{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:47:44Z","timestamp":1791798464146,"version":"4.3.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":273,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson&apos;s Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson&apos;s","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Parkinsonism &amp; Related Disorders"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.prdoa.2026.100508","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:37:06Z","timestamp":1790923026000},"page":"100508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comprehensive genetic screening of the South African Parkinson's disease study collection using the NeuroBooster array"],"prefix":"10.1016","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4054-7030","authenticated-orcid":false,"given":"Kathryn","family":"Step","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4862-7887","authenticated-orcid":false,"given":"Lusanda","family":"Madula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9847-0282","authenticated-orcid":false,"given":"Nicole","family":"Kuznetsov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3402-169X","authenticated-orcid":false,"given":"Elizna","family":"Maasdorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7677-426X","authenticated-orcid":false,"given":"Jonathan","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6250-363X","authenticated-orcid":false,"given":"Riaan","family":"van Coller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-6741","authenticated-orcid":false,"given":"Marlo","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-0633","authenticated-orcid":false,"given":"Ignacio F.","family":"Mata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-3438","authenticated-orcid":false,"given":"Soraya","family":"Bardien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prdoa.2026.100508_bb0005","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.parkreldis.2011.09.022","article-title":"Mutations in the parkin gene are a minor cause of Parkinson\u2019s disease in the south African population","volume":"18","author":"Haylett","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.prdoa.2026.100508_bb0010","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","article-title":"The genetic architecture of Parkinson\u2019s disease","volume":"19","author":"Blauwendraat","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.prdoa.2026.100508_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/genes13030471","article-title":"Monogenic Parkinson\u2019s disease: genotype, phenotype, pathophysiology, and genetic testing","volume":"13","author":"Jia","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.prdoa.2026.100508_bb0020","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/mds.29314","article-title":"Classification of GBA1 variants in Parkinson\u2019s disease: the GBA1-PD browser","volume":"38","author":"Parlar","year":"2023","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.prdoa.2026.100508_bb0025","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbag205","article-title":"CNV-Finder: streamlining copy number variation discovery","volume":"6","author":"Kuznetsov","year":"2026","journal-title":"Bioinform. Adv."},{"key":"10.1016\/j.prdoa.2026.100508_bb0030","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/mds.28710","article-title":"Copy number variation in Parkinson\u2019s disease: an update from sub-Saharan Africa","volume":"36","author":"M\u00fcller-Nedebock","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100508_bb0035","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1016\/j.ajhg.2025.08.012","article-title":"The Indian Ocean slave trade and colonial expansion resulted in strong sex-biased admixture in South Africa","volume":"112","author":"Reynolds","year":"2025","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.prdoa.2026.100508_bb0040","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00438-017-1296-2","article-title":"Population structure and infectious disease risk in southern Africa","volume":"292","author":"Uren","year":"2017","journal-title":"Mol. Gen. Genomics."},{"key":"10.1016\/j.prdoa.2026.100508_bb0045","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10048-019-00588-z","article-title":"Frequency of the LRRK2 G2019S mutation in south African patients with Parkinson\u2019s disease","volume":"20","author":"du Toit","year":"2019","journal-title":"Neurogenetics"},{"key":"10.1016\/j.prdoa.2026.100508_bb0050","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.prdoa.2026.100508_bb0055","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/mds.30051","article-title":"Advancing Parkinson\u2019s disease research in Africa: a strategic training framework of the global Parkinson\u2019s genetics program","volume":"40","author":"Step","year":"2025","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100508_bb0060","article-title":"Genome-wide association analyses reveal susceptibility variants linked to Parkinson\u2019s disease in the South African population using inferred global and local ancestry","author":"Step","year":"2025","journal-title":"medRxiv"},{"key":"10.1016\/j.prdoa.2026.100508_bb0065","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.prdoa.2026.100508_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2025.169413","article-title":"Assessing in silico tools for accurate pathogenicity prediction in CHD nucleosome remodelers","volume":"437","author":"Rabouhi","year":"2025","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.prdoa.2026.100508_bb0075","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msae263","article-title":"MEGA12: molecular evolutionary genetic analysis version 12 for adaptive and green computing","volume":"41","author":"Kumar","year":"2024","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.prdoa.2026.100508_bb0080","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10048-009-0229-6","article-title":"Analysis of exon dosage using MLPA in south African Parkinson\u2019s disease patients","volume":"11","author":"Keyser","year":"2010","journal-title":"Neurogenetics"},{"key":"10.1016\/j.prdoa.2026.100508_bb0085","doi-asserted-by":"crossref","first-page":"623","DOI":"10.7196\/SAMJ.2016.v106i6.10340","article-title":"Clinical findings and genetic screening for copy number variation mutations in a cohort of South African patients with Parkinson\u2019s disease","volume":"106","author":"Mahne","year":"2016","journal-title":"S. Afr. Med. J."},{"key":"10.1016\/j.prdoa.2026.100508_bb0090","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neulet.2016.03.028","article-title":"Exonic rearrangements in the known Parkinson\u2019s disease-causing genes are a rare cause of the disease in south African patients","volume":"619","author":"van der Merwe","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.prdoa.2026.100508_bb0095","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/mdc3.70057","article-title":"Deep brain stimulation improves symptoms in an individual with alpha-synuclein-gene-associated Parkinson\u2019s disease","volume":"12","author":"Braun","year":"2025","journal-title":"Mov. Disord. Clin. Pract."},{"key":"10.1016\/j.prdoa.2026.100508_bb0100","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/mds.28416","article-title":"ROPAD study group, The Rostock international Parkinson\u2019s disease (ROPAD) study: protocol and initial findings","volume":"36","author":"Skrahina","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100508_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002548","article-title":"Comprehensive research synopsis and systematic meta-analyses in Parkinson\u2019s disease genetics: the PDGene database","volume":"8","author":"Lill","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.prdoa.2026.100508_bb0140","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1093\/hmg\/ddv277","article-title":"Heterozygote carriers for CNVs in PARK2 are at increased risk of Parkinson\u2019s disease","volume":"24","author":"Huttenlocher","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.prdoa.2026.100508_bb0145","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00439-016-1749-4","article-title":"Copy number variability in Parkinson\u2019s disease: assembling the puzzle through a systems biology approach","volume":"136","author":"La Cognata","year":"2017","journal-title":"Hum. Genet."},{"key":"10.1016\/j.prdoa.2026.100508_bb0150","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/ana.27155","article-title":"The utility of long-read sequencing in diagnosing early onset Parkinson\u2019s disease","volume":"97","author":"Daida","year":"2025","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.prdoa.2026.100508_bb0155","article-title":"Large-scale genetic characterization of Parkinson\u2019s disease in the African and African admixed populations","author":"Ak\u00e7imen","year":"2025","journal-title":"Brain"},{"key":"10.1016\/j.prdoa.2026.100508_bb0160","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neulet.2013.07.013","article-title":"Detection of copy number changes in genes associated with Parkinson\u2019s disease in Iranian patients","volume":"551","author":"Darvish","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.prdoa.2026.100508_bb0165","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/mds.28828","article-title":"The South African Parkinson\u2019s disease study collection","volume":"37","author":"van Rensburg","year":"2022","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prdoa.2026.100508_bb0170","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/gepi.22326","article-title":"Sequencing and imputation in GWAS: cost-effective strategies to increase power and genomic coverage across diverse populations","volume":"44","author":"Quick","year":"2020","journal-title":"Genet. Epidemiol."}],"container-title":["Clinical Parkinsonism &amp; Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112526000885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590112526000885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:10:14Z","timestamp":1791796214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590112526000885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":28,"alternative-id":["S2590112526000885"],"URL":"https:\/\/doi.org\/10.1016\/j.prdoa.2026.100508","relation":{},"ISSN":["2590-1125"],"issn-type":[{"value":"2590-1125","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive genetic screening of the South African Parkinson's disease study collection using the NeuroBooster array","name":"articletitle","label":"Article Title"},{"value":"Clinical Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prdoa.2026.100508","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100508"}}