{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:58:44Z","timestamp":1788998324576,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004006","name":"Bilimsel Ara\u015ftirma Projeleri Birimi, Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.preghy.2019.04.004","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T11:09:49Z","timestamp":1555672189000},"page":"5-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Differential expression of candidate circulating microRNAs in maternal blood leukocytes of the patients with preeclampsia and gestational diabetes mellitus"],"prefix":"10.1016","volume":"17","author":[{"given":"Meryem","family":"Hocaoglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selin","family":"Demirer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Senturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkadir","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evrim","family":"Komurcu-Bayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preghy.2019.04.004_b0005","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1111\/1471-0528.13903","article-title":"Circulating microRNA expression profiles in pre-eclampsia: evidence of increased miR-885-5p levels","volume":"123","author":"Sandrim","year":"2016","journal-title":"BJOG"},{"issue":"367","key":"10.1016\/j.preghy.2019.04.004_b0010","first-page":"e1","article-title":"Differential expression of plasma microRNA in preeclamptic patients at delivery and 1 year postpartum","volume":"213","author":"Murphy","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2019.04.004_b0015","first-page":"1","article-title":"Higher levels of circulating TIMP-4 in preeclampsia is strongly associated with clinical parameters and microRNA","volume":"12","author":"Sandrim","year":"2017","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.preghy.2019.04.004_b0020","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/jog.12749","article-title":"Circulating chromosome 19 miR cluster microRNAs in pregnant women with severe pre-eclampsia","volume":"41","author":"Miura","year":"2015","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.preghy.2019.04.004_b0025","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1097\/AOG.0000000000002501","article-title":"ACOG practice bulletin No. 190: gestational diabetes mellitus","volume":"131","author":"Committee on Practice Bulletins\u2014Obstetrics","year":"2018","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2019.04.004_b0030","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/dmrr.390","article-title":"Intermediate metabolism in normal pregnancy and in gestational diabetes","volume":"19","author":"Di Cianni","year":"2003","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.preghy.2019.04.004_b0035","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1159\/000366386","article-title":"Distinct DNA methylomes of human placentas between pre-eclampsia and gestational diabetes mellitus","volume":"34","author":"Liu","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.preghy.2019.04.004_b0040","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s11892-015-0579-4","article-title":"Preeclampsia and diabetes","volume":"15","author":"Weissgerber","year":"2015","journal-title":"Curr. Diab. Rep."},{"issue":"116","key":"10.1016\/j.preghy.2019.04.004_b0045","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"23","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.preghy.2019.04.004_b0050","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"PNAS"},{"key":"10.1016\/j.preghy.2019.04.004_b0055","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1055\/s-0036-1586500","article-title":"Endocrine disruptors: a potential risk factor for gestational diabetes mellitus","volume":"33","author":"Ehrlich","year":"2016","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.preghy.2019.04.004_b0060","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1177\/1933719114561557","article-title":"Serum MicroRNAs as diagnostic biomarkers for macrosomia","volume":"22","author":"Jiang","year":"2015","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.preghy.2019.04.004_b0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1582-4934.2008.00556.x","article-title":"miR-21: a small multi-faceted RNA","volume":"13","author":"Krichevsky","year":"2009","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.preghy.2019.04.004_b0070","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.2337\/db11-0171","article-title":"MicroRNAs in \u03b2-cell biology, insulin resistance, diabetes and its complications","volume":"60","author":"Fernandez-Valverde","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.preghy.2019.04.004_b0075","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/jp.2014.58","article-title":"Aberrant upregulation of miR-21 in placental tissues of macrosomia","volume":"34","author":"Jiang","year":"2014","journal-title":"J. Perinatol."},{"key":"10.1016\/j.preghy.2019.04.004_b0080","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.3892\/mmr.2016.4892","article-title":"Decreased miR-143 and increased miR-21 placental expression levels are associated with macrosomia","volume":"13","author":"Zhang","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"466","key":"10.1016\/j.preghy.2019.04.004_b0085","first-page":"e1","article-title":"MicroRNA-155 contributes to preeclampsia by down-regulating CYR61","volume":"202","author":"Zhang","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2019.04.004_b0090","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1161\/HYPERTENSIONAHA.112.197301","article-title":"Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase","volume":"60","author":"Sun","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.preghy.2019.04.004_b0095","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1734-1140(09)70111-2","article-title":"Role of NF-kappa B in the pathogenesis of diabetes and its associated complications","volume":"61","author":"Patel","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.preghy.2019.04.004_b0100","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/jmcb\/mjr007","article-title":"MicroRNAs in NF-kappaB signaling","volume":"3","author":"Ma","year":"2011","journal-title":"J. Mol. Cell. Biol."},{"key":"10.1016\/j.preghy.2019.04.004_b0105","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s13105-015-0413-0","article-title":"A signature of microRNA-155 in the pathogenesis of diabetic complications","volume":"71","author":"Khamaneh","year":"2015","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.preghy.2019.04.004_b0110","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1055\/s-0033-1341516","article-title":"Dysregulated miR-155 expression in peripheral blood mononuclear cells from patients with type 2 diabetes","volume":"121","author":"Corral-Fern\u00e1ndez","year":"2013","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.preghy.2019.04.004_b0115","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1016\/j.yexcr.2010.07.007","article-title":"MicroRNA mir-16 is anti-proliferative in enterocytes and exhibits diurnal rhythmicity in intestinal crypts","volume":"316","author":"Balakrishnan","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.preghy.2019.04.004_b0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ijgo.2015.01.010","article-title":"Profiling maternal plasma microRNA expression in early pregnancy to predict gestational diabetes mellitus","volume":"130","author":"Zhu","year":"2015","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.preghy.2019.04.004_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diabres.2017.07.024","article-title":"Circulating early- and mid-pregnancy microRNAs and risk of gestational diabetes","volume":"132","author":"Wander","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.preghy.2019.04.004_b0130","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/jog.13317","article-title":"Plasma microRNA-16-5p, -17-5p and -20a-5p: novel diagnostic biomarkers for gestational diabetes mellitus","volume":"43","author":"Cao","year":"2017","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"627","key":"10.1016\/j.preghy.2019.04.004_b0135","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.gene.2017.07.010","article-title":"Circulating microRNA expression as predictor of preeclampsia and its severity","volume":"5","author":"Jairajpuri","year":"2017","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.preghy.2019.04.004_b0140","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12910-018-0262-9","article-title":"Ethical principles and placebo-controlled trials\u2013interpretation and implementation of the Declaration of Helsinki\u2019s placebo paragraph in medical research","volume":"19","author":"Sk\u0131erka","year":"2018","journal-title":"BMC Med. Ethics"},{"key":"10.1016\/j.preghy.2019.04.004_b0145","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of obstetricians and gynecologists\u2019 task force on hypertension in pregnancy","volume":"122","author":"American College of Obstetricians and Gynecologists, Task Force on Hypertension in Pregnancy","year":"2013","journal-title":"Obstet. Gynecol."},{"issue":"544","key":"10.1016\/j.preghy.2019.04.004_b0150","article-title":"Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease","volume":"209","author":"Lisonkova","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2019.04.004_b0155","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2337\/dc09-1848","article-title":"International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","author":"International Association of Diabetes and Pregnancy Study Groups Consensus Panel","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.preghy.2019.04.004_b0160","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.preghy.2019.04.004_b0165","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1189\/jlb.1209796","article-title":"Invasion of the leukocytes into the fetal-maternal interface during pregnancy","volume":"88","author":"Gomez-Lopez","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.preghy.2019.04.004_b0170","doi-asserted-by":"crossref","first-page":"8096","DOI":"10.4049\/jimmunol.175.12.8096","article-title":"A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells","volume":"175","author":"Abrahams","year":"2005","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.preghy.2019.04.004_b0175","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1189\/jlb.1112603","article-title":"Leading role for the immune system in the pathophysiology of preeclampsia","volume":"94","author":"Laresgoiti-Servitje","year":"2013","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.preghy.2019.04.004_b0180","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1081\/PRG-120021059","article-title":"Neutrophil activation and C-reactive protein concentration in preeclampsia","volume":"22","author":"Belo","year":"2003","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.preghy.2019.04.004_b0185","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3389\/fimmu.2017.00702","article-title":"Gestational Diabetes Mellitus is associated with altered neutrophil activity","volume":"8","author":"Stoikou","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.preghy.2019.04.004_b0190","first-page":"695","article-title":"Overexpression of miR-21 and miR-122 in preeclamptic placentas","volume":"36","author":"Lasabova","year":"2015","journal-title":"Neuro. Endocrinol. Lett."},{"key":"10.1016\/j.preghy.2019.04.004_b0195","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.placenta.2013.06.006","article-title":"Microrna expression profiles in placenta with severe preeclampsia using a pna-based microarray","volume":"34","author":"Choi","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.preghy.2019.04.004_b0200","article-title":"Maternal plasma miRs expression in preeclamptic pregnancies","author":"Li","year":"2013","journal-title":"Biomed. Res. Int."},{"issue":"8","key":"10.1016\/j.preghy.2019.04.004_b0205","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3389\/fendo.2017.00345","article-title":"Circulating microRNA (miR) expression profiling in plasma of patients with gestational diabetes mellitus reveals upregulation of miR miR-330-3p","volume":"12","author":"Sebastiani","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.preghy.2019.04.004_b0210","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.freeradbiomed.2017.01.010","article-title":"Aspirin prevents TNF-a-induced endothelial cell dysfunction by regulating the NF-kB-dependent miR- 155\/eNOS pathway: role of a miR-155\/eNOS axis in preeclampsia","volume":"104","author":"Kim","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.preghy.2019.04.004_b0215","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007515","article-title":"MiR-210 and miR-155 as potential diagnostic markers for pre-eclampsia pregnancies","volume":"96","author":"Gan","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.preghy.2019.04.004_b0220","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3892\/mmr.2014.2214","article-title":"MicroRNA-155 inhibits migration of trophoblast cells and contributes to the pathogenesis of severe preeclampsia by regulating endothelial nitric oxide synthase","volume":"10","author":"Li","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.preghy.2019.04.004_b0225","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1515\/CCLM.2009.228","article-title":"Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia","volume":"47","author":"Hu","year":"2009","journal-title":"Clin. Chem. Lab. Med."},{"issue":"10","key":"10.1016\/j.preghy.2019.04.004_b0230","article-title":"Cardiovascular and cerebrovascular disease associated micro RNAs are dysregulated in placental tissues affected with gestational hypertension, preeclampsia and intrauterine growth restriction","volume":"22","author":"Hromadnikova","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.preghy.2019.04.004_b0235","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.bcmd.2015.01.004","article-title":"Daily variations in the expression of miR-16 and miR-181a in human leukocytes","volume":"54","author":"Figueredo Dde","year":"2015","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.preghy.2019.04.004_b0240","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s40291-016-0233-0","article-title":"Maternal circulating microRNAs and pre-eclampsia: challenges for diagnostic potential","volume":"21","author":"Murphy","year":"2017","journal-title":"Mol. Diagn. Ther."}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778918306998?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778918306998?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:51:15Z","timestamp":1761897075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778918306998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":48,"alternative-id":["S2210778918306998"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2019.04.004","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential expression of candidate circulating microRNAs in maternal blood leukocytes of the patients with preeclampsia and gestational diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2019.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}