{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:50:29Z","timestamp":1793469029701,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.preghy.2022.01.011","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T11:59:57Z","timestamp":1643975997000},"page":"15-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Renin-angiotensin system in normal pregnancy and in preeclampsia: A comprehensive review"],"prefix":"10.1016","volume":"28","author":[{"given":"Caio Ribeiro Vieira","family":"Leal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Braga","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Costa","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre de Melo","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando M.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina","family":"Sim\u00f5es e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.preghy.2022.01.011_b0005","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1210\/en.2003-0150","article-title":"Minireview: overview of the renin-angiotensin system\u2013an endocrine and paracrine system","volume":"144","author":"Lavoie","year":"2003","journal-title":"Endocrinology"},{"issue":"17","key":"10.1016\/j.preghy.2022.01.011_b0010","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1177\/1535370216660211","article-title":"New agents modulating the renin-angiotensin-aldosterone system-Will there be a new therapeutic option?","volume":"241","author":"Gromotowicz-Poplawska","year":"2016","journal-title":"Exp. Biol. Med. (Maywood)."},{"issue":"3","key":"10.1016\/j.preghy.2022.01.011_b0015","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/bph.12159","article-title":"ACE2, angiotensin-(1\u20137) and Mas receptor axis in inflammation and fibrosis","volume":"169","author":"Sim\u00f5es e Silva","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.preghy.2022.01.011_b0020","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1681\/ASN.2006040356","article-title":"Renin-angiotensin-aldosterone system and progression of renal disease","volume":"17","author":"R\u00fcster","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.preghy.2022.01.011_b0025","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.sjbs.2020.01.026","article-title":"Role of brain renin angiotensin system in neurodegeneration: An update","volume":"27","author":"Abiodun","year":"2020","journal-title":"Saudi J Biol Sci."},{"issue":"4","key":"10.1016\/j.preghy.2022.01.011_b0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1249\/JES.0000000000000158","article-title":"The Renin-Angiotensin System and Skeletal Muscle","volume":"46","author":"Powers","year":"2018","journal-title":"Exerc. Sport Sci. Rev."},{"issue":"2","key":"10.1016\/j.preghy.2022.01.011_b0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5830\/CVJA-2016-021","article-title":"Physiological changes in pregnancy","volume":"27","author":"Soma-Pillay","year":"2016","journal-title":"Cardiovasc J Afr."},{"issue":"11","key":"10.1016\/j.preghy.2022.01.011_b0040","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.recesp.2011.07.009","article-title":"El coraz\u00f3n durante el embarazo [The heart during pregnancy]","volume":"64","author":"Hall","year":"2011","journal-title":"Rev. Esp. Cardiol."},{"issue":"9","key":"10.1016\/j.preghy.2022.01.011_b0045","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.placenta.2008.06.011","article-title":"The functional role of the renin-angiotensin system in pregnancy and preeclampsia","volume":"29","author":"Irani","year":"2008","journal-title":"Placenta"},{"issue":"10","key":"10.1016\/j.preghy.2022.01.011_b0050","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3389\/fendo.2019.00563","article-title":"Causes and Consequences of the Dysregulated Maternal Renin-Angiotensin System in Preeclampsia","volume":"10","author":"Lumbers","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)."},{"issue":"2","key":"10.1016\/j.preghy.2022.01.011_b0055","doi-asserted-by":"crossref","first-page":"R91","DOI":"10.1152\/ajpregu.00034.2013","article-title":"Roles of the circulating renin-angiotensin-aldosterone system in human pregnancy","volume":"306","author":"Lumbers","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"6","key":"10.1016\/j.preghy.2022.01.011_b0060","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global causes of maternal death: a WHO systematic analysis","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Glob Health."},{"key":"10.1016\/j.preghy.2022.01.011_b0065","doi-asserted-by":"crossref","unstructured":"Braunthal S, Brateanu A. Hypertension in pregnancy: Pathophysiology and treatment. SAGE Open Med. 2019;7:2050312119843700. doi:10.1177\/2050312119843700.","DOI":"10.1177\/2050312119843700"},{"issue":"9","key":"10.1016\/j.preghy.2022.01.011_b0070","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1042\/CS20200894","article-title":"Maternal microvascular dysfunction during preeclamptic pregnancy","volume":"135","author":"Stanhewicz","year":"2021","journal-title":"Clin. Sci. (Lond)."},{"key":"10.1016\/j.preghy.2022.01.011_b0075","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists' Committee on Practice Bulletins\u2014Obstetrics. Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222. Obstet Gynecol. 2020 Jun;135(6):e237-e260. doi: 10.1097\/AOG.0000000000003891.","DOI":"10.1097\/AOG.0000000000003891"},{"issue":"4","key":"10.1016\/j.preghy.2022.01.011_b0080","doi-asserted-by":"crossref","first-page":"e0175914","DOI":"10.1371\/journal.pone.0175914","article-title":"Comparison of risk factors and outcomes of gestational hypertension and pre-eclampsia","volume":"12","author":"Shen","year":"2017","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1016\/j.preghy.2022.01.011_b0085","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/jch.13302","article-title":"Risk factors for adverse maternal and perinatal outcomes in women with preeclampsia: analysis of 1396 cases","volume":"20","author":"Li","year":"2018","journal-title":"J. Clin. Hypertens (Greenwich)."},{"issue":"3","key":"10.1016\/j.preghy.2022.01.011_b0090","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.preghy.2022.01.011_b0095","doi-asserted-by":"crossref","first-page":"H958","DOI":"10.1152\/ajpheart.00723.2018","article-title":"The renin-angiotensin system: going beyond the classical paradigms","volume":"316","author":"Santos","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.preghy.2022.01.011_b0100","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/0929866527666200826104410","article-title":"Angiotensin-(1\u20137), angiotensin-converting enzyme 2 and Mas receptor in rat polycystic ovaries","volume":"28","author":"Pereira","year":"2021","journal-title":"Protein Pept. Lett."},{"issue":"2 Pt 2","key":"10.1016\/j.preghy.2022.01.011_b0105","first-page":"I153","article-title":"Converting enzyme activity and angiotensin metabolism in the dog brainstem","volume":"11","author":"Santos","year":"1988","journal-title":"Hypertension"},{"issue":"43","key":"10.1016\/j.preghy.2022.01.011_b0110","doi-asserted-by":"crossref","first-page":"33238","DOI":"10.1074\/jbc.M002615200","article-title":"A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase","volume":"275","author":"Tipnis","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.preghy.2022.01.011_b0115","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/01.RES.87.5.e1","article-title":"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1\u20139","volume":"87","author":"Donoghue","year":"2000","journal-title":"Circ. Res."},{"issue":"14","key":"10.1016\/j.preghy.2022.01.011_b0120","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1\u20137) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.preghy.2022.01.011_b0125","doi-asserted-by":"crossref","first-page":"R833","DOI":"10.1152\/ajpregu.00211.2021","article-title":"ACE2: a key modulator of the renin-angiotensin system and pregnancy","volume":"321","author":"Tamanna","year":"2021","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.preghy.2022.01.011_b0130","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.semnephrol.2010.10.005","article-title":"Renin angiotensin signaling in normal pregnancy and preeclampsia","volume":"31","author":"Irani","year":"2011","journal-title":"Semin. Nephrol."},{"issue":"2","key":"10.1016\/j.preghy.2022.01.011_b0135","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0002-9378(88)80071-1","article-title":"Sodium excretion in normal and hypertensive pregnancy: a prospective study","volume":"159","author":"Brown","year":"1988","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"7320","key":"10.1016\/j.preghy.2022.01.011_b0140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature09505","article-title":"A redox switch in angiotensinogen modulates angiotensin release","volume":"468","author":"Zhou","year":"2010","journal-title":"Nature"},{"issue":"6 Pt 1","key":"10.1016\/j.preghy.2022.01.011_b0145","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/ajh\/5.6.366","article-title":"Renin-aldosterone relationships in pregnancy-induced hypertension","volume":"5","author":"Brown","year":"1992","journal-title":"Am. J. Hypertens."},{"issue":"9","key":"10.1016\/j.preghy.2022.01.011_b0150","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nm0901-1003","article-title":"Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness","volume":"7","author":"AbdAlla","year":"2001","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.preghy.2022.01.011_b0155","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/icb.1970.49","article-title":"Peripheral vascular reactivity to angiotensin and noradrenaline in pregnant and non-pregnant women","volume":"48","author":"Lumbers","year":"1970","journal-title":"Aust. J. Exp. Biol. Med. Sci."},{"issue":"2","key":"10.1016\/j.preghy.2022.01.011_b0160","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0002-9378(61)90053-9","article-title":"Pressor response to angiotonin in pregnant and nonpregnant women","volume":"82","author":"Abdul-Karim","year":"1961","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.preghy.2022.01.011_b0165","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/00003081-196612000-00003","article-title":"Vascular reactivity in normal and toxemic pregnancy","volume":"9","author":"Chesley","year":"1966","journal-title":"Clin. Obstet. Gynecol."},{"issue":"11","key":"10.1016\/j.preghy.2022.01.011_b0170","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1172\/JCI107462","article-title":"A study of angiotensin II pressor response throughout primigravid pregnancy","volume":"52","author":"Gant","year":"1973","journal-title":"J Clin Invest."},{"issue":"5","key":"10.1016\/j.preghy.2022.01.011_b0175","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/biolre\/ioy130","article-title":"Pregnancy upregulates angiotensin type 2 receptor expression and increases blood flow in uterine arteries of rats","volume":"99","author":"Mishra","year":"2018","journal-title":"Biol. Reprod."},{"issue":"8","key":"10.1016\/j.preghy.2022.01.011_b0180","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.amjhyper.2004.03.680","article-title":"Roles of angiotensin type 1 and 2 receptors in pregnancy-associated blood pressure change","volume":"17","author":"Takeda-Matsubara","year":"2004","journal-title":"Am. J. Hypertens."},{"issue":"8","key":"10.1016\/j.preghy.2022.01.011_b0185","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1590\/S0100-879X2004000800017","article-title":"Enhanced expression of Ang-(1\u20137) during pregnancy","volume":"37","author":"Brosnihan","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"3","key":"10.1016\/j.preghy.2022.01.011_b0190","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1385\/ENDO:18:3:239","article-title":"Angiotensin-(1\u20137) in normal and preeclamptic pregnancy","volume":"18","author":"Merrill","year":"2002","journal-title":"Endocrine"},{"issue":"12","key":"10.1016\/j.preghy.2022.01.011_b0195","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.placenta.2011.09.020","article-title":"The expression and localization of the human placental prorenin\/renin-angiotensin system throughout pregnancy: roles in trophoblast invasion and angiogenesis?","volume":"32","author":"Pringle","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.preghy.2022.01.011_b0200","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.590787","article-title":"Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age","volume":"11","author":"Tamanna","year":"2020","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.preghy.2022.01.011_b0205","first-page":"14","article-title":"An Update on the Tissue Renin Angiotensin System and Its Role in Physiology and Pathology","volume":"6","author":"Nehme","year":"2019","journal-title":"J Cardiovasc Dev. Dis."},{"issue":"4","key":"10.1016\/j.preghy.2022.01.011_b0210","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/HYPERTENSIONAHA.107.103861","article-title":"Activation of local chorionic villi angiotensin II levels but not angiotensin (1\u20137) in preeclampsia","volume":"51","author":"Anton","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.preghy.2022.01.011_b0215","doi-asserted-by":"crossref","unstructured":"Anton L, Merrill DC, Neves LA, et al. The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancy. Endocrinology. 2009;150(9):4316-4325. doi:10.1210\/en.2009-0076.","DOI":"10.1210\/en.2009-0076"},{"key":"10.1016\/j.preghy.2022.01.011_b0220","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.peptides.2018.01.012","article-title":"Angiotensin peptides in the non-gravid uterus: Paracrine actions beyond circulation","volume":"101","author":"Casalechi","year":"2018","journal-title":"Peptides"},{"issue":"6","key":"10.1016\/j.preghy.2022.01.011_b0225","doi-asserted-by":"crossref","first-page":"R1953","DOI":"10.1152\/ajpregu.90592.2008","article-title":"ACE2 expression and activity are enhanced during pregnancy","volume":"295","author":"Levy","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"3","key":"10.1016\/j.preghy.2022.01.011_b0230","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.placenta.2010.12.006","article-title":"Molecular characterization of renin-angiotensin system components in human intrauterine tissues and fetal membranes from vaginal delivery and cesarean section","volume":"32","author":"Marques","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.preghy.2022.01.011_b0235","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1477-7827-7-79","article-title":"Vasodilator factors in the systemic and local adaptations to pregnancy","volume":"7","author":"Valdes","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"8","key":"10.1016\/j.preghy.2022.01.011_b0240","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/CS20130455","article-title":"The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad","volume":"126","author":"Verdonk","year":"2014","journal-title":"Clin. Sci. (Lond)."},{"issue":"3","key":"10.1016\/j.preghy.2022.01.011_b0245","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.mehy.2013.12.024","article-title":"The role of the renin-angiotensin system in the pathogenesis of preeclampsia - new insights into the renin-angiotensin system in preeclampsia","volume":"82","author":"Seki","year":"2014","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.preghy.2022.01.011_b0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/739274","article-title":"RAS in Pregnancy and Preeclampsia and Eclampsia","volume":"2012","author":"Rodriguez","year":"2012","journal-title":"Int. J. Hypertens."},{"issue":"12","key":"10.1016\/j.preghy.2022.01.011_b0255","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1097\/HJH.0000000000001474","article-title":"Angiotensin II responsiveness after preeclampsia: translational data from an experimental rat model and early-onset human preeclampsia","volume":"35","author":"van der Graaf","year":"2017","journal-title":"J. Hypertens."},{"issue":"2","key":"10.1016\/j.preghy.2022.01.011_b0260","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1161\/HYPERTENSIONAHA.117.09386","article-title":"Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia","volume":"70","author":"Stanhewicz","year":"2017","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.preghy.2022.01.011_b0265","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0029-7844(97)00660-1","article-title":"Plasma active renin, angiotensin I, and angiotensin II during pregnancy and in preeclampsia","volume":"91","author":"Langer","year":"1998","journal-title":"Obstet. Gynecol."},{"issue":"4 Pt 1","key":"10.1016\/j.preghy.2022.01.011_b0270","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0029-7844(96)00239-6","article-title":"Effect of angiotensin-converting enzyme gene polymorphism on pregnancy outcome, enzyme activity, and zinc concentration","volume":"88","author":"Tamura","year":"1996","journal-title":"Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.preghy.2022.01.011_b0275","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1210\/jcem.87.4.8422","article-title":"Possible activation of the renin-angiotensin system in the feto-placental unit in preeclampsia","volume":"87","author":"Ito","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.preghy.2022.01.011_b0280","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1590\/S0100-879X2007000400018","article-title":"Reduced plasma levels of angiotensin-(1\u20137) and renin activity in preeclamptic patients are associated with the angiotensin I- converting enzyme deletion\/deletion genotype","volume":"40","author":"Velloso","year":"2007","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"8","key":"10.1016\/j.preghy.2022.01.011_b0285","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1177\/1933719118813200","article-title":"Decreased Ang-(1\u20137) and Downregulated Intrarenal RAS May Contribute to the Direct Podocyte Injury With Proteinuria in Preeclampsia","volume":"26","author":"Chen","year":"2019","journal-title":"Reprod Sci."},{"issue":"1","key":"10.1016\/j.preghy.2022.01.011_b0290","doi-asserted-by":"crossref","first-page":"R151","DOI":"10.1152\/ajpregu.00514.2007","article-title":"ACE2 and ANG-(1\u20137) in the rat uterus during early and late gestation","volume":"294","author":"Neves","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.preghy.2022.01.011_b0295","first-page":"153","article-title":"Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure","volume":"6","author":"Danyel","year":"2013","journal-title":"Integr. Blood Press Control."},{"key":"10.1016\/j.preghy.2022.01.011_b0300","unstructured":"Velloso EP et. al. Abstract 1755: G-Protein-Coupled Receptor MAS Deficiency is Involved in Preeclampsia. Circulation. 2008;118:S383 - Abstract 1755."},{"issue":"4","key":"10.1016\/j.preghy.2022.01.011_b0305","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0143-4004(91)90339-H","article-title":"Current topic: pre-eclampsia and the placenta","volume":"12","author":"Redman","year":"1991","journal-title":"Placenta"},{"key":"10.1016\/j.preghy.2022.01.011_b0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2019.07.004","article-title":"The two-stage placental model of preeclampsia: An update","volume":"134\u2013135","author":"Staff","year":"2019","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.preghy.2022.01.011_b0315","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.preghy.2018.10.002","article-title":"Functional autoantibodies against Endothelin-1 receptor type A and Angiotensin II receptor type 1 in patients with preeclampsia","volume":"14","author":"Buttrup Larsen","year":"2018","journal-title":"Pregnancy Hypertens."},{"issue":"4","key":"10.1016\/j.preghy.2022.01.011_b0320","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/10641955.2020.1833215","article-title":"Angiotensin II type 1 receptor autoantibody blockade improves cerebral blood flow autoregulation and hypertension in a preclinical model of preeclampsia","volume":"39","author":"Duncan","year":"2020","journal-title":"Hypertens Pregnancy."}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778922000137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778922000137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:58:10Z","timestamp":1761897490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778922000137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":64,"alternative-id":["S2210778922000137"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2022.01.011","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Renin-angiotensin system in normal pregnancy and in preeclampsia: A comprehensive review","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2022.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}