{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:20:47Z","timestamp":1785147647220,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.preghy.2017.12.003","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T13:41:30Z","timestamp":1513863690000},"page":"18-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["The reduction in circulating levels of estrogen and progesterone in women with preeclampsia"],"prefix":"10.1016","volume":"11","author":[{"given":"Jiayi","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.preghy.2017.12.003_b0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.preghy.2014.02.001","article-title":"The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP","volume":"4","author":"Tranquilli","year":"2014","journal-title":"Pregnancy Hypertens."},{"issue":"8","key":"10.1016\/j.preghy.2017.12.003_b0010","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1034\/j.1600-0412.2003.00220.x","article-title":"Quantitative analysis of trophoblast invasion in preeclampsia","volume":"82","author":"Naicker","year":"2003","journal-title":"Acta Obstetricia Et Gynecologica Scandinavica"},{"issue":"1","key":"10.1016\/j.preghy.2017.12.003_b0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0925-4439(03)00043-7","article-title":"Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia","volume":"1638","author":"Kudo","year":"2003","journal-title":"Biochim. Biophys. Acta."},{"issue":"8","key":"10.1016\/j.preghy.2017.12.003_b0020","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0002-9378(72)90185-8","article-title":"Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy","volume":"112","author":"Tulchinsky","year":"1972","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.preghy.2017.12.003_b0025","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1210\/jcem-62-6-1163","article-title":"The relationship of estrogen to placental steroidogenesis in the baboon","volume":"62","author":"Castracane","year":"1986","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.preghy.2017.12.003_b0030","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0039-128X(99)00043-4","article-title":"Regulation of functional differentiation of the placental villous syncytiotrophoblast by estrogen during primate pregnancy","volume":"64","author":"Pepe","year":"1999","journal-title":"Steroids"},{"issue":"4","key":"10.1016\/j.preghy.2017.12.003_b0035","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/cvr\/cvu013","article-title":"Pregnancy as a cardiac stress model","volume":"101","author":"Chung","year":"2014","journal-title":"Cardiovasc Res."},{"issue":"4","key":"10.1016\/j.preghy.2017.12.003_b0040","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1097\/HJH.0000000000000844","article-title":"G protein-coupled receptor 30 regulates trophoblast invasion and its deficiency is associated with preeclampsia","volume":"34","author":"Tong","year":"2016","journal-title":"J. Hypertens."},{"issue":"Suppl 2","key":"10.1016\/j.preghy.2017.12.003_b0045","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/S0168-8227(01)00339-4","article-title":"Effect of estrogen on endothelial dysfunction in postmenopausal women with diabetes","volume":"54","author":"Lee","year":"2001","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"12","key":"10.1016\/j.preghy.2017.12.003_b0050","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3109\/09513590.2010.487601","article-title":"Effects of early pregnancy loss on hormone levels in the subsequent menstrual cycle","volume":"26","author":"Jukic","year":"2010","journal-title":"Gynecol. Endocrinol."},{"issue":"6","key":"10.1016\/j.preghy.2017.12.003_b0055","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/aji.12102","article-title":"Demystifying animal models of adverse pregnancy outcomes: touching bench and bedside","volume":"69","author":"Bonney","year":"2013","journal-title":"Am. J. Reprod. Immunol."},{"issue":"6","key":"10.1016\/j.preghy.2017.12.003_b0060","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1530\/rep.1.00625","article-title":"The role of progesterone in endometrial angiogenesis in pregnant and ovariectomised mice","volume":"129","author":"Walter","year":"2005","journal-title":"Reproduction"},{"issue":"12","key":"10.1016\/j.preghy.2017.12.003_b0065","first-page":"458","article-title":"Concentrations of estrogens in patients with preeclampsia","volume":"114","author":"Zeisler","year":"2002","journal-title":"Wiener klinische Wochenschrift"},{"issue":"7","key":"10.1016\/j.preghy.2017.12.003_b0070","first-page":"647","article-title":"Pregnancy hormones, pre-eclampsia, and implications for breast cancer risk in the offspring","volume":"12","author":"Tamimi","year":"2003","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"2","key":"10.1016\/j.preghy.2017.12.003_b0075","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/HYPERTENSIONAHA.111.201624","article-title":"Aberrant synthesis, metabolism, and plasma accumulation of circulating estrogens and estrogen metabolites in preeclampsia implications for vascular dysfunction","volume":"61","author":"Jobe","year":"2013","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.preghy.2017.12.003_b0080","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ajog.2010.06.011","article-title":"Steroid profiling in preeclamptic women: evidence for aromatase deficiency","volume":"203","author":"Hertig","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.preghy.2017.12.003_b0085","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1055\/s-0042-107078","article-title":"Maternal Serum Lipid, Estradiol, and Progesterone Levels in Pregnancy, and the Impact of Placental and Hepatic Pathologies","volume":"76","author":"Pecks","year":"2016","journal-title":"Geburtshilfe Frauenheilkd"},{"issue":"3","key":"10.1016\/j.preghy.2017.12.003_b0090","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3892\/mmr.2013.1262","article-title":"Differential expression of estradiol and estrogen receptor alpha in severe preeclamptic pregnancies compared with normal pregnancies","volume":"7","author":"Yin","year":"2013","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.preghy.2017.12.003_b0095","first-page":"1122","article-title":"Report of the American college of obstetricians and gynecologists' task force on hypertension in pregnancy","volume":"122","author":"Hypertension in pregnancy","year":"2013","journal-title":"Obstet. Gynecol."},{"issue":"10\u201311","key":"10.1016\/j.preghy.2017.12.003_b0100","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0039-128X(00)00117-3","article-title":"Ovarian steroids in endometrial angiogenesis","volume":"65","author":"Perrot-Applanat","year":"2000","journal-title":"Steroids"},{"issue":"1","key":"10.1016\/j.preghy.2017.12.003_b0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/01.ATV.21.1.6","article-title":"Estrogen and angiogenesis: a review","volume":"21","author":"Losordo","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"3","key":"10.1016\/j.preghy.2017.12.003_b0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.preghy.2016.08.019","article-title":"18 Hydrogen sulfide stimulates human myometrial angiogensis: influence of endogenous estrogens","volume":"6","author":"Dongbao Chen","year":"2016","journal-title":"Pregnancy Hypertens."},{"issue":"6","key":"10.1016\/j.preghy.2017.12.003_b0115","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1159\/000369662","article-title":"Decreased maternal serum 2-methoxyestradiol levels are associated with the development of preeclampsia","volume":"34","author":"Shen","year":"2014","journal-title":"Cell Physiol. Biochem."},{"issue":"7198","key":"10.1016\/j.preghy.2017.12.003_b0120","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature06951","article-title":"Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia","volume":"453","author":"Kanasaki","year":"2008","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.preghy.2017.12.003_b0125","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2353\/ajpath.2010.090513","article-title":"Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions","volume":"176","author":"Lee","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preghy.2017.12.003_b0130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1477-7827-1-13","article-title":"Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol","volume":"1","author":"Bukovsky","year":"2003","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.preghy.2017.12.003_b0135","first-page":"62","article-title":"Dissemination of syncytial trophoblastic cells in the maternal blood stream during pregnancy","volume":"20","author":"Ikle","year":"1964","journal-title":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften"},{"issue":"8407","key":"10.1016\/j.preghy.2017.12.003_b0140","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0140-6736(84)90875-4","article-title":"Trophoblast cells in peripheral blood from pregnant women","volume":"2","author":"Covone","year":"1984","journal-title":"Lancet"},{"issue":"5728","key":"10.1016\/j.preghy.2017.12.003_b0145","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.preghy.2017.12.003_b0150","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1471-0528.1961.tb02778.x","article-title":"Embolism to the lungs by trophoblast","volume":"68","author":"Attwood","year":"1961","journal-title":"BJOG: Int. J. Obstetr. Gynaecol."},{"issue":"3","key":"10.1016\/j.preghy.2017.12.003_b0155","doi-asserted-by":"crossref","first-page":"a023028","DOI":"10.1101\/cshperspect.a023028","article-title":"Placental extracellular vesicles and feto-maternal communication","volume":"5","author":"Tong","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"4","key":"10.1016\/j.preghy.2017.12.003_b0160","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S1726-4901(09)70052-8","article-title":"Roles of estrogen and progesterone in endometrial hemodynamics and vascular endothelial growth factor production","volume":"72","author":"Wen","year":"2009","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.preghy.2017.12.003_b0165","article-title":"Progesterone for preventing pre-eclampsia and its complications","volume":"4","author":"Meher","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"issue":"4","key":"10.1016\/j.preghy.2017.12.003_b0170","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1210\/jcem.87.4.8405","article-title":"First trimester insulin resistance and subsequent preeclampsia: a prospective study","volume":"87","author":"Wolf","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"40","key":"10.1016\/j.preghy.2017.12.003_b0175","doi-asserted-by":"crossref","first-page":"36869","DOI":"10.1074\/jbc.R100029200","article-title":"The multifaceted mechanisms of estradiol and estrogen receptor signaling","volume":"276","author":"Hall","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.preghy.2017.12.003_b0180","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1177\/1933719108317975","article-title":"Steroid hormones and uterine vascular adaptation to pregnancy","volume":"15","author":"Chang","year":"2008","journal-title":"Reprod. Sci. (Thousand Oaks, Calif)"}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778917301204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778917301204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:49:57Z","timestamp":1761896997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778917301204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":36,"alternative-id":["S2210778917301204"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2017.12.003","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The reduction in circulating levels of estrogen and progesterone in women with preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2017.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}