{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:06:41Z","timestamp":1789636001252,"version":"4.0.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL168874"],"award-info":[{"award-number":["R01HL168874"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL174001"],"award-info":[{"award-number":["R01HL174001"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016257","name":"University of California Davis School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM142690"],"award-info":[{"award-number":["R35GM142690"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprecisionmedicine.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Precision Medicine: Health and Disease"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.premed.2026.100050","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:55:51Z","timestamp":1784217351000},"page":"100050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["From lipid dynamics to precision predictions: A new approach methodology for precision modeling of phosphoinositide signaling"],"prefix":"10.1016","volume":"7","author":[{"given":"Gonzalo","family":"Hernandez-Hernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Tieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Vivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Fernando","family":"Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6849-4885","authenticated-orcid":false,"given":"Colleen E.","family":"Clancy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.premed.2026.100050_bib1","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1152\/physrev.00028.2012","article-title":"Phosphoinositides: Tiny lipids with giant impact on cell regulation","volume":"93","author":"Balla","year":"2013","journal-title":"Physiological Reviews"},{"issue":"6410","key":"10.1016\/j.premed.2026.100050_bib2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/361315a0","article-title":"Inositol trisphosphate and calcium signalling","volume":"361","author":"Berridge","year":"1993","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.premed.2026.100050_bib3","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.bbamcr.2008.10.005","article-title":"Inositol trisphosphate and calcium signalling mechanisms","volume":"1793","author":"Berridge","year":"2009","journal-title":"Biochimica et Biophysica Acta"},{"issue":"5992","key":"10.1016\/j.premed.2026.100050_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/312315a0","article-title":"Inositol trisphosphate, a novel second messenger in cellular signal transduction","volume":"312","author":"Berridge","year":"1984","journal-title":"Nature"},{"issue":"6239","key":"10.1016\/j.premed.2026.100050_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/341197a0","article-title":"Inositol phosphates and cell signalling","volume":"341","author":"Berridge","year":"1989","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.premed.2026.100050_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41573-022-00582-5","article-title":"Beyond PI3Ks: Targeting phosphoinositide kinases in disease","volume":"22","author":"Burke","year":"2023","journal-title":"Nature Reviews Drug Discovery"},{"issue":"3","key":"10.1016\/j.premed.2026.100050_bib7","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202113001","article-title":"Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis","volume":"154","author":"de la Cruz","year":"2022","journal-title":"The Journal of General Physiology"},{"issue":"5","key":"10.1016\/j.premed.2026.100050_bib8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1085\/jgp.201210886","article-title":"Quantitative properties and receptor reserve of the IP(3) and calcium branch of G(q)-coupled receptor signaling","volume":"141","author":"Dickson","year":"2013","journal-title":"The Journal of General Physiology"},{"issue":"5","key":"10.1016\/j.premed.2026.100050_bib9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1085\/jgp.201210887","article-title":"Quantitative properties and receptor reserve of the DAG and PKC branch of G(q)-coupled receptor signaling","volume":"141","author":"Falkenburger","year":"2013","journal-title":"The Journal of General Physiology"},{"issue":"2","key":"10.1016\/j.premed.2026.100050_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1085\/jgp.200910345","article-title":"Kinetics of PIP2 metabolism and KCNQ2\/3 channel regulation studied with a voltage-sensitive phosphatase in living cells","volume":"135","author":"Falkenburger","year":"2010","journal-title":"Journal of General Physiology"},{"issue":"35","key":"10.1016\/j.premed.2026.100050_bib11","doi-asserted-by":"crossref","first-page":"14438","DOI":"10.1074\/jbc.M117.791467","article-title":"Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle","volume":"292","author":"Grabon","year":"2017","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.premed.2026.100050_bib12","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.90604","article-title":"A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle","volume":"12","author":"Hernandez-Hernandez","year":"2024","journal-title":"eLife"},{"issue":"17","key":"10.1016\/j.premed.2026.100050_bib13","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1113\/JP277724","article-title":"A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources","volume":"597","author":"Kernik","year":"2019","journal-title":"The Journal of Physiology"},{"issue":"5","key":"10.1016\/j.premed.2026.100050_bib14","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.devcel.2015.04.028","article-title":"Phosphatidylinositol-Phosphatidic acid exchange by Nir2 at ER-PM contact sites maintains phosphoinositide signaling competence","volume":"33","author":"Kim","year":"2015","journal-title":"Developmental Cell"},{"issue":"4","key":"10.1016\/j.premed.2026.100050_bib15","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1523\/JNEUROSCI.3535-15.2016","article-title":"Dynamics of phosphoinositide-dependent signaling in sympathetic neurons","volume":"36","author":"Kruse","year":"2016","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.premed.2026.100050_bib16","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.79582","article-title":"Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2","volume":"11","author":"Lu","year":"2022","journal-title":"eLife"},{"issue":"3","key":"10.1016\/j.premed.2026.100050_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150761","article-title":"Parameterization for In-Silico modeling of ion channel interactions with drugs","volume":"11","author":"Moreno","year":"2016","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.premed.2026.100050_bib18","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.ajhg.2023.06.012","article-title":"De novo missense variants in phosphatidylinositol kinase PIP5KI\u03b3 underlie a neurodevelopmental syndrome associated with altered phosphoinositide signaling","volume":"110","author":"Morleo","year":"2023","journal-title":"The American Journal of Human Genetics"},{"issue":"6","key":"10.1016\/j.premed.2026.100050_bib19","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1083\/jcb.201206095","article-title":"PtdIns4P synthesis by PI4KIII\u03b1 at the plasma membrane and its impact on plasma membrane identity","volume":"199","author":"Nakatsu","year":"2012","journal-title":"Journal of Cell Biology"},{"issue":"3","key":"10.1016\/j.premed.2026.100050_bib20","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1086\/520771","article-title":"Lethal contractural syndrome type 3 (LCCS3) is caused by a mutation in PIP5K1C, which encodes PIPKI\u03b3 of the phophatidylinsitol pathway","volume":"81","author":"Narkis","year":"2007","journal-title":"The American Journal of Human Genetics"},{"issue":"2","key":"10.1016\/j.premed.2026.100050_bib21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/tra.12709","article-title":"Integrated regulation of the phosphatidylinositol cycle and phosphoinositide-driven lipid transport at ER-PM contact sites","volume":"21","author":"Pemberton","year":"2020","journal-title":"Traffic"},{"issue":"25","key":"10.1016\/j.premed.2026.100050_bib22","article-title":"Fueling the heartbeat: Dynamic regulation of intracellular ATP during excitation-contraction coupling in ventricular myocytes","volume":"121","author":"Rhana","year":"2024","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"12","key":"10.1016\/j.premed.2026.100050_bib23","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1093\/brain\/awab313","article-title":"Biallelic PI4KA variants cause neurological, intestinal and immunological disease","volume":"144","author":"Salter","year":"2021","journal-title":"Brain"},{"issue":"51","key":"10.1016\/j.premed.2026.100050_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adp6660","article-title":"Molecular basis for plasma membrane recruitment of PI4KA by EFR3","volume":"10","author":"Suresh","year":"2024","journal-title":"Science Advances"},{"issue":"9","key":"10.1016\/j.premed.2026.100050_bib25","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1093\/brain\/awab124","article-title":"Biallelic PI4KA variants cause a novel neurodevelopmental syndrome with hypomyelinating leukodystrophy","volume":"144","author":"Verdura","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.premed.2026.100050_bib26","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.biochi.2015.09.005","article-title":"Phosphoinositides: Important lipids in the coordination of cell dynamics","volume":"125","author":"Viaud","year":"2016","journal-title":"Biochimie"},{"issue":"7","key":"10.1016\/j.premed.2026.100050_bib27","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.celrep.2019.04.070","article-title":"PIP4Ks suppress insulin signaling through a catalytic-independent mechanism","volume":"27","author":"Wang","year":"2019","journal-title":"Cell Reports"},{"issue":"9","key":"10.1016\/j.premed.2026.100050_bib28","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1074\/jbc.273.9.5037","article-title":"Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells","volume":"273","author":"Willars","year":"1998","journal-title":"Journal of Biological Chemistry"},{"issue":"16","key":"10.1016\/j.premed.2026.100050_bib29","doi-asserted-by":"crossref","first-page":"jcs261494","DOI":"10.1242\/jcs.261494","article-title":"A novel homeostatic mechanism tunes PI(4,5)P2-dependent signaling at the plasma membrane","volume":"136","author":"Wills","year":"2023","journal-title":"Journal of Cell Science"},{"issue":"4","key":"10.1016\/j.premed.2026.100050_bib30","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1083\/jcb.200301070","article-title":"Kinetic analysis of receptor-activated phosphoinositide turnover","volume":"161","author":"Xu","year":"2003","journal-title":"The Journal of Cell Biology"},{"issue":"2","key":"10.1016\/j.premed.2026.100050_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021709","article-title":"Lipidomics\u2014paving the road towards better insight and precision medicine in rare metabolic diseases","volume":"24","author":"Zandl-Lang","year":"2023","journal-title":"International Journal of Molecular Sciences"}],"container-title":["The Journal of Precision Medicine: Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050632826000235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050632826000235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:54:47Z","timestamp":1789635287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3050632826000235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":31,"alternative-id":["S3050632826000235"],"URL":"https:\/\/doi.org\/10.1016\/j.premed.2026.100050","relation":{},"ISSN":["3050-6328"],"issn-type":[{"value":"3050-6328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From lipid dynamics to precision predictions: A new approach methodology for precision modeling of phosphoinositide signaling","name":"articletitle","label":"Article Title"},{"value":"The Journal of Precision Medicine: Health and Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.premed.2026.100050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of The Physiological Society.","name":"copyright","label":"Copyright"}],"article-number":"100050"}}