{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:03:50Z","timestamp":1780905830834,"version":"3.54.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy Hypertension"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.preghy.2026.101459","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:47:22Z","timestamp":1774360042000},"page":"101459","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Methylenetetrahydrofolate reductase gene (C677T) mutation as a genetic risk factor for preeclampsia in Ethiopian pregnant women"],"prefix":"10.1016","volume":"44","author":[{"given":"Hassen Ahmed","family":"Yesuf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meseret Derbew","family":"Molla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesfahun","family":"Bekele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mequanint","family":"Melesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kibur","family":"Hunie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amare","family":"Nigatu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadelew","family":"Yimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.preghy.2026.101459_b0005","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.preghy.2026.101459_b0010","first-page":"e1","article-title":"ACOG practice bulletin no. 202: gestational hypertension and preeclampsia","volume":"133","author":"Obstetricians ACo, Gynecologists","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.preghy.2026.101459_b0015","doi-asserted-by":"crossref","unstructured":"Musarandega R, Nyakura M, Machekano R, Pattinson R, Munjanja SP. Causes of maternal mortality in Sub-Saharan Africa: A systematic review of studies published from 2015 to 2020. Journal of Global Health. 2021;11.","DOI":"10.7189\/jogh.11.04048"},{"issue":"1","key":"10.1016\/j.preghy.2026.101459_b0020","doi-asserted-by":"crossref","first-page":"103","DOI":"10.9734\/jammr\/2020\/v32i130357","article-title":"Magnitude, Trends and causes of maternal mortality: a 7 year review at a Tertiary Hospital in River State, Nigeria","volume":"32","author":"Awoyesuku","year":"2020","journal-title":"JAMMR"},{"key":"10.1016\/j.preghy.2026.101459_b0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejogrb.2020.03.043","article-title":"Prevalence of preeclampsia and eclampsia in adolescent pregnancy: a systematic review and meta-analysis of 291,247 adolescents worldwide since 1969","volume":"248","author":"Macedo","year":"2020","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology."},{"key":"10.1016\/j.preghy.2026.101459_b0030","article-title":"Prevalence of hypertensive disorders of pregnancy and pregnancy outcomes in Sub-Saharan Africa: a systematic review and meta-analysis","volume":"16","author":"Gemechu","year":"2020","journal-title":"Womens Health"},{"key":"10.1016\/j.preghy.2026.101459_b0035","doi-asserted-by":"crossref","unstructured":"Noubiap JJ, Bigna JJ. The burden of hypertensive disorders of pregnancy in Africa: A systematic review and meta-analysis. 2019;21(4):479-88.","DOI":"10.1111\/jch.13514"},{"issue":"1","key":"10.1016\/j.preghy.2026.101459_b0040","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1186\/s13104-015-1821-5","article-title":"Assessment of prevalence of preeclampsia from Dilla region of Ethiopia","volume":"8","author":"Vata","year":"2015","journal-title":"BMC. Res. Notes"},{"key":"10.1016\/j.preghy.2026.101459_b0045","doi-asserted-by":"crossref","unstructured":"Shegaze M, Markos Y, Estifaons W, Taye I, Gemeda E. Magnitude and associated factors of preeclampsia among pregnant women who attend antenatal Care Service in Public Health Institutions in Arba Minch town, southern Ethiopia, 2016. Gynecol Obstet (Sunnyvale). 2016;6(419):2161-0932.1000419.","DOI":"10.4172\/2161-0932.1000419"},{"key":"10.1016\/j.preghy.2026.101459_b0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.preghy.2019.03.007","article-title":"Hypertensive disorder of pregnancy prevalence and associated factors among pregnant women attending ante natal care at Gondar town health institutions, North West Ethiopia 2017","volume":"16","author":"Walle","year":"2019","journal-title":"Pregnancy Hypertension."},{"issue":"1","key":"10.1016\/j.preghy.2026.101459_b0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12884-015-0502-7","article-title":"Preeclampsia and associated factors among pregnant women attending antenatal care in Dessie referral hospital, Northeast Ethiopia: a hospital-based study","volume":"15","author":"Tessema","year":"2015","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.preghy.2026.101459_b0060","doi-asserted-by":"crossref","unstructured":"Tranquilli A, Dekker G, Magee L, Roberts J, Sibai B, Steyn W, et al. The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP. Elsevier; 2014. p. 97-104.","DOI":"10.1016\/j.preghy.2014.02.001"},{"issue":"2","key":"10.1016\/j.preghy.2026.101459_b0065","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/14767058.2017.1376643","article-title":"Adverse maternal and neonatal outcomes in women with preeclampsia in Iran","volume":"32","author":"Omani-Samani","year":"2019","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"3","key":"10.1016\/j.preghy.2026.101459_b0070","doi-asserted-by":"crossref","first-page":"561","DOI":"10.31083\/j.ceog.2021.03.2369","article-title":"Frequency of cesarean section in pregnant women with risk factors for preeclampsia: prospective cohort study","volume":"48","author":"Kameri\u0107","year":"2021","journal-title":"Clin. Exp. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.preghy.2026.101459_b0075","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tjog.2018.04.035","article-title":"Preeclampsia-eclampsia and future cardiovascular risk among women in Taiwan","volume":"57","author":"Kuo","year":"2018","journal-title":"Taiwanese Journal of Obstetrics and Gynecology."},{"issue":"9","key":"10.1016\/j.preghy.2026.101459_b0080","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/1471-0528.16683","article-title":"Pre\u2010eclampsia and long\u2010term health outcomes for mother and infant: an umbrella review","volume":"128","author":"Pittara","year":"2021","journal-title":"BJOG"},{"issue":"19","key":"10.1016\/j.preghy.2026.101459_b0085","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.3390\/ijerph16193571","article-title":"Incidence and risk factors of pre-eclampsia in the paropakar maternity and women\u2019s hospital, Nepal: a retrospective study","volume":"16","author":"Das","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"6","key":"10.1016\/j.preghy.2026.101459_b0090","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10389-017-0825-0","article-title":"Risk factors of preeclampsia: a case control study among mothers in Sana\u2019a","volume":"25","author":"Al-Tairi","year":"2017","journal-title":"Yemen. Journal of Public Health."},{"key":"10.1016\/j.preghy.2026.101459_b0095","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2147\/IJWH.S251342","article-title":"Determinants of preeclampsia among pregnant mothers attending antenatal care (ANC) and delivery service in gedeo zone, southern Ethiopia: case control-study","volume":"12","author":"Mareg","year":"2020","journal-title":"Int. J. Womens Health"},{"issue":"8","key":"10.1016\/j.preghy.2026.101459_b0100","article-title":"Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa","volume":"15","author":"Meazaw","year":"2020","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.preghy.2026.101459_b0105","doi-asserted-by":"crossref","first-page":"247","DOI":"10.26502\/fjwhd.2644-28840035","article-title":"Prevalence and risk factors of hypertensive disorders in pregnancy: case of mezam division, NWR Cameroon","volume":"3","author":"Njukang","year":"2020","journal-title":"Journal of Womens Health and Development."},{"key":"10.1016\/j.preghy.2026.101459_b0110","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/4654828","article-title":"Determinants of Preeclampsia among Women Attending delivery Services in Public Hospitals of Central Tigray, Northern Ethiopia: a Case-Control Study","volume":"2021","author":"Haile","year":"2021","journal-title":"J. Pregnancy"},{"issue":"12","key":"10.1016\/j.preghy.2026.101459_b0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208137","article-title":"Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: a case-control study","volume":"13","author":"Serrano","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.preghy.2026.101459_b0120","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.enfcli.2019.07.161","article-title":"Serum levels of folic acid in severe preeclampsia at the mother and child hospital of Makassar city","volume":"30","author":"Manurung","year":"2020","journal-title":"Enfermer\u00eda Cl\u00ednica."},{"key":"10.1016\/j.preghy.2026.101459_b0125","unstructured":"Organization WH. WHO antenatal care recommendations for a positive pregnancy experience: nutritional interventions update: multiple micronutrient supplements during pregnancy. 2020."},{"key":"10.1016\/j.preghy.2026.101459_b0130","unstructured":"MOH F. Federal Democratic Republic of Ethiopian, Ministry of Health, National Antenatal Care Guideline; http:\/\/e-library.moh.gov.et\/library\/wp-content\/uploads\/2022\/03\/ANC-GUIDELINE_Feb-24-2022.pdf Accessed on June 5,2022."},{"issue":"3","key":"10.1016\/j.preghy.2026.101459_b0135","doi-asserted-by":"crossref","first-page":"164","DOI":"10.5455\/medarh.2018.72.164-169","article-title":"The frequency of the 677C> T and 1298A> C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene in the population","volume":"72","author":"Nefic","year":"2018","journal-title":"Med. Arch."},{"key":"10.1016\/j.preghy.2026.101459_b0140","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.placenta.2022.01.004","article-title":"Associations between AGT, MTHFR, and VEGF gene polymorphisms and preeclampsia in the chinese population","volume":"118","author":"Ding","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.preghy.2026.101459_b0145","doi-asserted-by":"crossref","unstructured":"Ward K, Laivuori H, Taylor RN. Chapter 3 - Genetic Factors in the Etiology of Preeclampsia\/Eclampsia. In: Taylor RN, Conrad KP, Davidge ST, Staff AC, Roberts JM, editors. Chesley's Hypertensive Disorders in Pregnancy (Fifth Edition): Academic Press; 2022. p. 45-69.","DOI":"10.1016\/B978-0-12-818417-2.00002-6"},{"issue":"8","key":"10.1016\/j.preghy.2026.101459_b0150","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s003359900838","article-title":"Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)","volume":"9","author":"Goyette","year":"1998","journal-title":"Mammalian Genome: Official Journal of the International Mammalian Genome Society."},{"issue":"1\u20132","key":"10.1016\/j.preghy.2026.101459_b0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11010-013-1869-2","article-title":"Nutriepigenetic regulation by folate-homocysteine-methionine axis: a review","volume":"387","author":"Bhargava","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.preghy.2026.101459_b0160","unstructured":"Leclerc D, Sibani S, Rozen R. Molecular biology of methylenetetrahydrofolate reductase (MTHFR) and overview of mutations\/polymorphisms. MTHFR Polymorphisms and Disease Georgetown, TX: Landes Bioscience\/Eurekah com. 2005:1-20."},{"issue":"2","key":"10.1016\/j.preghy.2026.101459_b0165","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/1098-1004(200008)16:2<132::AID-HUMU5>3.0.CO;2-T","article-title":"The thermolabile variant 677C\u2013>T can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase","volume":"16","author":"Goyette","year":"2000","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.preghy.2026.101459_b0170","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejogrb.2021.06.003","article-title":"Homocysteine, vitamin B status and MTHFR polymorphisms in italian infertile women","volume":"263","author":"Cirillo","year":"2021","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology."},{"issue":"1","key":"10.1016\/j.preghy.2026.101459_b0175","article-title":"Association between decreased plasma folate levels and MTHFR C677T, and MTRR A66G gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women","volume":"7","author":"Song","year":"2018","journal-title":"Hered. Genet. Curr. Res."},{"issue":"1","key":"10.1016\/j.preghy.2026.101459_b0180","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1152\/physrev.00003.2018","article-title":"Homocysteine modification in protein structure\/function and human disease","volume":"99","author":"Jakubowski","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.preghy.2026.101459_b0185","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejogrb.2015.03.009","article-title":"The importance of MTHFR, MTR, MTRR and CSE expression levels in Caucasian women with preeclampsia","volume":"188","author":"Seremak-Mrozikiewicz","year":"2015","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.preghy.2026.101459_b0190","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.preghy.2020.02.001","article-title":"Methylene tetrahydrofolate reductase and methionine synthase gene polymorphisms as genetic determinants of pre-eclampsia","volume":"20","author":"Osunkalu","year":"2020","journal-title":"Pregnancy Hypertension"},{"issue":"5","key":"10.1016\/j.preghy.2026.101459_b0195","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/15513815.2019.1655819","article-title":"Association of MTHFR C677T Polymorphism with Preeclampsia in North East of Iran (Khorasan Province)","volume":"39","author":"Azimi-Nezhad","year":"2020","journal-title":"Fetal Pediatr. Pathol."},{"key":"10.1016\/j.preghy.2026.101459_b0200","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ejogrb.2020.06.012","article-title":"Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy","volume":"253","author":"Ferrazzi","year":"2020","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology."},{"issue":"9","key":"10.1016\/j.preghy.2026.101459_b0205","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.4236\/ojog.2021.119103","article-title":"Comparative Study between the use of Regular Folic Acid Supplement versus the use of L-Methyl Folate in patients with Methyl Tetrahydrofolate Reductase (MTHFR) Gene Mutation with Recurrent Pregnancy loss","volume":"11","author":"Essmat","year":"2021","journal-title":"Open Journal of Obstetrics and Gynecology."},{"issue":"2","key":"10.1016\/j.preghy.2026.101459_b0210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/10641955.2020.1725037","article-title":"Association of methylenetetrahydrofolate reductase C677T and reduced-f carrier-1 G80A gene polymorphism with preeclampsia in Sudanese women","volume":"39","author":"Ahmed","year":"2020","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.preghy.2026.101459_b0215","doi-asserted-by":"crossref","unstructured":"Challa F, Getahun T, Sileshi M, Nigassie B, Geto Z, Ashibire G, et al. Prevalence of hyperhomocysteinaemia and associated factors among ethiopian adult population in a 2015 national survey. BioMed Research International. 2020;2020.","DOI":"10.1155\/2020\/9210261"},{"key":"10.1016\/j.preghy.2026.101459_b0220","unstructured":"University of Gondar Comprhensive Specialized Hospital GaO, Monhtly Registary Report, August. 2022."},{"key":"10.1016\/j.preghy.2026.101459_b0225","unstructured":"Health FMo. Management protocol on selected obstetrics topics. Federal Democratic Republic of Ethiopia; 2010."},{"key":"10.1016\/j.preghy.2026.101459_b0230","doi-asserted-by":"crossref","first-page":"17 -","DOI":"10.3352\/jeehp.2021.18.17","article-title":"Sample size determination and power analysis using the G*Power software","volume":"18","author":"Kang","year":"2021","journal-title":"Journal of Educational Evaluation for Health Professions."},{"key":"10.1016\/j.preghy.2026.101459_b0235","doi-asserted-by":"crossref","unstructured":"Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16(3):1215.","DOI":"10.1093\/nar\/16.3.1215"},{"issue":"3","key":"10.1016\/j.preghy.2026.101459_b0355","doi-asserted-by":"crossref","first-page":"164","DOI":"10.5455\/medarh.2018.72.164-169","article-title":"The Frequency of the 677C>T and 1298A>C Polymorphisms in the Methylenetetrahydrofolate Reductase (MTHFR) Gene in the Population","volume":"72","author":"Nefic","year":"2018","journal-title":"Med. Arch."},{"key":"10.1016\/j.preghy.2026.101459_b0240","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/B978-0-444-51862-0.50018-6","article-title":"BIC and recent advances in model selection","author":"Chakrabarti","year":"2011","journal-title":"Philosophy of Statistics"},{"issue":"4","key":"10.1016\/j.preghy.2026.101459_b0245","first-page":"8","article-title":"Prevalence and Determinants of Maternal and Perinatal Outcome of Preeclampsia at a Tertiary Hospital in Ethiopia. Ethiopian Journal of","volume":"11","author":"Legesse","year":"2019","journal-title":"Reprod. Health"},{"issue":"5","key":"10.1016\/j.preghy.2026.101459_b0250","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1291\/hypres.31.1015","article-title":"Methylenetetrahydrofolate Reductase C677T and Glutathione S\u2212Transferase P1 A313G are Associated with a Reduced risk of Preeclampsia in Maya-Mestizo Women","volume":"31","author":"Canto","year":"2008","journal-title":"Hypertens. Res."},{"issue":"7","key":"10.1016\/j.preghy.2026.101459_b0255","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3109\/09513590.2015.1031104","article-title":"Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in the placenta of pregnancies complicated with preeclampsia","volume":"31","author":"Chedraui","year":"2015","journal-title":"Gynecol. Endocrinol."},{"issue":"2","key":"10.1016\/j.preghy.2026.101459_b0260","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mefs.2011.09.005","article-title":"Methylenetetrahydrofolate C677T polymorphism and pre-eclamptic Egyptian women","volume":"17","author":"Ibrahim","year":"2012","journal-title":"Middle East Fertility Society Journal"},{"key":"10.1016\/j.preghy.2026.101459_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.mgene.2020.100775","article-title":"Increased homocysteine expression associated with genetic changes in the folate pathway as a key determinant of preeclampsia: a prospective study from lower Assam, India","volume":"26","author":"Sultana","year":"2020","journal-title":"Meta Gene."},{"issue":"4","key":"10.1016\/j.preghy.2026.101459_b0270","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s13224-019-01215-5","article-title":"Methylenetetrahydrofolate reductase enzyme level and antioxidant activity in women with gestational hypertension and pre-eclampsia in Lagos, Nigeria","volume":"69","author":"Osunkalu","year":"2019","journal-title":"The Journal of Obstetrics and Gynecology of India."},{"issue":"5","key":"10.1016\/j.preghy.2026.101459_b0275","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.0001-6349.2004.0355.x","article-title":"Methylenetetrahydrofolate reductase gene polymorphisms in black South Africans and the association with preeclampsia","volume":"83","author":"Pegoraro","year":"2004","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"4","key":"10.1016\/j.preghy.2026.101459_b0280","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/09513590.2019.1658188","article-title":"Association of methylenetetrahydrofolate reductase C677T polymorphism with the pre-eclampsia risk in Hakka pregnant women in Southern China","volume":"36","author":"Hou","year":"2020","journal-title":"Gynecol. Endocrinol."},{"issue":"2","key":"10.1016\/j.preghy.2026.101459_b0285","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00404-006-0223-2","article-title":"Homocysteine, folic acid and B12 serum levels in pregnancy complicated with preeclampsia","volume":"275","author":"Makedos","year":"2007","journal-title":"Arch. Gynecol. Obstet."},{"issue":"6","key":"10.1016\/j.preghy.2026.101459_b0290","first-page":"10129","article-title":"The Role of Hyperhomocystinemia in Recurrent Pregnancy loss","volume":"25","author":"Shibbl","year":"2021","journal-title":"Annals of the Romanian Society for Cell Biology."},{"key":"10.1016\/j.preghy.2026.101459_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijchy.2021.100084","article-title":"Association of family history with incidence and gestational hypertension outcomes of preeclampsia","volume":"9","author":"Wu","year":"2021","journal-title":"Int J Cardiol Hypertens."},{"issue":"1","key":"10.1016\/j.preghy.2026.101459_b0300","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12884-017-1507-1","article-title":"Determinants of pre-eclampsia\/Eclampsia among women attending delivery Services in Selected Public Hospitals of Addis Ababa, Ethiopia: a case control study","volume":"17","author":"Grum","year":"2017","journal-title":"BMC Pregnancy Childbirth"},{"issue":"4","key":"10.1016\/j.preghy.2026.101459_b0305","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ajmg.a.30257","article-title":"Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population\u2010based swedish cohort study","volume":"130","author":"Cnattingius","year":"2004","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.preghy.2026.101459_b0310","series-title":"Chesley's Hypertensive Disorders in Pregnancy","first-page":"51","article-title":"Chapter 4 - Genetic Factors in the Etiology of Preeclampsia\/Eclampsia","author":"Ward","year":"2009"},{"issue":"4","key":"10.1016\/j.preghy.2026.101459_b0315","first-page":"874","article-title":"Overweight and obesity at risk factors for hypertensive states of pregnancy: a retrospective cohort study","volume":"35","author":"Jj","year":"2018","journal-title":"Nutr. Hosp."},{"issue":"1","key":"10.1016\/j.preghy.2026.101459_b0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12884-018-1687-3","article-title":"The association between pre pregnancy body mass index and risk of preeclampsia: a registry based study from Tanzania","volume":"18","author":"Mrema","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"10.1016\/j.preghy.2026.101459_b0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2007.01.004","article-title":"Shi J-s, Du G-h. Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein-induced apoptosis in human umbilical vein endothelial cells: role of reactive oxygen species","volume":"47","author":"Chen","year":"2007","journal-title":"Vasc.Pharmacol."},{"issue":"7","key":"10.1016\/j.preghy.2026.101459_b0335","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1128\/MCB.00858-12","article-title":"Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor \u03b3","volume":"33","author":"Alex","year":"2013","journal-title":"Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.preghy.2026.101459_b0340","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1128\/JVI.01779-09","article-title":"Activation of peroxisome proliferator-activated receptor gamma by human cytomegalovirus for de novo replication impairs migration and invasiveness of cytotrophoblasts from early placentas","volume":"84","author":"Rauwel","year":"2010","journal-title":"J. Virol."},{"issue":"13","key":"10.1016\/j.preghy.2026.101459_b0345","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3109\/14767058.2013.858319","article-title":"Leptin and paraoxonase activity in cord blood from obese mothers","volume":"27","author":"Ferretti","year":"2014","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.preghy.2026.101459_b0350","first-page":"1","article-title":"Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways","volume":"90(6):129","author":"Aye","year":"2014","journal-title":"Biol. Reprod."},{"issue":"5","key":"10.1016\/j.preghy.2026.101459_b0325","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1194\/jlr.M062539","article-title":"Oxidized LDL signals through Rho-GTPase to induce endothelial cell stiffening and promote capillary formation [S]","volume":"57","author":"Oh","year":"2016","journal-title":"J. Lipid Res."}],"container-title":["Pregnancy Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778926000474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210778926000474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T07:53:43Z","timestamp":1780905223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210778926000474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":71,"alternative-id":["S2210778926000474"],"URL":"https:\/\/doi.org\/10.1016\/j.preghy.2026.101459","relation":{},"ISSN":["2210-7789"],"issn-type":[{"value":"2210-7789","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylenetetrahydrofolate reductase gene (C677T) mutation as a genetic risk factor for preeclampsia in Ethiopian pregnant women","name":"articletitle","label":"Article Title"},{"value":"Pregnancy Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preghy.2026.101459","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101459"}}