{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:32:54Z","timestamp":1775061174692,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.preghy.2021.10.003","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T18:52:31Z","timestamp":1634237551000},"page":"95-101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Elevated expression of galectin-3, thioredoxin and thioredoxin interacting protein in preeclampsia"],"prefix":"10.1016","volume":"26","author":[{"given":"Sivan","family":"Farladansky-Gershnabel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishai","family":"Heusler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Biron-Shental","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil","family":"Shechter-Maor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliza","family":"Amiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Kidron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avivit","family":"Weisz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Einbinder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keren","family":"Cohen-Hagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney","family":"Benchetrit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tali","family":"Zitman-Gal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"98\u2013114","key":"10.1016\/j.preghy.2021.10.003_b0005","first-page":"quiz 20","article-title":"Mechanisms of disease: pre-eclampsia","volume":"1","author":"Noris","year":"2005","journal-title":"Nat. Clin. Pract. Nephrol."},{"key":"10.1016\/j.preghy.2021.10.003_b0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semnephrol.2010.10.004","article-title":"Angiogenic factors and preeclampsia","volume":"31","author":"Maynard","year":"2011","journal-title":"Semin. Nephrol."},{"issue":"9461","key":"10.1016\/j.preghy.2021.10.003_b0015","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.preghy.2021.10.003_b0020","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1538-7836.2008.03259.x","article-title":"Vascular biology of preeclampsia","volume":"7","author":"Myatt","year":"2009","journal-title":"J. Thromb. Haemost."},{"issue":"Suppl 1","key":"10.1016\/j.preghy.2021.10.003_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijgo.12926","article-title":"FIGO (International Federation of Gynecology and Obstetrics) Postpregnancy initiative: long-term maternal implications of pregnancy complications-follow-up considerations","volume":"147","author":"Sheiner","year":"2019","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.preghy.2021.10.003_b0030","first-page":"599","article-title":"Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)","volume":"41","author":"Dong","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.preghy.2021.10.003_b0035","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1515\/cclm-2014-0187","article-title":"Galectin-3 in diabetic patients","volume":"52","author":"Pugliese","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.preghy.2021.10.003_b0040","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3892\/br.2016.696","article-title":"Association between circulating galectin-3 levels and the immunological, inflammatory and nutritional parameters in patients with colorectal cancer","volume":"5","author":"Shimura","year":"2016","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.preghy.2021.10.003_b0045","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.placenta.2004.03.006","article-title":"Galectin-1 and galectin-3 in the trophoblast of the gestational trophoblastic disease","volume":"25","author":"Bozic","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.preghy.2021.10.003_b0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/DMSO.S232221","article-title":"Thioredoxin-interacting protein as a novel potential therapeutic target in diabetes mellitus and its underlying complications","volume":"13","author":"Wondafrash","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.preghy.2021.10.003_b0055","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1210\/me.2014-1095","article-title":"Minireview: Thioredoxin-interacting protein: regulation and function in the pancreatic beta-cell","volume":"28","author":"Shalev","year":"2014","journal-title":"Mol. Endocrinol."},{"issue":"8","key":"10.1016\/j.preghy.2021.10.003_b0060","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1089\/ars.2010.3114","article-title":"Structure, function, and mechanism of thioredoxin proteins","volume":"13","author":"Collet","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.preghy.2021.10.003_b0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3164\/jcbn.12-71","article-title":"Thioredoxin-1 and oxidative stress status in pregnant women at early third trimester of pregnancy: relation to maternal and neonatal characteristics","volume":"52","author":"Nakatsukasa","year":"2013","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"2","key":"10.1016\/j.preghy.2021.10.003_b0070","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s11033-019-05221-8","article-title":"Thioredoxin, thioredoxin interacting protein and transducer and activator of transcription 3 in gestational diabetes","volume":"47","author":"Pasternak","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.preghy.2021.10.003_b0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0234732","article-title":"Elevated galectin-3 in women with gestational diabetes mellitus, a new surrogate for cardiovascular disease in women","volume":"15","author":"Talmor-Barkan","year":"2020","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.preghy.2021.10.003_b0080","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/1753-0407.13088","article-title":"Association of circulating galectin-3 with gestational diabetes mellitus, progesterone, and insulin resistance","volume":"13","author":"Zhang","year":"2021","journal-title":"J. Diabetes"},{"issue":"6","key":"10.1016\/j.preghy.2021.10.003_b0085","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.numecd.2021.03.002","article-title":"Enhanced expression of Galectin-3 in gestational diabetes","volume":"31","author":"Heusler","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"issue":"5","key":"10.1016\/j.preghy.2021.10.003_b0090","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.placenta.2004.07.003","article-title":"The correlation between sampling site and gene expression in the term human placenta","volume":"26","author":"Wyatt","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.preghy.2021.10.003_b0095","doi-asserted-by":"crossref","DOI":"10.1177\/2040622320968412","article-title":"Galectin-3 levels are elevated following nintedanib treatment","volume":"11","author":"Shochet","year":"2020","journal-title":"Ther. Adv. Chronic Dis."},{"issue":"1","key":"10.1016\/j.preghy.2021.10.003_b0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preghy.2021.10.003_b0105","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.4049\/jimmunol.154.8.3771","article-title":"Human placental HLA-G expression is restricted to differentiated cytotrophoblasts","volume":"154","author":"McMaster","year":"1995","journal-title":"J. Immunol."},{"issue":"17","key":"10.1016\/j.preghy.2021.10.003_b0110","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.3390\/ijms20174246","article-title":"Preeclampsia: maternal systemic vascular disorder caused by generalized endothelial dysfunction due to placental antiangiogenic factors","volume":"20","author":"Tomimatsu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"25","key":"10.1016\/j.preghy.2021.10.003_b0115","doi-asserted-by":"crossref","first-page":"17125","DOI":"10.1016\/S0021-9258(17)32529-2","article-title":"Interleukin-1 beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro","volume":"269","author":"Librach","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.preghy.2021.10.003_b0120","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000100798","article-title":"Oxidative stress alters the integrity of cell-free mRNA fragments associated with placenta-derived syncytiotrophoblast microparticles","volume":"22","author":"Rusterholz","year":"2007","journal-title":"Fetal Diagn. Ther."},{"key":"10.1016\/j.preghy.2021.10.003_b0125","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fphar.2014.00119","article-title":"The therapeutic potential of antioxidants, ER chaperones, NO and H2S donors, and statins for treatment of preeclampsia","volume":"5","author":"Cindrova-Davies","year":"2014","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.preghy.2021.10.003_b0130","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/jhh.2014.35","article-title":"MiR-101 regulates apoptosis of trophoblast HTR-8\/SVneo cells by targeting endoplasmic reticulum (ER) protein 44 during preeclampsia","volume":"28","author":"Zou","year":"2014","journal-title":"J. Hum. Hypertens."},{"issue":"9","key":"10.1016\/j.preghy.2021.10.003_b0135","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/1933719118811644","article-title":"Telomere homeostasis and senescence markers are differently expressed in placentas from pregnancies with early- versus late-onset preeclampsia","volume":"26","author":"Farladansky-Gershnabel","year":"2019","journal-title":"Reprod. Sci."},{"issue":"283","key":"10.1016\/j.preghy.2021.10.003_b0140","first-page":"e1","article-title":"Telomere homeostasis in trophoblasts and in cord blood cells from pregnancies complicated with preeclampsia","volume":"214","author":"Sukenik-Halevy","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.preghy.2021.10.003_b0145","doi-asserted-by":"crossref","first-page":"165354","DOI":"10.1016\/j.bbadis.2018.12.005","article-title":"Oxidative stress: normal pregnancy versus preeclampsia","volume":"1866","author":"Chiarello","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.preghy.2021.10.003_b0150","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biocel.2018.09.016","article-title":"Trophoblast: the central unit of fetal growth, protection and programming","volume":"105","author":"Staud","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.preghy.2021.10.003_b0155","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-065X.2009.00794.x","article-title":"The regulation of inflammation by galectin-3","volume":"230","author":"Henderson","year":"2009","journal-title":"Immunol Rev."},{"key":"10.1016\/j.preghy.2021.10.003_b0160","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/glycob\/cwn104","article-title":"Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils","volume":"19","author":"Karlsson","year":"2009","journal-title":"Glycobiology"},{"issue":"4","key":"10.1016\/j.preghy.2021.10.003_b0165","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.4049\/jimmunol.165.4.2156","article-title":"Human galectin-3 is a novel chemoattractant for monocytes and macrophages","volume":"165","author":"Sano","year":"2000","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.preghy.2021.10.003_b0170","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1159\/000495331","article-title":"Galectin-3-mediated transdifferentiation of pulmonary artery endothelial cells contributes to hypoxic pulmonary vascular remodeling","volume":"51","author":"Zhang","year":"2018","journal-title":"Cell Physiol. Biochem."},{"issue":"11-12","key":"10.1016\/j.preghy.2021.10.003_b0175","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.placenta.2007.06.006","article-title":"Expression of galectin-1, -3 (gal-1, gal-3) and the Thomsen-Friedenreich (TF) antigen in normal, IUGR, preeclamptic and HELLP placentas","volume":"28","author":"Jeschke","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.preghy.2021.10.003_b0180","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.placenta.2017.02.007","article-title":"Implantation and extravillous trophoblast invasion: from rare archival specimens to modern biobanking","volume":"56","author":"Moser","year":"2017","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.preghy.2021.10.003_b0185","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00441-019-03104-9","article-title":"Endoplasmic reticulum stress may activate NLRP3 inflammasomes via TXNIP in preeclampsia","volume":"379","author":"Yang","year":"2020","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.preghy.2021.10.003_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00519","article-title":"NLRP3 inflammasome as a molecular marker in diabetic cardiomyopathy","volume":"8","author":"Luo","year":"2017","journal-title":"Front Physiol."},{"issue":"1","key":"10.1016\/j.preghy.2021.10.003_b0195","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/cei.13130","article-title":"Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts","volume":"193","author":"St\u00f8dle","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.preghy.2021.10.003_b0200","first-page":"39","article-title":"Gal-3 is a potential biomarker for spinal cord injury and Gal-3 deficiency attenuates neuroinflammation through ROS\/TXNIP\/NLRP3 signaling pathway","author":"Ren","year":"2019","journal-title":"Biosci Rep."},{"issue":"1","key":"10.1016\/j.preghy.2021.10.003_b0205","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1053\/plac.1998.0338","article-title":"Localization of thioredoxin reductase and thioredoxin in normal human placenta and their protective effect against oxidative stress","volume":"20","author":"Ejima","year":"1999","journal-title":"Placenta"}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778921005262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778921005262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:54:25Z","timestamp":1761897265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778921005262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":41,"alternative-id":["S2210778921005262"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2021.10.003","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated expression of galectin-3, thioredoxin and thioredoxin interacting protein in preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2021.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}