{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:36:23Z","timestamp":1787668583867,"version":"build-2736575974"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Sichuan Provincial People's Hospital","award":["2022QN37"],"award-info":[{"award-number":["2022QN37"]}]},{"name":"Sichuan Provincial People's Hospital","award":["2022QN16"],"award-info":[{"award-number":["2022QN16"]}]},{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024NSFSC1671"],"award-info":[{"award-number":["2024NSFSC1671"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023NSFSC1605"],"award-info":[{"award-number":["2023NSFSC1605"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Maternal and Child Health Association","award":["22FXYB03"],"award-info":[{"award-number":["22FXYB03"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.preghy.2025.101233","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T14:57:34Z","timestamp":1750172254000},"page":"101233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Rosiglitazone as a potential therapeutic drug in early intervention of preeclampsia"],"prefix":"10.1016","volume":"41","author":[{"given":"Fulin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Degrelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedia","family":"Zitouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.preghy.2025.101233_b0005","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1097\/AOG.0000000000003892","article-title":"ACOG Practice Bulletin Summary, Number 222","volume":"135","author":"Gestational Hypertension and Preeclampsia","year":"2020","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2025.101233_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.110699","article-title":"Endovascular trophoblast and spiral artery remodeling","volume":"503","author":"Sato","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2S","key":"10.1016\/j.preghy.2025.101233_b0015","doi-asserted-by":"crossref","first-page":"S1108","DOI":"10.1016\/j.ajog.2020.08.045","article-title":"Prevention of preeclampsia with aspirin","volume":"226","author":"Rolnik","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0020","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12958-024-01289-5","article-title":"Discussion on the evaluation of the therapeutic efficacy of uterine artery blood flow parameters and serum PLGF and sFlt-1 in patients with recurrent spontaneous abortion","volume":"22","author":"Lian","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0025","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/1471-0528.16361","article-title":"Implementation of routine first trimester combined screening for pre-eclampsia: a clinical effectiveness study","volume":"128","author":"Guy","year":"2021","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0030","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1186\/s12916-022-02582-z","article-title":"Systematic evaluation of the pre-eclampsia drugs, dietary supplements and biologicals pipeline using target product profiles","volume":"20","author":"McDougall","year":"2022","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0035","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s12916-024-03628-0","article-title":"Metformin use and preeclampsia risk in women with diabetes: a two-country cohort analysis","volume":"22","author":"Gordon","year":"2024","journal-title":"BMC Med."},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2023.101260","article-title":"The role of pravastatin in preventing preeclampsia in high-risk pregnant women: a meta-analysis with trial sequential analysis","volume":"6","author":"Provinciatto","year":"2024","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"issue":"9","key":"10.1016\/j.preghy.2025.101233_b0045","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1055\/a-1798-1925","article-title":"INOVASIA study: a multicenter randomized clinical trial of pravastatin to prevent preeclampsia in high-risk patients","volume":"41","author":"Akbar","year":"2024","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.preghy.2025.101233_b0050","article-title":"Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial","volume":"374","author":"Cluver","year":"2021","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0055","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s13104-020-05029-x","article-title":"Differences in expression of peroxisome proliferator-activated receptor-gamma in early-onset preeclampsia and late-onset preeclampsia","volume":"13","author":"Permadi","year":"2020","journal-title":"BMC. Res. Notes"},{"key":"10.1016\/j.preghy.2025.101233_b0060","unstructured":"GlaxoSmithKline, Full Prescribing Information of AVANDIA, Available at: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2016\/021071s051lbl.pdf (2016)."},{"issue":"9\u201310","key":"10.1016\/j.preghy.2025.101233_b0065","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.placenta.2005.12.006","article-title":"The uterine spiral arteries in human pregnancy: facts and controversies","volume":"27","author":"Pijnenborg","year":"2006","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0070","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1067\/mob.2001.111935","article-title":"Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks' gestation","volume":"184","author":"Jauniaux","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.preghy.2025.101233_b0075","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0002-9378(99)70518-1","article-title":"Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited","volume":"181","author":"Burton","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"7220","key":"10.1016\/j.preghy.2025.101233_b0080","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature07413","article-title":"Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA","volume":"456","author":"Chandra","year":"2008","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0085","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/ATVBAHA.108.179689","article-title":"Fibrates, glitazones, and peroxisome proliferator-activated receptors","volume":"30","author":"Lalloyer","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0090","first-page":"121","article-title":"Peroxisome proliferator-activated receptors: insight into multiple cellular functions","volume":"448","author":"Escher","year":"2000","journal-title":"Mutat. Res."},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0095","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jri.2011.05.003","article-title":"PPARgamma and human trophoblast differentiation","volume":"90","author":"Fournier","year":"2011","journal-title":"J. Reprod. Immunol."},{"issue":"3","key":"10.1016\/j.preghy.2025.101233_b0100","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1172\/JCI28859","article-title":"Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality","volume":"117","author":"Duan","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.preghy.2025.101233_b0105","doi-asserted-by":"crossref","first-page":"e8055","DOI":"10.1371\/journal.pone.0008055","article-title":"PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation","volume":"4","author":"Parast","year":"2009","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.preghy.2025.101233_b0110","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S1097-2765(00)80209-9","article-title":"PPAR gamma is required for placental, cardiac, and adipose tissue development","volume":"4","author":"Barak","year":"1999","journal-title":"Mol. Cell"},{"issue":"10","key":"10.1016\/j.preghy.2025.101233_b0115","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1210\/endo.142.10.8448","article-title":"PPAR gamma\/RXR alpha heterodimers are involved in human CG beta synthesis and human trophoblast differentiation","volume":"142","author":"Tarrade","year":"2001","journal-title":"Endocrinology"},{"issue":"14","key":"10.1016\/j.preghy.2025.101233_b0120","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1242\/dev.107409","article-title":"Essential role of the ERK\/MAPK pathway in blood-placental barrier formation","volume":"141","author":"Nadeau","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.preghy.2025.101233_b0125","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/637251","article-title":"PPAR- gamma Regulates Trophoblast Differentiation in the BeWo Cell Model","volume":"2014","author":"Levytska","year":"2014","journal-title":"PPAR Res."},{"issue":"10","key":"10.1016\/j.preghy.2025.101233_b0130","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1210\/en.2007-0286","article-title":"Human chorionic gonadotropin produced by the invasive trophoblast but not the villous trophoblast promotes cell invasion and is down-regulated by peroxisome proliferator-activated receptor-gamma","volume":"148","author":"Handschuh","year":"2007","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.preghy.2025.101233_b0135","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/carcin\/bgg074","article-title":"Human invasive trophoblasts transformed with simian virus 40 provide a new tool to study the role of PPARgamma in cell invasion process","volume":"24","author":"Pavan","year":"2003","journal-title":"Carcinogenesis"},{"issue":"8","key":"10.1016\/j.preghy.2025.101233_b0140","doi-asserted-by":"crossref","first-page":"E950","DOI":"10.1152\/ajpendo.00087.2012","article-title":"Comparative expression of hCG beta-genes in human trophoblast from early and late first-trimester placentas","volume":"303","author":"Cocquebert","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.preghy.2025.101233_b0145","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.placenta.2009.09.006","article-title":"Expression and regulation by PPARgamma of hCG alpha- and beta-subunits: comparison between villous and invasive extravillous trophoblastic cells","volume":"30","author":"Handschuh","year":"2009","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ydbio.2012.08.021","article-title":"Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network","volume":"372","author":"Shalom-Barak","year":"2012","journal-title":"Dev. Biol."},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0155","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1210\/en.2017-03024","article-title":"Redox-sensitive transcription factor NRF2 enhances trophoblast differentiation via induction of miR-1246 and aromatase","volume":"159","author":"Muralimanoharan","year":"2018","journal-title":"Endocrinology"},{"issue":"1\u20133","key":"10.1016\/j.preghy.2025.101233_b0160","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbalip.2004.11.017","article-title":"Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation","volume":"1687","author":"Daoud","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"21","key":"10.1016\/j.preghy.2025.101233_b0165","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1089\/scd.2012.0596","article-title":"Hypoxia and trophoblast differentiation: a key role for PPARgamma","volume":"22","author":"Tache","year":"2013","journal-title":"Stem Cells Dev."},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0170","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12011-015-0433-1","article-title":"Iodine affects differentiation and migration process in trophoblastic cells","volume":"169","author":"Olivo-Vidal","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.preghy.2025.101233_b0175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.placenta.2017.01.125","article-title":"Down-regulation of the placental BCRP\/ABCG2 transporter in response to hypoxia signaling","volume":"51","author":"Francois","year":"2017","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0180","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/jog.13149","article-title":"Differential expression of thioredoxin binding protein-2\/Txnip in human placenta: possible involvement of hypoxia in its suppression during early pregnancy","volume":"43","author":"Mogami","year":"2017","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"9","key":"10.1016\/j.preghy.2025.101233_b0185","doi-asserted-by":"crossref","first-page":"e3054","DOI":"10.1038\/cddis.2017.419","article-title":"ANGPTL4 mediates the protective role of PPARgamma activators in the pathogenesis of preeclampsia","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.preghy.2025.101233_b0190","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1507\/endocrj.EJ12-0241","article-title":"Improvement of insulin sensitivity promotes extravillous trophoblast cell migration stimulated by insulin-like growth factor-I","volume":"60","author":"Mayama","year":"2013","journal-title":"Endocr. J."},{"key":"10.1016\/j.preghy.2025.101233_b0195","doi-asserted-by":"crossref","unstructured":"K. Handschuh, J. Guibourdenche, M. Guesnon, I. Laurendeau, D. Evain-Brion, T. Fournier, Modulation of PAPP-A expression by PPARgamma in human first trimester trophoblast, Placenta 27 Suppl A (2006) S127-34.","DOI":"10.1016\/j.placenta.2005.10.012"},{"issue":"11","key":"10.1016\/j.preghy.2025.101233_b0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079413","article-title":"Transcriptome analysis of PPARgamma target genes reveals the involvement of lysyl oxidase in human placental cytotrophoblast invasion","volume":"8","author":"Segond","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.preghy.2025.101233_b0205","first-page":"174","article-title":"Effects of peroxisome proliferator-activated receptor gamma and its ligands on cytotrophoblast invasion in first trimester of pregnancy and mechanism thereof","volume":"87","author":"Li","year":"2007","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.preghy.2025.101233_b0210","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.taap.2017.04.014","article-title":"Mono-2-ethylhexyl phthalate inhibits human extravillous trophoblast invasion via the PPARgamma pathway","volume":"327","author":"Gao","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"7","key":"10.1016\/j.preghy.2025.101233_b0215","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/jcb.24110","article-title":"Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARgamma\/RXRalpha in placentogenesis","volume":"113","author":"Ruebner","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.preghy.2025.101233_b0220","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.theriogenology.2020.04.024","article-title":"Peroxisome proliferator-activated receptor beta\/delta and gamma agonists differentially affect prostaglandin E2 and cytokine synthesis and nutrient transporter expression in porcine trophoblast cells during implantation","volume":"152","author":"Blitek","year":"2020","journal-title":"Theriogenology"},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0225","first-page":"400","article-title":"Visfatin is regulated by interleukin\u20116 and affected by the PPAR\u2011gamma pathway in BeWo cells","volume":"19","author":"Zhang","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"12","key":"10.1016\/j.preghy.2025.101233_b0230","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1210\/jc.2003-030628","article-title":"The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma\/retinoid X receptor","volume":"88","author":"Bildirici","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.preghy.2025.101233_b0235","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1210\/jc.2004-2265","article-title":"Peroxisome proliferator-activated receptor-gamma and retinoid X receptor signaling regulate fatty acid uptake by primary human placental trophoblasts","volume":"90","author":"Schaiff","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0240","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1096\/fj.02-0351fje","article-title":"A variable fold change threshold determines significance for expression microarrays","volume":"17","author":"Mariani","year":"2003","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051206","article-title":"Molecular Characterization of Microtubule Affinity-Regulating Kinase4 from Sus scrofa and Promotion of Lipogenesis in Primary Porcine Placental Trophoblasts","volume":"20","author":"Tian","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.preghy.2025.101233_b0250","doi-asserted-by":"crossref","unstructured":"C.R. Cawyer, D. Horvat, D. Leonard, S.R. Allen, R.O. Jones, D.C. Zawieja, T.J. Kuehl, M.N. Uddin, Hyperglycemia impairs cytotrophoblast function via stress signaling, Am J Obstet Gynecol 211(5) (2014) 541 e1-8.","DOI":"10.1016\/j.ajog.2014.04.033"},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0255","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3109\/10641955.2015.1122035","article-title":"Attenuation of hyperglycemia-induced apoptotic signaling and anti-angiogenic milieu in cultured cytotrophoblast cells","volume":"35","author":"Cawyer","year":"2016","journal-title":"Hypertens. Pregnancy"},{"issue":"Suppl","key":"10.1016\/j.preghy.2025.101233_b0260","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/j.placenta.2012.11.024","article-title":"Review: Adiponectin\u2013the missing link between maternal adiposity, placental transport and fetal growth?","volume":"34","author":"Aye","year":"2013","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0265","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/HYPERTENSIONAHA.121.17267","article-title":"Induction of the PPARgamma (peroxisome proliferator-activated receptor gamma)-GCM1 (glial cell missing 1) syncytialization axis reduces sFLT1 (soluble fms-like tyrosine kinase 1) in the preeclamptic placenta","volume":"78","author":"Armistead","year":"2021","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.preghy.2025.101233_b0270","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1902\/jop.2016.150677","article-title":"Evidence linking the role of placental expressions of peroxisome proliferator-activated receptor-gamma and nuclear factor-Kappa B in the pathogenesis of preeclampsia associated with periodontitis","volume":"87","author":"Mahendra","year":"2016","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0275","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1210\/en.2013-1350","article-title":"Reduced expression of 11beta-hydroxysteroid dehydrogenase type 2 in preeclamptic placentas is associated with decreased PPARgamma but increased PPARalpha expression","volume":"155","author":"He","year":"2014","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.preghy.2025.101233_b0280","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.placenta.2009.12.009","article-title":"Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsia","volume":"31","author":"Holdsworth-Carson","year":"2010","journal-title":"Placenta"},{"issue":"10","key":"10.1016\/j.preghy.2025.101233_b0285","article-title":"C1431T Variant of PPARgamma is associated with preeclampsia in pregnant women","volume":"11","author":"Liu","year":"2021","journal-title":"Life (Basel)"},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0290","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1414838","article-title":"Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia","volume":"374","author":"Zeisler","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.preghy.2025.101233_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106127","article-title":"Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2\/PPARgamma\/sFlt-1 axis in preeclampsia","volume":"177","author":"Liu","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.preghy.2025.101233_b0300","doi-asserted-by":"crossref","first-page":"R201","DOI":"10.1530\/JME-17-0315","article-title":"The role of Sirtuin1-PPARgamma axis in placental development and function","volume":"60","author":"Pham","year":"2018","journal-title":"J. Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0305","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1080\/21655979.2021.2020468","article-title":"Interleukin-17 promotes proliferation, migration, and invasion of trophoblasts via regulating PPAR-gamma\/RXR-alpha\/Wnt signaling","volume":"13","author":"Zhang","year":"2022","journal-title":"Bioengineered"},{"issue":"22","key":"10.1016\/j.preghy.2025.101233_b0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212469","article-title":"Regulation of epigenetic modifications in the placenta during preeclampsia: PPARgamma Influences H3K4me3 and H3K9ac in extravillous trophoblast cells","volume":"22","author":"Meister","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.preghy.2025.101233_b0315","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1177\/1933719118756746","article-title":"Aspirin ameliorates preeclampsia induced by a peroxisome proliferator-activated receptor antagonist","volume":"25","author":"Zhang","year":"2018","journal-title":"Reprod. Sci."},{"issue":"22","key":"10.1016\/j.preghy.2025.101233_b0320","doi-asserted-by":"crossref","first-page":"19649","DOI":"10.1074\/jbc.M200743200","article-title":"T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0325","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1186\/s12884-022-04901-x","article-title":"The preventive effect of low-dose aspirin in a PPAR-gamma antagonist treated mouse model of preeclampsia","volume":"22","author":"Guo","year":"2022","journal-title":"BMC Pregnancy Childbirth"},{"issue":"9","key":"10.1016\/j.preghy.2025.101233_b0330","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8091429","article-title":"Effect of low-dose aspirin on soluble FMS-Like tyrosine kinase 1\/placental growth factor (sFlt-1\/PlGF Ratio) in pregnancies at high risk for the development of preeclampsia","volume":"8","author":"Mayer-Pickel","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.preghy.2025.101233_b0335","doi-asserted-by":"crossref","unstructured":"A.A. Gaea Moore, Annalisa Post, Virginia Winn, Henry Galan, Kent Heyborne, Preeclampsia risk with low placental growth factor (PlGF) is not modified by early aspirin prophylaxis, AJOG 210(1) (2014) 237 \u2013 386.","DOI":"10.1016\/j.ajog.2013.10.304"},{"issue":"Pt A","key":"10.1016\/j.preghy.2025.101233_b0340","article-title":"CTRP6 regulates M1 macrophage polarization via the PPAR-gamma\/NF-kappaB pathway and reprogramming glycolysis in recurrent spontaneous abortion","volume":"124","author":"Yan","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"10","key":"10.1016\/j.preghy.2025.101233_b0345","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/1471-0528.12195","article-title":"Angiogenic factors combined with clinical risk factors to predict preterm pre-eclampsia in nulliparous women: a predictive test accuracy study","volume":"120","author":"Myers","year":"2013","journal-title":"BJOG"},{"issue":"3","key":"10.1016\/j.preghy.2025.101233_b0350","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/uog.26082","article-title":"Predictive accuracy of early mid-trimester placental markers for recurrence of placenta-mediated pregnancy complications","volume":"61","author":"Ashwal","year":"2023","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.preghy.2025.101233_b0355","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1161\/HYPERTENSIONAHA.121.17047","article-title":"PlGF (placental growth factor) testing in clinical practice: evidence from a canadian tertiary maternity referral center","volume":"77","author":"McLaughlin","year":"2021","journal-title":"Hypertension"},{"issue":"2S","key":"10.1016\/j.preghy.2025.101233_b0360","doi-asserted-by":"crossref","first-page":"S803","DOI":"10.1016\/j.ajog.2017.11.575","article-title":"A placenta clinic approach to the diagnosis and management of fetal growth restriction","volume":"218","author":"Kingdom","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"9","key":"10.1016\/j.preghy.2025.101233_b0365","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.humpath.2010.11.018","article-title":"Placental expression of vascular endothelial growth factor receptor-1\/soluble vascular endothelial growth factor receptor-1 correlates with severity of clinical preeclampsia and villous hypermaturity","volume":"42","author":"Tache","year":"2011","journal-title":"Hum. Pathol."},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0370","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1038\/s41598-017-06178-z","article-title":"Endothelial dysfunction in severe preeclampsia is mediated by soluble factors, rather than extracellular vesicles","volume":"7","author":"O'Brien","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0375","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/HYPERTENSIONAHA.111.182170","article-title":"Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia","volume":"59","author":"Rajakumar","year":"2012","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.preghy.2025.101233_b0380","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/CIRCULATIONAHA.111.054361","article-title":"Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia","volume":"125","author":"Rana","year":"2012","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.preghy.2025.101233_b0385","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: pathophysiology, challenges, and perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.preghy.2025.101233_b0390","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1161\/HYPERTENSIONAHA.116.07252","article-title":"Circulating antiangiogenic factors and myocardial dysfunction in hypertensive disorders of pregnancy","volume":"67","author":"Shahul","year":"2016","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0395","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0400","doi-asserted-by":"crossref","first-page":"12139","DOI":"10.1038\/s41598-017-11639-6","article-title":"FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia","volume":"7","author":"Ashar-Patel","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0405","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051496","article-title":"Oxidative stress in preeclampsia and placental diseases","volume":"19","author":"Aouache","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0410","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/HYPERTENSIONAHA.111.172627","article-title":"Peroxisome proliferator-activated receptor-gamma as a potential therapeutic target in the treatment of preeclampsia","volume":"58","author":"McCarthy","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.preghy.2025.101233_b0415","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3389\/fgene.2013.00190","article-title":"Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling","volume":"4","author":"Knofler","year":"2013","journal-title":"Front. Genet."},{"issue":"3","key":"10.1016\/j.preghy.2025.101233_b0420","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1161\/HYPERTENSIONAHA.111.183939","article-title":"Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice","volume":"59","author":"Bainbridge","year":"2012","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0425","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/cdd.2009.1","article-title":"Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast","volume":"16","author":"Baczyk","year":"2009","journal-title":"Cell Death Differ."},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0430","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1095\/biolreprod.107.065599","article-title":"Glial cell missing 1 regulates placental growth factor (PGF) gene transcription in human trophoblast","volume":"78","author":"Chang","year":"2008","journal-title":"Biol. Reprod."},{"issue":"6","key":"10.1016\/j.preghy.2025.101233_b0435","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.placenta.2003.12.004","article-title":"Complex patterns of GCM1 mRNA and protein in villous and extravillous trophoblast cells of the human placenta","volume":"25","author":"Baczyk","year":"2004","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0440","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jsgi.2005.03.004","article-title":"Human placental peroxisome proliferator-activated receptor delta and gamma expression in healthy pregnancy and in preeclampsia and intrauterine growth restriction","volume":"12","author":"Rodie","year":"2005","journal-title":"J. Soc. Gynecol. Investig."},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0445","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1210\/jc.2004-0849","article-title":"Circulating activators of peroxisome proliferator-activated receptors are reduced in preeclamptic pregnancy","volume":"90","author":"Waite","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0450","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.placenta.2003.10.014","article-title":"Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia","volume":"25","author":"Chen","year":"2004","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0455","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/19396368.2014.991881","article-title":"The balancing act - PPAR-gamma's roles at the maternal-fetal interface","volume":"61","author":"Kadam","year":"2015","journal-title":"Syst. Biol. Reprod. Med."},{"issue":"21","key":"10.1016\/j.preghy.2025.101233_b0460","doi-asserted-by":"crossref","DOI":"10.3390\/cells11213514","article-title":"The potential for placental activation of PPARgamma to improve the angiogenic profile in preeclampsia","volume":"11","author":"Grimaldi","year":"2022","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.preghy.2025.101233_b0465","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/14767058.2019.1608175","article-title":"Placental hypoplasia and maternal organic vascular disorder in pregnant women with gestational hypertension and preeclampsia","volume":"34","author":"Owaki","year":"2021","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0470","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3109\/14767058.2011.591461","article-title":"Late-onset preeclampsia is associated with an imbalance of angiogenic and anti-angiogenic factors in patients with and without placental lesions consistent with maternal underperfusion","volume":"25","author":"Soto","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0475","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semnephrol.2010.10.004","article-title":"Angiogenic factors and preeclampsia","volume":"31","author":"Maynard","year":"2011","journal-title":"Semin. Nephrol."},{"issue":"11","key":"10.1016\/j.preghy.2025.101233_b0480","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1161\/HYPERTENSIONAHA.123.21645","article-title":"Rosiglitazone-mediated activation of PPARgamma restores HO1 expression in the human preeclamptic placenta","volume":"80","author":"Grimaldi","year":"2023","journal-title":"Hypertension"},{"key":"10.1016\/j.preghy.2025.101233_b0485","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fphar.2015.00084","article-title":"Heme oxygenase and the immune system in normal and pathological pregnancies","volume":"6","author":"Ozen","year":"2015","journal-title":"Front. Pharmacol."},{"issue":"9741","key":"10.1016\/j.preghy.2025.101233_b0490","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"issue":"9181","key":"10.1016\/j.preghy.2025.101233_b0495","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0140-6736(99)80002-6","article-title":"Is oxidative stress the link in the two-stage model of pre-eclampsia?","volume":"354","author":"Roberts","year":"1999","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0500","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1055\/s-2007-1016256","article-title":"Maternal-placental interactions of oxidative stress and antioxidants in preeclampsia","volume":"16","author":"Walsh","year":"1998","journal-title":"Semin. Reprod. Endocrinol."},{"issue":"4","key":"10.1016\/j.preghy.2025.101233_b0505","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.placenta.2009.01.003","article-title":"Potential biomarkers of preeclampsia: inverse correlation between hydrogen peroxide and nitric oxide early in maternal circulation and at term in placenta of women with preeclampsia","volume":"30","author":"Aris","year":"2009","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0510","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/biolre\/ioy186","article-title":"Rosiglitazone augments antioxidant response in the human trophoblast and prevents apoptosisdagger","volume":"100","author":"Kohan-Ghadr","year":"2019","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.preghy.2025.101233_b0515","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0143-4004(97)80064-1","article-title":"Variations in expression of copper\/zinc superoxide dismutase in villous trophoblast of the human placenta with gestational age","volume":"18","author":"Watson","year":"1997","journal-title":"Placenta"},{"issue":"11","key":"10.1016\/j.preghy.2025.101233_b0520","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.4049\/jimmunol.1400378","article-title":"Acute-phase protein alpha1-antitrypsin\u2013a novel regulator of angiopoietin-like protein 4 transcription and secretion","volume":"192","author":"Frenzel","year":"2014","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.preghy.2025.101233_b0525","doi-asserted-by":"crossref","first-page":"E1056","DOI":"10.1152\/ajpendo.90345.2008","article-title":"Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production","volume":"295","author":"Gealekman","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0530","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/ajh.2007.39","article-title":"Lipoxygenase-derived metabolites are regulators of peroxisome proliferator-activated receptor gamma-2 expression in human vascular smooth muscle cells","volume":"21","author":"Limor","year":"2008","journal-title":"Am. J. Hypertens."},{"issue":"4","key":"10.1016\/j.preghy.2025.101233_b0535","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.reprotox.2004.02.014","article-title":"Normal pregnancy outcome following inadvertent exposure to rosiglitazone, gliclazide, and atorvastatin in a diabetic and hypertensive woman","volume":"18","author":"Yaris","year":"2004","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.preghy.2025.101233_b0540","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.reprotox.2004.11.003","article-title":"A case of rosiglitazone exposure in the second trimester of pregnancy","volume":"19","author":"Kalyoncu","year":"2005","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.preghy.2025.101233_b0545","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.reprotox.2008.08.001","article-title":"Case series of rosiglitazone used during the first trimester of pregnancy","volume":"26","author":"Haddad","year":"2008","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.preghy.2025.101233_b0550","doi-asserted-by":"crossref","first-page":"31","DOI":"10.29271\/jcpsp.2018.01.31","article-title":"The potential therapeutic role of peroxisome proliferator activated receptors agonist in preeclamptic pregnant rats","volume":"28","author":"Allam","year":"2018","journal-title":"J. Coll. Physicians Surg. Pak."}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778925000492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778925000492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:26:59Z","timestamp":1778840819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778925000492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":110,"alternative-id":["S2210778925000492"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2025.101233","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rosiglitazone as a potential therapeutic drug in early intervention of preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2025.101233","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101233"}}