{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:01:05Z","timestamp":1787065265252,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006396","name":"Alexion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006668","name":"Oregon Health and Science University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005278","name":"Universidad de Antioquia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009450","name":"Universidad Pontificia Bolivariana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009450","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.preghy.2020.10.004","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T03:30:43Z","timestamp":1602646243000},"page":"204-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Plasma CD59 concentrations are increased in preeclampsia with severe features and correlate with laboratory measures of end-organ injury"],"prefix":"10.1016","volume":"22","author":[{"given":"Jes\u00fas A.","family":"Vel\u00e1squez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Burwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa R.","family":"Hersh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime L.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Lenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamile","family":"Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge H.","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Edna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Trujillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Tolosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.preghy.2020.10.004_b0005","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global causes of maternal death: a WHO systematic analysis","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Glob. Heal."},{"issue":"5","key":"10.1016\/j.preghy.2020.10.004_b0010","first-page":"1122","article-title":"Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Hypertension in Pregnancy","volume":"122","author":"American College of Obstetricians","year":"2013","journal-title":"Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.preghy.2020.10.004_b0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0002-9378(16)32330-4","article-title":"Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy","volume":"142","author":"Weinstein","year":"1982","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.preghy.2020.10.004_b0020","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.preghy.2020.10.004_b0025","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1161\/HYPERTENSIONAHA.113.01420","article-title":"Urinary excretion of C5b\u20139 in severe preeclampsia: tipping the balance of complement activation in pregnancy","volume":"62","author":"Burwick","year":"2013","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.preghy.2020.10.004_b0030","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1161\/HYPERTENSIONAHA.112.194324","article-title":"Preeclampsia is characterized by placental complement dysregulation","volume":"60","author":"Buurma","year":"2012","journal-title":"Hypertens (Dallas, Tex 1979)"},{"issue":"6","key":"10.1016\/j.preghy.2020.10.004_b0035","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1097\/AOG.0000000000002980","article-title":"Terminal complement activation in preeclampsia","volume":"132","author":"Burwick","year":"2018","journal-title":"Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.preghy.2020.10.004_b0040","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.placenta.2012.11.014","article-title":"Eculizumab for the treatment of preeclampsia\/HELLP syndrome","volume":"34","author":"Burwick","year":"2013","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.preghy.2020.10.004_b0045","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/joim.12606","article-title":"The role of complement inhibitors beyond controlling inflammation","volume":"282","author":"Blom","year":"2017","journal-title":"J. Intern. Med."},{"issue":"1\u20133","key":"10.1016\/j.preghy.2020.10.004_b0050","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.molimm.2006.06.019","article-title":"Alternative roles for CD59","volume":"44","author":"Kimberley","year":"2007","journal-title":"Mol. Immunol."},{"issue":"5","key":"10.1016\/j.preghy.2020.10.004_b0055","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13033","article-title":"Upregulation and release of soluble fms-like tyrosine kinase receptor 1 mediated by complement activation in human syncytiotrophoblast cells","volume":"80","author":"Banadakoppa","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"issue":"9","key":"10.1016\/j.preghy.2020.10.004_b0060","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.4049\/jimmunol.144.9.3478","article-title":"The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b\u20139","volume":"144","author":"Rollins","year":"1990","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.preghy.2020.10.004_b0065","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/eji.1830220635","article-title":"Complement regulatory proteins at the feto-maternal interface during human placental development: distribution of CD59 by comparison with membrane cofactor protein (CD46) and decay accelerating factor (CD55)","volume":"22","author":"Holmes","year":"1992","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.preghy.2020.10.004_b0070","first-page":"532","article-title":"Distribution of protectin (CD59), a complement membrane attack inhibitor, in normal human tissues","volume":"65","author":"Meri","year":"1991","journal-title":"Lab. Invest."},{"issue":"3","key":"10.1016\/j.preghy.2020.10.004_b0075","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.4049\/jimmunol.151.3.1562","article-title":"Susceptibility of human trophoblast to killing by human complement and the role of the complement regulatory proteins","volume":"151","author":"Tedesco","year":"1993","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.preghy.2020.10.004_b0080","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11906-017-0784-4","article-title":"The complement system and preeclampsia","volume":"19","author":"Regal","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.preghy.2020.10.004_b0085","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.12659\/MSM.915777","article-title":"Serum levels of complement factors C1q, Bb, and H in normal pregnancy and severe pre-eclampsia","volume":"25","author":"Jia","year":"2019","journal-title":"Med. Sci. Monit."},{"issue":"2","key":"10.1016\/j.preghy.2020.10.004_b0090","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/aji.12439","article-title":"The relationship of longitudinal levels of complement bb during pregnancy with preeclampsia","volume":"75","author":"Lynch","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"issue":"6","key":"10.1016\/j.preghy.2020.10.004_b0095","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.ekir.2019.03.012","article-title":"Diagnostic indicators of superimposed preeclampsia in women with CKD","volume":"4","author":"Wiles","year":"2019","journal-title":"Kidney Int. Rep."},{"issue":"6","key":"10.1016\/j.preghy.2020.10.004_b0100","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99128","article-title":"Germline mutations in the alternative pathway of complement predispose to HELLP syndrome","volume":"3","author":"Vaught","year":"2018","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.preghy.2020.10.004_b0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001013","article-title":"Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort","volume":"8","author":"Salmon","year":"2011","journal-title":"PLoS Med."},{"issue":"1\u20132","key":"10.1016\/j.preghy.2020.10.004_b0110","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molimm.2013.04.009","article-title":"Complement activation is critical for placental ischemia-induced hypertension in the rat","volume":"56","author":"Lillegard","year":"2013","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.preghy.2020.10.004_b0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/aji.12000","article-title":"Complement in pregnancy: a delicate balance","volume":"69","author":"Denny","year":"2013","journal-title":"Am. J. Reprod. Immunol."},{"issue":"3","key":"10.1016\/j.preghy.2020.10.004_b0120","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/10641955.2019.1640725","article-title":"Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia","volume":"38","author":"Yonekura Collier","year":"2019","journal-title":"Hypertens. Pregnancy"},{"issue":"19","key":"10.1016\/j.preghy.2020.10.004_b0125","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.1074\/jbc.RA118.002639","article-title":"Brain microvascular endothelial cells exhibit lower activation of the alternative complement pathway than glomerular microvascular endothelial cells","volume":"293","author":"Sartain","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.preghy.2020.10.004_b0130","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1161\/HYPERTENSIONAHA.114.03456","article-title":"Complement activation and kidney injury molecule-1-associated proximal tubule injury in severe preeclampsia","volume":"64","author":"Burwick","year":"2014","journal-title":"Hypertens (Dallas, Tex 1979)"},{"issue":"4","key":"10.1016\/j.preghy.2020.10.004_b0135","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/10409238.2018.1485627","article-title":"Organization of GPI-anchored proteins at the cell surface and its physiopathological relevance","volume":"53","author":"Lebreton","year":"2018","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.preghy.2020.10.004_b0140","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/bs.ctm.2015.03.006","article-title":"Trafficking and membrane organization of GPI-anchored proteins in health and diseases","volume":"75","author":"Paladino","year":"2015","journal-title":"Curr. Top. Membr."},{"key":"10.1016\/j.preghy.2020.10.004_b0145","doi-asserted-by":"crossref","first-page":"9514546","DOI":"10.1155\/2019\/9514546","article-title":"Glycosylation profile of the transferrin receptor in gestational iron deficiency and early-onset severe preeclampsia","volume":"2019","author":"Gomez-Gutierrez","year":"2019","journal-title":"J. Pregnancy"},{"issue":"10","key":"10.1016\/j.preghy.2020.10.004_b0150","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.2337\/diabetes.53.10.2653","article-title":"Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes","volume":"53","author":"Qin","year":"2004","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.preghy.2020.10.004_b0155","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1073\/pnas.97.10.5450","article-title":"Molecular basis for a link between complement and the vascular complications of diabetes","volume":"97","author":"Acosta","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.preghy.2020.10.004_b0160","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.3892\/ol.2017.6555","article-title":"CD55 and CD59 expression protects HER2-overexpressing breast cancer cells from trastuzumab-induced complement-dependent cytotoxicity","volume":"14","author":"Wang","year":"2017","journal-title":"Oncol. Lett."},{"issue":"6","key":"10.1016\/j.preghy.2020.10.004_b0165","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1158\/0008-5472.CAN-10-3016","article-title":"Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis","volume":"71","author":"Hu","year":"2011","journal-title":"Cancer Res."},{"issue":"40","key":"10.1016\/j.preghy.2020.10.004_b0170","doi-asserted-by":"crossref","first-page":"34073","DOI":"10.1074\/jbc.M504922200","article-title":"Insights into the human CD59 complement binding interface toward engineering new therapeutics","volume":"280","author":"Huang","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221077892030129X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221077892030129X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:55:07Z","timestamp":1761897307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221077892030129X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":34,"alternative-id":["S221077892030129X"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2020.10.004","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma CD59 concentrations are increased in preeclampsia with severe features and correlate with laboratory measures of end-organ injury","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2020.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}