{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:09:02Z","timestamp":1778843342966,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021QH233"],"award-info":[{"award-number":["ZR2021QH233"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019MH127"],"award-info":[{"award-number":["ZR2019MH127"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.preghy.2025.101259","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T07:30:36Z","timestamp":1759303836000},"page":"101259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association of SIRT1 rs12415800 and SIRT6 rs350844 polymorphisms with preeclampsia: A case-control study"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7596-4723","authenticated-orcid":false,"given":"Chao","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanxuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialiang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.preghy.2025.101259_b0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.preghy.2014.02.001","article-title":"The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP","volume":"4","author":"Tranquilli","year":"2014","journal-title":"Pregnancy Hypertens."},{"issue":"9879","key":"10.1016\/j.preghy.2025.101259_b0010","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0140-6736(13)60686-8","article-title":"Moving beyond essential interventions for reduction of maternal mortality (the WHO Multicountry Survey on Maternal and Newborn Health): a cross-sectional study","volume":"381","author":"Souza","year":"2013","journal-title":"Lancet"},{"issue":"10022","key":"10.1016\/j.preghy.2025.101259_b0015","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(15)00070-7","article-title":"Pre-eclampsia","volume":"387","author":"Mol","year":"2016","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.preghy.2025.101259_b0020","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3109\/10641955.2015.1117099","article-title":"Comprehensive analysis of DNA methylation and gene expression of placental tissue in preeclampsia patients","volume":"35","author":"Xuan","year":"2016","journal-title":"Hypertens. Pregnancy"},{"issue":"10","key":"10.1016\/j.preghy.2025.101259_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8101625","article-title":"Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring","volume":"8","author":"Fox","year":"2019","journal-title":"J. Clin. Med."},{"issue":"11","key":"10.1016\/j.preghy.2025.101259_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20112837","article-title":"The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia","volume":"20","author":"Apicella","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.preghy.2025.101259_b0035","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1160\/TH14-10-0848","article-title":"The physiologic anticoagulant and anti-inflammatory role of heparins and their utility in the prevention of pregnancy complications","volume":"113","author":"Mastrolia","year":"2015","journal-title":"Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.preghy.2025.101259_b0040","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.preghy.2025.101259_b0045","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1517\/14712598.2013.764410","article-title":"Epigenetics in osteoarthritis and its implication for future therapeutics","volume":"13","author":"Im","year":"2013","journal-title":"Expert Opin. Biol. Ther."},{"issue":"22","key":"10.1016\/j.preghy.2025.101259_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216210","article-title":"The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta","volume":"24","author":"Watroba","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.preghy.2025.101259_b0055","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.freeradbiomed.2021.01.002","article-title":"A role for 4-hydroxy-2-nonenal in premature placental senescence in preeclampsia and intrauterine growth restriction","volume":"164","author":"Tasta","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.preghy.2025.101259_b0060","doi-asserted-by":"crossref","first-page":"993","DOI":"10.7150\/ijms.73012","article-title":"SIRT1: a Novel protective Molecule in Pre-eclampsia","volume":"19","author":"Liu","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.preghy.2025.101259_b0065","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4561083","article-title":"Analysis of SIRT1 Expression in Plasma and in an In Vitro Model of Preeclampsia","volume":"2020","author":"Viana-Mattioli","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"7","key":"10.1016\/j.preghy.2025.101259_b0070","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s10815-021-02158-5","article-title":"Protective role of SIRT1-mediated Sonic Hedgehog signaling pathway in the preeclampsia rat models","volume":"38","author":"Huang","year":"2021","journal-title":"J. Assist. Reprod. Genet."},{"issue":"21","key":"10.1016\/j.preghy.2025.101259_b0075","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1101\/gad.1467506","article-title":"Mammalian sirtuins\u2013emerging roles in physiology, aging, and calorie restriction","volume":"20","author":"Haigis","year":"2006","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.preghy.2025.101259_b0080","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2005.11.044","article-title":"Genomic instability and aging-like phenotype in the absence of mammalian SIRT6","volume":"124","author":"Mostoslavsky","year":"2006","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.preghy.2025.101259_b0085","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/physrev.00030.2018","article-title":"SIRT6, a Mammalian Deacylase with Multitasking Abilities","volume":"100","author":"Chang","year":"2020","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.preghy.2025.101259_b0090","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.tcb.2021.06.009","article-title":"Sirtuin 6: linking longevity with genome and epigenome stability","volume":"31","author":"Korotkov","year":"2021","journal-title":"Trends Cell Biol."},{"issue":"1","key":"10.1016\/j.preghy.2025.101259_b0095","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1095\/biolreprod.112.105163","article-title":"SIRT6 is decreased with preterm labor and regulates key terminal effector pathways of human labor in fetal membranes","volume":"88","author":"Lim","year":"2013","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.preghy.2025.101259_b0100","first-page":"1","article-title":"202: Gestational Hypertension and Preeclampsia","volume":"133","author":"ACOG Practice Bulletin No","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2025.101259_b0105","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6972732","article-title":"Small Molecule, big prospects: MicroRNA in Pregnancy and its Complications","volume":"2017","author":"Cai","year":"2017","journal-title":"J. Pregnancy"},{"issue":"5","key":"10.1016\/j.preghy.2025.101259_b0110","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/biof.1542","article-title":"The role of epigenetic changes in preeclampsia","volume":"45","author":"Kamrani","year":"2019","journal-title":"Biofactors"},{"issue":"11","key":"10.1016\/j.preghy.2025.101259_b0115","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.2174\/13816128113199990517","article-title":"DNA methylation, an epigenetic mode of gene expression regulation in reproductive science","volume":"20","author":"Calicchio","year":"2014","journal-title":"Curr. Pharm. Des."},{"issue":"3","key":"10.1016\/j.preghy.2025.101259_b0120","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1007\/s10753-021-01413-2","article-title":"Melatonin Alleviates Cardiac Dysfunction Via increasing Sirt1-Mediated Beclin-1 Deacetylation and Autophagy during Sepsis","volume":"44","author":"Pi","year":"2021","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.preghy.2025.101259_b0125","doi-asserted-by":"crossref","first-page":"R201","DOI":"10.1530\/JME-17-0315","article-title":"The role of Sirtuin1-PPARgamma axis in placental development and function","volume":"60","author":"Pham","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.preghy.2025.101259_b0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.placenta.2020.01.002","article-title":"Resveratrol induces SIRT1-Dependent autophagy to prevent H(2)O(2)-Induced oxidative stress and apoptosis in HTR8\/SVneo cells","volume":"91","author":"Wang","year":"2020","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.preghy.2025.101259_b0135","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5483\/BMBRep.2019.52.1.290","article-title":"Sirtuin signaling in cellular senescence and aging","volume":"52","author":"Lee","year":"2019","journal-title":"BMB Rep."},{"issue":"9","key":"10.1016\/j.preghy.2025.101259_b0140","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1111\/jcmm.13734","article-title":"Kallistatin attenuates endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway","volume":"22","author":"Guo","year":"2018","journal-title":"J. Cell Mol. Med."},{"issue":"5","key":"10.1016\/j.preghy.2025.101259_b0145","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10753-020-01242-9","article-title":"Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative stress and Inflammation","volume":"43","author":"Singh","year":"2020","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.preghy.2025.101259_b0150","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10735-020-09945-x","article-title":"MiR-217 promotes endothelial cell senescence through the SIRT1\/p53 signaling pathway","volume":"52","author":"Wang","year":"2021","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.preghy.2025.101259_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113951","article-title":"Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK\/SIRT1\/Nrf2 signaling pathway","volume":"177","author":"Chen","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.preghy.2025.101259_b0160","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3389\/fphar.2019.00421","article-title":"Resveratrol Promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc Signaling Pathway-Mediated Angiogenesis","volume":"10","author":"Huang","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.preghy.2025.101259_b0165","doi-asserted-by":"crossref","first-page":"10271","DOI":"10.1038\/s41598-024-60265-6","article-title":"Association of lncRNA MEG3 rs941576 polymorphism, expression profile, and its related targets with the risk of obesity-related colorectal cancer: potential clinical insights","volume":"14","author":"Senousy","year":"2024","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.preghy.2025.101259_b0170","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s40618-023-02190-5","article-title":"Effect of SIRT1 gene single-nucleotide polymorphisms on susceptibility to type 1 diabetes in a Han chinese population","volume":"47","author":"Li","year":"2024","journal-title":"J. Endocrinol. Invest."},{"issue":"20","key":"10.1016\/j.preghy.2025.101259_b0175","article-title":"Role of SIRT1 Gene Polymorphisms and Serum Levels in patients with Multiple Sclerosis","volume":"13","author":"Kaikaryte","year":"2023","journal-title":"Diagnostics (basel)"},{"issue":"8","key":"10.1016\/j.preghy.2025.101259_b0180","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s00018-022-04429-5","article-title":"SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency","volume":"79","author":"Carrizzo","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.preghy.2025.101259_b0185","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/HYPERTENSIONAHA.120.16635","article-title":"Role of Klotho in the Development of Essential Hypertension","volume":"77","author":"Kanbay","year":"2021","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.preghy.2025.101259_b0190","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3233\/CBM-210264","article-title":"Association of SIRT1 single gene nucleotide polymorphisms and serum SIRT1 levels with laryngeal squamous cell carcinoma patient survival rate","volume":"34","author":"Vaiciulis","year":"2022","journal-title":"Cancer Biomark."},{"issue":"7","key":"10.1016\/j.preghy.2025.101259_b0195","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/stem.3358","article-title":"A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair, generating improved genetically stable human induced pluripotent stem cells","volume":"39","author":"Alvarez-Palomo","year":"2021","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.preghy.2025.101259_b0200","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41398-019-0675-3","article-title":"The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in chinese population","volume":"9","author":"Liu","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.preghy.2025.101259_b0205","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.2147\/NDT.S129081","article-title":"Role of SIRT1\/PGC-1alpha in mitochondrial oxidative stress in autistic spectrum disorder","volume":"13","author":"Bu","year":"2017","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"2","key":"10.1016\/j.preghy.2025.101259_b0210","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/med.21753","article-title":"Emerging roles of SIRT6 in human diseases and its modulators","volume":"41","author":"Liu","year":"2021","journal-title":"Med. Res. Rev."},{"issue":"5\u20136","key":"10.1016\/j.preghy.2025.101259_b0215","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1101\/gad.307330.117","article-title":"An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality","volume":"32","author":"Ferrer","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.preghy.2025.101259_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102639","article-title":"SIRT6 mitigates oxidative stress and RSL3-induced ferroptosis in HTR-8\/SVneo cells","volume":"93","author":"Qi","year":"2025","journal-title":"Tissue Cell"},{"issue":"5","key":"10.1016\/j.preghy.2025.101259_b0225","article-title":"Oxidative stress, Lipid Peroxidation and Ferroptosis are Major Pathophysiological Signatures in the Placental Tissue of Women with Late-Onset Preeclampsia","volume":"13","author":"Ortega","year":"2024","journal-title":"Antioxidants (basel)"},{"key":"10.1016\/j.preghy.2025.101259_b0230","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.placenta.2016.12.018","article-title":"Protective proteins and telomere length in placentas from patients with pre-eclampsia in the last trimester of gestation","volume":"50","author":"Broady","year":"2017","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.preghy.2025.101259_b0235","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-022-01257-8","article-title":"The sirtuin family in health and disease","volume":"7","author":"Wu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.preghy.2025.101259_b0240","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jgg.2014.08.001","article-title":"Endothelial cell senescence and age-related vascular diseases","volume":"41","author":"Tian","year":"2014","journal-title":"J. Genet. Genomics"},{"issue":"19","key":"10.1016\/j.preghy.2025.101259_b0245","doi-asserted-by":"crossref","first-page":"17657","DOI":"10.1021\/acs.jmedchem.4c01649","article-title":"Discovery of SIRT1-Activating Hydrogen Sulfide donating Derivatives for Efficient Resistant of Myocardial Ischemic Injury","volume":"67","author":"Wang","year":"2024","journal-title":"J. Med. Chem."}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778925000753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778925000753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:26:28Z","timestamp":1778840788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778925000753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":49,"alternative-id":["S2210778925000753"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2025.101259","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of SIRT1 rs12415800 and SIRT6 rs350844 polymorphisms with preeclampsia: A case-control study","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2025.101259","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101259"}}