{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:33:41Z","timestamp":1761899621374,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000190","name":"University of Alberta","doi-asserted-by":"publisher","award":["170425"],"award-info":[{"award-number":["170425"]}],"id":[{"id":"10.13039\/501100000190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010322","name":"Stollery Children\u2019s Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["BPF \u2013 170425","FS154313"],"award-info":[{"award-number":["BPF \u2013 170425","FS154313"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.preghy.2021.09.007","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T10:32:06Z","timestamp":1632738726000},"page":"87-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Increased oxidative stress and endothelial activation in umbilical veins from pregnancies diagnosed with preeclampsia"],"prefix":"10.1016","volume":"26","author":[{"given":"Tamara","family":"S\u00e1ez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Wiley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Quon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floor","family":"Spaans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra T.","family":"Davidge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.preghy.2021.09.007_b0005","first-page":"987.e15","article-title":"Secular Trends in Preeclampsia Incidence and Outcomes in a Large Canada Database: A Longitudinal Study Over 24 Years","volume":"32","author":"Auger","year":"2016","journal-title":"Can. J. Cardiol."},{"issue":"3","key":"10.1016\/j.preghy.2021.09.007_b0010","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1055\/s-0039-1695004","article-title":"Lasting Effects of Intrauterine Exposure to Preeclampsia on Offspring and the Underlying Mechanism","volume":"9","author":"Lu","year":"2019","journal-title":"AJP Rep."},{"key":"10.1016\/j.preghy.2021.09.007_b0015","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fphar.2014.00134","article-title":"Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming","volume":"5","author":"Escudero","year":"2014","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.preghy.2021.09.007_b0020","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.placenta.2014.12.007","article-title":"Insulin restores L-arginine transport requiring adenosine receptors activation in umbilical vein endothelium from late-onset preeclampsia","volume":"36","author":"Salsoso","year":"2015","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.preghy.2021.09.007_b0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejogrb.2007.06.014","article-title":"Adhesion molecules changes at 20 gestation weeks in pregnancies complicated by preeclampsia","volume":"137","author":"Chavarria","year":"2008","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.preghy.2021.09.007_b0030","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1055\/s-2002-34467","article-title":"Neonatal and Maternal Serum Levels of Soluble ICAM-1 in Preeclamptic and Normal Pregnancies","volume":"19","author":"Didem","year":"2002","journal-title":"Am. J. Perinatol."},{"issue":"6","key":"10.1016\/j.preghy.2021.09.007_b0035","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1442-200x.2005.02146.x","article-title":"Oxidative stress in infants born to preeclamptic mothers","volume":"47","author":"Tastekin","year":"2005","journal-title":"Pediatr. Int."},{"issue":"8","key":"10.1016\/j.preghy.2021.09.007_b0040","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1096\/fj.15-271627","article-title":"Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor","volume":"29","author":"Yamamoto","year":"2015","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.preghy.2021.09.007_b0045","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.yexcr.2017.08.030","article-title":"Inhibition of angiotension II type 1 receptor reduced human endothelial inflammation induced by low shear stress","volume":"360","author":"Chao","year":"2017","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.preghy.2021.09.007_b0050","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1124\/jpet.102.034959","article-title":"Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1","volume":"302","author":"Li","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.preghy.2021.09.007_b0055","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/ajh\/hps035","article-title":"Inhibition of Lectin-Like Oxidized Low-Density Lipoprotein-1 Receptor Protects Against Plasma-Mediated Vascular Dysfunction Associated With Pre-Eclampsia","volume":"26","author":"English","year":"2013","journal-title":"Am. J. Hypertens."},{"issue":"3","key":"10.1016\/j.preghy.2021.09.007_b0060","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.HYP.0000257797.49289.71","article-title":"Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia","volume":"49","author":"Herse","year":"2007","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.preghy.2021.09.007_b0065","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1161\/HYPERTENSIONAHA.108.122630","article-title":"Increased Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Expression in the Maternal Vasculature of Women With Preeclampsia","volume":"53","author":"Sankaralingam","year":"2009","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.preghy.2021.09.007_b0070","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/micc.12079","article-title":"Vascular dysfunction in preeclampsia","volume":"21","author":"Brennan","year":"2014","journal-title":"Microcirculation"},{"issue":"3","key":"10.1016\/j.preghy.2021.09.007_b0075","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/10641950600912950","article-title":"Increased superoxide generation and decreased stress protein Hsp90 expression in human umbilical cord vein endothelial cells (HUVECs) from pregnancies complicated by preeclampsia","volume":"25","author":"Gu","year":"2006","journal-title":"Hypertens Pregnancy."},{"issue":"11","key":"10.1016\/j.preghy.2021.09.007_b0080","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.placenta.2014.08.090","article-title":"Intrauterine growth restriction is associated with structural alterations in human umbilical cord and decreased nitric oxide-induced relaxation of umbilical vein","volume":"35","author":"Peyter","year":"2014","journal-title":"Placenta"},{"issue":"12","key":"10.1016\/j.preghy.2021.09.007_b0085","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3109\/09513590.2015.1065483","article-title":"Comparison of maternal and umbilical cord blood HIF-1alpha and nitric oxide levels in early and late onset preeclamptic pregnancies","volume":"31","author":"Demircan Sezer","year":"2015","journal-title":"Gynecol. Endocrinol."},{"issue":"11","key":"10.1016\/j.preghy.2021.09.007_b0090","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1097\/00004872-199411000-00005","article-title":"Nitric oxide production by human umbilical vessels in severe pre-eclampsia","volume":"12","author":"Akar","year":"1994","journal-title":"J. Hypertens."},{"issue":"2","key":"10.1016\/j.preghy.2021.09.007_b0095","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1172\/JCI66843","article-title":"Linking endothelial dysfunction with endothelial cell activation","volume":"123","author":"Liao","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.preghy.2021.09.007_b0100","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-3083.2008.02029.x","article-title":"Soluble ICAM-1 and VCAM-1 as markers of endothelial activation","volume":"67","author":"Videm","year":"2008","journal-title":"Scand. J. Immunol."},{"issue":"2","key":"10.1016\/j.preghy.2021.09.007_b0105","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1373\/clinchem.2011.168559","article-title":"Circulating soluble intercellular adhesion molecule 1 and subclinical atherosclerosis: the Coronary Artery Risk Development in Young Adults Study","volume":"58","author":"Gross","year":"2012","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.preghy.2021.09.007_b0110","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0301-2115(98)00010-4","article-title":"Fetal plasma levels of circulating endothelial cell adhesion molecules in normal and preeclamptic pregnancies","volume":"78","author":"Krauss","year":"1998","journal-title":"Eur. J. Obstetr. Gynecol. Reprod. Biol."},{"issue":"5","key":"10.1016\/j.preghy.2021.09.007_b0115","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s00404-014-3294-5","article-title":"Comparison of maternal and umbilical cord blood soluble lectin-like oxidized low-density lipoprotein receptor 1 levels in early- and late-onset preeclampsia","volume":"290","author":"Tuten","year":"2014","journal-title":"Arch. Gynecol. Obstet."},{"issue":"8","key":"10.1016\/j.preghy.2021.09.007_b0120","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/hr.2014.71","article-title":"A longitudinal study of circulating angiogenic and antiangiogenic factors and AT1-AA levels in preeclampsia","volume":"37","author":"Sahay","year":"2014","journal-title":"Hypertens. Res."},{"issue":"3","key":"10.1016\/j.preghy.2021.09.007_b0125","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/ped.12552","article-title":"Serum ischemia-modified albumin and oxidized LDL in cord blood and serum of neonates born to pre-eclamptic mothers","volume":"57","author":"Mehmetoglu","year":"2015","journal-title":"Pediatr. Int."}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778921005225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778921005225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:56:26Z","timestamp":1761897386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778921005225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":25,"alternative-id":["S2210778921005225"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2021.09.007","relation":{},"ISSN":["2210-7789"],"issn-type":[{"type":"print","value":"2210-7789"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased oxidative stress and endothelial activation in umbilical veins from pregnancies diagnosed with preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2021.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}