{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:13:32Z","timestamp":1784229212539,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["pregnancyhypertension.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.preghy.2015.01.004","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T14:55:32Z","timestamp":1423493732000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Pregnancy and pulmonary arterial hypertension: A clinical conundrum"],"prefix":"10.1016","volume":"5","author":[{"given":"Sonu","family":"Sahni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul V.","family":"Palkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton L.","family":"Rochelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiktor","family":"K\u0119pa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunabh","family":"Talwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.preghy.2015.01.004_b0005","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra035488","article-title":"Pulmonary arterial hypertension","volume":"351","author":"Farber","year":"2004","journal-title":"N Engl J Med"},{"issue":"Suppl. 25","key":"10.1016\/j.preghy.2015.01.004_b0010","doi-asserted-by":"crossref","first-page":"D34","DOI":"10.1016\/j.jacc.2013.10.029","article-title":"Updated clinical classification of pulmonary hypertension","volume":"62","author":"Simonneau","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"123","key":"10.1016\/j.preghy.2015.01.004_b0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1183\/09059180.00008211","article-title":"REVEAL: a contemporary US pulmonary arterial hypertension registry","volume":"21","author":"McGoon","year":"2012","journal-title":"Eur Respir Rev"},{"issue":"Suppl. 1","key":"10.1016\/j.preghy.2015.01.004_b0020","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.1378\/chest.126.1_suppl.35S","article-title":"Medical therapy for pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines","volume":"126","author":"Badesch","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.preghy.2015.01.004_b0025","series-title":"United Kingdom obstetric surveillance system (UKOSS) annual report 2007","author":"Knight","year":"2007"},{"key":"10.1016\/j.preghy.2015.01.004_b0030","series-title":"Obstetrics and gynecology","first-page":"51","article-title":"Maternal\u2013fetal physiology","author":"Beckmann","year":"2006"},{"issue":"3","key":"10.1016\/j.preghy.2015.01.004_b0035","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/eurheartj\/ehn597","article-title":"Has there been any progress made on pregnancy outcomes among women with pulmonary arterial hypertension?","volume":"30","author":"B\u00e9dard","year":"2009","journal-title":"Eur Heart J"},{"issue":"7","key":"10.1016\/j.preghy.2015.01.004_b0040","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/S0735-1097(98)00162-4","article-title":"Outcome of pulmonary vascular disease in pregnancy: a systematic overview from 1978 through 1996","volume":"31","author":"Weiss","year":"1998","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl. 1","key":"10.1016\/j.preghy.2015.01.004_b0045","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.jacc.2009.04.011","article-title":"Diagnosis and assessment of pulmonary arterial hypertension","volume":"54","author":"Badesch","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.preghy.2015.01.004_b0050","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1053\/euhj.1999.1701","article-title":"Pulmonary vascular disease and pregnancy: current controversies, management strategies, and perspectives","volume":"21","author":"Weiss","year":"2000","journal-title":"Eur Heart J"},{"issue":"9","key":"10.1016\/j.preghy.2015.01.004_b0055","doi-asserted-by":"crossref","first-page":"745","DOI":"10.7326\/0003-4819-128-9-199805010-00008","article-title":"The Eisenmenger syndrome in adults","volume":"128","author":"Vongpatanasin","year":"1998","journal-title":"Ann Intern Med"},{"issue":"6607","key":"10.1016\/j.preghy.2015.01.004_b0060","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1136\/bmj.295.6607.1169","article-title":"Cardiac output during labour","volume":"295","author":"Robson","year":"1987","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"2","key":"10.1016\/j.preghy.2015.01.004_b0065","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0733-8651(18)30368-0","article-title":"Pulmonary artery pressure estimation by doppler and two-dimensional echocardiography","volume":"8","author":"Schiller","year":"1990","journal-title":"Cardiol Clin"},{"issue":"7","key":"10.1016\/j.preghy.2015.01.004_b0070","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1067\/mob.2001.114857","article-title":"A comparison of echocardiography and pulmonary artery catheterization for evaluation of pulmonary artery pressures in pregnant patients with suspected pulmonary hypertension","volume":"184","author":"Penning","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.preghy.2015.01.004_b0075","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/00006254-196408000-00001","article-title":"Primary pulmonary hypertension in pregnancy","volume":"19","author":"McCaffrey","year":"1964","journal-title":"Obstet Gynecol Surv"},{"issue":"8","key":"10.1016\/j.preghy.2015.01.004_b0080","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1471-0528.1998.tb10240.x","article-title":"Eisenmenger\u2019s syndrome in pregnancy: maternal and fetal mortality in the 1990s","volume":"105","author":"Yentis","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"issue":"3","key":"10.1016\/j.preghy.2015.01.004_b0085","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1378\/chest.89.3.383","article-title":"Primary pulmonary hypertension and pregnancy","volume":"89","author":"Dawkins","year":"1986","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.preghy.2015.01.004_b0090","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1378\/chest.114.3.787","article-title":"The short-term effects of digoxin in patients with right ventricular dysfunction from pulmonary hypertension","volume":"114","author":"Rich","year":"1998","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.preghy.2015.01.004_b0095","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1186\/cc9264","article-title":"Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review","volume":"14","author":"Price","year":"2010","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.preghy.2015.01.004_b0100","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4103\/2045-8932.83449","article-title":"Vasoreactivity to inhaled nitric oxide with oxygen predicts long-term survival in pulmonary arterial hypertension","volume":"1","author":"Malhotra","year":"2011","journal-title":"Pulm Circ"},{"issue":"6","key":"10.1016\/j.preghy.2015.01.004_b0105","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/00000542-198812000-00028","article-title":"Primary pulmonary hypertension and pregnancy: anesthetic management for delivery","volume":"69","author":"Slomka","year":"1988","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.preghy.2015.01.004_b0110","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.reprotox.2008.05.065","article-title":"The safety of calcium channel blockers during pregnancy: a prospective, multicenter, observational study","volume":"26","author":"Weber-Schoendorfer","year":"2008","journal-title":"Reprod Toxicol"},{"issue":"12","key":"10.1016\/j.preghy.2015.01.004_b0115","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/01.CIR.0000029100.82385.58","article-title":"Survival in primary pulmonary hypertension: the impact of epoprostenol therapy","volume":"106","author":"McLaughlin","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.preghy.2015.01.004_b0120","first-page":"149","article-title":"Twin pregnancy in a woman on long-term epoprostenol therapy for primary pulmonary hypertension. A case report","volume":"45","author":"Badalian","year":"2000","journal-title":"J Reprod Med"},{"issue":"2","key":"10.1016\/j.preghy.2015.01.004_b0125","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/bja\/87.2.295","article-title":"Primary pulmonary hypertension in pregnancy; a role for novel vasodilators","volume":"87","author":"Monnery","year":"2001","journal-title":"Br J Anaesth"},{"issue":"5","key":"10.1016\/j.preghy.2015.01.004_b0130","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/bja\/81.5.790","article-title":"Anaesthesia for caesarean section in the presence of severe primary pulmonary hypertension","volume":"81","author":"O\u2019Hare","year":"1998","journal-title":"Br J Anaesth"},{"issue":"3","key":"10.1016\/j.preghy.2015.01.004_b0135","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1378\/chest.119.3.973","article-title":"Pregnancy and primary pulmonary hypertension : successful outcome with epoprostenol therapy","volume":"119","author":"Stewart","year":"2001","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.preghy.2015.01.004_b0140","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0029-7844(98)00524-9","article-title":"Pulmonary hypertension in pregnancy: treatment with pulmonary vasodilators","volume":"93","author":"Easterling","year":"1999","journal-title":"Obstet Gynecol"},{"issue":"12","key":"10.1016\/j.preghy.2015.01.004_b0145","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/0002-9149(93)90590-9","article-title":"Successful management of labor and delivery in primary pulmonary hypertension","volume":"71","author":"Nootens","year":"1993","journal-title":"Am J Cardiol"},{"issue":"3","key":"10.1016\/j.preghy.2015.01.004_b0150","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1378\/chest.124.3.1170","article-title":"Successful management of pregnancy in a patient with Eisenmenger syndrome with epoprostenol","volume":"124","author":"Geohas","year":"2003","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.preghy.2015.01.004_b0155","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1164\/ajrccm.165.6.2106079","article-title":"Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial","volume":"165","author":"Simonneau","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.preghy.2015.01.004_b0160","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCULATIONAHA.112.124388","article-title":"Efficacy and safety of oral treprostinil monotherapy for the treatment of pulmonary arterial hypertension: a randomized, controlled trial","volume":"127","author":"Jing","year":"2013","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.preghy.2015.01.004_b0165","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJMoa020204","article-title":"Inhaled iloprost for severe pulmonary hypertension","volume":"347","author":"Olschewski","year":"2002","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.preghy.2015.01.004_b0170","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/014107680109401010","article-title":"Primary pulmonary hypertension in pregnancy","volume":"94","author":"Wong","year":"2001","journal-title":"J R Soc Med"},{"issue":"5 Pt 2","key":"10.1016\/j.preghy.2015.01.004_b0175","first-page":"206","article-title":"Pregnancy outcome in patients with pulmonary arterial hypertension receiving prostacyclin therapy","volume":"106","author":"Bendayan","year":"2005","journal-title":"Obstet Gynecol"},{"issue":"11","key":"10.1016\/j.preghy.2015.01.004_b0180","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1445-5994.2009.02051.x","article-title":"Pulmonary hypertension in pregnancy: two cases and review of the literature","volume":"39","author":"Higton","year":"2009","journal-title":"Intern Med J"},{"issue":"1","key":"10.1016\/j.preghy.2015.01.004_b0185","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1378\/chest.124.1.247","article-title":"Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: a 1-year follow-up study","volume":"124","author":"Sitbon","year":"2003","journal-title":"Chest"},{"issue":"9630","key":"10.1016\/j.preghy.2015.01.004_b0190","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0140-6736(08)60919-8","article-title":"Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial","volume":"371","author":"Gali\u00e8","year":"2008","journal-title":"Lancet"},{"issue":"21","key":"10.1016\/j.preghy.2015.01.004_b0195","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/j.jacc.2009.07.033","article-title":"Long-term ambrisentan therapy for the treatment of pulmonary arterial hypertension","volume":"54","author":"Oudiz","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.preghy.2015.01.004_b0200","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1750-1172-8-97","article-title":"Pulmonary arterial hypertension","volume":"8","author":"Montani","year":"2013","journal-title":"Orphanet J Rare Dis"},{"issue":"5","key":"10.1016\/j.preghy.2015.01.004_b0205","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1378\/chest.10-0969","article-title":"Long-term treatment with sildenafil citrate in pulmonary arterial hypertension: the SUPER-2 study","volume":"140","author":"Rubin","year":"2011","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.preghy.2015.01.004_b0210","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1378\/chest.12-0528","article-title":"Management of pulmonary arterial hypertension during pregnancy: a retrospective, multicenter experience","volume":"143","author":"Duarte","year":"2013","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.preghy.2015.01.004_b0215","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00404-013-2761-8","article-title":"Pregnancy outcome in women with pulmonary arterial hypertension: single-center experience from India","volume":"288","author":"Subbaiah","year":"2013","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"10.1016\/j.preghy.2015.01.004_b0220","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1056\/NEJMoa1209657","article-title":"Riociguat for the treatment of chronic thromboembolic pulmonary hypertension","volume":"369","author":"Ghofrani","year":"2013","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.preghy.2015.01.004_b0225","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00408-011-9345-9","article-title":"Pulmonary arterial hypertension in the setting of pregnancy: a case series and standard treatment approach","volume":"190","author":"Smith","year":"2012","journal-title":"Lung"},{"issue":"6","key":"10.1016\/j.preghy.2015.01.004_b0230","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1471-0528.2012.03295.x","article-title":"Pulmonary hypertension and pregnancy\u2013a review of 12 pregnancies in nine women","volume":"119","author":"Curry","year":"2013","journal-title":"BJOG"},{"issue":"Suppl. 3","key":"10.1016\/j.preghy.2015.01.004_b0235","first-page":"58s","article-title":"Peripartum heart failure due to primary pulmonary hypertension","volume":"62","author":"Nelson","year":"1983","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.preghy.2015.01.004_b0240","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00000542-198802000-00020","article-title":"Epidural analgesia with low-dose bupivacaine and fentanyl for labor and delivery in a parturient with severe pulmonary hypertension","volume":"68","author":"Robinson","year":"1988","journal-title":"Anesthesiology"}],"container-title":["Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778915000112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778915000112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T19:51:50Z","timestamp":1566330710000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778915000112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S2210778915000112"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2015.01.004","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pregnancy and pulmonary arterial hypertension: A clinical conundrum","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2015.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}