{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:40:17Z","timestamp":1783057217589,"version":"3.54.6"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011102","name":"European Union 7th Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.preghy.2019.01.001","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T17:47:31Z","timestamp":1547142451000},"page":"141-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Aspirin causes endothelium-dependent vasodilation of resistance arteries from non-gravid and gravid rats"],"prefix":"10.1016","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5422-1947","authenticated-orcid":false,"given":"Helga","family":"Helgadottir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Tropea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-3313","authenticated-orcid":false,"given":"Sveinbjorn","family":"Gizurarson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamutal","family":"Meiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Mandal\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.preghy.2019.01.001_b0005","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1999.79.4.1193","article-title":"Prostanoid receptors: structures, properties, and functions","volume":"79","author":"Narumiya","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.preghy.2019.01.001_b0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1034\/j.1600-0773.2002.910201.x","article-title":"The public health potential of aspirin","volume":"91","author":"Vainio","year":"2002","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.preghy.2019.01.001_b0015","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1161\/CIRCULATIONAHA.105.595793","article-title":"Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events","volume":"113","author":"Chan","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.preghy.2019.01.001_b0020","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/pds.732","article-title":"Frequency of use of acetaminophen, nonsteroidal anti-inflammatory drugs, and aspirin in US women","volume":"11","author":"Curhan","year":"2002","journal-title":"Pharmacoepidem Drug Safety"},{"key":"10.1016\/j.preghy.2019.01.001_b0025","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.jacc.2004.08.071","article-title":"Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patients","volume":"46","author":"Hermida","year":"2005","journal-title":"J. Am. College Cardiol."},{"key":"10.1016\/j.preghy.2019.01.001_b0030","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1182\/blood.V83.4.885.885","article-title":"Aspirin, platelets, and thrombosis: theory and practice","volume":"83","author":"Roth","year":"1994","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.preghy.2019.01.001_b0035","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/sj.bjp.0705907","article-title":"Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action","volume":"143","author":"Taubert","year":"2004","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.preghy.2019.01.001_b0040","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1161\/01.HYP.0000172623.36098.4e","article-title":"Differing administration time-dependent effects of aspirin on blood pressure in dipper and non-dipper hypertensives","volume":"46","author":"Hermida","year":"2005","journal-title":"Hypertension"},{"issue":"2 Pt 1","key":"10.1016\/j.preghy.2019.01.001_b0045","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/AOG.0b013e3181e9322a","article-title":"Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis","volume":"116","author":"Bujold","year":"2010","journal-title":"Obstet Gynecol."},{"issue":"8130","key":"10.1016\/j.preghy.2019.01.001_b0050","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0140-6736(79)91996-2","article-title":"Effect of aspirin on incidence of pre-eclampsia","volume":"1","author":"Crandon","year":"1979","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.preghy.2019.01.001_b0055","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/uog.6215","article-title":"Low-dose aspirin reduces uteroplacental vascular impedance in early and midgestation in IVF and ICSI patients: a randomized, placebo-controlled double-blind study","volume":"32","author":"Haapsamo","year":"2008","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"9575","key":"10.1016\/j.preghy.2019.01.001_b0060","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(07)60712-0","article-title":"Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data","volume":"369","author":"Askie","year":"2007","journal-title":"Lancet"},{"issue":"5\u20136","key":"10.1016\/j.preghy.2019.01.001_b0065","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1159\/000178465","article-title":"Influence of constriction, wall tension, smooth muscle activation and cellular deformation on rat resistance artery vasodilator reactivity","volume":"29","author":"Colton","year":"2012","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.preghy.2019.01.001_b0070","first-page":"58","article-title":"Maternal uterine vascular remodeling during pregnancy","volume":"24","author":"Osol","year":"2009","journal-title":"Physiology (Bethesda)"},{"issue":"7","key":"10.1016\/j.preghy.2019.01.001_b0075","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJMoa1704559","article-title":"Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia","volume":"377","author":"Rolnik","year":"2017","journal-title":"N. England J. Med."},{"issue":"1","key":"10.1016\/j.preghy.2019.01.001_b0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1742-7843.2011.00793.x","article-title":"Physiological remodelling of the maternal uterine circulation during pregnancy","volume":"110","author":"Mandala","year":"2012","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"5","key":"10.1016\/j.preghy.2019.01.001_b0085","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1515\/JPM.2002.060","article-title":"Doppler sonography of uterine arteries at 20\u201323 weeks: risk assessment of adverse pregnancy outcome by quantification of impedance and notch","volume":"30","author":"Becker","year":"2002","journal-title":"J. Perinat. Med."},{"issue":"7","key":"10.1016\/j.preghy.2019.01.001_b0090","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3109\/14767058.2011.601364","article-title":"First trimester uterine artery Doppler for the prediction of preeclampsia and foetal growth restriction","volume":"25","author":"Carbillon","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"11","key":"10.1016\/j.preghy.2019.01.001_b0095","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S1701-2163(16)34346-8","article-title":"Low-dose ASA response using the PFA-100 in women with high-risk pregnancy","volume":"31","author":"Caron","year":"2009","journal-title":"J. Obstet. Gynaecol. Can."},{"issue":"1","key":"10.1016\/j.preghy.2019.01.001_b0100","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.fertnstert.2008.05.045","article-title":"Low-dose aspirin and omega-3 fatty acids improve uterine artery blood flow velocity in women with recurrent miscarriage due to impaired uterine perfusion","volume":"92","author":"Lazzarin","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.preghy.2019.01.001_b0105","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.phrs.2017.04.012","article-title":"Effects of low-dose aspirin on maternal blood pressure and vascular function in an experimental model of gestational hypertension","volume":"120","author":"Osikoya","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.preghy.2019.01.001_b0110","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/HYPERTENSIONAHA.117.09321","article-title":"Placental vesicles carry active endothelial nitric oxide synthase and their activity is reduced in preeclampsia","volume":"70","author":"Motta-Mejia","year":"2017","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.preghy.2019.01.001_b0115","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1161\/01.RES.87.5.406","article-title":"Increased nitric oxide synthase activity and expression in the human uterine artery during pregnancy","volume":"87","author":"Nelson","year":"2000","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.preghy.2019.01.001_b0120","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11906-017-0774-6","article-title":"Altered endothelial nitric oxide signaling as a paradigm for maternal vascular maladaptation in preeclampsia","volume":"19","author":"Osol","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"issue":"2","key":"10.1016\/j.preghy.2019.01.001_b0125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1161\/HYPERTENSIONAHA.117.09113","article-title":"Cyclic nucleotides differentially regulate Cx43 gap junction function in uterine artery endothelial cells from pregnant ewes","volume":"70","author":"Ampey","year":"2017","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.preghy.2019.01.001_b0130","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1161\/01.HYP.31.4.943","article-title":"Adenosine inhibits collagen and protein synthesis in cardiac fibroblasts: role of A2B receptors","volume":"31","author":"Dubey","year":"1998","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.preghy.2019.01.001_b0135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejogrb.2004.06.014","article-title":"Phosphodiesterase-5 inhibitors and omental and placental small artery function in normal pregnancy and pre-eclampsia","volume":"127","author":"Wareing","year":"2006","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"3","key":"10.1016\/j.preghy.2019.01.001_b0140","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1161\/HYPERTENSIONAHA.115.06071","article-title":"Sildenafil treatment ameliorates the maternal syndrome of preeclampsia and rescues fetal growth in the Dahl salt-sensitive rat","volume":"67","author":"Gillis","year":"2016","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.preghy.2019.01.001_b0145","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00007691-198010000-00010","article-title":"Measurement and pharmacokinetics of acetylsalicylic acid by a novel high performance liquid chromatographic assay","volume":"2","author":"Cham","year":"1980","journal-title":"Ther. Drug Monit."},{"issue":"1","key":"10.1016\/j.preghy.2019.01.001_b0150","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/cvr\/cvp084","article-title":"Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA\/Rho-kinase activation","volume":"83","author":"Ying","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"10","key":"10.1016\/j.preghy.2019.01.001_b0155","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1161\/01.CIR.0000140985.89766.CB","article-title":"Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone","volume":"110","author":"von der Weid","year":"2004","journal-title":"Circulation"}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778918300370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778918300370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:50:46Z","timestamp":1761897046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778918300370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":31,"alternative-id":["S2210778918300370"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2019.01.001","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aspirin causes endothelium-dependent vasodilation of resistance arteries from non-gravid and gravid rats","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2019.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V. on behalf of International Society for the Study of Hypertension in Pregnancy.","name":"copyright","label":"Copyright"}]}}