{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:16:52Z","timestamp":1789755412209,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.preghy.2012.09.002","type":"journal-article","created":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T06:35:05Z","timestamp":1348814105000},"page":"28-33","source":"Crossref","is-referenced-by-count":19,"title":["Chlamydia trachomatis infection may increase the risk of preeclampsia"],"prefix":"10.1016","volume":"3","author":[{"given":"Catherine L.","family":"Haggerty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Panum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soren A.","family":"Uldum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra C.","family":"Bass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorn","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Darville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie M.","family":"Eastman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyagriv N.","family":"Simhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta B.","family":"Ness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preghy.2012.09.002_b0005","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1001\/jama.287.24.3183","article-title":"Contemporary concepts of the pathogenesis and management of preeclampsia","volume":"287","author":"Lain","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.preghy.2012.09.002_b0010","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S0140-6736(02)11283-9","article-title":"Pre-eclampsia and expression of heparin-binding EGF-like growth factor","volume":"360","author":"Leach","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.preghy.2012.09.002_b0015","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0002-9378(99)70239-5","article-title":"Preeclampsia: an excessive maternal inflammatory response to pregnancy","volume":"180","author":"Redman","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.preghy.2012.09.002_b0020","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0002-9378(98)70254-6","article-title":"Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis.[comment]","volume":"179","author":"Sacks","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.preghy.2012.09.002_b0025","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1161\/01.HYP.0000143849.67254.ca","article-title":"Short- and long-term changes in plasma inflammatory markers associated with preeclampsia","volume":"44","author":"Freeman","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.preghy.2012.09.002_b0030","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00004872-200302000-00032","article-title":"Neutrophil activation and production of reactive oxygen species in pre-eclampsia","volume":"21","author":"Lee","year":"2003","journal-title":"J Hypertens"},{"key":"10.1016\/j.preghy.2012.09.002_b0035","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1042\/cs0920037","article-title":"Neutrophil CD11B expression and neutrophil activation in pre-eclampsia","volume":"92","author":"Barden","year":"1997","journal-title":"Clin Sci"},{"key":"10.1016\/j.preghy.2012.09.002_b0040","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.preghy.2012.09.002_b0045","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0029-7844(00)01179-0","article-title":"Increased systemic activation of neutrophils but not complement in preeclampsia","volume":"97","author":"Mellembakken","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.preghy.2012.09.002_b0050","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1600-0897.2005.00253.x","article-title":"Tumor necrosis factor-alpha in the placenta is not elevated in pre-eclamptic patients despite its elevation in peripheral blood","volume":"53","author":"Hayashi","year":"2005","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.preghy.2012.09.002_b0055","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1189\/jlb.72.5.874","article-title":"Monocytes are progressively activated in the circulation of pregnant women","volume":"72","author":"Luppi","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.preghy.2012.09.002_b0060","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0167-5699(98)01393-0","article-title":"An innate view of human pregnancy","volume":"20","author":"Sacks","year":"1999","journal-title":"Immunol Today"},{"key":"10.1016\/j.preghy.2012.09.002_b0065","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1034\/j.1600-0412.2001.801112.x","article-title":"Is preeclampsia an infectious disease?","volume":"80","author":"Trogstad","year":"2001","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.preghy.2012.09.002_b0070","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1034\/j.1600-0897.2002.01076.x","article-title":"Preeclampsia: a multifactorial disease resulting from the interaction of the feto-maternal HLA genotype and HCMV infection","volume":"48","author":"Carreiras","year":"2002","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.preghy.2012.09.002_b0075","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0029-7844(02)02591-7","article-title":"Seroprevalence of antibodies to Chlamydia pneumoniae in women with preeclampsia","volume":"101","author":"Heine","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.preghy.2012.09.002_b0080","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1471-0528.2003.02481.x","article-title":"Levels of antibodies against cytomegalovirus and Chlamydophila pneumoniae are increased in early onset pre-eclampsia","volume":"110","author":"von Dadelszen","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.preghy.2012.09.002_b0085","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1081\/PRG-120028284","article-title":"Preeclampsia and Chlamydia pneumoniae: is there a link?","volume":"23","author":"Raynor","year":"2004","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.preghy.2012.09.002_b0090","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijgo.2005.09.024","article-title":"Chlamydia pneumoniae seropositivity in women with pre-eclampsia","volume":"92","author":"Aral","year":"2006","journal-title":"Int J Gynaecol Obstet"},{"issue":"4","key":"10.1016\/j.preghy.2012.09.002_b0095","first-page":"375","article-title":"Comparing serum IgG titers against Chlamydia pneumoniae in patients with early and late-onset pre-eclampsia and healthy individuals","volume":"7","author":"Mokhtari","year":"2007","journal-title":"Med J Reprod Infertil"},{"key":"10.1016\/j.preghy.2012.09.002_b0100","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/10641950701885188","article-title":"Maternal serum Chlamydia pneumoniae antibodies and CRP levels in women with preeclampsia and gestational hypertension","volume":"27","author":"Karinen","year":"2008","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.preghy.2012.09.002_b0105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/humrep\/dem360","article-title":"Adverse reproductive outcomes in urban women with adeno-associated virus-2 infections in early pregnancy","volume":"23","author":"Arechavaleta-Velasco","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.preghy.2012.09.002_b0110","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ajog.2009.03.001","article-title":"Trophoblast infection with Chlamydia pneumoniae and adverse pregnancy outcomes associated with placental dysfunction","volume":"200","author":"Gomez","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.preghy.2012.09.002_b0115","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3109\/10641950903242642","article-title":"Chlamydia pneumoniae infection in preeclampsia","volume":"29","author":"Xie","year":"2010","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.preghy.2012.09.002_b0120","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijgo.2010.11.014","article-title":"Impact of seroconversion and antichlamydial treatment on the rate of pre-eclampsia among Egyptian primigravidae","volume":"113","author":"El Shourbagy","year":"2011","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.preghy.2012.09.002_b0125","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0002-9378(96)70056-X","article-title":"Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications","volume":"175","author":"Ness","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.preghy.2012.09.002_b0130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/aje\/kwm139","article-title":"Validity of preeclampsia-related diagnoses recorded in a national hospital registry and in a postpartum interview of the women","volume":"166","author":"Klemmensen","year":"2007","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.preghy.2012.09.002_b0135","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/jmv.1890220109","article-title":"An Enzyme Labelled Nuclear Antigen Immunoassay for Detection of Cytomegalovirus IgM antibodies in Human Serum: Specific and non-specific Reactions","volume":"22","author":"Nielsen","year":"1987","journal-title":"J Med Virol"},{"key":"10.1016\/j.preghy.2012.09.002_b0140","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0166-0934(87)90004-8","article-title":"A biotin-avidin-amplified inhibition enzyme immunoassay for detection of CMV antibodies in human serum","volume":"16","author":"Nielsen","year":"1987","journal-title":"J Virol Methods"},{"key":"10.1016\/j.preghy.2012.09.002_b0145","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0140-6736(96)90321-9","article-title":"Malaria associated pre-eclampsia in senegal","volume":"347","author":"Sartelet","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.preghy.2012.09.002_b0150","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0020-7292(95)02373-K","article-title":"Urogenital infection in preeclampsia","volume":"49","author":"Hsu","year":"1995","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.preghy.2012.09.002_b0155","first-page":"491","article-title":"Preeclampsia. A nested, case-control study of risk factors and their interactions","volume":"41","author":"Mittendorf","year":"1996","journal-title":"J Reprod Med"},{"key":"10.1016\/j.preghy.2012.09.002_b0160","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajog.2007.07.040","article-title":"Maternal infection and risk of preeclampsia: systematic review and metaanalysis","volume":"198","author":"Conde-Agudelo","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.preghy.2012.09.002_b0165","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3109\/00016349.2010.499449","article-title":"An association between cytomegalovirus infection and pre-eclampsia: a case-control study and data synthesis","volume":"89","author":"Xie","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.preghy.2012.09.002_b0170","first-page":"S74","article-title":"Serological association between primary infections with herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), cytomegalovirus (CMV) and epstein barr virus (EBV) and the risk of preeclampsia","volume":"157","author":"Rustveld","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.preghy.2012.09.002_b0175","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3109\/10641955.2010.506235","article-title":"Acute and chronic chlamydia pneumoniae infection in pregnancy complicated with preeclampsia","volume":"30","author":"Chrisoulidou","year":"2011","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.preghy.2012.09.002_b0180","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/14767050400028816","article-title":"Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia","volume":"17","author":"Chaiworapongsa","year":"2005","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778912003649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778912003649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T21:37:20Z","timestamp":1714426640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778912003649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S2210778912003649"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2012.09.002","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}