{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:48:31Z","timestamp":1791658111523,"version":"4.3.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":166,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.prdoa.2026.100467","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:11:42Z","timestamp":1781827902000},"page":"100467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Clinical and autonomic correlates of chronic Sialorrhea in Parkinson's disease: a questionnaire-based study with cluster analysis of autonomic and dysphagia burden"],"prefix":"10.1016","volume":"15","author":[{"given":"Shohei","family":"Okusa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Nukariya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Nihei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morinobu","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.prdoa.2026.100467_bb0005","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1136\/practneurol-2016-001515","article-title":"Management of oral secretions in neurological disease","volume":"17","author":"McGeachan","year":"2017","journal-title":"Pract. Neurol."},{"issue":"7","key":"10.1016\/j.prdoa.2026.100467_bb0010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.parkreldis.2009.12.003","article-title":"The impact of and the factors associated with drooling in Parkinson\u2019s disease","volume":"16","author":"Leibner","year":"2010","journal-title":"Parkinsonism Relat. Disord."},{"issue":"9","key":"10.1016\/j.prdoa.2026.100467_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13091395","article-title":"Pharmacokinetics of levodopa and 3-O-methyldopa in parkinsonian patients treated with levodopa and Ropinirole and in patients with motor complications","volume":"13","author":"Adamiak-Giera","year":"2021","journal-title":"Pharmaceutics"},{"issue":"11","key":"10.1016\/j.prdoa.2026.100467_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12110691","article-title":"Sialorrhea in Parkinson\u2019s disease","volume":"12","author":"Isaacson","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.prdoa.2026.100467_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.prdoa.2023.100223","article-title":"Recommendations for a paradigm shift in approach to increase the recognition and treatment of sialorrhea in Parkinson's disease","volume":"9","author":"Bergmans","year":"2023","journal-title":"Clinical parkinsonism & related disorders"},{"issue":"6","key":"10.1016\/j.prdoa.2026.100467_bb0030","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s00455-020-10102-5","article-title":"Drooling in Parkinson\u2019s disease: prevalence and progression from the non-motor international longitudinal study","volume":"35","author":"van Wamelen","year":"2020","journal-title":"Dysphagia"},{"issue":"15","key":"10.1016\/j.prdoa.2026.100467_bb0035","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1212\/WNL.0b013e3181d8c1b7","article-title":"Glycopyrrolate for sialorrhea in Parkinson disease: a randomized, double-blind, crossover trial","volume":"74","author":"Arbouw","year":"2010","journal-title":"Neurology"},{"issue":"10423","key":"10.1016\/j.prdoa.2026.100467_bb0040","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0140-6736(23)01429-0","article-title":"Medical, surgical, and physical treatments for Parkinson's disease","volume":"403","author":"Foltynie","year":"2024","journal-title":"Lancet (London, England)"},{"issue":"11","key":"10.1016\/j.prdoa.2026.100467_bb0045","first-page":"2628","article-title":"Sialorrhea: a management challenge","volume":"69","author":"Hockstein","year":"2004","journal-title":"Am. Fam. Physician"},{"issue":"1","key":"10.1016\/j.prdoa.2026.100467_bb0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/ene.15083","article-title":"Efficacy and safety of botulinum toxin for treating sialorrhea: a systematic review and meta-analysis","volume":"29","author":"Yu","year":"2022","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.prdoa.2026.100467_bb0055","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/mdc3.70259","article-title":"Efficacy and Safety of IncobotulinumtoxinA for Treatment of Sialorrhea: A Multicenter, Phase 3 Study in Japan","volume":"13","author":"Hattori","year":"2026","journal-title":"Mov. Disord. Clin. Pract."},{"issue":"11","key":"10.1016\/j.prdoa.2026.100467_bb0060","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.parkreldis.2014.08.013","article-title":"Drooling in Parkinson\u2019s disease: a review","volume":"20","author":"Srivanitchapoom","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"issue":"2","key":"10.1016\/j.prdoa.2026.100467_bb0065","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/mds.20189","article-title":"Salivary production in Parkinson\u2019s disease","volume":"20","author":"Proulx","year":"2005","journal-title":"Movement disorders\u202f: official journal of the Movement Disorder Society"},{"issue":"16","key":"10.1016\/j.prdoa.2026.100467_bb0070","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1002\/mds.21646","article-title":"Sialorrhea in Parkinson\u2019s disease: a review","volume":"22","author":"Chou","year":"2007","journal-title":"Movement disorders\u202f: official journal of the Movement Disorder Society"},{"issue":"2","key":"10.1016\/j.prdoa.2026.100467_bb0075","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00415-024-12739-w","article-title":"Predictors of drooling severity in people with Parkinson\u2019s disease","volume":"272","author":"Nascimento","year":"2025","journal-title":"J. Neurol."},{"issue":"4","key":"10.1016\/j.prdoa.2026.100467_bb0080","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13259","article-title":"Drooling is no early sign of dysphagia in Parkinson\u2019s disease","volume":"30","author":"Nienstedt","year":"2018","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.prdoa.2026.100467_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2025.108069","article-title":"Drooling in Parkinson\u2019s disease: a potential clinical marker of disease severity","volume":"140","author":"Igami","year":"2025","journal-title":"Parkinsonism Relat. Disord."},{"issue":"12","key":"10.1016\/j.prdoa.2026.100467_bb0090","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Movement disorders\u202f: official journal of the Movement Disorder Society"},{"issue":"15","key":"10.1016\/j.prdoa.2026.100467_bb0095","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement Disorder Society-sponsored revision of the unified Parkinson\u2019s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Movement disorders\u202f: official journal of the Movement Disorder Society"},{"key":"10.1016\/j.prdoa.2026.100467_bb0100","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.clineuro.2014.07.007","article-title":"Reliability of the Japanese version of the scales for outcomes in Parkinson\u2019s disease-autonomic questionnaire","volume":"124","author":"Matsushima","year":"2014","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"7","key":"10.1016\/j.prdoa.2026.100467_bb0105","first-page":"1299","article-title":"Validation of the Japanese translation of the swallowing disturbance questionnaire in Parkinson\u2019s disease patients","volume":"21","author":"Yamamoto","year":"2012","journal-title":"Qual. Life Res. Int. J. Qual. Life Asp. Treat. Care Rehab."},{"issue":"2","key":"10.1016\/j.prdoa.2026.100467_bb0110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF02412423","article-title":"Three treatment approaches and clinical factors in the reduction of drooling","volume":"3","author":"Thomas-Stonell","year":"1988","journal-title":"Dysphagia"},{"issue":"1","key":"10.1016\/j.prdoa.2026.100467_bb0115","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/mds.27862","article-title":"The movement disorder society nonmotor rating scale: initial validation study","volume":"35","author":"Chaudhuri","year":"2020","journal-title":"Movement disorders\u202f: official journal of the Movement Disorder Society"},{"issue":"1","key":"10.1016\/j.prdoa.2026.100467_bb0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00415-013-7135-4","article-title":"Is reduced myocardial sympathetic innervation associated with clinical symptoms of autonomic impairment in idiopathic Parkinson\u2019s disease?","volume":"261","author":"Guidez","year":"2014","journal-title":"J. Neurol."},{"key":"10.1016\/j.prdoa.2026.100467_bb0125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.parkreldis.2020.01.012","article-title":"Quantitative assessment of posture in healthy controls and patients with Parkinson\u2019s disease","volume":"76","author":"Schlenstedt","year":"2020","journal-title":"Parkinsonism Relat. Disord."},{"issue":"4","key":"10.1016\/j.prdoa.2026.100467_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12041329","article-title":"sex differences in motor and non-motor symptoms among Spanish patients with Parkinson\u2019s disease","volume":"12","author":"Santos-Garc\u00eda","year":"2023","journal-title":"J. Clin. Med."},{"issue":"21","key":"10.1016\/j.prdoa.2026.100467_bb0135","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1212\/WNL.0000000000001609","article-title":"Potential sex differences in nonmotor symptoms in early drug-naive Parkinson disease","volume":"84","author":"Liu","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.prdoa.2026.100467_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2025.107902","article-title":"Gender-specific cardiovascular autonomic responses in Parkinson\u2019s disease: insights from an observational study","volume":"137","author":"Meksi","year":"2025","journal-title":"Parkinsonism Relat. Disord."}],"container-title":["Clinical Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112526000472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112526000472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:51:10Z","timestamp":1791654670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590112526000472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":28,"alternative-id":["S2590112526000472"],"URL":"https:\/\/doi.org\/10.1016\/j.prdoa.2026.100467","relation":{},"ISSN":["2590-1125"],"issn-type":[{"value":"2590-1125","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and autonomic correlates of chronic Sialorrhea in Parkinson's disease: a questionnaire-based study with cluster analysis of autonomic and dysphagia burden","name":"articletitle","label":"Article Title"},{"value":"Clinical Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prdoa.2026.100467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100467"}}