{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:01:43Z","timestamp":1780905703791,"version":"3.54.1"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010443","name":"RACP Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.preghy.2026.101456","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T01:04:00Z","timestamp":1774141440000},"page":"101456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Calcineurin inhibitors and the risk of preeclampsia in solid organ transplantation \u2013 Should we rethink our approach during pregnancy?"],"prefix":"10.1016","volume":"44","author":[{"given":"Jennifer H.","family":"Yo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten R.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"27","key":"10.1016\/j.preghy.2026.101456_b0005","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.preghy.2021.09.008","article-title":"The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice","volume":"1","author":"Magee","year":"2022","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.preghy.2026.101456_b0010","first-page":"1","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Pre-Eclampsia. Nat Rev Dis Primer."},{"issue":"6","key":"10.1016\/j.preghy.2026.101456_b0015","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/HYPERTENSIONAHA.116.06421","article-title":"Angiogenic factors in preeclampsia: from diagnosis to therapy","volume":"67","author":"Karumanchi","year":"2016","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.preghy.2026.101456_b0020","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating Angiogenic Factors and the risk of Preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.preghy.2026.101456_b0025","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia","author":"Levine","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.preghy.2026.101456_b0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.molmed.2014.11.009","article-title":"Molecular mechanisms of maternal vascular dysfunction in preeclampsia","volume":"21","author":"Goulopoulou","year":"2015","journal-title":"Trends Mol. Med."},{"issue":"8","key":"10.1016\/j.preghy.2026.101456_b0035","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.2215\/CJN.12811213","article-title":"Association of preeclampsia with podocyte turnover","volume":"9","author":"Penning","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.preghy.2026.101456_b0040","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.healun.2022.10.015","article-title":"The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients","volume":"42","author":"Velleca","year":"2023","journal-title":"J Heart Lung Transplant"},{"issue":"5","key":"10.1016\/j.preghy.2026.101456_b0045","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/TP.0000000000002147","article-title":"International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant Recipients","volume":"102","author":"Charlton","year":"2018","journal-title":"Transplantation"},{"key":"10.1016\/j.preghy.2026.101456_b0050","doi-asserted-by":"crossref","unstructured":"Eckardt KU, Kasiske BL, Zeier MG. Special Issue: KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients. Am J Transplant. 2009 Nov;9:S1\u2013155.","DOI":"10.1111\/j.1600-6143.2009.02834.x"},{"issue":"6","key":"10.1016\/j.preghy.2026.101456_b0055","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2165\/00003088-199529060-00003","article-title":"Clinical Pharmacokinetics of Tacrolimus","volume":"29","author":"Venkataramanan","year":"1995","journal-title":"Clin. Pharmacokinet."},{"issue":"7","key":"10.1016\/j.preghy.2026.101456_b0060","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/ATVBAHA.107.144808","article-title":"Removal of Fkbp12\/12.6 from endothelial ryanodine receptors leads to an intracellular calcium leak and endothelial dysfunction","volume":"27","author":"Long","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"7\u20138","key":"10.1016\/j.preghy.2026.101456_b0065","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000515933","article-title":"Calcineurin Inhibitor Toxicity in Solid Organ Transplantation","volume":"106","author":"Karolin","year":"2021","journal-title":"Pharmacology"},{"issue":"8","key":"10.1016\/j.preghy.2026.101456_b0070","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.30913","article-title":"Adverse Pregnancy Outcomes in Solid Organ Transplant Recipients","volume":"7","author":"Yo","year":"2024","journal-title":"JAMA Netw. Open"},{"issue":"2","key":"10.1016\/j.preghy.2026.101456_b0075","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2215\/CJN.06170612","article-title":"Pregnancy in renal transplant recipients: a UK national cohort study","volume":"8","author":"Bramham","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"4605","key":"10.1016\/j.preghy.2026.101456_b0080","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1126\/science.6407111","article-title":"Drug transforms transplant medicine","volume":"221","author":"Kolata","year":"1983","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.preghy.2026.101456_b0085","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/BF01973261","article-title":"Biological effects of cyclosporin a: a new antilyphocytic agent","volume":"6","author":"Borel","year":"1976","journal-title":"Agents Actions"},{"issue":"1","key":"10.1016\/j.preghy.2026.101456_b0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1749-6632.1993.tb35846.x","article-title":"Discovery of FK\u2010506 and Update","volume":"685","author":"Kino","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.preghy.2026.101456_b0095","doi-asserted-by":"crossref","unstructured":"Vincenti F, Jensik SC, Filo RS, Miller J, Pirsch J. A LONG-TERM COMPARISON OF TACROLIMUS (FK506) AND CYCLOSPORINE IN KIDNEY TRANSPLANTATION: EVIDENCE FOR IMPROVED ALLOGRAFT SURVIVAL AT FIVE YEARS 1 [Internet]. Vol. 73, TRANSPLANTATION. 2002 p. 775\u201382. Available from: http:\/\/journals.lww.com\/transplantjournal.","DOI":"10.1097\/00007890-200203150-00021"},{"key":"10.1016\/j.preghy.2026.101456_b0100","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S0041-1345(02)02942-1","article-title":"Chronic rejection and Graft Half-Life: Five-Year follow-up of the European Tacrolimus Multicenter Renal Study","volume":"34","author":"Mayer","year":"2002","journal-title":"Transpl. Proc."},{"key":"10.1016\/j.preghy.2026.101456_b0105","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1056\/NEJMoa067411","article-title":"Reduced Exposure to Calcineurin Inhibitors in Renal Transplantation","volume":"357","author":"Ekberg","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.preghy.2026.101456_b0110","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.ajt.2024.01.012","article-title":"OPTN\/SRTR 2022 Annual Data Report: Kidney","volume":"24","author":"Lentine","year":"2024","journal-title":"Am. J. Transplant."},{"issue":"8","key":"10.1016\/j.preghy.2026.101456_b0115","first-page":"4760","article-title":"Identification of the Immunophilins Capable of Mediating Inhibition of Signal Transduction by Cyclosporin a and FK506: Roles of Calcineurin Binding and Cellular Location","volume":"13","author":"Bram","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.preghy.2026.101456_b0120","unstructured":"Aiiamburu SE, Rao A, Klee$ CB. Calcineurin: From Structure to Function. Vol. 36, CURRENT TOPICS IN CELLULAR REGULATION. 2000."},{"key":"10.1016\/j.preghy.2026.101456_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2020.108515","article-title":"The IL-2 \u2013 IL-2 receptor pathway in health and disease: the role of the soluble IL-2 receptor","author":"Damoiseaux","year":"2020","journal-title":"Clin. Immunol."},{"issue":"114","key":"10.1016\/j.preghy.2026.101456_b0130","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ejps.2017.12.017","article-title":"An updated review on delivering strategies for multifarious diseases","volume":"1","author":"Dheer","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.preghy.2026.101456_b0135","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2215\/CJN.04800908","article-title":"Calcineurin inhibitor nephrotoxicity","volume":"4","author":"Naesens","year":"2009","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.preghy.2026.101456_b0140","doi-asserted-by":"crossref","first-page":"167","DOI":"10.33549\/physiolres.933332","article-title":"Pathophysiological Mechanisms of Calcineurin Inhibitor-Induced Nephrotoxicity and Arterial Hypertension","volume":"66","author":"Ho\u0161kov\u00e1","year":"2017","journal-title":"Physiol. Res."},{"key":"10.1016\/j.preghy.2026.101456_b0145","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-25445-2","article-title":"Calcineurin inhibitors\u2019 impact on cardiovascular and renal function, a descriptive study in lung transplant recipients from the North of Spain","author":"Nogueiras-\u00c1lvarez","year":"2022","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.preghy.2026.101456_b0150","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1681\/ASN.2007040394","article-title":"Chronic kidney disease after nonrenal solid-organ transplantation","volume":"18","author":"Bloom","year":"2007","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"10.1016\/j.preghy.2026.101456_b0155","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/00007890-199703150-00009","article-title":"Cyclosporine-associated end-stage nephropathy after cardiac transplantation: incidence and progression","volume":"63","author":"Goldstein","year":"1997","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.preghy.2026.101456_b0160","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/ki.1985.196","article-title":"Effect of cyclosporine administration on renal hemodynamics in conscious rats","volume":"28","author":"Murray","year":"1985","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.preghy.2026.101456_b0165","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1172\/JCI116440","article-title":"Effects of endothelin receptor antagonist on cyclosporine-induced vasoconstriction in isolated rat renal arterioles","volume":"91","author":"Lanese","year":"1993","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.preghy.2026.101456_b0170","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ki.1987.166","article-title":"Glomerular hemodynamics and hormonal participation on cyclosporine nephrotoxicity","volume":"32","author":"Barros","year":"1987","journal-title":"Kidney Int."},{"issue":"NOV","key":"10.1016\/j.preghy.2026.101456_b0175","article-title":"Does mineralocorticoid receptor antagonism prevent calcineurin inhibitor-induced nephrotoxicity?","volume":"4","author":"Mortensen","year":"2017","journal-title":"Front. Med."},{"issue":"7","key":"10.1016\/j.preghy.2026.101456_b0180","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/ki.2008.697","article-title":"Tacrolimus reduces nitric oxide synthase function by binding to FKBP rather than by its calcineurin effect","volume":"75","author":"Cook","year":"2009","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.preghy.2026.101456_b0185","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1161\/01.HYP.0000257914.80918.72","article-title":"FK506 binding protein 12\/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure","volume":"49","author":"Long","year":"2007","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.preghy.2026.101456_b0190","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1523-1755.2005.00472.x","article-title":"Cellular mechanisms of vascular injury mediated by calcineurin inhibitors","volume":"68","author":"Lamas","year":"2005","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.preghy.2026.101456_b0195","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1159\/000339494","article-title":"Tacrolimus Induces Glomerular Injury via Endothelial Dysfunction Caused by Reactive Oxygen Species and Inflammatory Change","volume":"35","author":"Kidokoro","year":"2012","journal-title":"Kidney Blood Press. Res."},{"issue":"11","key":"10.1016\/j.preghy.2026.101456_b0200","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM198409133111103","article-title":"Cyclosporine-associated chronic nephropathy","volume":"311","author":"Myers","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.preghy.2026.101456_b0205","doi-asserted-by":"crossref","unstructured":"Pichler RH, Franceschini N, Young BA, Hugo C, Andoh TF, Burdmann EA, et al. Pathogenesis of Cyclosporine Nephropathy: Roles of Angiotensin II and Osteopontin1 [Internet]. Vol. 6. 1995 p. 1995. Available from: http:\/\/journals.lww.com\/jasn.","DOI":"10.1681\/ASN.V641186"},{"issue":"2","key":"10.1016\/j.preghy.2026.101456_b0210","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/01.ASN.0000042168.43665.9B","article-title":"Therapeutic role of TGF-\u03b2-neutralizing antibody in mouse Cyclosporin a nephropathy: Morphologic improvement associated with functional preservation","volume":"14","author":"Ling","year":"2003","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.preghy.2026.101456_b0215","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1046\/j.1523-1755.1999.00288.x","article-title":"Nature and mediators of renal lesions in kidney transplant patients given cyclosporine for more than one year","volume":"55","author":"Benigni","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.preghy.2026.101456_b0220","doi-asserted-by":"crossref","unstructured":"Elzinga LW, Rosen S, Bennett WM, Elzinga LW, Bennett WM, Rosen S. Dissociation of Glomerular Filtration Rate From Tubulointerstitial Fibrosis in Experimental Chronic Cyclosporine Nephropathy: Role of Sodium Intake1 [Internet]. Vol. 4. 1993. Available from: http:\/\/journals.lww.com\/jasn.","DOI":"10.1681\/ASN.V42214"},{"issue":"45","key":"10.1016\/j.preghy.2026.101456_b0225","doi-asserted-by":"crossref","first-page":"47326","DOI":"10.1074\/jbc.M408789200","article-title":"NFATc3 regulates Kv2.1 expression in arterial smooth muscle","volume":"279","author":"Amberg","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.preghy.2026.101456_b0230","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1074\/jbc.M608822200","article-title":"Activation of NFATc3 down-regulates the \u03b21 subunit of large conductance, calcium-activated K+ channels in arterial smooth muscle and contributes to hypertension","volume":"282","author":"Nieves-Cintr\u00f3n","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preghy.2026.101456_b0235","doi-asserted-by":"crossref","unstructured":"Graef IA, Chen F, Chen L, Kuo A, Crabtree GR. Signals Transduced by Ca 2 \/Calcineurin and NFATc3\/c4 Pattern the Developing Vasculature paths that meet and probably anticipate the oxygenation needs of the growing tissues of the embryo. The mecha-nisms underlying these patterning events are poorly un. Vol. 105, Cell. 2001 p. 863\u201375.","DOI":"10.1016\/S0092-8674(01)00396-8"},{"issue":"3","key":"10.1016\/j.preghy.2026.101456_b0240","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5301\/jn.5000174","article-title":"Pathogenesis of calcineurin inhibitor-induced hypertension","volume":"25","author":"Hoorn","year":"2012","journal-title":"J. Nephrol."},{"issue":"1","key":"10.1016\/j.preghy.2026.101456_b0245","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0272-6386(96)90045-1","article-title":"Endothelin in Organ Transplantation","volume":"27","author":"Watschinger","year":"1996","journal-title":"Am. J. Kidney Dis."},{"issue":"11","key":"10.1016\/j.preghy.2026.101456_b0250","doi-asserted-by":"crossref","first-page":"121S","DOI":"10.1016\/0895-7061(96)00288-9","article-title":"Sympathetic Neural Mechanisms of Cyclosporine-Induced Hypertension","volume":"9","author":"Sander","year":"1996","journal-title":"Am. J. Hypertens."},{"issue":"2","key":"10.1016\/j.preghy.2026.101456_b0255","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1096\/fj.02-0321fje","article-title":"AT2 receptor activation regulates myocardial eNOS expression via the calcineurin-NF-AT pathway","volume":"17","author":"Ritter","year":"2003","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.preghy.2026.101456_b0260","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/FTD.0000000000000640","article-title":"Therapeutic Drug monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report","volume":"41","author":"Brunet","year":"2019","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.preghy.2026.101456_b0265","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.717148","article-title":"Case Report: Low Hematocrit Leading to Tacrolimus Toxicity","author":"Piletta-Zanin","year":"2021","journal-title":"Front Pharmacol [internet]."},{"issue":"1","key":"10.1016\/j.preghy.2026.101456_b0270","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/FTD.0000000000001274","article-title":"Examining whole Blood, Total and Free Plasma Tacrolimus in elderly Kidney Transplant Recipients","volume":"47","author":"Cossart","year":"2025","journal-title":"Ther. Drug Monit."},{"issue":"5","key":"10.1016\/j.preghy.2026.101456_b0275","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.transproceed.2004.04.097","article-title":"Effect of hematocrit on pharmacokinetics of tacrolimus in adult living donor liver transplant recipients","volume":"36","author":"Minematsu","year":"2004","journal-title":"Transplant. Proc."},{"issue":"6","key":"10.1016\/j.preghy.2026.101456_b0280","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.clinbiochem.2005.02.011","article-title":"Effects of some hematological parameters on whole blood tacrolimus concentration measured by two immunoassay-based analytical methods","volume":"38","author":"Akbas","year":"2005","journal-title":"Clin. Biochem."},{"issue":"1","key":"10.1016\/j.preghy.2026.101456_b0285","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1056-8719(02)00158-2","article-title":"Validation of methods to study the distribution and protein binding of tacrolimus in human blood","volume":"46","author":"Zahir","year":"2001","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"1222","key":"10.1016\/j.preghy.2026.101456_b0290","article-title":"Expeditious quantification of plasma tacrolimus with liquid chromatography tandem mass spectrometry in solid organ transplantation","volume":"1","author":"Zijp","year":"2023","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.preghy.2026.101456_b0295","first-page":"1222","article-title":"Expeditious quantification of plasma tacrolimus with liquid chromatography tandem mass spectrometry in solid organ transplantation","volume":"1","author":"Zijp","year":"2023","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"1547","key":"10.1016\/j.preghy.2026.101456_b0300","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.chroma.2018.03.010","article-title":"A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples","volume":"27","author":"Bittersohl","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.preghy.2026.101456_b0305","doi-asserted-by":"crossref","unstructured":"Stienstra NA, Sikma MA, Van Dapperen AL, De Lange DW, Van Maarseveen EM. Development of a Simple and Rapid Method to Measure the Free Fraction of Tacrolimus in Plasma Using Ultrafiltration and LC-MS\/MS. 2016.","DOI":"10.1097\/FTD.0000000000000351"},{"issue":"6","key":"10.1016\/j.preghy.2026.101456_b0310","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/FTD.0b013e3182708edf","article-title":"Pharmacokinetics of tacrolimus during pregnancy","volume":"34","author":"Zheng","year":"2012","journal-title":"Ther. Drug Monit."},{"issue":"12","key":"10.1016\/j.preghy.2026.101456_b0315","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1161\/CIRCULATIONAHA.114.009029","article-title":"Cardiovascular physiology of pregnancy","volume":"130","author":"Sanghavi","year":"2014","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.preghy.2026.101456_b0320","doi-asserted-by":"crossref","first-page":"E325","DOI":"10.1097\/TP.0000000000002903","article-title":"Immunosuppression and reproductive health after kidney transplantation","volume":"103","author":"Chandra","year":"2019","journal-title":"Transplantation"},{"issue":"7","key":"10.1016\/j.preghy.2026.101456_b0325","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1097\/TP.0b013e318278d367","article-title":"Interpreting tacrolimus concentrations during pregnancy and postpartum","volume":"95","author":"Hebert","year":"2013","journal-title":"Transplantation"},{"issue":"6","key":"10.1016\/j.preghy.2026.101456_b0330","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1097\/01.TP.0000117564.50117.FB","article-title":"Pregnancy after kidney and kidney-pancreas transplantation under tacrolimus: a single center\u2019s experience","volume":"77","author":"Jain","year":"2004","journal-title":"Transplantation"},{"issue":"12","key":"10.1016\/j.preghy.2026.101456_b0335","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1111\/tri.14156","article-title":"Comparison of pregnancy outcomes in Dutch kidney recipients with and without calcineurin inhibitor exposure: a retrospective study","volume":"34","author":"Koenjer","year":"2021","journal-title":"Transpl. Int."},{"key":"10.1016\/j.preghy.2026.101456_b0340","article-title":"Obstetric outcomes among women with a liver transplant*","author":"Thornton","year":"2019","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"12","key":"10.1016\/j.preghy.2026.101456_b0345","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.jchf.2023.08.018","article-title":"Maternal and Pregnancy Outcomes following Heart Transplantation in the United States","volume":"11","author":"Craig","year":"2023","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.preghy.2026.101456_b0350","doi-asserted-by":"crossref","first-page":"99","DOI":"10.6002\/ect.MESOT2018.O42","article-title":"Pregnancy after renal transplant: Single center experience from the middle east in patients using different calcineurin inhibitors","volume":"17","author":"Al-Otaibi","year":"2019","journal-title":"Exp. Clin. Transplant."},{"key":"10.1016\/j.preghy.2026.101456_b0355","doi-asserted-by":"crossref","DOI":"10.1002\/lt.24182","article-title":"Outcomes of pregnancy following liver transplantation: the King\u2019s College Hospital experience","author":"Westbrook","year":"2015","journal-title":"Liver Transpl."},{"issue":"7","key":"10.1016\/j.preghy.2026.101456_b0360","doi-asserted-by":"crossref","first-page":"920","DOI":"10.2215\/CJN.0000000000000155","article-title":"Preeclampsia after Kidney Transplantation","volume":"18","author":"Lu","year":"2023","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.preghy.2026.101456_b0365","doi-asserted-by":"crossref","unstructured":"Gosselink ME, van Buren MC, Kooiman J, Groen H, Ganzevoort W, van Hamersvelt HW, et al. A nationwide Dutch cohort study shows relatively good pregnancy outcomes after kidney transplantation and finds risk factors for adverse outcomes. Kidney Int [Internet]. 2022 June; Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253822004689.","DOI":"10.1016\/j.kint.2022.06.006"},{"issue":"1","key":"10.1016\/j.preghy.2026.101456_b0370","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00007890-199107000-00022","article-title":"The effect of two new immunosuppressive agents, FK506 and didemnin B, in murine pregnancy","volume":"52","author":"Farley","year":"1991","journal-title":"Transplantation"},{"key":"10.1016\/j.preghy.2026.101456_b0375","first-page":"106","article-title":"Reproductive and developmental studies of tacrolimus (FK506)in rats and rabbits","volume":"52","author":"Saegusa","year":"1992","journal-title":"KisotoRinsho"},{"key":"10.1016\/j.preghy.2026.101456_b0380","doi-asserted-by":"crossref","DOI":"10.1161\/HYPERTENSIONAHA.107.097790","article-title":"Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin\/nuclear factor of activated T-cells signaling","author":"Zhou","year":"2008","journal-title":"Hypertension"},{"issue":"48","key":"10.1016\/j.preghy.2026.101456_b0385","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.placenta.2016.10.013","article-title":"Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta","volume":"1","author":"Ye","year":"2016","journal-title":"Placenta"},{"issue":"11","key":"10.1016\/j.preghy.2026.101456_b0390","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nm.1877","article-title":"Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma","volume":"14","author":"Jinnin","year":"2008","journal-title":"Nat. Med."},{"issue":"53","key":"10.1016\/j.preghy.2026.101456_b0395","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tiv.2018.07.017","article-title":"Tacrolimus inhibits angiogenesis and induces disaggregation of endothelial cells in spheroids \u2013 Toxicity testing in a 3D cell culture approach","volume":"1","author":"Thoms","year":"2018","journal-title":"Toxicol. In Vitro"},{"issue":"11","key":"10.1016\/j.preghy.2026.101456_b0400","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1084\/jem.20040474","article-title":"Nuclear factor of activated T cells balances angiogenesis activation and inhibition","volume":"199","author":"Zaichuk","year":"2004","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.preghy.2026.101456_b0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020412","article-title":"The Role of calcineurin\/NFAT in SFRP2 induced angiogenesis-a rationale for breast cancer treatment with the calcineurin inhibitor Tacrolimus","volume":"6","author":"Siamakpour-Reihani","year":"2011","journal-title":"PLoS One"},{"issue":"48","key":"10.1016\/j.preghy.2026.101456_b0410","doi-asserted-by":"crossref","first-page":"50537","DOI":"10.1074\/jbc.M406454200","article-title":"Vascular endothelial growth factor- and thrombin-induced termination factor, down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis","volume":"279","author":"Minami","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preghy.2026.101456_b0415","first-page":"145","article-title":"Angiogenesis modulation-mediated inhibitory effects of tacrolimus on hypertrophic scar formation","volume":"1","author":"Shen","year":"2023","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.preghy.2026.101456_b0420","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.placenta.2024.12.010","article-title":"Immunosuppressant drug tacrolimus inhibits HUVEC angiogenesis and production of placental growth factor","volume":"159","author":"Yo","year":"2025","journal-title":"Placenta"}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778926000449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778926000449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T07:47:40Z","timestamp":1780904860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778926000449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":84,"alternative-id":["S2210778926000449"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2026.101456","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calcineurin inhibitors and the risk of preeclampsia in solid organ transplantation \u2013 Should we rethink our approach during pregnancy?","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2026.101456","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of International Society for the Study of Hypertension in Pregnancy.","name":"copyright","label":"Copyright"}],"article-number":"101456"}}