{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T02:06:48Z","timestamp":1794103608095,"version":"4.8.0"},"reference-count":271,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Retinal and Eye Research"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.preteyeres.2009.06.001","type":"journal-article","created":{"date-parts":[[2009,6,27]],"date-time":"2009-06-27T04:57:52Z","timestamp":1246078672000},"page":"348-368","source":"Crossref","is-referenced-by-count":568,"title":["Para-inflammation in the aging retina"],"prefix":"10.1016","volume":"28","author":[{"given":"Heping","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V.","family":"Forrester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preteyeres.2009.06.001_bib1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0002-9394(01)01127-8","article-title":"Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus","volume":"132","author":"Abu El-Asrar","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib2","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1073\/pnas.97.10.5450","article-title":"Molecular basis for a link between complement and the vascular complications of diabetes","volume":"97","author":"Acosta","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00281-008-0111-x","article-title":"Immunological mechanisms in the pathogenesis of diabetic retinopathy","volume":"30","author":"Adamis","year":"2008","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.crvi.2004.04.002","article-title":"Functions of toll-like receptors: lessons from KO mice","volume":"327","author":"Akira","year":"2004","journal-title":"C.R. Biol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9394(02)01624-0","article-title":"A role for local inflammation in the formation of drusen in the aging eye","volume":"134","author":"Anderson","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.exer.2003.10.011","article-title":"Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration","volume":"78","author":"Anderson","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3109\/08820539909069543","article-title":"Molecular mechanisms of vascular permeability in diabetic retinopathy","volume":"14","author":"Antonetti","year":"1999","journal-title":"Semin. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ejphar.2004.07.046","article-title":"Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas","volume":"498","author":"Ayalasomayajula","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1749-6632.1999.tb07640.x","article-title":"Expression of chemokine receptors in the rat brain","volume":"876","author":"Bajetto","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/cne.20729","article-title":"Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1\/CCL2 on calcium mobilization in primary cultured neurons","volume":"492","author":"Banisadr","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib11","doi-asserted-by":"crossref","first-page":"758","DOI":"10.2174\/156652407783220778","article-title":"RAGE and its ligands in retinal disease","volume":"7","author":"Barile","year":"2007","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib12","first-page":"1153","article-title":"Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes","volume":"41","author":"Barouch","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib13","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1085536","article-title":"Toll-like receptor signaling pathways","volume":"300","author":"Barton","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0014-5793(01)03275-6","article-title":"Expression and regulation of the nuclear receptor RORalpha in human vascular cells","volume":"511","author":"Besnard","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-065X.2007.00574.x","article-title":"High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity","volume":"220","author":"Bianchi","year":"2007","journal-title":"Immunol. Rev."},{"issue":"Pt 6","key":"10.1016\/j.preteyeres.2009.06.001_bib16","first-page":"674","article-title":"Retinal pigment epithelial detachments in the elderly","volume":"105","author":"Bird","year":"1986","journal-title":"Trans. Ophthalmol. Soc. U. K."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib17","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.molimm.2006.03.007","article-title":"Role of complement in neurodegeneration and neuroinflammation","volume":"44","author":"Bonifati","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib18","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.4049\/jimmunol.178.3.1783","article-title":"CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration","volume":"178","author":"Bora","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.4049\/jimmunol.174.1.491","article-title":"Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization","volume":"174","author":"Bora","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib20","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1167\/iovs.07-1337","article-title":"Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA\/2J mouse model of glaucoma","volume":"49","author":"Bosco","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1350-9462(99)00009-9","article-title":"Oxidative damage and protection of the RPE","volume":"19","author":"Cai","year":"2000","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/187152806779010936","article-title":"Hyaluronan: the Jekyll and Hyde molecule","volume":"5","author":"Cantor","year":"2006","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib23","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1006\/niox.2000.0312","article-title":"Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood\u2013retinal barrier permeability","volume":"4","author":"Carmo","year":"2000","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/01.RES.83.3.279","article-title":"Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats","volume":"83","author":"Cernadas","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/10739680601073451","article-title":"Inflammation and breakdown of the blood\u2013retinal barrier during \u201cphysiological aging\u201d in the rat retina: a model for CNS aging","volume":"14","author":"Chan-Ling","year":"2007","journal-title":"Microcirculation"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib26","doi-asserted-by":"crossref","first-page":"e2339","DOI":"10.1371\/journal.pone.0002339","article-title":"The aged retinal pigment epithelium\/choroid: a potential substratum for the pathogenesis of age-related macular degeneration","volume":"3","author":"Chen","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib28","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.exer.2008.09.005","article-title":"Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina","volume":"87","author":"Chen","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib27","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.exer.2006.11.015","article-title":"Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments","volume":"84","author":"Chen","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0304-3940(02)00804-2","article-title":"Nitric oxide synthase expression in the transient ischemic rat retina: neuroprotection of betaxolol","volume":"330","author":"Cheon","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib30","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1442-9071.2006.01281.x","article-title":"Retinal autoantibody profile in early age-related macular degeneration: preliminary findings from the Blue Mountains Eye Study","volume":"34","author":"Cherepanoff","year":"2006","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2217\/14796708.3.3.309","article-title":"Autophagy in neuroprotection and neurodegeneration: a question of balance","volume":"3","author":"Cherra","year":"2008","journal-title":"Future Neurol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib32","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2174\/156652407783220714","article-title":"Receptor for AGE (RAGE): weaving tangled webs within the inflammatory response","volume":"7","author":"Clynes","year":"2007","journal-title":"Curr. Mol. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.preteyeres.2009.06.001_bib33","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.survophthal.2008.08.006","article-title":"Risk factors for glaucoma onset and progression","volume":"53","author":"Coleman","year":"2008","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib34","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1172\/JCI31692","article-title":"CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration","volume":"117","author":"Combadiere","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib35","doi-asserted-by":"crossref","first-page":"580","DOI":"10.2353\/ajpath.2007.070272","article-title":"Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis","volume":"171","author":"Copland","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0002-9440(10)64354-4","article-title":"CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils","volume":"160","author":"Coraci","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0304-3940(01)02191-7","article-title":"Evidence that the HIV-1 coat protein gp120 causes neuronal apoptosis in the neocortex of rat via a mechanism involving CXCR4 chemokine receptor","volume":"312","author":"Corasaniti","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib38","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.amjhyper.2006.06.002","article-title":"Nitric oxide release is impaired in hypertensive individuals with familial history of stroke","volume":"19","author":"Cosentino","year":"2006","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib39","doi-asserted-by":"crossref","first-page":"14682","DOI":"10.1073\/pnas.222551899","article-title":"Drusen proteome analysis: an approach to the etiology of age-related macular degeneration","volume":"99","author":"Crabb","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib40","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.freeradbiomed.2005.01.019","article-title":"Reactive oxygen species and the modulation of stroke","volume":"38","author":"Crack","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib41","first-page":"3278","article-title":"Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina","volume":"34","author":"Curcio","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1172\/JCI7535","article-title":"Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle","volume":"105","author":"Cusi","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib43","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1365-2567.2004.02086.x","article-title":"Glycation of CD59 impairs complement regulation on erythrocytes from diabetic subjects","volume":"114","author":"Davies","year":"2005","journal-title":"Immunology"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib44","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0300-9629(85)90933-8","article-title":"Changes in the macrophage function with aging","volume":"81","author":"De La","year":"1985","journal-title":"Comp. Biochem. Physiol. A"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib45","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/S0024-3205(00)00799-2","article-title":"Effect of aging on the modulation of macrophage functions by neuropeptides","volume":"67","author":"De La","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1189\/jlb.1102535","article-title":"Control of myeloid activity during retinal inflammation","volume":"74","author":"Dick","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib47","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1474-9726.2008.00438.x","article-title":"Aging is associated with greater nuclear NFkappaB, reduced IkappaBalpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans","volume":"7","author":"Donato","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib48","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.0022-3042.2001.00737.x","article-title":"Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine","volume":"80","author":"Du","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib49","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1002\/eji.200526066","article-title":"Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells","volume":"35","author":"Dumitriu","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib50","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.it.2005.04.009","article-title":"HMGB1: guiding immunity from within","volume":"26","author":"Dumitriu","year":"2005","journal-title":"Trends Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib51","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1006\/bbrc.2002.6756","article-title":"Human retinal pigment epithelial cells express scavenger receptors BI and BII","volume":"292","author":"Duncan","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib52","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000103235","article-title":"Distinct functions between toll-like receptors 3 and 9 in retinal pigment epithelial cells","volume":"39","author":"Ebihara","year":"2007","journal-title":"Ophtha. Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib53","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0169-409X(00)00049-1","article-title":"Modulation of epithelial and endothelial paracellular permeability by leukocytes","volume":"41","author":"Edens","year":"2000","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib54","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1110189","article-title":"Complement factor H polymorphism and age-related macular degeneration","volume":"308","author":"Edwards","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib55","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1172\/JCI1112","article-title":"Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine\/paracrine mechanisms involving TGF-beta, PGE2, and PAF","volume":"101","author":"Fadok","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib56","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1042\/bst0260653","article-title":"Regulation of macrophage cytokine production by phagocytosis of apoptotic and post-apoptotic cells","volume":"26","author":"Fadok","year":"1998","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib57","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0006-8993(00)03090-0","article-title":"Increased chemokine gene expression during aging in the murine brain","volume":"890","author":"Felzien","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib58","doi-asserted-by":"crossref","first-page":"20745","DOI":"10.1074\/jbc.M800268200","article-title":"Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8","volume":"283","author":"Fernandes","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib59","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1167\/iovs.07-1363","article-title":"Expression of nitrotyrosine and oxidative consequences in the trabecular meshwork of patients with primary open-angle glaucoma","volume":"49","author":"Fernandez-Durango","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Suppl. 9","key":"10.1016\/j.preteyeres.2009.06.001_bib60","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3109\/02713689008999440","article-title":"Regulation of the local immune response by retinal cells","author":"Forrester","year":"1990","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib61","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/bjo.2004.054197","article-title":"Choroidal dendritic cells require activation to present antigen and resident choroidal macrophages potentiate this response","volume":"89","author":"Forrester","year":"2005","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib62","first-page":"64","article-title":"Localization and characterization of major histocompatibility complex class II-positive cells in the posterior segment of the eye: implications for induction of autoimmune uveoretinitis","volume":"35","author":"Forrester","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib63","first-page":"412","article-title":"Biology of disease: free radicals and tissue injury","volume":"47","author":"Freeman","year":"1982","journal-title":"Lab. Invest."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib64","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/archopht.122.4.564","article-title":"Prevalence of age-related macular degeneration in the United States","volume":"122","author":"Friedman","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib65","first-page":"1","article-title":"Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells","volume":"33","author":"Gao","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib66","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0165-0173(94)00015-H","article-title":"Microglia: intrinsic immuneffector cell of the brain","volume":"20","author":"Gehrmann","year":"1995","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib67","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3109\/13550289909021291","article-title":"Sentries at the gate: chemokines and the blood\u2013brain barrier","volume":"5","author":"Glabinski","year":"1999","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib68","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1167\/iovs.08-1724","article-title":"Advanced glycation end product (AGE) accumulation on Bruch's membrane: links to age-related RPE dysfunction","volume":"50","author":"Glenn","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib69","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib70","doi-asserted-by":"crossref","first-page":"7902","DOI":"10.4049\/jimmunol.181.11.7902","article-title":"Complement receptor of the Ig superfamily enhances complement-mediated phagocytosis in a subpopulation of tissue resident macrophages","volume":"181","author":"Gorgani","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib71","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10384-004-0213-5","article-title":"Contribution of nitric oxide-producing cells in normal and diabetic rat retina","volume":"49","author":"Goto","year":"2005","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib72","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0074-7742(07)82002-2","article-title":"Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins","volume":"82","author":"Griffiths","year":"2007","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib73","doi-asserted-by":"crossref","first-page":"42027","DOI":"10.1074\/jbc.M305460200","article-title":"Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration","volume":"278","author":"Gu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib74","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S0161-6420(91)32252-8","article-title":"Antiretinal antibodies in serum of patients with age-related macular degeneration","volume":"98","author":"Gurne","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib75","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1073\/pnas.0501536102","article-title":"From the cover: a common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration","volume":"102","author":"Hageman","year":"2005","journal-title":"PNAS"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib76","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1126\/science.1110359","article-title":"Complement factor H variant increases the risk of age-related macular degeneration","volume":"308","author":"Haines","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib77","doi-asserted-by":"crossref","first-page":"024012","DOI":"10.1117\/1.2717522","article-title":"Age-related structural abnormalities in the human retina-choroid complex revealed by two-photon excited autofluorescence imaging","volume":"12","author":"Han","year":"2007","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib78","first-page":"775","article-title":"Increase in the advanced glycation end product pentosidine in Bruch's membrane with age","volume":"40","author":"Handa","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib79","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.pathol.1.110304.100100","article-title":"Inflammation and atherosclerosis","volume":"1","author":"Hansson","year":"2006","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib80","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.biocel.2003.08.007","article-title":"Regulation of tight junctions and loss of barrier function in pathophysiology","volume":"36","author":"Harhaj","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib81","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","article-title":"Aging: a theory based on free radical and radiation chemistry","volume":"11","author":"Harman","year":"1956","journal-title":"J. Gerontol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib82","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.1073\/pnas.78.11.7124","article-title":"The aging process","volume":"78","author":"Harman","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Suppl. 3","key":"10.1016\/j.preteyeres.2009.06.001_bib83","doi-asserted-by":"crossref","first-page":"C11","DOI":"10.2337\/diacare.21.3.C11","article-title":"Diabetes in America: epidemiology and scope of the problem","volume":"21","author":"Harris","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib84","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.4049\/jimmunol.159.5.2445","article-title":"Enhanced expression of inducible cyclooxygenase with age in murine macrophages","volume":"159","author":"Hayek","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib85","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/385645a0","article-title":"CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia","volume":"385","author":"He","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib86","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.cell.2005.12.039","article-title":"CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens","volume":"124","author":"Helmy","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib87","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1189\/jlb.1206751","article-title":"Receptor for advanced glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress","volume":"82","author":"Herold","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib88","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0531-5565(01)00205-4","article-title":"Immunosenescence of macrophages: reduced MHC class II gene expression","volume":"37","author":"Herrero","year":"2002","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib89","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1167\/iovs.02-0742","article-title":"Induction of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments","volume":"44","author":"Higgins","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib90","first-page":"2767","article-title":"Hyaluronan and the functional organization of the interphotoreceptor matrix","volume":"40","author":"Hollyfield","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib91","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nm1709","article-title":"Oxidative damage-induced inflammation initiates age-related macular degeneration","volume":"14","author":"Hollyfield","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib92","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/exer.1997.0422","article-title":"Hyaluronan in the interphotoreceptor matrix of the eye: species differences in content, distribution, ligand binding and degradation","volume":"66","author":"Hollyfield","year":"1998","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib93","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-1-4615-0067-4_11","article-title":"Proteomic approaches to understanding age-related macular degeneration","volume":"533","author":"Hollyfield","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib94","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1167\/iovs.04-0404","article-title":"Receptor for advanced glycation end products and age-related macular degeneration","volume":"45","author":"Howes","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib95","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1167\/iovs.02-0824","article-title":"Generation of activated sialoadhesin-positive microglia during retinal degeneration","volume":"44","author":"Hughes","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib96","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0003-9861(92)90431-U","article-title":"Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase","volume":"298","author":"Ischiropoulos","year":"1992","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib97","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1016\/j.molimm.2007.06.145","article-title":"The role of complement system in ocular diseases including uveitis and macular degeneration","volume":"44","author":"Jha","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib98","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1167\/iovs.05-1062","article-title":"The complement system plays a critical role in the development of experimental autoimmune anterior uveitis","volume":"47","author":"Jha","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib99","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm1315","article-title":"Regulation of lung injury and repair by Toll-like receptors and hyaluronan","volume":"11","author":"Jiang","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib100","first-page":"3347","article-title":"Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts","volume":"34","author":"Jiang","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib101","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.immuni.2008.07.007","article-title":"Structures of the toll-like receptor family and its ligand complexes","volume":"29","author":"Jin","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib102","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1076\/ceyr.18.2.79.5386","article-title":"Increased vasodilatory prostaglandin production in the diabetic rat retinal vasculature","volume":"18","author":"Johnson","year":"1999","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib103","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0002-9440(10)63952-1","article-title":"Leukocyte-mediated endothelial cell injury and death in the diabetic retina","volume":"158","author":"Joussen","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib104","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0002-9440(10)64869-9","article-title":"Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo","volume":"160","author":"Joussen","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib105","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1097\/00001756-200112210-00043","article-title":"Sodium nitroprusside selectively induces apoptotic cell death in the outer retina of the rat","volume":"12","author":"Ju","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib106","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by Toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib107","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.smim.2006.12.004","article-title":"TLR signaling","volume":"19","author":"Kawai","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib108","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1172\/JCI32430","article-title":"Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice","volume":"117","author":"Kelly","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib109","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1167\/iovs.07-0953","article-title":"Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye","volume":"49","author":"Kezic","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib110","first-page":"285","article-title":"Effect of aging on the tumoricidal functions of murine peritoneal macrophages","volume":"15","author":"Khare","year":"1996","journal-title":"Nat. Immun."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib111","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1167\/iovs.07-1607","article-title":"Mitochondrial oxidative DNA damage in experimental autoimmune uveitis","volume":"49","author":"Khurana","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib112","doi-asserted-by":"crossref","DOI":"10.1007\/s00417-009-1049-y","article-title":"Regulated secretion of complement factor H by RPE and its role in RPE migration","author":"Kim","year":"2009","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib113","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1902\/jop.2008.080246","article-title":"The role of inflammatory cytokines in diabetes and its complications","volume":"79","author":"King","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib114","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1093\/nar\/21.10.2473","article-title":"\u2018Footprinting\u2019 proteins on DNA with peroxonitrous acid","volume":"21","author":"King","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000163938","article-title":"Comparative studies on vascular endothelium in vitro. 3. Effects of cytokines on the expression of E-selectin, ICAM-1 and VCAM-1 by cultured human endothelial cells obtained from different passages","volume":"63","author":"Klein","year":"1995","journal-title":"Pathobiology"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib116","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib117","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ajo.2003.11.069","article-title":"The epidemiology of age-related macular degeneration","volume":"137","author":"Klein","year":"2004","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib118","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nri2215","article-title":"How dying cells alert the immune system to danger","volume":"8","author":"Kono","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib119","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1136\/bjo.2003.038133","article-title":"Role of interleukin-1beta in the pathogenesis of diabetic retinopathy","volume":"88","author":"Kowluru","year":"2004","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib120","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.2337\/diabetes.54.5.1559","article-title":"Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy","volume":"54","author":"Krady","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib121","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1074\/jbc.274.6.3734","article-title":"Photo-oxidative stress down-modulates the activity of nuclear factor-kappaB via involvement of caspase-1, leading to apoptosis of photoreceptor cells","volume":"274","author":"Krishnamoorthy","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib122","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.exer.2006.03.002","article-title":"Retinal synthesis and deposition of complement components induced by ocular hypertension","volume":"83","author":"Kuehn","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib123","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jneuroim.2004.04.018","article-title":"Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells","volume":"153","author":"Kumar","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib124","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.brainresrev.2004.12.009","article-title":"Microglial cell population dynamics in the injured adult central nervous system","volume":"48","author":"Ladeby","year":"2005","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib125","first-page":"1035","article-title":"CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons","volume":"151","author":"Lavi","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib126","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1167\/iovs.07-0112","article-title":"Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood\u2013retinal barrier breakdown in diabetic retinopathy","volume":"48","author":"Leal","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib127","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.brainres.2007.10.073","article-title":"Oxidative-induced apoptosis to an immortalized ganglion cell line is caspase independent but involves the activation of poly(ADP-ribose)polymerase and apoptosis-inducing factor","volume":"1188","author":"Li","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib128","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0002-9440(10)64913-9","article-title":"Nitric oxide mediates apoptosis through formation of peroxynitrite and Fas\/Fas-ligand interactions in experimental autoimmune uveitis","volume":"160","author":"Liversidge","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib129","first-page":"404","article-title":"Rat retinal pigment epithelial cells express an inducible form of nitric oxide synthase and produce nitric oxide in response to inflammatory cytokines and activated T cells","volume":"83","author":"Liversidge","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib130","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1006\/cimm.1993.1158","article-title":"Retinal pigment epithelial cells modulate lymphocyte function at the blood\u2013retina barrier by autocrine PGE2 and membrane-bound mechanisms","volume":"149","author":"Liversidge","year":"1993","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib131","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0531-5565(02)00125-0","article-title":"Effect of aging on macrophage function","volume":"37","author":"Lloberas","year":"2002","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib132","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/glia.20678","article-title":"Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity","volume":"56","author":"Lopes","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib133","first-page":"2384","article-title":"Contribution of microglia as passenger leukocytes to the fate of intraocular neuronal retinal grafts","volume":"39","author":"Ma","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib134","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.4049\/jimmunol.162.8.4482","article-title":"T cell immunity induced by allogeneic microglia in relation to neuronal retina transplantation","volume":"162","author":"Ma","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib135","doi-asserted-by":"crossref","first-page":"G367","DOI":"10.1152\/ajpgi.00173.2003","article-title":"TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation","volume":"286","author":"Ma","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib136","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.preteyeres.2004.05.001","article-title":"Do blue light filters confer protection against age-related macular degeneration?","volume":"23","author":"Margrain","year":"2004","journal-title":"Prog. Retin. Eye Res."},{"issue":"Suppl. 1","key":"10.1016\/j.preteyeres.2009.06.001_bib137","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neurobiolaging.2005.08.008","article-title":"Inflammation, the complement system and the diseases of aging","volume":"26","author":"McGeer","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib138","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1196\/annals.1332.007","article-title":"Inflammation and the degenerative diseases of aging","volume":"1035","author":"McGeer","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib139","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1172\/JCI119054","article-title":"Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44","volume":"98","author":"McKee","year":"1996","journal-title":"J. Clin. Invest."},{"issue":"Pt 2","key":"10.1016\/j.preteyeres.2009.06.001_bib140","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/eye.1997.49","article-title":"The distribution of immune cells in the uveal tract of the normal eye","volume":"11","author":"McMenamin","year":"1997","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib141","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/bjo.83.5.598","article-title":"Dendritic cells and macrophages in the uveal tract of the normal mouse eye","volume":"83","author":"McMenamin","year":"1999","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib142","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s004290050303","article-title":"Subretinal macrophages in the developing eye of eutherian mammals and marsupials","volume":"200","author":"McMenamin","year":"1999","journal-title":"Anat. Embryol. (Berl.)"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib143","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/ar.1092270213","article-title":"Cells resembling intraventricular macrophages are present in the subretinal space of human foetal eyes","volume":"227","author":"McMenamin","year":"1990","journal-title":"Anat. Rec."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib144","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib145","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1034\/j.1600-065X.2000.917309.x","article-title":"Innate immune recognition: mechanisms and pathways","volume":"173","author":"Medzhitov","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib146","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0966-842X(00)01845-X","article-title":"The Toll receptor family and microbial recognition","volume":"8","author":"Medzhitov","year":"2000","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib147","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/smim.2000.0230","article-title":"How does the immune system distinguish self from nonself?","volume":"12","author":"Medzhitov","year":"2000","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib148","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.1068883","article-title":"Decoding the patterns of self and nonself by the innate immune system","volume":"296","author":"Medzhitov","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib149","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib150","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/IJG.0b013e318188b21f","article-title":"Oxidative stress and open angle glaucoma: is oxidative stress a mechanism for glaucomatous damage or a by-product of topical antiglaucoma medication?","volume":"17","author":"Mehdizadeh","year":"2008","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib151","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1749-6632.2000.tb05615.x","article-title":"Opsonization of apoptotic cells. Implications for uptake and autoimmunity","volume":"926","author":"Mevorach","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib152","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1084\/jem.188.12.2313","article-title":"Complement-dependent clearance of apoptotic cells by human macrophages","volume":"188","author":"Mevorach","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib153","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2006.12.002","article-title":"Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors","volume":"19","author":"Miyake","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib154","first-page":"2190","article-title":"In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats","volume":"39","author":"Miyamoto","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib155","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1172\/JCI118889","article-title":"The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis","volume":"98","author":"Miyata","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib156","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/IAE.0b013e31802e3e9b","article-title":"Role of genetic factors and inflammation in age-related macular degeneration","volume":"27","author":"Moshfeghi","year":"2007","journal-title":"Retina"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib157","first-page":"224","article-title":"Oxygen and blood flow: players in the pathogenesis of glaucoma","volume":"14","author":"Mozaffarieh","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib158","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neurobiolaging.2004.05.010","article-title":"Glia and their cytokines in progression of neurodegeneration","volume":"26","author":"Mrak","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib159","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1096\/fasebj.14.7.835","article-title":"Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease","volume":"14","author":"Mullins","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib160","first-page":"2962","article-title":"Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma","volume":"43","author":"Naskar","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib161","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3109\/02713688409000813","article-title":"Arachidonic acid metabolism by retinas of rats with streptozotocin-induced diabetes","volume":"3","author":"Naveh-Floman","year":"1984","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib162","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1001\/archopht.117.8.1050","article-title":"Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma","volume":"117","author":"Neufeld","year":"1999","journal-title":"Arch. Ophthalmol."},{"issue":"Suppl. 1","key":"10.1016\/j.preteyeres.2009.06.001_bib163","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1016\/S0039-6257(99)00010-7","article-title":"Nitric oxide: a potential mediator of retinal ganglion cell damage in glaucoma","volume":"43","author":"Neufeld","year":"1999","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib164","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3109\/02713688709025231","article-title":"Bruch's membrane age-related changes vary by region","volume":"6","author":"Newsome","year":"1987","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib165","first-page":"3301","article-title":"Light-induced migration of retinal microglia into the subretinal space","volume":"42","author":"Ng","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib166","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1084\/jem.183.5.2373","article-title":"Hyaluronan fragments activate an NF-kappa B\/I-kappa B alpha autoregulatory loop in murine macrophages","volume":"183","author":"Noble","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib167","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1189\/jlb.1004623","article-title":"Autoantigens act as tissue-specific chemoattractants","volume":"77","author":"Oppenheim","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib168","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.preteyeres.2003.12.001","article-title":"Retinal ischemia: mechanisms of damage and potential therapeutic strategies","volume":"23","author":"Osborne","year":"2004","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib169","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1167\/iovs.04-0147","article-title":"Metipranolol blunts nitric oxide-induced lipid peroxidation and death of retinal photoreceptors: a comparison with other anti-glaucoma drugs","volume":"45","author":"Osborne","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib170","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2174\/138161207780487566","article-title":"Restoring the dysfunctional endothelium","volume":"13","author":"Osto","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib171","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000268006","article-title":"Monocyte-macrophage differentiation induced by coculture of retinal pigment epithelium cells with monocytes","volume":"29","author":"Osusky","year":"1997","journal-title":"Ophthal. Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib172","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000267988","article-title":"Retinal pigment epithelium cells promote the maturation of monocytes to macrophages in vitro","volume":"29","author":"Osusky","year":"1997","journal-title":"Ophthal. Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib173","doi-asserted-by":"crossref","first-page":"C917","DOI":"10.1152\/ajpcell.00401.2005","article-title":"High mobility group box 1 protein interacts with multiple Toll-like receptors","volume":"290","author":"Park","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib174","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1016\/j.visres.2007.07.011","article-title":"Expression of neuronal nitric oxide synthase in the retina of a rat model of chronic glaucoma","volume":"47","author":"Park","year":"2007","journal-title":"Vis. Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib175","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00281-008-0112-9","article-title":"Immunopathological aspects of age-related macular degeneration","volume":"30","author":"Patel","year":"2008","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib176","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1365-2567.2005.02173.x","article-title":"Circulating anti-retinal antibodies as immune markers in age-related macular degeneration","volume":"115","author":"Patel","year":"2005","journal-title":"Immunology"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib177","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1350-9462(00)00025-2","article-title":"Immunological and aetiological aspects of macular degeneration","volume":"20","author":"Penfold","year":"2001","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib178","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/BF00920033","article-title":"Autoantibodies to retinal astrocytes associated with age-related macular degeneration","volume":"228","author":"Penfold","year":"1990","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib179","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1474-9728.2004.00102.x","article-title":"Innate immunity in aging: impact on macrophage function","volume":"3","author":"Plowden","year":"2004","journal-title":"Aging Cell"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib180","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1172\/JCI0213776","article-title":"Acute intensive insulin therapy exacerbates diabetic blood\u2013retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF","volume":"109","author":"Poulaki","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib181","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.2337\/diabetes.53.10.2653","article-title":"Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes","volume":"53","author":"Qin","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib182","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib183","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0003-9861(91)90224-7","article-title":"Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide","volume":"288","author":"Radi","year":"1991","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib184","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/abbi.1994.1013","article-title":"Inhibition of mitochondrial electron transport by peroxynitrite","volume":"308","author":"Radi","year":"1994","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib185","doi-asserted-by":"crossref","first-page":"9580","DOI":"10.1073\/pnas.92.21.9580","article-title":"The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68","volume":"92","author":"Ramprasad","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib186","first-page":"2857","article-title":"Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging","volume":"35","author":"Ramrattan","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib187","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1080\/10715760600911303","article-title":"Theories of biological aging: genes, proteins, and free radicals","volume":"40","author":"Rattan","year":"2006","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib188","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.169.9.4697","article-title":"Cutting edge: impaired Toll-like receptor expression and function in aging","volume":"169","author":"Renshaw","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib189","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000071710","article-title":"Circulating vascular cell adhesion molecules VCAM-1, ICAM-1, and E-selectin in dependence on aging","volume":"49","author":"Richter","year":"2003","journal-title":"Gerontology"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib190","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1073\/pnas.95.2.588","article-title":"A family of human receptors structurally related to Drosophila Toll","volume":"95","author":"Rock","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib191","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.pathmechdis.3.121806.151456","article-title":"The inflammatory response to cell death","volume":"3","author":"Rock","year":"2008","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib192","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000099293","article-title":"Inflammation in dry age-related macular degeneration","volume":"221","author":"Rodrigues","year":"2007","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib193","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1167\/iovs.07-0282","article-title":"Eliminating complement factor D reduces photoreceptor susceptibility to light-induced damage","volume":"48","author":"Rohrer","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib194","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1167\/iovs.08-2222","article-title":"A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration","volume":"50","author":"Rohrer","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib195","first-page":"1971","article-title":"Glial reactivity, an early feature of diabetic retinopathy","volume":"41","author":"Rungger-Brandle","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib196","first-page":"183","article-title":"Acute inflammation. A review","volume":"86","author":"Ryan","year":"1977","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib197","doi-asserted-by":"crossref","first-page":"20536","DOI":"10.1074\/jbc.271.34.20536","article-title":"Binding of anionic phospholipids to retinal pigment epithelium may be mediated by the scavenger receptor CD36","volume":"271","author":"Ryeom","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib198","doi-asserted-by":"crossref","first-page":"39268","DOI":"10.1074\/jbc.M402202200","article-title":"Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6","volume":"279","author":"Sanvicens","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib199","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1167\/iovs.07-1355","article-title":"Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure","volume":"49","author":"Sappington","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib200","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000119869","article-title":"Photoreceptor mitochondrial oxidative stress in experimental autoimmune uveitis","volume":"40","author":"Saraswathy","year":"2008","journal-title":"Ophthalmic Res."},{"issue":"Suppl. 2","key":"10.1016\/j.preteyeres.2009.06.001_bib201","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/00005344-200111002-00002","article-title":"A critical review of the role of endothelial factors in the pathogenesis of hypertension","volume":"38","author":"Schiffrin","year":"2001","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib202","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1073\/pnas.91.19.8807","article-title":"Receptor for advanced glycation end products (AGEs) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins","volume":"91","author":"Schmidt","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib203","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1172\/JCI118175","article-title":"Advanced glycation end products interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes","volume":"96","author":"Schmidt","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib204","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1172\/JCI200114002","article-title":"The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses","volume":"108","author":"Schmidt","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib205","doi-asserted-by":"crossref","first-page":"e2593","DOI":"10.1371\/journal.pone.0002593","article-title":"Systemic complement activation in age-related macular degeneration","volume":"3","author":"Scholl","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib206","first-page":"81","article-title":"Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy","volume":"139","author":"Schroder","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib270","unstructured":"Serra, A.M., Waddell, J.M., Cotter, M.A., Xu, H., Forrester, J.F., 2007. Entrapment of CD11b positive monocyte in diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 48: E-abstract 4986."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib207","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.pneurobio.2003.08.001","article-title":"Yin and Yang: complement activation and regulation in Alzheimer's disease","volume":"70","author":"Shen","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib208","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1046\/j.1365-2990.1998.00122.x","article-title":"Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer's disease","volume":"24","author":"Sheng","year":"1998","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib209","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s004010050792","article-title":"Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain","volume":"95","author":"Sheng","year":"1998","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib210","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/eye.2008.206","article-title":"Macrophages in neovascular age-related macular degeneration: friends or foes?","volume":"23","author":"Skeie","year":"2008","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib211","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000099261","article-title":"Complement, innate immunity and ocular disease","volume":"92","author":"Sohn","year":"2007","journal-title":"Chem. Immunol. Allergy"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib212","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.freeradbiomed.2006.03.013","article-title":"Peroxyl radicals: inductors of neurodegenerative and other inflammatory diseases. Their origin and how they transform cholesterol, phospholipids, plasmalogens, polyunsaturated fatty acids, sugars, and proteins into deleterious products","volume":"41","author":"Spiteller","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib213","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1021\/tx960133r","article-title":"Reactive oxygen-mediated protein oxidation in aging and disease","volume":"10","author":"Stadtman","year":"1997","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib214","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1242\/jcs.00755","article-title":"Potential role of MCP-1 in endothelial cell tight junction \u2018opening\u2019: signaling via Rho and Rho kinase","volume":"116","author":"Stamatovic","year":"2003","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib215","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1167\/iovs.05-0830","article-title":"Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes","volume":"47","author":"Stasi","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib216","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/gerona\/63.2.135","article-title":"Normal aging involves altered expression of growth factors in the rat choroid","volume":"63","author":"Steinle","year":"2008","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib217","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/gerona\/gln052","article-title":"Normal aging involves modulation of specific inflammatory markers in the rat retina and choroid","volume":"64","author":"Steinle","year":"2009","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib218","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.ejcb.2006.05.009","article-title":"Hyaluronan fragments: an information-rich system","volume":"85","author":"Stern","year":"2006","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib219","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0042-6989(01)00185-7","article-title":"Immunobiology and privilege of neuronal retina and pigment epithelium transplants","volume":"42","author":"Streilein","year":"2002","journal-title":"Vis. Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib220","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/glia.10319","article-title":"Dystrophic microglia in the aging human brain","volume":"45","author":"Streit","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib221","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1677\/JME-06-0032","article-title":"CXC chemokine receptor 4 regulates neuronal migration and axonal pathfinding in the developing nervous system: implications for neuronal regeneration in the adult brain","volume":"38","author":"Stumm","year":"2007","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib222","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/sj.mn.7800141","article-title":"The inflammatory aspect of the microcirculation in hypertension: oxidative stress, leukocytes\/endothelial interaction, apoptosis","volume":"9","author":"Suematsu","year":"2002","journal-title":"Microcirculation"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib223","doi-asserted-by":"crossref","first-page":"7525","DOI":"10.4049\/jimmunol.181.11.7525","article-title":"Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells","volume":"181","author":"Sugita","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib224","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1167\/iovs.08-2846","article-title":"T cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions","volume":"50","author":"Sugita","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.preteyeres.2009.06.001_bib225","doi-asserted-by":"crossref","first-page":"R174","DOI":"10.1093\/hmg\/ddm212","article-title":"Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits","volume":"16","author":"Swaroop","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib226","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1179\/096805102125001073","article-title":"Recognition of lipopeptides by Toll-like receptors","volume":"8","author":"Takeda","year":"2002","journal-title":"J. Endotoxin Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib227","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0014-5793(96)01197-0","article-title":"Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells","volume":"397","author":"Takizawa","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib228","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0165-5728(02)00317-X","article-title":"Immune response gene expression increases in the aging murine hippocampus","volume":"132","author":"Terao","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib229","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1167\/iovs.02-1136","article-title":"Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma","volume":"44","author":"Tezel","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib230","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1001\/archopht.122.9.1348","article-title":"Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head","volume":"122","author":"Tezel","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib231","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0361-9230(03)00074-1","article-title":"Heat shock proteins, immunity and glaucoma","volume":"62","author":"Tezel","year":"2004","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib232","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/sj.eye.6701978","article-title":"Smoking and age-related macular degeneration: a review of association","volume":"19","author":"Thornton","year":"2005","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib233","doi-asserted-by":"crossref","first-page":"11846","DOI":"10.1073\/pnas.0504759102","article-title":"Advanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response","volume":"102","author":"Tian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib234","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1189\/jlb.0902436","article-title":"The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization","volume":"74","author":"Tsutsumi","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib235","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.exer.2007.09.007","article-title":"Functional expression of B7H1 on retinal pigment epithelial cells","volume":"86","author":"Usui","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib236","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/S0161-6420(00)00175-5","article-title":"The prevalence of age-related maculopathy: the visual impairment project","volume":"107","author":"VanNewkirk","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib237","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/bjo.70.1.60","article-title":"Complement activation in uveitis","volume":"70","author":"Vergani","year":"1986","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib238","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tcm.2005.12.001","article-title":"Atherosclerosis and the lectin-like oxidized low-density lipoprotein scavenger receptor","volume":"16","author":"Vohra","year":"2006","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib239","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/37022","article-title":"Immunosuppressive effects of apoptotic cells","volume":"390","author":"Voll","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib240","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.expneurol.2008.09.003","article-title":"Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: a potential mechanism leading to chronic inflammation","volume":"215","author":"Walker","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib241","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4161\/auto.5.4.8163","article-title":"Autophagy, exosomes and drusen formation in age-related macular degeneration","volume":"5","author":"Wang","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib242","first-page":"644","article-title":"Increased mitochondrial DNA damage and down-regulation of DNA repair enzymes in aged rodent retinal pigment epithelium and choroid","volume":"14","author":"Wang","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib243","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.exer.2004.03.013","article-title":"Differential gene expression of early and late passage retinal pigment epithelial cells","volume":"79","author":"Wang","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib244","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.exer.2009.02.005","article-title":"Immunoregulation of retinal ganglion cells fate in glaucoma","volume":"88","author":"Wax","year":"2009","journal-title":"Exp. Eye Res"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib245","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0161-6420(00)00525-X","article-title":"Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United States","volume":"108","author":"Wax","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib246","doi-asserted-by":"crossref","first-page":"12085","DOI":"10.1523\/JNEUROSCI.3200-08.2008","article-title":"Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand","volume":"28","author":"Wax","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib247","first-page":"3202","article-title":"Immune privilege is extended, then withdrawn, from allogeneic tumor cell grafts placed in the subretinal space","volume":"40","author":"Wenkel","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib248","first-page":"3467","article-title":"Evidence that retinal pigment epithelium functions as an immune-privileged tissue","volume":"41","author":"Wenkel","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib249","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/092986708783330665","article-title":"Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury","volume":"15","author":"Wong","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib250","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1474-9726.2007.00351.x","article-title":"Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice","volume":"7","author":"Xu","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib251","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/glia.20535","article-title":"Turnover of resident retinal microglia in the normal adult mouse","volume":"55","author":"Xu","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib252","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1167\/iovs.06-0783","article-title":"LYVE positive macrophages are present in normal murine eyes","volume":"48","author":"Xu","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib253","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1167\/iovs.06-0697","article-title":"Identification of novel dendritic cell populations in normal mouse retina","volume":"48","author":"Xu","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib254","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1167\/iovs.04-1333","article-title":"Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood\u2013retina barrier","volume":"46","author":"Xu","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib271","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.exer.2005.10.005","article-title":"The expression of advanced glycation endproduct receptors in RPE cells associated with basal deposits in human maculas","volume":"82","author":"Yamada","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib255","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0925-4439(00)00041-7","article-title":"Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide","volume":"1502","author":"Yan","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib256","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/sj.ijo.0803173","article-title":"Relationships among acylation stimulating protein, adiponectin and complement C3 in lean vs obese type 2 diabetes","volume":"30","author":"Yang","year":"2006","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib257","first-page":"1631","article-title":"Differential chemokine regulation by Th2 cytokines during human RPE-monocyte coculture","volume":"42","author":"Yoshida","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib258","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/1098-1136(200010)32:1<42::AID-GLIA40>3.0.CO;2-3","article-title":"Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head","volume":"32","author":"Yuan","year":"2000","journal-title":"Glia"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib259","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/jnr.1104","article-title":"Activated microglia in the human glaucomatous optic nerve head","volume":"64","author":"Yuan","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib260","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000099259","article-title":"Immunosuppressive properties of the pigmented epithelial cells and the subretinal space","volume":"92","author":"Zamiri","year":"2007","journal-title":"Chem. Immunol. Allergy"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib261","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/IJG.0b013e31815c3a7f","article-title":"Oxidative stress in primary open-angle glaucoma","volume":"17","author":"Zanon-Moreno","year":"2008","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib262","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1001\/archopht.122.4.598","article-title":"Current concepts in the pathogenesis of age-related macular degeneration","volume":"122","author":"Zarbin","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib263","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1001\/archophthalmol.2007.65","article-title":"Microglial activation in human diabetic retinopathy","volume":"126","author":"Zeng","year":"2008","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib264","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/01.fjc.0000242058.72471.0c","article-title":"Selective inhibition by grape seed proanthocyanidin extracts of cell adhesion molecule expression induced by advanced glycation end products in endothelial cells","volume":"48","author":"Zhang","year":"2006","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib265","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.2337\/diabetes.51.12.3499","article-title":"Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy","volume":"51","author":"Zhang","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.preteyeres.2009.06.001_bib266","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1007\/s00018-006-6189-1","article-title":"Mammalian toll-like receptors: from endogenous ligands to tissue regeneration","volume":"63","author":"Zhang","year":"2006","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib267","doi-asserted-by":"crossref","first-page":"31240","DOI":"10.1074\/jbc.M502641200","article-title":"Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma","volume":"280","author":"Zhou","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib268","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.exer.2005.06.005","article-title":"Constitutive nitric oxide synthase activity is required to trigger ischemic tolerance in mouse retina","volume":"82","author":"Zhu","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2009.06.001_bib269","first-page":"51","article-title":"Age-related decrease in accessory cell function of human alveolar macrophages","volume":"47","author":"Zissel","year":"1999","journal-title":"J. Investig. Med."}],"container-title":["Progress in Retinal and Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946209000342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946209000342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T16:34:06Z","timestamp":1685032446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350946209000342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":271,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S1350946209000342"],"URL":"https:\/\/doi.org\/10.1016\/j.preteyeres.2009.06.001","relation":{},"ISSN":["1350-9462"],"issn-type":[{"value":"1350-9462","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}