{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:48:17Z","timestamp":1791658097122,"version":"4.3.4"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":253,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.prdoa.2026.100502","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:58:16Z","timestamp":1789516696000},"page":"100502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Impact of type 2 diabetes mellitus on acute levodopa responsiveness in Parkinson's disease: A Multicenter retrospective study"],"prefix":"10.1016","volume":"15","author":[{"given":"Olga","family":"Stockmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Buhmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Maass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"van Riesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Weinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Wegner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"H\u00f6llerhage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"P\u00f6tter-Nerger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Klietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.prdoa.2026.100502_bb0005","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"Global, regional, and national burden of Parkinson\u2019s disease, 1990\u20132016: a systematic analysis for the global burden of disease study 2016","volume":"17","author":"Dorsey","year":"2018","journal-title":"The Lancet Neurology."},{"issue":"6","key":"10.1016\/j.prdoa.2026.100502_bb0010","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s40266-019-00654-z","article-title":"Safety and tolerability of pharmacotherapies for Parkinson\u2019s disease in geriatric patients","volume":"36","author":"Klietz","year":"2019","journal-title":"Drugs Aging"},{"issue":"5","key":"10.1016\/j.prdoa.2026.100502_bb0015","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.parkreldis.2013.01.016","article-title":"Diabetes is associated with postural instability and gait difficulty in Parkinson disease","volume":"19","author":"Kotagal","year":"2013","journal-title":"Parkinsonism Relat. Disord."},{"issue":"5","key":"10.1016\/j.prdoa.2026.100502_bb0020","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00702-025-02882-7","article-title":"Impact of diabetes mellitus type two on incidence and progression of Parkinson\u2019s disease: a systematic review of longitudinal patient cohorts","volume":"132","author":"Stockmann","year":"2025","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.prdoa.2026.100502_bb0025","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.parkreldis.2018.08.023","article-title":"Detrimental effect of type 2 diabetes mellitus in a large case series of Parkinson\u2019s disease","volume":"64","author":"Chung","year":"2019","journal-title":"Parkinsonism Relat. Disord."},{"issue":"12","key":"10.1016\/j.prdoa.2026.100502_bb0030","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/mds.27516","article-title":"Identification of a large homozygous VPS13C deletion in a patient with early-onset parkinsonism","volume":"33","author":"Darvish","year":"2018","journal-title":"Movement Disorders: Official J. Movement Disorder Soc."},{"issue":"19","key":"10.1016\/j.prdoa.2026.100502_bb0035","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1212\/WNL.0b013e3182553cc9","article-title":"Clinical features of Parkinson disease when onset of diabetes came first: a case-control study","volume":"78","author":"Cereda","year":"2012","journal-title":"Neurology"},{"issue":"16","key":"10.1016\/j.prdoa.2026.100502_bb0040","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1001\/jama.2014.3654","article-title":"Pharmacological treatment of Parkinson disease: a review","volume":"311","author":"Connolly","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.prdoa.2026.100502_bb0045","article-title":"Acute levodopa challenge in atypical parkinsonism","volume":"10","author":"Ye","year":"2024","journal-title":"Brain Sci."},{"issue":"1","key":"10.1016\/j.prdoa.2026.100502_bb0050","article-title":"Standardised neuropsychological assessment for the selection of patients undergoing DBS for Parkinson\u2019s disease","volume":"2018","author":"Foley","year":"2018","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.prdoa.2026.100502_bb0055","series-title":"Diagnosis and classification of diabetes: standards of care in diabetes\u20142025Diabetes Care","first-page":"S27","volume":"48","year":"2025"},{"issue":"12","key":"10.1016\/j.prdoa.2026.100502_bb0060","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"issue":"10","key":"10.1016\/j.prdoa.2026.100502_bb0065","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1093\/brain\/awz261","article-title":"Cerebral differences between dopamine-resistant and dopamine-responsive Parkinson\u2019s tremor","volume":"142","author":"Dirkx","year":"2019","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.prdoa.2026.100502_bb0070","doi-asserted-by":"crossref","first-page":"e1461","DOI":"10.1212\/WNL.0000000000010316","article-title":"Dopamine-responsive and dopamine-resistant resting tremor in Parkinson disease","volume":"95","author":"Zach","year":"2020","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.prdoa.2026.100502_bb0075","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.2337\/dc20-0892","article-title":"Metformin use is associated with slowed cognitive decline and reduced incident dementia in older adults with type 2 diabetes: the Sydney memory and ageing study","volume":"43","author":"Samaras","year":"2020","journal-title":"Diabetes Care"},{"issue":"12","key":"10.1016\/j.prdoa.2026.100502_bb0080","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.2337\/dc21-1046","article-title":"Effect of metformin and lifestyle interventions on mortality in the diabetes prevention program and diabetes prevention program outcomes study","volume":"44","author":"Lee","year":"2021","journal-title":"Diabetes Care"}],"container-title":["Clinical Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112526000824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112526000824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:48:57Z","timestamp":1791654537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590112526000824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":16,"alternative-id":["S2590112526000824"],"URL":"https:\/\/doi.org\/10.1016\/j.prdoa.2026.100502","relation":{},"ISSN":["2590-1125"],"issn-type":[{"value":"2590-1125","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of type 2 diabetes mellitus on acute levodopa responsiveness in Parkinson's disease: A Multicenter retrospective study","name":"articletitle","label":"Article Title"},{"value":"Clinical Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prdoa.2026.100502","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100502"}}