{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T19:37:16Z","timestamp":1770579436796,"version":"3.49.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005609","name":"University of Turku, Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.preghy.2019.08.001","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T11:46:29Z","timestamp":1565351189000},"page":"9-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["PlGF isoform 3 in maternal serum and placental tissue"],"prefix":"10.1016","volume":"18","author":[{"given":"Heini","family":"Frang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pertti","family":"Hurskainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kypros","family":"Nicolaides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Sairanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.preghy.2019.08.001_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3858\/emm.2012.44.1.025","article-title":"The discovery of placental growth factor and its biological activity","volume":"44","author":"De Falco","year":"2012","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.preghy.2019.08.001_b0010","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/uog.15816","article-title":"Maternal serum placental growth factor at 12, 22, 32 and 36 weeks' gestation in screening for pre-eclampsia","volume":"47","author":"Tsiakkas","year":"2016","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.preghy.2019.08.001_b0015","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJMoa1704559","article-title":"Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia","volume":"377","author":"Rolnik","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.preghy.2019.08.001_b0020","article-title":"Performance of commercially available placental growth factor tests in women with suspected preterm pre-eclampsia; the COMPARE study","author":"McCarthy","year":"2018","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.preghy.2019.08.001_b0025","first-page":"925","article-title":"Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14","volume":"8","author":"Maglione","year":"1993","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.preghy.2019.08.001_b0030","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/08977199308991586","article-title":"A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta","volume":"9","author":"Hauser","year":"1993","journal-title":"Growth Factors"},{"issue":"2","key":"10.1016\/j.preghy.2019.08.001_b0035","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000357842","article-title":"Maternal serum placental growth factor (PlGF) isoforms 1 and 2 at 11\u201313 weeks' gestation in normal and pathological pregnancies","volume":"36","author":"Nucci","year":"2014","journal-title":"Fetal Diagn. Ther."},{"issue":"4","key":"10.1016\/j.preghy.2019.08.001_b0040","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000358595","article-title":"Maternal serum placental growth factor isoforms 1 and 2 at 11\u201313, 20\u201324 and 30\u201334 weeks' gestation in late-onset pre-eclampsia and small for gestational age neonates","volume":"35","author":"Nucci","year":"2014","journal-title":"Fetal Diagn. Ther."},{"issue":"1","key":"10.1016\/j.preghy.2019.08.001_b0045","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.preghy.2014.10.158","article-title":"[152-POS]: measurement of placental growth factor isoform 2 in first trimester of pregnancy","volume":"5","author":"Hurskainen","year":"2015","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.preghy.2019.08.001_b0050","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1006\/bbrc.1997.6813","article-title":"Placental growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing","volume":"235","author":"Cao","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.preghy.2019.08.001_b0055","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0165-0378(03)00082-2","article-title":"Evidence of a novel isoform of placental growth factor (PlGF-4) expressed in human trophoblast and endothelial cells","volume":"60","author":"Yang","year":"2003","journal-title":"J. Reproduct. Immun."},{"key":"10.1016\/j.preghy.2019.08.001_b0060","doi-asserted-by":"crossref","first-page":"25646","DOI":"10.1016\/S0021-9258(18)47298-5","article-title":"Placenta growth factor: potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1\/KDR","volume":"269","author":"Park","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"35","key":"10.1016\/j.preghy.2019.08.001_b0065","doi-asserted-by":"crossref","first-page":"22272","DOI":"10.1074\/jbc.273.35.22272","article-title":"Neuropilin-1 is a placenta growth factor-2 receptor","volume":"273","author":"Migdal","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.preghy.2019.08.001_b0070","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/jmbi.1999.3444","article-title":"Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides","volume":"296","author":"Knappik","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.preghy.2019.08.001_b0075","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0003-2697(84)90095-2","article-title":"Europium as a label in time-resolved immunofluorometric assays","volume":"137","author":"Hemmil\u00e4","year":"1984","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.preghy.2019.08.001_b0080","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000345090","article-title":"Maternal serum placental growth factor, pregnancy-associated plasma protein-A and free \u03b2-human chorionic gonadotrophin at 30\u201333 weeks in the prediction of pre-eclampsia","volume":"33","author":"Lai","year":"2013","journal-title":"Fetal Diagn. Ther."},{"key":"10.1016\/j.preghy.2019.08.001_b0085","doi-asserted-by":"crossref","DOI":"10.1081\/PRG-100104165","article-title":"The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP)","volume":"20","author":"Brown","year":"2001","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.preghy.2019.08.001_b0090","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000338655","article-title":"Birthweight with gestation and maternal characteristics in live births and stillbirths","volume":"32","author":"Poon","year":"2012","journal-title":"Fetal Diagn. Ther."},{"key":"10.1016\/j.preghy.2019.08.001_bib91","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.preghy.2019.06.004","article-title":"Inter-manufacturer comparison of automated immunoassays for the measurement of soluble FMS-like tyrosine kinase-1 and placental growth factor","volume":"17","author":"Yue","year":"2019","journal-title":"Pregnancy Hypertens."}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778919300716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778919300716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:53:53Z","timestamp":1761897233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778919300716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":19,"alternative-id":["S2210778919300716"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2019.08.001","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PlGF isoform 3 in maternal serum and placental tissue","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2019.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}