Expression of steroid receptor coactivator-1 mRNA in the developing mouse embryo: a possible role in olfactory epithelium development","volume":"140","author":"Misiti","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.prdoa.2026.100453_b0475","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.gendis.2021.06.009","article-title":"Steroid receptor coactivator-1: the central intermediator linking multiple signals and functions in the brain and spinal cord","volume":"9","author":"Meng","year":"2022","journal-title":"Genes Dis."},{"key":"10.1016\/j.prdoa.2026.100453_b0480","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1210\/endo.141.6.7489","article-title":"Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary","volume":"141","author":"Meijer","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.prdoa.2026.100453_b0485","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13195-019-0469-0","article-title":"Alzheimer\u2019s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph","volume":"11","author":"Magno","year":"2019","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.prdoa.2026.100453_b0490","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11010-008-9911-5","article-title":"Expression of signal transducers and activator of transcription 3 (STAT3) determines differentiation of olfactory bulb cells","volume":"320","author":"Yu","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.prdoa.2026.100453_b0495","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.stem.2019.08.011","article-title":"Chronic inflammation directs an olfactory stem cell functional switch from neuroregeneration to immune defense","volume":"25","author":"Chen","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.prdoa.2026.100453_b0500","doi-asserted-by":"crossref","DOI":"10.3389\/falgy.2022.835151","article-title":"Studies on clinical features, mechanisms, and management of olfactory dysfunction secondary to chronic rhinosinusitis","volume":"3","author":"Lin","year":"2022","journal-title":"Front. Allergy"},{"key":"10.1016\/j.prdoa.2026.100453_b0505","doi-asserted-by":"crossref","DOI":"10.1172\/JCI155506","article-title":"Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans","volume":"132","author":"Oliva","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.prdoa.2026.100453_b0510","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-022-02657-x","article-title":"Effects of nasal inflammation on the olfactory bulb","volume":"19","author":"LaFever","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.prdoa.2026.100453_b0515","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.add0484","article-title":"Persistent post\u2013COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium","volume":"14","author":"Finlay","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.prdoa.2026.100453_b0520","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2020858118","article-title":"Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder","volume":"118","author":"Farmen","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.prdoa.2026.100453_b0525","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-025-07333-5","article-title":"Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson\u2019s disease model mice","volume":"16","author":"Song","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.prdoa.2026.100453_b0530","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1571074","article-title":"Peripheral monocyte transcriptional signatures of inflammation and oxidative stress in Parkinson\u2019s disease","volume":"16","author":"Thome","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prdoa.2026.100453_b0535","doi-asserted-by":"crossref","first-page":"6386","DOI":"10.1007\/s00415-022-11258-w","article-title":"Dysregulation of peripheral monocytes and pro-inflammation of alpha-synuclein in Parkinson\u2019s disease","volume":"269","author":"Su","year":"2022","journal-title":"J. Neurol."},{"key":"10.1016\/j.prdoa.2026.100453_b0540","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00401-021-02384-2","article-title":"Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function","volume":"143","author":"Spiteri","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.prdoa.2026.100453_b0545","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.celrep.2018.09.003","article-title":"Type I interferon receptor signaling of neurons and astrocytes regulates microglia activation during viral encephalitis","volume":"25","author":"Chhatbar","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.prdoa.2026.100453_b0550","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2102434118","article-title":"The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages","volume":"118","author":"Vadevoo","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.prdoa.2026.100453_b0555","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1093\/cvr\/cvae153","article-title":"Olfr2-positive macrophages originate from monocytes proliferate in situ and present a pro-inflammatory foamy-like phenotype","volume":"120","author":"Suthahar","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.prdoa.2026.100453_b0560","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1029244","article-title":"Olfactory receptors in macrophages and inflammation","volume":"13","author":"Orecchioni","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prdoa.2026.100453_b0565","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1126\/science.abg3067","article-title":"Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production","volume":"375","author":"Orecchioni","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.prdoa.2026.100453_b0570","doi-asserted-by":"crossref","unstructured":"F. Merah-Mourah, S.O. Cohen, D. Charron, N. Mooney, A. Haziot, Identification of novel human monocyte subsets and evidence for phenotypic groups defined by interindividual variations of expression of adhesion molecules, Scientific Reports 2020 10:1 10 (2020) 4397-. https:\/\/doi.org\/10.1038\/s41598-020-61022-1.","DOI":"10.1038\/s41598-020-61022-1"},{"key":"10.1016\/j.prdoa.2026.100453_b0575","doi-asserted-by":"crossref","first-page":"168-","DOI":"10.1186\/s13046-020-01673-0","article-title":"CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET","volume":"39","author":"Wang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.prdoa.2026.100453_b0580","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/jleuko\/qiaf058","article-title":"Transcriptional programs underlying human monocyte differentiation and diversity","volume":"117","author":"Komaravolu","year":"2025","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.prdoa.2026.100453_b0585","doi-asserted-by":"crossref","unstructured":"X. Long, Y. Li, S. Qiu, J. Liu, L. He, Y. Peng, MiR-582-5p\/miR-590-5p targeted CREB1\/CREB5\u2013NF-\u03baB signaling and caused opioid-induced immunosuppression in human monocytes, Transl. Psychiatry 2016 6:3 6 (2016) e757\u2013e757. https:\/\/doi.org\/10.1038\/tp.2016.4.","DOI":"10.1038\/tp.2016.4"},{"key":"10.1016\/j.prdoa.2026.100453_b0590","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.4049\/jimmunol.1001829","article-title":"The role of the transcription factor CREB in immune function","volume":"185","author":"Wen","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.prdoa.2026.100453_b0595","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s10072-022-06500-2","article-title":"RNAseq analysis of olfactory neuroepithelium cytological samples in individuals with down syndrome compared to euploid controls: a pilot study","volume":"44","author":"Brozzetti","year":"2022","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.prdoa.2026.100453_b0600","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4161\/21541248.2014.973770","article-title":"Regulation and function of P-Rex family Rac-GEFs","volume":"6","author":"Welch","year":"2015","journal-title":"Small GTPases"},{"key":"10.1016\/j.prdoa.2026.100453_b0605","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.prostaglandins.2008.04.001","article-title":"Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis","volume":"87","author":"Wang","year":"2008","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.prdoa.2026.100453_b0610","article-title":"Rac1 plays a crucial role in MCP-1-induced monocyte adhesion and migration","volume":"401\u2013402","author":"Datta","year":"2024","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.prdoa.2026.100453_b0615","doi-asserted-by":"crossref","DOI":"10.3390\/cells10092474","article-title":"P-rex1 controls sphingosine 1-phosphate receptor signalling, morphology, and cell-cycle progression in neuronal cells","volume":"10","author":"Hampson","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.prdoa.2026.100453_b0620","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s12264-019-00408-2","article-title":"P-Rex1 overexpression results in aberrant neuronal polarity and psychosis-related behaviors","volume":"35","author":"Li","year":"2019","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.prdoa.2026.100453_b0625","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.70286","article-title":"Upregulation of PREX1 expression by POU2F2 promotes the malignant progression of acute myeloid leukemia via the mTOR pathway","volume":"39","author":"Hossain","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.prdoa.2026.100453_b0630","first-page":"001","article-title":"Deciphering the intricate role of mTOR signaling and autophagy in Parkinson\u2019s disease and therapeutic prospects","volume":"14","author":"Narayanan","year":"2024","journal-title":"J. Appl. Pharm. Sci."},{"key":"10.1016\/j.prdoa.2026.100453_b0635","unstructured":"Immune cell - ITPK1 - The Human Protein Atlas, (n.d.). https:\/\/v22.proteinatlas.org\/ENSG00000100605-ITPK1\/immune+cell (accessed November 20, 2025)."},{"key":"10.1016\/j.prdoa.2026.100453_b0640","doi-asserted-by":"crossref","first-page":"28117","DOI":"10.1074\/jbc.M703121200","article-title":"Integration of inositol phosphate signaling pathways via human ITPK1","volume":"282","author":"Chamberlain","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prdoa.2026.100453_b0645","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-12311-5","article-title":"Human PI3K\u03b3 deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology","volume":"10","author":"Takeda","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prdoa.2026.100453_b0650","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41577-022-00701-8","article-title":"The role of PI3K\u03b3 in the immune system: new insights and translational implications","volume":"22","author":"Lanahan","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.prdoa.2026.100453_b0655","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030404","article-title":"TLR signaling paralyzes monocyte chemotaxis through synergized effects of p38 MAPK and global Rap-1 activation","volume":"7","author":"Yi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.prdoa.2026.100453_b0660","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0092-8674(00)81444-0","article-title":"Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses","volume":"93","author":"Teglund","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.prdoa.2026.100453_b0665","doi-asserted-by":"crossref","unstructured":"X. Hu, J. li, M. Fu, X. Zhao, W. Wang, The JAK\/STAT signaling pathway: from bench to clinic, Signal Transduction and Targeted Therapy 2021 6:1 6 (2021) 402-. https:\/\/doi.org\/10.1038\/s41392-021-00791-1.","DOI":"10.1038\/s41392-021-00791-1"},{"key":"10.1016\/j.prdoa.2026.100453_b0670","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1025373","article-title":"STAT5b: a master regulator of key biological pathways","volume":"13","author":"Smith","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prdoa.2026.100453_b0675","unstructured":"Single cell type - ATP6V1B2 - The Human Protein Atlas, (n.d.). https:\/\/www.proteinatlas.org\/ENSG00000147416-ATP6V1B2\/single+cell (accessed November 20, 2025)."},{"key":"10.1016\/j.prdoa.2026.100453_b0680","unstructured":"ATP6V1B2 - V-type proton ATPase subunit B, brain isoform - Homo sapiens (Human) | UniProtKB | UniProt, (n.d.). https:\/\/www.uniprot.org\/uniprotkb\/P21281\/entry (accessed November 20, 2025)."},{"key":"10.1016\/j.prdoa.2026.100453_b0685","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.cmet.2014.01.013","article-title":"Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes","volume":"19","author":"Lee","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.prdoa.2026.100453_b0690","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1111\/jcpe.14203","article-title":"KAT6A promotes macrophage inflammation and periodontitis","volume":"52","author":"Huang","year":"2025","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.prdoa.2026.100453_b0695","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/jcb.24653","article-title":"PLC\u03b32 and PKC are important to myeloid lineage commitment triggered by M-SCF and G-CSF","volume":"115","author":"Barbosa","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.prdoa.2026.100453_b0700","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1080\/15548627.2015.1034406","article-title":"The PRKAA1\/AMPK\u03b11 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML","volume":"11","author":"Obba","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.prdoa.2026.100453_b0705","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1002\/jcb.24571","article-title":"Monocytes and smooth muscle cells cross-talk activates STAT3 and induces resistin and reactive oxygen species production [corrected]","volume":"114","author":"Gan","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.prdoa.2026.100453_b0710","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035070","article-title":"STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass","volume":"7","author":"de Jong","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.prdoa.2026.100453_b0715","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/1566524016666160324130031","article-title":"STAT3 activation in circulating monocytes contributes to neovascular age-related macular degeneration","volume":"16","author":"Chen","year":"2016","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.prdoa.2026.100453_b0720","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1160719","article-title":"Advances in the role of STAT3 in macrophage polarization","volume":"14","author":"Xia","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prdoa.2026.100453_b0725","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s43587-021-00088-6","article-title":"RNA sequencing of whole blood reveals early alterations in immune cells and gene expression in Parkinson\u2019s disease","volume":"1","author":"Craig","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.prdoa.2026.100453_b0730","doi-asserted-by":"crossref","unstructured":"A. Beric, Y. Sun, S. Sanchez, C. Martin, T. Powell, J.A. Pardo, J. Sanford, J.A. Botia, C. Cruchaga, L. Ibanez, Circulating blood circular RNA in Parkinson\u2019s Disease; a systematic study, MedRxiv (2024) 2024.01.22.24301623. https:\/\/doi.org\/10.1101\/2024.01.22.24301623.","DOI":"10.1101\/2024.01.22.24301623"},{"key":"10.1016\/j.prdoa.2026.100453_b0735","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000025888","article-title":"RNA-sequencing of peripheral blood circular RNAs in Parkinson disease","volume":"100","author":"Kong","year":"2021","journal-title":"Medicine"}],"container-title":["Clinical Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112526000332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112526000332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:20:05Z","timestamp":1783930805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590112526000332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":147,"alternative-id":["S2590112526000332"],"URL":"https:\/\/doi.org\/10.1016\/j.prdoa.2026.100453","relation":{},"ISSN":["2590-1125"],"issn-type":[{"value":"2590-1125","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of genes associated with smell dysfunction in Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Clinical Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prdoa.2026.100453","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100453"}}