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Lett."},{"key":"10.1016\/j.preteyeres.2011.02.004_bib64","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jnr.10390","article-title":"Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging","volume":"70","author":"Iwata","year":"2002","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.preteyeres.2011.02.004_bib65","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1126\/science.1059946","article-title":"Metabolic regulation of brain Abeta by neprilysin","volume":"292","author":"Iwata","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2011.02.004_bib66","doi-asserted-by":"crossref","first-page":"29241","DOI":"10.1074\/jbc.M704587200","article-title":"Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition","volume":"282","author":"Janssen","year":"2007","journal-title":"J.\u00a0Biol. 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