{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:44:35Z","timestamp":1786995875467,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.preghy.2020.11.014","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T19:48:44Z","timestamp":1607716124000},"page":"123-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Effects of statins on preeclampsia: A systematic review"],"prefix":"10.1016","volume":"23","author":[{"given":"Amir","family":"Vahedian-Azimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u017deljko","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Makvandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9741","key":"10.1016\/j.preghy.2020.11.014_b0005","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.preghy.2020.11.014_b0010","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.preghy.2020.11.014_b0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2393-9-8","article-title":"The HELLP syndrome: clinical issues and management. A review","volume":"9","author":"Haram","year":"2009","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.preghy.2020.11.014_b0020","doi-asserted-by":"crossref","unstructured":"E. Vaisbuch, J.E. Whitty, S.S. Hassan, R. Romero, J.P. Kusanovic, D.B. Cotton, et al., Circulating angiogenic and antiangiogenic factors in women with eclampsia, Am. J. Obstet. Gynecol. 204(2) (2011) 152. e1-.e9.","DOI":"10.1016\/j.ajog.2010.08.049"},{"key":"10.1016\/j.preghy.2020.11.014_b0025","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3027363","article-title":"Placental growth factor, soluble fms-like tyrosine kinase 1, soluble endoglin, IL-6, and IL-16 as biomarkers in preeclampsia","volume":"2016","author":"R\u0103dulescu","year":"2016","journal-title":"Mediators Inflamm."},{"issue":"8","key":"10.1016\/j.preghy.2020.11.014_b0030","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrcardio.2013.80","article-title":"Statins in the primary prevention of cardiovascular disease","volume":"10","author":"Reiner","year":"2013","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.preghy.2020.11.014_b0035","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.atherosclerosis.2016.07.897","article-title":"Impact of statin therapy on plasma adiponectin concentrations: a systematic review and meta-analysis of 43 randomized controlled trial arms","volume":"253","author":"Chru\u015bciel","year":"2016","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.preghy.2020.11.014_b0040","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11745-010-3517-x","article-title":"Simvastatin therapy reduces prooxidant-antioxidant balance: results of a placebo-controlled cross-over trial","volume":"46","author":"Parizadeh","year":"2011","journal-title":"Lipids"},{"key":"10.1016\/j.preghy.2020.11.014_b0045","article-title":"Effects of statins on brain tumors: a review","author":"Afshari","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.preghy.2020.11.014_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101024","article-title":"Effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ageing: Molecular mechanisms","volume":"58","author":"Bahrami","year":"2020","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.preghy.2020.11.014_b0055","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1160\/th15-08-0620","article-title":"The impact of statin therapy on plasma levels of von Willebrand factor antigen: systematic review and meta-analysis of Randomised placebo-controlled trials","volume":"115","author":"Sahebkar","year":"2016","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.preghy.2020.11.014_b0060","doi-asserted-by":"crossref","DOI":"10.1038\/srep09902","article-title":"A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations","volume":"5","author":"Serban","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preghy.2020.11.014_b0065","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.plipres.2015.08.003","article-title":"Effect of statin therapy on paraoxonase-1 status: a systematic review and meta-analysis of 25 clinical trials","volume":"60","author":"Ferretti","year":"2015","journal-title":"Prog. Lipid Res."},{"issue":"2","key":"10.1016\/j.preghy.2020.11.014_b0070","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/bmjebm-2017-110853","article-title":"Methodological quality and synthesis of case series and case reports","volume":"23","author":"Murad","year":"2018","journal-title":"BMJ Evid.-Based Med."},{"key":"10.1016\/j.preghy.2020.11.014_b0075","article-title":"Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial","author":"Ahmed","year":"2019","journal-title":"BJOG: Int. J. Obstet. Gynaecol."},{"issue":"3","key":"10.1016\/j.preghy.2020.11.014_b0080","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/HYPERTENSIONAHA.115.05445","article-title":"Effects of pravastatin on human placenta, endothelium, and women with severe preeclampsia","volume":"66","author":"Brownfoot","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.preghy.2020.11.014_b0085","doi-asserted-by":"crossref","unstructured":"M.M. Costantine, K. Cleary, M.F. Hebert, M.S. Ahmed, L.M. Brown, Z. Ren, et al., Safety and pharmacokinetics of pravastatin used for the prevention of preeclampsia in high-risk pregnant women: a pilot randomized controlled trial, Am. J. Obstet. Gynecol. 214(6) (2016) 720. e1-. e17.","DOI":"10.1016\/j.ajog.2015.12.038"},{"issue":"42","key":"10.1016\/j.preghy.2020.11.014_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MD.0000000000008229","article-title":"Pravastatin for prevention of HELLP syndrome: a case report","volume":"96","author":"Otten","year":"2017","journal-title":"Medicine"},{"key":"10.1016\/j.preghy.2020.11.014_b0095","unstructured":"S. Kavak, E. Celik Kavak, B. Keser, I. Batmaz, G. Yener, Pravastatin in the follow up and treatment of preeclampsia a casereport, World Congress of Perinatal Medicine; Istanbul, 2019, p. 369."},{"issue":"1","key":"10.1016\/j.preghy.2020.11.014_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12884-019-2507-0","article-title":"Pravastatin induces NO synthesis by enhancing microsomal arginine uptake in healthy and preeclamptic placentas","volume":"19","author":"P\u00e1ncz\u00e9l","year":"2019","journal-title":"BMC Pregnancy Childbirth"},{"issue":"9","key":"10.1016\/j.preghy.2020.11.014_b0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107644","article-title":"In-vitro study of the effect of anti-hypertensive drugs on placental hormones and angiogenic proteins synthesis in pre-eclampsia","volume":"9","author":"Gangooly","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.preghy.2020.11.014_b0110","doi-asserted-by":"crossref","unstructured":"E. Lefkou, A. Mamopoulos, T. Dagklis, C. Vosnakis, C. Anthoulakis, G. Mavromatidis, et al., editors. Clinical improvement and successful pregnancy in three patients with antiphospholipid antibodies (APL) and ischemic placental disease treated with pravastatin. Thrombosis Research; 2015: Pergamon-Elsevier Science Ltd the Boulevard, Langford Lane, Kidlington\u2026.","DOI":"10.1161\/HYPERTENSIONAHA.114.03115"},{"issue":"8","key":"10.1016\/j.preghy.2020.11.014_b0115","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1172\/JCI86957","article-title":"Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy","volume":"126","author":"Lefkou","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preghy.2020.11.014_b0120","first-page":"157","article-title":"Pravastatin in treatment of high risk pregnancy with antiphospholipide syndrome","volume":"45","author":"Lefkou","year":"2017","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.preghy.2020.11.014_b0125","doi-asserted-by":"crossref","unstructured":"F.C. Brownfoot, S. Tong, N.J. Hannan, R. Hastie, P. Cannon, J. Tu\u2019uhevaha, Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta, BMC Pregnancy Childbirth 16(1) (2016) 117.","DOI":"10.1186\/s12884-016-0902-3"},{"issue":"2","key":"10.1016\/j.preghy.2020.11.014_b0130","first-page":"967","article-title":"Role of lovastatin on level of soluble FMS-Like tyrokenase-1 (sFlt-1), placental growth factor (PIGF) in preeclampsia-induced human umbilcal vein endhothelial cell (HUVEC)","volume":"15","author":"Putra","year":"2018","journal-title":"Biosci. Res."},{"issue":"4\u20135","key":"10.1016\/j.preghy.2020.11.014_b0135","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.placenta.2005.04.011","article-title":"Reduced L-arginine level and decreased placental eNOS activity in preeclampsia","volume":"27","author":"Kim","year":"2006","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.preghy.2020.11.014_b0140","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.preghy.2020.11.014_b0145","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble endoglin and other circulating antiangiogenic factors in preeclampsia","volume":"355","author":"Levine","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"2 0 1","key":"10.1016\/j.preghy.2020.11.014_b0150","article-title":"Pravastatin for the prevention of preeclampsia in high-risk pregnant women","volume":"121","author":"Costantine","year":"2013","journal-title":"Obstet. Gynecol."},{"issue":"13","key":"10.1016\/j.preghy.2020.11.014_b0155","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1161\/CIRCULATIONAHA.106.660134","article-title":"Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1","volume":"115","author":"Cudmore","year":"2007","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.preghy.2020.11.014_b0160","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.preghy.2020.11.014_b0165","doi-asserted-by":"crossref","first-page":"h1035","DOI":"10.1136\/bmj.h1035","article-title":"Statins and congenital malformations: cohort study","volume":"350","author":"Bateman","year":"2015","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.preghy.2020.11.014_b0170","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jacl.2016.07.002","article-title":"The risks of statin use in pregnancy: a systematic review","volume":"10","author":"Karalis","year":"2016","journal-title":"J. Clin. Lipidol."}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778920301604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778920301604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:53:34Z","timestamp":1761897214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778920301604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":34,"alternative-id":["S2210778920301604"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2020.11.014","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of statins on preeclampsia: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2020.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}