{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:45:25Z","timestamp":1770536725253,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.preghy.2022.02.007","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T16:57:28Z","timestamp":1645808248000},"page":"100-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["miR-204-5p promotes preeclampsia serum-induced injury in human umbilical vein endothelial cells through regulation of the PTPRJ\/Notch axis"],"prefix":"10.1016","volume":"28","author":[{"given":"Xiaoping","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.preghy.2022.02.007_b0005","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: Pathophysiology, Challenges, and Perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ Res."},{"issue":"9","key":"10.1016\/j.preghy.2022.02.007_b0010","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1055\/s-0037-1604471","article-title":"Preeclampsia","volume":"39","author":"Ramos","year":"2017","journal-title":"Rev Bras Ginecol Obstet."},{"issue":"5","key":"10.1016\/j.preghy.2022.02.007_b0015","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat Rev Nephrol."},{"issue":"5","key":"10.1016\/j.preghy.2022.02.007_b0020","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.tjog.2017.08.004","article-title":"Preeclampsia: A review of the pathogenesis and possible management strategies based on its pathophysiological derangements","volume":"56","author":"El-Sayed","year":"2017","journal-title":"Taiwan J Obstet Gynecol."},{"issue":"17","key":"10.1016\/j.preghy.2022.02.007_b0025","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.3390\/ijms20174246","article-title":"Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors","volume":"20","author":"Tomimatsu","year":"2019","journal-title":"Int J Mol Sci."},{"issue":"1","key":"10.1016\/j.preghy.2022.02.007_b0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/2211536607666180813123303","article-title":"MicroRNAs in Preeclampsia","volume":"8","author":"Skalis","year":"2019","journal-title":"Microrna."},{"issue":"5","key":"10.1016\/j.preghy.2022.02.007_b0035","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.3892\/etm.2017.4212","article-title":"An exploratory study into the role of miR-204-5p in pregnancy-induced hypertension","volume":"13","author":"Mei","year":"2017","journal-title":"Exp Ther Med."},{"issue":"1","key":"10.1016\/j.preghy.2022.02.007_b0040","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bbrc.2019.09.099","article-title":"Treatment with metformin prevents pre-eclampsia by suppressing migration of trophoblast cells via modulating the signaling pathway of UCA1\/miR-204\/MMP-9","volume":"520","author":"Ding","year":"2019","journal-title":"Biochem Biophys Res Commun."},{"issue":"4","key":"10.1016\/j.preghy.2022.02.007_b0045","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/1440-1681.13058","article-title":"Long non-coding RNA TUG1 regulates the migration and invasion of trophoblast-like cells through sponging miR-204-5p","volume":"46","author":"Yu","year":"2019","journal-title":"Clin Exp Pharmacol Physiol."},{"issue":"2","key":"10.1016\/j.preghy.2022.02.007_b0050","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10456-019-09683-z","article-title":"The protein tyrosine phosphatase PTPRJ\/DEP-1 contributes to the regulation of the Notch-signaling pathway and sprouting angiogenesis","volume":"23","author":"Fournier","year":"2020","journal-title":"Angiogenesis."},{"issue":"6","key":"10.1016\/j.preghy.2022.02.007_b0055","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.cellsig.2014.02.008","article-title":"Phosphorylation of DEP-1\/PTPRJ on threonine 1318 regulates Src activation and endothelial cell permeability induced by vascular endothelial growth factor","volume":"26","author":"Spring","year":"2014","journal-title":"Cell Signal."},{"issue":"13","key":"10.1016\/j.preghy.2022.02.007_b0060","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1182\/blood-2011-12-398040","article-title":"Tyrosine phosphorylation of DEP-1\/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation","volume":"120","author":"Spring","year":"2012","journal-title":"Blood."},{"key":"10.1016\/j.preghy.2022.02.007_b0065","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.placenta.2017.01.117","article-title":"Notch signalling in placental development and gestational diseases","volume":"56","author":"Haider","year":"2017","journal-title":"Placenta."},{"issue":"6","key":"10.1016\/j.preghy.2022.02.007_b0070","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1161\/CIRCRESAHA.117.310696","article-title":"SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling","volume":"121","author":"Zhu","year":"2017","journal-title":"Circ Res."},{"issue":"4","key":"10.1016\/j.preghy.2022.02.007_b0075","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.3892\/mmr.2017.6240","article-title":"Slit2 suppresses endothelial cell proliferation and migration by inhibiting the VEGF-Notch signaling pathway","volume":"15","author":"Li","year":"2017","journal-title":"Mol Med Rep."},{"issue":"4","key":"10.1016\/j.preghy.2022.02.007_b0080","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"issue":"2","key":"10.1016\/j.preghy.2022.02.007_b0085","doi-asserted-by":"crossref","first-page":"100483","DOI":"10.1016\/j.repbio.2021.100483","article-title":"MiR-141-3p downregulation promotes tube formation, migration, invasion and inhibits apoptosis in hypoxia-induced human umbilical vein endothelial cells by targeting Notch2","volume":"21","author":"Ling","year":"2021","journal-title":"Reprod Biol."},{"key":"10.1016\/j.preghy.2022.02.007_b0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41420-020-0269-0","article-title":"Elevated microRNA-125b inhibits cytotrophoblast invasion and impairs endothelial cell function in preeclampsia","volume":"6","author":"Li","year":"2020","journal-title":"Cell Death Discov."},{"issue":"7","key":"10.1016\/j.preghy.2022.02.007_b0095","doi-asserted-by":"crossref","first-page":"e40742","DOI":"10.1371\/journal.pone.0040742","article-title":"Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors","volume":"7","author":"Smart","year":"2012","journal-title":"PLoS One."},{"issue":"6","key":"10.1016\/j.preghy.2022.02.007_b0100","doi-asserted-by":"crossref","first-page":"447","DOI":"10.7150\/ijms.4593","article-title":"Notch signaling pathway and human placenta","volume":"9","author":"Zhao","year":"2012","journal-title":"Int J Med Sci."},{"key":"10.1016\/j.preghy.2022.02.007_b0105","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/bs.apha.2016.04.008","article-title":"Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia","volume":"77","author":"Possomato-Vieira","year":"2016","journal-title":"Adv Pharmacol."},{"issue":"1","key":"10.1016\/j.preghy.2022.02.007_b0110","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3892\/ijmm.2020.4793","article-title":"A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K\/mTOR\/HIF1alpha pathway","volume":"47","author":"Xue","year":"2021","journal-title":"Int J Mol Med."},{"issue":"10","key":"10.1016\/j.preghy.2022.02.007_b0115","first-page":"239","article-title":"Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia","volume":"10","author":"Kornacki","year":"2020","journal-title":"Life (Basel)"},{"issue":"6","key":"10.1016\/j.preghy.2022.02.007_b0120","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20200740","article-title":"LPS promotes the progression of sepsis by activation of lncRNA HULC\/miR-204-5p\/TRPM7 network in HUVECs","volume":"40","author":"Chen","year":"2020","journal-title":"Biosci Rep."},{"issue":"7","key":"10.1016\/j.preghy.2022.02.007_b0125","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1167\/iovs.13-13619","article-title":"Angiopoietin-1 is regulated by miR-204 and contributes to corneal neovascularization in KLEIP-deficient mice","volume":"55","author":"Kather","year":"2014","journal-title":"Invest Ophthalmol Vis Sci."},{"issue":"4","key":"10.1016\/j.preghy.2022.02.007_b0130","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1182\/blood-2005-10-4296","article-title":"A monoclonal antibody against CD148, a receptor-like tyrosine phosphatase, inhibits endothelial-cell growth and angiogenesis","volume":"108","author":"Takahashi","year":"2006","journal-title":"Blood."},{"issue":"5","key":"10.1016\/j.preghy.2022.02.007_b0135","doi-asserted-by":"crossref","first-page":"e0154916","DOI":"10.1371\/journal.pone.0154916","article-title":"Determination of the CD148-Interacting Region in Thrombospondin-1","volume":"11","author":"Takahashi","year":"2016","journal-title":"PLoS One."},{"issue":"1","key":"10.1016\/j.preghy.2022.02.007_b0140","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1128\/MCB.01374-08","article-title":"New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival","volume":"29","author":"Chabot","year":"2009","journal-title":"Mol Cell Biol."},{"issue":"11","key":"10.1016\/j.preghy.2022.02.007_b0145","doi-asserted-by":"crossref","first-page":"867","DOI":"10.7150\/ijms.12935","article-title":"Effects of Notch2 and Notch3 on Cell Proliferation and Apoptosis of Trophoblast Cell Lines","volume":"12","author":"Zhao","year":"2015","journal-title":"Int J Med Sci."},{"issue":"6","key":"10.1016\/j.preghy.2022.02.007_b0150","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.3892\/ijo.2017.4173","article-title":"BANCR contributes to the growth and invasion of melanoma by functioning as a competing endogenous RNA to upregulate Notch2 expression by sponging miR204","volume":"51","author":"Cai","year":"2017","journal-title":"Int J Oncol."},{"issue":"4","key":"10.1016\/j.preghy.2022.02.007_b0155","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bbrc.2020.05.032","article-title":"Delta-Like 4-Notch signaling regulates trophoblast migration and invasion by targeting EphrinB2","volume":"527","author":"Luo","year":"2020","journal-title":"Biochem Biophys Res Commun."},{"key":"10.1016\/j.preghy.2022.02.007_b0160","doi-asserted-by":"crossref","first-page":"113566","DOI":"10.1016\/j.ijheh.2020.113566","article-title":"Perfluoroctanoic acid (PFOA) enhances NOTCH-signaling in an angiogenesis model of placental trophoblast cells","volume":"229","author":"Poteser","year":"2020","journal-title":"Int J Hyg Environ Health."},{"key":"10.1016\/j.preghy.2022.02.007_b0165","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.vph.2018.10.004","article-title":"Protective effect of rapamycin on endothelial-to-mesenchymal transition in HUVECs through the Notch signaling pathway","volume":"113","author":"Tian","year":"2019","journal-title":"Vascul Pharmacol."},{"issue":"6","key":"10.1016\/j.preghy.2022.02.007_b0170","first-page":"2681","article-title":"Targeting Notch1 inhibits invasion and angiogenesis of human breast cancer cells via inhibition Nuclear Factor-kappaB signaling","volume":"8","author":"Liu","year":"2016","journal-title":"Am J Transl Res."},{"issue":"2","key":"10.1016\/j.preghy.2022.02.007_b0175","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/clc.22892","article-title":"Hypertension in pregnancy: Taking cues from pathophysiology for clinical practice","volume":"41","author":"Sava","year":"2018","journal-title":"Clin Cardiol."}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778922000289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778922000289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:55:42Z","timestamp":1761897342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778922000289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":35,"alternative-id":["S2210778922000289"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2022.02.007","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-204-5p promotes preeclampsia serum-induced injury in human umbilical vein endothelial cells through regulation of the PTPRJ\/Notch axis","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2022.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}