{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:55:42Z","timestamp":1782755742620,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.preghy.2017.08.003","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T08:46:12Z","timestamp":1502527572000},"page":"165-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["An intermediate sFlt-1\/PlGF ratio indicates an increased risk for adverse pregnancy outcome"],"prefix":"10.1016","volume":"10","author":[{"given":"Janine","family":"Hoffmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Ossada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Stepan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preghy.2017.08.003_b0005","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/OGX.0b013e31828738ce","article-title":"Obesity in pregnancy: a big problem and getting bigger","volume":"68","author":"Mission","year":"2013","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1016\/j.preghy.2017.08.003_b0010","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.preghy.2017.08.003_b0015","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1081\/PRG-120016792","article-title":"Summary of the NHLBI working group on research on hypertension during pregnancy","volume":"22","author":"Roberts","year":"2003","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.preghy.2017.08.003_b0020","first-page":"98","article-title":"Mechanisms of disease: pre-eclampsia, nature clinical practice","volume":"1","author":"Noris","year":"2005","journal-title":"Nephrology"},{"key":"10.1016\/j.preghy.2017.08.003_b0025","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1172\/JCI116316","article-title":"Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts","volume":"91","author":"Zhou","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preghy.2017.08.003_b0030","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3346\/jkms.2007.22.5.873","article-title":"Increased sFlt-1 to PlGF ratio in women who subsequently develop preeclampsia","volume":"22","author":"Kim","year":"2007","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.preghy.2017.08.003_b0035","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preghy.2017.08.003_b0040","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.ajog.2004.03.004","article-title":"Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia develop","volume":"191","author":"McKeeman","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2017.08.003_b0045","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/01.grf.0000160313.82606.d7","article-title":"Circulating angiogenic factors in preeclampsia","volume":"48","author":"Levine","year":"2005","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2017.08.003_b0050","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.preghy.2017.08.003_b0055","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.clinbiochem.2010.02.010","article-title":"Multicenter evaluation of the first automated Elecsys sFlt-1 and PlGF assays in normal pregnancies and preeclampsia","volume":"43","author":"Schiettecatte","year":"2010","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.preghy.2017.08.003_b0060","doi-asserted-by":"crossref","first-page":"161.e1","DOI":"10.1016\/j.ajog.2009.09.016","article-title":"An automated method for the determination of the sFlt-1\/PIGF ratio in the assessment of preeclampsia","volume":"202","author":"Verlohren","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2014","key":"10.1016\/j.preghy.2017.08.003_b0065","first-page":"346","article-title":"New gestational phase-specific cutoff values for the use of the soluble fms-like tyrosine kinase-1\/placental growth factor ratio as a diagnostic test for preeclampsia","volume":"63","author":"Verlohren","year":"1979","journal-title":"Hypertension (Dallas Tex. 1979)"},{"key":"10.1016\/j.preghy.2017.08.003_b0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1414838","article-title":"Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia","volume":"374","author":"Zeisler","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.preghy.2017.08.003_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2007.10.783","article-title":"Twin pregnancy and the risk of preeclampsia: bigger placenta or relative ischemia?","volume":"198","author":"Bdolah","year":"2008","journal-title":"Am. J. Obst. Gynecol."},{"key":"10.1016\/j.preghy.2017.08.003_b0080","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/10641955.2013.837175","article-title":"The association of circulating angiogenic factors and HbA1c with the risk of preeclampsia in women with preexisting diabetes","volume":"33","author":"Cohen","year":"2014","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.preghy.2017.08.003_b0085","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.preghy.2011.08.014","article-title":"L13. The routine measurement of the sFlt1\/PlGF ratio allows differential diagnosis of hypertensive pregnancy disorders and has prognostic potential in preeclamptic patients","volume":"1","author":"Verlohren","year":"2011","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.preghy.2017.08.003_b0090","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/10641955.2013.784788","article-title":"Clinical characterization and outcomes of preeclampsia with normal angiogenic profile","volume":"32","author":"Rana","year":"2013","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.preghy.2017.08.003_b0095","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/CIRCULATIONAHA.111.054361","article-title":"Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia","volume":"125","author":"Rana","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.preghy.2017.08.003_b0100","unstructured":"Kuse-F\u00f6hl S., Klockenbusch W., Rath W., Schauf B., Schlembach D., Stepan H., 015\/018 \u2013 S1-Leitlinie: Diagnostik und Therapie hypertensiver Schwangerschaftserkrankungen aktueller Stand: 12\/2013. AWMF-Register Nr. 015\/018 Klasse: S1, available at: http:\/\/www.awmf.org\/uploads\/tx_szleitlinien\/015-018l_S1_Diagnostik_Therapie_hypertensiver_Schwangerschaftserkrankungen_2014-verlaengert.pdf."},{"key":"10.1016\/j.preghy.2017.08.003_b0105","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1471-0528.2006.00882.x","article-title":"Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction","volume":"113","author":"Egbor","year":"2006","journal-title":"BJOG"},{"key":"10.1016\/j.preghy.2017.08.003_b0110","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3109\/14767058.2011.591461","article-title":"Late-onset preeclampsia is associated with an imbalance of angiogenic and anti-angiogenic factors in patients with and without placental lesions consistent with maternal underperfusion","volume":"25","author":"Soto","year":"2012","journal-title":"J. Maternal Fetal Neonatal Med."},{"key":"10.1016\/j.preghy.2017.08.003_b0115","doi-asserted-by":"crossref","first-page":"108.e1","DOI":"10.1016\/j.ajog.2015.09.066","article-title":"Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study","volume":"214","author":"Kim","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2017.08.003_b0120","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1515\/jpm-2013-0074","article-title":"The importance of repeated measurements of the sFlt-1\/PlGF ratio for the prediction of preeclampsia and intrauterine growth restriction","volume":"42","author":"Schoofs","year":"2014","journal-title":"J. Perinatal Med."},{"key":"10.1016\/j.preghy.2017.08.003_b0125","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1152\/ajpregu.00440.2016","article-title":"Metabolic abnormalities and obesity\u2019s impact on the risk for developing preeclampsia","volume":"312","author":"Spradley","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.preghy.2017.08.003_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2013.03.017","article-title":"Gestational angiogenic biomarker patterns in high risk preeclampsia groups","volume":"209","author":"Maynard","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2017.08.003_b0135","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1053\/j.ackd.2013.02.001","article-title":"Pregnancy in chronic kidney disease","volume":"20","author":"Vellanki","year":"2013","journal-title":"Adv. Chron. Kidney Dis."},{"key":"10.1016\/j.preghy.2017.08.003_b0140","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/AOG.0000000000001525","article-title":"Soluble fms-like tyrosine kinase-1-to-placental growth factor ratio and time to delivery in women with suspected preeclampsia","volume":"128","author":"Zeisler","year":"2016","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2017.08.003_b0145","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/uog.14760","article-title":"Maternal serum sFlt-1\/PlGF ratio in twin pregnancies with and without pre-eclampsia in comparison with singleton pregnancies","volume":"45","author":"Dr\u00f6ge","year":"2015","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2017.08.003_b0150","doi-asserted-by":"crossref","first-page":"287.e1","DOI":"10.1016\/j.ajog.2013.01.016","article-title":"Maternal plasma concentrations of angiogenic\/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia","volume":"208","author":"Chaiworapongsa","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2017.08.003_b0155","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/14767050701413022","article-title":"Unexplained fetal death: another anti-angiogenic state","volume":"20","author":"Espinoza","year":"2007","journal-title":"J. Maternal Fetal Neonatal Med."}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778917300685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778917300685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:52:15Z","timestamp":1761897135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778917300685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":31,"alternative-id":["S2210778917300685"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2017.08.003","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An intermediate sFlt-1\/PlGF ratio indicates an increased risk for adverse pregnancy outcome","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2017.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}