{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:46:19Z","timestamp":1793148379346,"version":"4.5.0"},"reference-count":148,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Retinal and Eye Research"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.preteyeres.2007.07.004","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T11:53:21Z","timestamp":1187092401000},"page":"649-673","source":"Crossref","is-referenced-by-count":208,"title":["Iron homeostasis and toxicity in retinal degeneration"],"prefix":"10.1016","volume":"26","author":[{"given":"Xining","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Iacovelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bhisitkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Massaro-Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L.","family":"Dunaief","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preteyeres.2007.07.004_bib1","doi-asserted-by":"crossref","first-page":"19906","DOI":"10.1074\/jbc.M000713200","article-title":"A novel mammalian iron-regulated protein involved in intracellular iron metabolism","volume":"275","author":"Abboud","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S1357-2725(01)00063-2","article-title":"Chemistry and biology of eukaryotic iron metabolism","volume":"33","author":"Aisen","year":"2001","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib3","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0140-6736(02)09740-4","article-title":"Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia","volume":"360","author":"Anderson","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0020-1693(02)01040-X","article-title":"Evaluation of new iron chelators and their therapeutic potential","volume":"339","author":"Aouad","year":"2002","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib5","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/archopht.119.10.1417","article-title":"A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8","volume":"119","year":"2001","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib6","series-title":"Iron Metabolism in Health and Disease","first-page":"63","article-title":"Iron transport","author":"Baker","year":"1994"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0039-6257(00)00140-5","article-title":"The role of oxidative stress in the pathogenesis of age-related macular degeneration","volume":"45","author":"Beatty","year":"2000","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0014-5793(96)00140-8","article-title":"Redox control of gene expression involving iron\u2013sulfur proteins. Change of oxidation-state or assembly\/disassembly of Fe\u2013S clusters?","volume":"382","author":"Beinert","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib9","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1182\/blood.V99.8.3019","article-title":"HBED ligand: preclinical studies of a potential alternative to deferoxamine for treatment of chronic iron overload and acute iron poisoning","volume":"99","author":"Bergeron","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib10","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2006-12-065433","article-title":"Selective iron chelation in Friedreich ataxia. Biological and clinical implications","author":"Boddaert","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2214\/ajr.156.3.1899759","article-title":"Deferoxamine-induced bone dysplasia in patients with thalassemia major","volume":"156","author":"Brill","year":"1991","journal-title":"Am. J. Roentgenol. (AJR)"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib12","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0306-4522(99)00207-9","article-title":"Cellular distribution of iron in the brain of the Belgrade rat","volume":"93","author":"Burdo","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib13","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/jnr.1256","article-title":"Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat","volume":"66","author":"Burdo","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib14","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0306-4522(03)00590-6","article-title":"Mechanisms and regulation of transferrin and iron transport in a model blood\u2013brain barrier system","volume":"121","author":"Burdo","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/156652307779940252","article-title":"Gene therapy for ocular neovascularization","volume":"7","author":"Campochiaro","year":"2007","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib16","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1182\/blood-2002-07-2006","article-title":"Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia","volume":"101","author":"Cazzola","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1046\/j.1365-2141.2002.03554.x","article-title":"The safety and effectiveness of deferiprone in a large-scale, 3-year study in Italian patients","volume":"118","author":"Ceci","year":"2002","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neuron.2006.07.011","article-title":"NMDA receptor\u2014nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1","volume":"51","author":"Cheah","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib19","first-page":"151","article-title":"Increased expression of ceruloplasmin in the retina following photic injury","volume":"9","author":"Chen","year":"2003","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib20","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1167\/iovs.05-1135","article-title":"The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration","volume":"47","author":"Chowers","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib21","first-page":"180","article-title":"Clinical aspects of ocular siderosis and hemosiderosis","volume":"62","author":"Cibis","year":"1959","journal-title":"AMA Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib22","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1182\/blood-2002-10-3280","article-title":"Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone","volume":"102","author":"Cohen","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib23","doi-asserted-by":"crossref","first-page":"25122","DOI":"10.1074\/jbc.M003797200","article-title":"Overexpression of wild type and mutated human ferritin H-chain in HeLa cells: in vivo role of ferritin ferroxidase activity","volume":"275","author":"Cozzi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib24","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1073\/pnas.80.8.2258","article-title":"pH and the recycling of transferrin during receptor-mediated endocytosis","volume":"80","author":"Dautry-Varsat","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib25","doi-asserted-by":"crossref","first-page":"8955","DOI":"10.1073\/pnas.0503804102","article-title":"The molecular basis of ferroportin-linked hemochromatosis","volume":"102","author":"De Domenico","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib26","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0022-3476(88)80375-5","article-title":"Deferoxamine-induced growth retardation in patients with thalassemia major","volume":"113","author":"De Virgiliis","year":"1988","journal-title":"J. Pediatr."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib27","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1001\/archopht.1977.04450060138014","article-title":"Experimental siderosis in the rabbit: correlation between electroretinography and histopathology","volume":"95","author":"Declercq","year":"1977","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib28","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1001\/archopht.123.12.1745","article-title":"Strong labeling for iron and the iron-handling proteins ferritin and ferroportin in the photoreceptor layer in age-related macular degeneration","volume":"123","author":"Dentchev","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib29","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/35001596","article-title":"Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter","volume":"403","author":"Donovan","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cmet.2005.01.003","article-title":"The iron exporter ferroportin\/Slc40a1 is essential for iron homeostasis","volume":"1","author":"Donovan","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib31","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2214\/ajr.149.2.357","article-title":"Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: increased iron content?","volume":"149","author":"Drayer","year":"1987","journal-title":"Am. J. Roentgenol. (AJR)"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib32","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1167\/iovs.06-0568","article-title":"Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture","volume":"47","author":"Dunaief","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib33","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.ophtha.2004.12.029","article-title":"Macular degeneration in a patient with aceruloplasminemia, a disease associated with retinal iron overload","volume":"112","author":"Dunaief","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib34","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1167\/iovs.03-0872","article-title":"Increased expression of iron-regulating genes in monkey and human glaucoma","volume":"45","author":"Farkas","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib35","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng0896-399","article-title":"A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis","volume":"13","author":"Feder","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib36","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1073\/pnas.95.4.1472","article-title":"The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding","volume":"95","author":"Feder","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib37","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/0091270003253350","article-title":"Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to beta-thalassemia","volume":"43","author":"Galanello","year":"2003","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib38","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1167\/iovs.04-0860","article-title":"Expression of acute-phase response proteins in retinal Muller cells in diabetes","volume":"46","author":"Gerhardinger","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib39","first-page":"1068","article-title":"Absorption of retinal and subretinal hemorrhages","volume":"15","author":"Gillies","year":"1983","journal-title":"Ann. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib40","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/0002-9394(82)90301-4","article-title":"Experimental subretinal hemorrhage in rabbits","volume":"94","author":"Glatt","year":"1982","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib41","first-page":"1721","article-title":"Overexpression of H- and L-ferritin subunits in lens epithelial cells: Fe metabolism and cellular response to UVB irradiation","volume":"42","author":"Goralska","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib42","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/41343","article-title":"Cloning and characterization of a mammalian proton-coupled metal\u2013ion transporter","volume":"388","author":"Gunshin","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib43","doi-asserted-by":"crossref","first-page":"21645","DOI":"10.1074\/jbc.270.37.21645","article-title":"Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome","volume":"270","author":"Guo","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib44","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1001\/archopht.121.8.1099","article-title":"Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane","volume":"121","author":"Hahn","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib45","first-page":"598","article-title":"Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina","volume":"10","author":"Hahn","year":"2004","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib46","doi-asserted-by":"crossref","first-page":"13850","DOI":"10.1073\/pnas.0405146101","article-title":"Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration","volume":"101","author":"Hahn","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib47","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1097\/WNR.0b013e3280107776","article-title":"Iron levels in human retina: sex difference and increase with age","volume":"17","author":"Hahn","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib48","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0161-6420(01)00947-2","article-title":"The expanded clinical spectrum of deferoxamine retinopathy","volume":"109","author":"Haimovici","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2190001","article-title":"Oxygen toxicity, oxygen radicals, transition metals and disease","volume":"219","author":"Halliwell","year":"1984","journal-title":"Biochem. J."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib50","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.exer.2006.01.018","article-title":"Lens epithelial cells synthesize and secrete ceruloplasmin: effects of ceruloplasmin and transferrin on iron efflux and intracellular iron dynamics","volume":"83","author":"Harned","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib51","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1073\/pnas.92.7.2539","article-title":"Aceruloplasminemia: molecular characterization of this disorder of iron metabolism","volume":"92","author":"Harris","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib52","doi-asserted-by":"crossref","first-page":"10812","DOI":"10.1073\/pnas.96.19.10812","article-title":"Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux","volume":"96","author":"Harris","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib53","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3109\/02713688609015133","article-title":"Contribution of plasma proteins to the vitreous of the rat","volume":"5","author":"Hawkins","year":"1986","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib54","doi-asserted-by":"crossref","first-page":"8175","DOI":"10.1073\/pnas.93.16.8175","article-title":"Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress","volume":"93","author":"Hentze","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib55","first-page":"110","article-title":"Iron chelation therapy","volume":"4","author":"Hershko","year":"2005","journal-title":"Curr. Hematol. Rep."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib56","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/jcp.1041520114","article-title":"Release of iron by human retinal pigment epithelial cells","volume":"152","author":"Hunt","year":"1992","journal-title":"J. Cell. Physiol."},{"issue":"Part 4","key":"10.1016\/j.preteyeres.2007.07.004_bib57","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1242\/jcs.92.4.655","article-title":"Transferrin receptors on the surfaces of retinal pigment epithelial cells are associated with the cytoskeleton","volume":"92","author":"Hunt","year":"1989","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib58","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/(SICI)1097-4652(199607)168:1<71::AID-JCP9>3.0.CO;2-5","article-title":"Hemopexin in the human retina: protection of the retina against heme-mediated toxicity","volume":"168","author":"Hunt","year":"1996","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib59","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1006\/abbi.1995.1116","article-title":"Hemoglobin-induced lipid peroxidation in the retina: a possible mechanism for macular degeneration","volume":"316","author":"Ito","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib60","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1073\/pnas.95.9.4924","article-title":"Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins","volume":"95","author":"Iwai","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib61","doi-asserted-by":"crossref","first-page":"27144","DOI":"10.1074\/jbc.M301988200","article-title":"Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system","volume":"278","author":"Jeong","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib62","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1124\/pr.57.4.2","article-title":"The evolution of iron chelators for the treatment of iron overload disease and cancer","volume":"57","author":"Kalinowski","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib63","first-page":"182","article-title":"The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity","volume":"36","author":"Klein","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib64","doi-asserted-by":"crossref","first-page":"163","DOI":"10.14712\/18059694.2019.27","article-title":"A study of potential toxic effects after repeated 10-week administration of a new iron chelator\u2013salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits","volume":"46","author":"Klimtova","year":"2003","journal-title":"Acta Med. (Hradec Kralove)"},{"issue":"Suppl.","key":"10.1016\/j.preteyeres.2007.07.004_bib65","first-page":"4","article-title":"Electroretinography in eyes with retained intraocular metallic foreign bodies","volume":"100","author":"Knave","year":"1969","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib66","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1073\/pnas.0409409102","article-title":"Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin","volume":"102","author":"Knutson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib67","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0887-8994(01)00269-7","article-title":"Iron in the Hallervorden\u2013Spatz syndrome","volume":"25","author":"Koeppen","year":"2001","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib68","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0014-5793(00)01920-7","article-title":"LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity","volume":"480","author":"Krause","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib69","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/hmg\/ddi005","article-title":"Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia","volume":"14","author":"Kuo","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib70","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1006\/exer.1994.1129","article-title":"Transferrin, one of the major vitreous proteins, is produced within the eye","volume":"59","author":"Laicine","year":"1994","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib71","first-page":"640","article-title":"Intravenous infusion pharmacokinetics of desferrioxamine in thalassaemic patients","volume":"21","author":"Lee","year":"1993","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib72","first-page":"335","article-title":"The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973\u20131975","volume":"24","author":"Leibowitz","year":"1980","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib73","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1006\/jmbi.1994.1325","article-title":"The role of the L-chain in ferritin iron incorporation. Studies of homo and heteropolymers","volume":"238","author":"Levi","year":"1994","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib74","doi-asserted-by":"crossref","first-page":"24437","DOI":"10.1074\/jbc.C100141200","article-title":"A human mitochondrial ferritin encoded by an intronless gene","volume":"276","author":"Levi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib75","first-page":"157","article-title":"Expression of ceruloplasmin in the retina: induction after optic nerve crush","volume":"39","author":"Levin","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib76","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/jnr.490260415","article-title":"Iron-enriched oligodendrocytes: a reexamination of their spatial distribution","volume":"26","author":"LeVine","year":"1990","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib77","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.exer.2003.10.016","article-title":"Cluster analysis of genes with significant change in expression in cells conditioned to survive TBOOH","volume":"78","author":"Li","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib78","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.preteyeres.2004.08.004","article-title":"Nuclear ferritin in corneal epithelial cells: tissue-specific nuclear transport and protection from UV-damage","volume":"24","author":"Linsenmayer","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib79","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/med.1027","article-title":"Design of clinically useful iron(III)-selective chelators","volume":"22","author":"Liu","year":"2002","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib80","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0002-9394(14)78308-4","article-title":"Ocular clinicopathologic correlation of Hallervorden\u2013Spatz syndrome with acanthocytosis and pigmentary retinopathy","volume":"95","author":"Luckenbach","year":"1983","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib81","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1167\/iovs.06-0026","article-title":"Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium","volume":"47","author":"Martin","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib82","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/0002-9394(72)90826-4","article-title":"Experimental ocular siderosis in the squirrel monkey","volume":"74","author":"Masciulli","year":"1972","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib83","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0047-6374(85)90020-X","article-title":"Iron accumulation during development and ageing of Drosophila","volume":"29","author":"Massie","year":"1985","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib84","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0047-6374(93)90001-8","article-title":"Inhibition of iron absorption prolongs the life span of Drosophila","volume":"67","author":"Massie","year":"1993","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib85","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1042\/cs0710071","article-title":"Lactulose, 51Cr-labelled ethylenediaminetetra-acetate, l-rhamnose and polyethyleneglycol 400 [corrected] as probe markers for assessment in vivo of human intestinal permeability","volume":"71","author":"Maxton","year":"1986","journal-title":"Clin. Sci. (London)"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib86","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3109\/02713688609015131","article-title":"Antioxidant activity of aqueous and vitreous humor from the inflamed rabbit eye","volume":"5","author":"McGahan","year":"1986","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib87","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1006\/exer.1994.1140","article-title":"Regulation of ferritin levels in cultured lens epithelial cells","volume":"59","author":"McGahan","year":"1994","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib88","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0014-4835(05)80008-9","article-title":"Transferrin secretion by lens epithelial cells in culture","volume":"60","author":"McGahan","year":"1995","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib89","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1097-2765(00)80425-6","article-title":"A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation","volume":"5","author":"McKie","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib90","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1167\/iovs.02-1032","article-title":"Gene microarray analysis of experimental glaucomatous retina from cynomologous monkey","volume":"44","author":"Miyahara","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib91","doi-asserted-by":"crossref","first-page":"12413","DOI":"10.1073\/pnas.0503460102","article-title":"RPE65 is the isomerohydrolase in the retinoid visual cycle","volume":"102","author":"Moiseyev","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib92","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000147312","article-title":"Histochemical distribution of non-haem iron in the human brain","volume":"144","author":"Morris","year":"1992","journal-title":"Acta Anat. (Basel)"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib93","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.nutr.26.061505.111303","article-title":"Regulation of iron metabolism by hepcidin","volume":"26","author":"Nemeth","year":"2006","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib94","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib95","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0002-9394(79)90648-2","article-title":"Pigmentary degeneration of the retina in the Hallervorden\u2013Spatz syndrome","volume":"88","author":"Newell","year":"1979","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib96","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1073\/pnas.151179498","article-title":"Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice","volume":"98","author":"Nicolas","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib97","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1073\/pnas.072632499","article-title":"Severe iron deficiency anemia in transgenic mice expressing liver hepcidin","volume":"99","author":"Nicolas","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib98","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1172\/JCI0215686","article-title":"The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation","volume":"110","author":"Nicolas","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib99","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJM198604033141402","article-title":"Visual and auditory neurotoxicity in patients receiving subcutaneous deferoxamine infusions","volume":"314","author":"Olivieri","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib100","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1016\/S0021-9258(18)99669-9","article-title":"Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)","volume":"241","author":"Osaki","year":"1966","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib101","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1016\/S0021-9258(18)96527-0","article-title":"The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum","volume":"241","author":"Osaki","year":"1966","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib102","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1074\/jbc.M008922200","article-title":"Hepcidin, a urinary antimicrobial peptide synthesized in the liver","volume":"276","author":"Park","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib103","doi-asserted-by":"crossref","first-page":"20185","DOI":"10.1074\/jbc.272.32.20185","article-title":"A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes","volume":"272","author":"Patel","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib104","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1074\/jbc.275.6.4305","article-title":"Alternative RNA splicing generates a glycosylphosphatidylinositol-anchored form of ceruloplasmin in mammalian brain","volume":"275","author":"Patel","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib105","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1523\/JNEUROSCI.22-15-06578.2002","article-title":"Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury","volume":"22","author":"Patel","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib106","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bcmd.2003.08.003","article-title":"The ferroportin disease","volume":"32","author":"Pietrangelo","year":"2004","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib107","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1055\/s-2005-923316","article-title":"Non-HFE hemochromatosis","volume":"25","author":"Pietrangelo","year":"2005","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib108","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbamcr.2006.05.013","article-title":"Hereditary hemochromatosis","volume":"1763","author":"Pietrangelo","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib109","first-page":"5a","article-title":"Phase II study of oral chelator ICL670 in thalassemia patients with transfusional iron overload: efficacy, safety pharmacokinetics and pharmacokinetics and pharmacodynamics after 6 months of therapy [abstract]","volume":"100","author":"Piga","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib110","doi-asserted-by":"crossref","first-page":"7811","DOI":"10.1074\/jbc.M008923200","article-title":"A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload","volume":"276","author":"Pigeon","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib111","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0950-3536(89)80020-4","article-title":"Desferrioxamine-induced iron excretion in humans","volume":"2","author":"Pippard","year":"1989","journal-title":"Baillieres Clin. Haematol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib112","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archopht.125.2.273","article-title":"Catastrophic visual loss in a patient with Friedreich ataxia","volume":"125","author":"Porter","year":"2007","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib113","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1073\/pnas.94.20.10919","article-title":"Heme oxygenase 1 is required for mammalian iron reutilization","volume":"94","author":"Poss","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib114","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1196\/annals.1306.026","article-title":"Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions","volume":"1012","author":"Richardson","year":"2004","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0020-1693(00)80471-5","article-title":"Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Part I. Ionization characteristics of the ligands and their relevance to biological properties","volume":"170","author":"Richardson","year":"1990","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib116","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1167\/iovs.06-0528","article-title":"Differential sensitivity of cones to iron-mediated oxidative damage","volume":"48","author":"Rogers","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib117","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/ajcn\/68.3.683","article-title":"Evidence of altered central nervous system development in infants with iron deficiency anemia at 6mo: delayed maturation of auditory brainstem responses","volume":"68","author":"Roncagliolo","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib118","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/archopht.1972.01000020509003","article-title":"Ocular pathologic changes in primary hemochromatosis","volume":"87","author":"Roth","year":"1972","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib119","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/bcmd.2002.0571","article-title":"Post-transcriptional regulation of human iron metabolism by iron regulatory proteins","volume":"29","author":"Rouault","year":"2002","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib120","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.spen.2006.08.002","article-title":"Brain iron metabolism","volume":"13","author":"Rouault","year":"2006","journal-title":"Semin. Pediatr. Neurol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib121","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0968-0004(96)10024-4","article-title":"Iron\u2013sulfur clusters as biosensors of oxidants and iron","volume":"21","author":"Rouault","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib122","doi-asserted-by":"crossref","first-page":"44018","DOI":"10.1074\/jbc.M304926200","article-title":"Role of ceruloplasmin in macrophage iron efflux during hypoxia","volume":"278","author":"Sarkar","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib123","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0014-4835(69)80081-3","article-title":"Microsomal electron transport system of bovine retinal pigment epithelium","volume":"8","author":"Schichi","year":"1969","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib124","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0002-9394(00)00718-2","article-title":"Fluorescein angiographic findings in ocular siderosis","volume":"131","author":"Shaikh","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib125","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.yjmcc.2005.05.008","article-title":"SIH\u2014a novel lipophilic iron chelator\u2014protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death","volume":"39","author":"Simunek","year":"2005","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib126","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1016\/S0021-9258(18)92931-5","article-title":"Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH","volume":"266","author":"Sipe","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib127","doi-asserted-by":"crossref","first-page":"9866","DOI":"10.1073\/pnas.94.18.9866","article-title":"Iron accumulation in Alzheimer disease is a source of redox-generated free radicals","volume":"94","author":"Smith","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib128","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1001\/archopht.1988.01060140143041","article-title":"Ocular siderosis","volume":"106","author":"Sneed","year":"1988","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib129","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.lab.2004.10.006","article-title":"Is stored iron safe?","volume":"144","author":"Sullivan","year":"2004","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib130","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0161-6420(85)34090-3","article-title":"Ultrastructural studies of cornea, iris and lens in a case of siderosis bulbi","volume":"92","author":"Talamo","year":"1985","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib131","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0140-6736(92)90598-W","article-title":"Pulmonary toxic effects of continuous desferrioxamine administration in acute iron poisoning","volume":"339","author":"Tenenbein","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib132","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0161-6420(86)33681-9","article-title":"Visual results and prognostic factors for vision following surgery for stage V retinopathy of prematurity","volume":"93","author":"Trese","year":"1986","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib133","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0014-4835(90)90016-N","article-title":"Aqueous humor of cat contains fibroblast growth factor and transferrin similar to those in man","volume":"50","author":"Tripathi","year":"1990","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib134","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1345\/aph.1G566","article-title":"Deferasirox\u2014an oral agent for chronic iron overload","volume":"40","author":"Vanorden","year":"2006","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib135","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000463202","article-title":"Binding of iron to the 5th component of human complement directs oxygen radical-mediated conversion to specific sites and causes nonenzymic activation","volume":"8","author":"Vogi","year":"1991","journal-title":"Complement Inflamm."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib136","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/5979","article-title":"Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the Sla mouse","volume":"21","author":"Vulpe","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib137","series-title":"Topics in Neurochemistry and Neuropharmacology","first-page":"25","article-title":"Iron-dependent enzymes in the brain","author":"Wigglesworth","year":"1988"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib138","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000027251","article-title":"Retinal degeneration in hereditary ceruloplasmin deficiency","volume":"212","author":"Yamaguchi","year":"1998","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib139","doi-asserted-by":"crossref","first-page":"L932","DOI":"10.1152\/ajplung.00114.2002","article-title":"Iron increases expression of iron-export protein MTP1 in lung cells","volume":"283","author":"Yang","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib140","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.ne.12.030189.001445","article-title":"Cyclic GMP-activated conductance of retinal photoreceptor cells","volume":"12","author":"Yau","year":"1989","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib141","first-page":"2343","article-title":"Iron, ferritin, transferrin, and transferrin receptor in the adult rat retina","volume":"41","author":"Yefimova","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib142","first-page":"537","article-title":"Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats","volume":"43","author":"Yefimova","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib143","series-title":"Brain, Behavior, and Iron in the Infant Diet","first-page":"83","article-title":"Neuropharmacological and neurobiochemical aspects of iron deficiency","author":"Youdim","year":"1990"},{"key":"10.1016\/j.preteyeres.2007.07.004_bib144","article-title":"Deferoxamine reduced retinal toxicity from subretinal blood","volume":"43","author":"Youssef","year":"2002","journal-title":"Invest. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib145","first-page":"268","article-title":"Quantitative study of characteristic aqueous humor transferrin, serum transferrin and desialized serum transferrin in aqueous humor","volume":"32","author":"Yu","year":"1988","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib146","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1001\/archopht.122.4.598","article-title":"Current concepts in the pathogenesis of age-related macular degeneration","volume":"122","author":"Zarbin","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib147","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bmc.2004.10.037","article-title":"Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases","volume":"13","author":"Zheng","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.preteyeres.2007.07.004_bib148","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng572","article-title":"A novel pantothenate kinase gene (PANK2) is defective in Hallervorden\u2013Spatz syndrome","volume":"28","author":"Zhou","year":"2001","journal-title":"Nat. Genet."}],"container-title":["Progress in Retinal and Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946207000547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946207000547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T18:39:51Z","timestamp":1629571191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350946207000547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":148,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S1350946207000547"],"URL":"https:\/\/doi.org\/10.1016\/j.preteyeres.2007.07.004","relation":{},"ISSN":["1350-9462"],"issn-type":[{"value":"1350-9462","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}