{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:36:17Z","timestamp":1792089377057,"version":"4.4.0"},"reference-count":263,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Retinal and Eye Research"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.preteyeres.2013.01.001","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T21:00:59Z","timestamp":1358802059000},"page":"89-124","source":"Crossref","is-referenced-by-count":153,"special_numbering":"C","title":["Novel anti(lymph)angiogenic treatment strategies for corneal and ocular surface diseases"],"prefix":"10.1016","volume":"34","author":[{"given":"Felix","family":"Bock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuichi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Regenfuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Hos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Steven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig M.","family":"Heindl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Cursiefen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preteyeres.2013.01.001_bib1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1196\/annals.1413.020","article-title":"Molecular control of lymphatic metastasis","volume":"1131","author":"Achen","year":"2008","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ar.1092370204","article-title":"Scanning and transmission electron microscopy and high resolution intravital video-microscopy of capillaries in the mouse exocrine pancreas, with special emphasis on endothelial cells","volume":"237","author":"Aharinejad","year":"1993","journal-title":"The Anatomical Record"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib3","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nm.2018","article-title":"Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth","volume":"15","author":"Albuquerque","year":"2009","journal-title":"Nature Medicine"},{"issue":"11","key":"10.1016\/j.preteyeres.2013.01.001_bib4","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s00417-012-1988-6","article-title":"Morphometric analysis of postoperative corneal neovascularization after high-risk keratoplasty: herpetic versus non-herpetic disease","volume":"250","author":"Altenburger","year":"2012","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology\u00a0=\u00a0Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib5","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nature05249","article-title":"Corneal avascularity is due to soluble VEGF receptor-1","volume":"443","author":"Ambati","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/bjo.2006.107417","article-title":"Soluble vascular endothelial growth factor receptor-1 contributes to the corneal antiangiogenic barrier","volume":"91","author":"Ambati","year":"2007","journal-title":"British Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib7","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ophtha.2011.09.019","article-title":"Risk of corneal transplant rejection significantly reduced with Descemet's membrane endothelial keratoplasty","volume":"119","author":"Anshu","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00535-009-0152-5","article-title":"Expression of LYVE-1 in sinusoidal endothelium is reduced in chronically inflamed human livers","volume":"45","author":"Arimoto","year":"2010","journal-title":"Journal of Gastroenterology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0945-053X(03)00005-2","article-title":"Thrombospondins 1 and 2 function as inhibitors of angiogenesis","volume":"22","author":"Armstrong","year":"2003","journal-title":"Matrix Biology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib10","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib11","first-page":"339","article-title":"Ovarian angiogenesis. Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression","volume":"147","author":"Augustin","year":"1995","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/archopht.126.1.71","article-title":"Promotion of graft survival by vascular endothelial growth factor a neutralization after high-risk corneal transplantation","volume":"126","author":"Bachmann","year":"2008","journal-title":"Archives of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib13","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1136\/bjo.2008.145128","article-title":"Transient postoperative vascular endothelial growth factor (VEGF)-neutralisation improves graft survival in corneas with partly regressed inflammatory neovascularisation","volume":"93","author":"Bachmann","year":"2009","journal-title":"British Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib14","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.ophtha.2010.01.039","article-title":"Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis","volume":"117","author":"Bachmann","year":"2010","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.preteyeres.2013.01.001_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1755-3768.2011.02312.x","article-title":"The association between corneal neovascularization and visual acuity: a systematic review","volume":"91","author":"Bachmann","year":"2013","journal-title":"Acta Ophthalmologica"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/1523-1747.ep12613450","article-title":"Human keratinocytes express the three major splice forms of vascular endothelial growth factor","volume":"104","author":"Ballaun","year":"1995","journal-title":"Journal of Investigative Dermatology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ajo.2004.04.007","article-title":"Treatment of conjunctival squamous cell carcinoma with photodynamic therapy","volume":"138","author":"Barbazetto","year":"2004","journal-title":"American Journal of Ophthalmology"},{"issue":"5","key":"10.1016\/j.preteyeres.2013.01.001_bib260","first-page":"1315","article-title":"Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer","volume":"62","author":"Beasley","year":"2002","journal-title":"Cancer Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib18","first-page":"492","article-title":"The side effects of corticosteroids","volume":"3","author":"Becker","year":"1964","journal-title":"Investigative Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1172\/JCI5028","article-title":"Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal","volume":"103","author":"Benjamin","year":"1999","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/carcin\/19.2.337","article-title":"Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse","volume":"19","author":"Biozzi","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-374203-2.00108-1","article-title":"The Immunological Aspects of Aqueous Humor Turnover","author":"Bock","year":"2010"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib22","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1167\/iovs.06-0570","article-title":"Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis","volume":"48","author":"Bock","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00417-007-0684-4","article-title":"Bevacizumab (Avastin) eye drops inhibit corneal neovascularization","volume":"246","author":"Bock","year":"2008","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology\u00a0=\u00a0Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00417-007-0683-5","article-title":"Blockade of VEGFR3-signalling specifically inhibits lymphangiogenesis in inflammatory corneal neovascularisation","volume":"246","author":"Bock","year":"2008","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology\u00a0=\u00a0Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib25","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1167\/iovs.07-1129","article-title":"Safety profile of topical VEGF neutralization at the cornea","volume":"50","author":"Bock","year":"2009","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib26","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s00347-010-2262-0","article-title":"Antiangiogenic therapy at the ocular surface: when, what and why?","volume":"108","author":"Bock","year":"2011","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib27","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1167\/iovs.10-6101","article-title":"Time-lapse in\u00a0vivo imaging of corneal angiogenesis: the role of inflammatory cells in capillary sprouting","volume":"52","author":"Bourghardt Peebo","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib28","article-title":"Topical Ranibizumab inhibits inflammatory corneal hem- and lymphangiogenesis","author":"Bucher","year":"2012","journal-title":"Acta Ophthalmologica"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-213X-8-43","article-title":"Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics","volume":"8","author":"Buttler","year":"2008","journal-title":"BMC Developmental Biology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib30","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1182\/blood.V99.12.4434","article-title":"Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in\u00a0vivo","volume":"99","author":"Byzova","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib31","first-page":"1646","article-title":"In\u00a0vivo protection of photoreceptors from light damage by pigment epithelium-derived factor","volume":"42","author":"Cao","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1167\/iovs.03-0869","article-title":"Mouse strain-dependent heterogeneity of resting limbal vasculature","volume":"45","author":"Chan","year":"2004","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/labinvest.3700277","article-title":"Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization","volume":"85","author":"Chan","year":"2005","journal-title":"Laboratory Investigation; a Journal of Technical Methods and Pathology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib35","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/00055735-200108000-00002","article-title":"Corneal neovascularization","volume":"12","author":"Chang","year":"2001","journal-title":"Current Opinion in Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib36","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0165-5728(99)00189-7","article-title":"Cytokine, chemokine and chemokine receptor mRNA expression in different strains of normal mice: implications for establishment of a Th1\/Th2 bias","volume":"100","author":"Charles","year":"1999","journal-title":"Journal of Neuroimmunology"},{"issue":"17","key":"10.1016\/j.preteyeres.2013.01.001_bib37","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1182\/blood-2011-01-332049","article-title":"A novel pro-lymphangiogenic function for Th17\/IL-17","volume":"118","author":"Chauhan","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib38","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/00005344-200010000-00013","article-title":"Inhibition of vascular endothelial growth factor activity by transfection with the soluble FLT-1 gene","volume":"36","author":"Chen","year":"2000","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib39","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1167\/iovs.05-0975","article-title":"Novel expression and characterization of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1) by conjunctival cells","volume":"46","author":"Chen","year":"2005","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib40","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2567.2008.02868.x","article-title":"Turnover of bone marrow-derived cells in the irradiated mouse cornea","volume":"125","author":"Chinnery","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib41","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.4049\/jimmunol.180.9.5779","article-title":"Cutting edge: membrane nanotubes in\u00a0vivo: a feature of MHC class II+ cells in the mouse cornea","volume":"180","author":"Chinnery","year":"2008","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib42","first-page":"1111","article-title":"Preliminary evidence of the presence of lymphatic vessels immunoreactive for D2-40 and Prox-1 in human pterygium","volume":"26","author":"Cimpean","year":"2011","journal-title":"Oncology Reports"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib43","first-page":"1422","article-title":"Lack of lymphangiogenesis despite coexpression of VEGF-C and its receptor Flt-4 in uveal melanoma","volume":"42","author":"Clarijs","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib44","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1167\/iovs.11-9064","article-title":"Antiangiogenic activity of aganirsen in nonhuman primate and rodent models of retinal neovascular disease after topical administration","volume":"53","author":"Cloutier","year":"2012","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib45","first-page":"457","article-title":"Vascularization of the cornea. Its experimental induction by small lesions and a new theory of its pathogenesis","volume":"46","author":"Cogan","year":"1948","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib46","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.survophthal.2007.12.005","article-title":"Intravitreal steroids for macular edema: the past, the present, and the future","volume":"53","author":"Cunningham","year":"2008","journal-title":"Survey of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib47","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00347-011-2331-z","article-title":"Perspectives of deep anterior lamellar keratoplasty","volume":"108","author":"Cursiefen","year":"2011","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib48","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/00003226-199811000-00008","article-title":"Angiogenesis in corneal diseases: histopathologic evaluation of 254 human corneal buttons with neovascularization","volume":"17","author":"Cursiefen","year":"1998","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib49","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00003226-200007000-00025","article-title":"Immunohistochemical localization of vascular endothelial growth factor, transforming growth factor alpha, and transforming growth factor beta1 in human corneas with neovascularization","volume":"19","author":"Cursiefen","year":"2000","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib50","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s004170100313","article-title":"Impact of short-term versus long-term topical steroids on corneal neovascularization after non-high-risk keratoplasty","volume":"239","author":"Cursiefen","year":"2001","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology\u00a0=\u00a0Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib51","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/00003226-200210000-00003","article-title":"Corneal neovascularization after nonmechanical versus mechanical corneal trephination for non-high-risk keratoplasty","volume":"21","author":"Cursiefen","year":"2002","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib52","first-page":"2127","article-title":"Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin","volume":"43","author":"Cursiefen","year":"2002","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib53","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00003226-200304000-00021","article-title":"Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology","volume":"22","author":"Cursiefen","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib54","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/bjo.87.1.101","article-title":"Pericyte recruitment in human corneal angiogenesis: an ultrastructural study with clinicopathological correlation","volume":"87","author":"Cursiefen","year":"2003","journal-title":"British Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib55","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s00347-003-0798-y","article-title":"Angiogenesis and lymphangiogenesis in the cornea. Pathogenesis, clinical implications and treatment options","volume":"100","author":"Cursiefen","year":"2003","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib56","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1167\/iovs.03-1380","article-title":"Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival","volume":"45","author":"Cursiefen","year":"2004","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib57","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1172\/JCI20465","article-title":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment","volume":"113","author":"Cursiefen","year":"2004","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib58","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1167\/iovs.03-0940","article-title":"Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis","volume":"45","author":"Cursiefen","year":"2004","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"5","key":"10.1016\/j.preteyeres.2013.01.001_bib261","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0002-9440(10)62355-3","article-title":"Spontaneous corneal hem- and lymphangiogenesis in mice with destrin-mutation depend on VEGFR3 signaling","volume":"166","author":"Cursiefen","year":"2005","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib59","doi-asserted-by":"crossref","first-page":"11405","DOI":"10.1073\/pnas.0506112103","article-title":"Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision","volume":"103","author":"Cursiefen","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib60","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/01.ico.0000183485.85636.ff","article-title":"Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation","volume":"25","author":"Cursiefen","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib61","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/01.ico.0000214230.21238.3d","article-title":"Absence of blood and lymphatic vessels in the developing human cornea","volume":"25","author":"Cursiefen","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib62","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.ophtha.2009.04.016","article-title":"GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial","volume":"116","author":"Cursiefen","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib63","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1084\/jem.20092277","article-title":"Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes","volume":"208","author":"Cursiefen","year":"2011","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/bjo.2011.204701","article-title":"Consensus statement on indications for anti-angiogenic therapy in the management of corneal diseases associated with neovascularisation: outcome of an expert roundtable","volume":"96","author":"Cursiefen","year":"2012","journal-title":"British Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib65","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000099253","article-title":"Immune privilege and angiogenic privilege of the cornea","volume":"92","author":"Cursiefen","year":"2007","journal-title":"Chemical Immunology and Allergy"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib66","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0002-9440(10)64328-3","article-title":"Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival","volume":"162","author":"Dadras","year":"2003","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib67","first-page":"2485","article-title":"Loss and restoration of immune privilege in eyes with corneal neovascularization","volume":"37","author":"Dana","year":"1996","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib68","series-title":"Viral Diseases of the Eye","first-page":"296","article-title":"Follicular conjunctivitis","author":"Darrell","year":"1985"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib69","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.1167\/iovs.11-7871","article-title":"Corneal penetration of topical and subconjunctival bevacizumab","volume":"52","author":"Dastjerdi","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib70","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1167\/iovs.07-0069","article-title":"Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma","volume":"48","author":"De Paiva","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib71","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/mi.2009.5","article-title":"IL-17 disrupts corneal barrier following desiccating stress","volume":"2","author":"De Paiva","year":"2009","journal-title":"Mucosal Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib72","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1006\/exer.1997.0359","article-title":"Steroid-induced cataract: new perspective from in\u00a0vitro and lens culture studies","volume":"65","author":"Dickerson","year":"1997","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib73","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2353\/ajpath.2007.060896","article-title":"Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade","volume":"171","author":"Dietrich","year":"2007","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib74","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4049\/jimmunol.0903180","article-title":"Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation","volume":"184","author":"Dietrich","year":"2010","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib75","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00006982-200001000-00014","article-title":"Intraocular melanoma spread to regional lymph nodes: report of two cases","volume":"20","author":"Dithmar","year":"2000","journal-title":"Retina"},{"issue":"5","key":"10.1016\/j.preteyeres.2013.01.001_bib76","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1167\/iovs.09-4505","article-title":"Differential distribution of blood and lymphatic vessels in the murine cornea","volume":"51","author":"Ecoiffier","year":"2010","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib77","first-page":"1963","article-title":"Proliferation of vascular endothelial cells stimulated in\u00a0vitro by corneal epithelium","volume":"28","author":"Eliason","year":"1987","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib78","first-page":"1087","article-title":"Leukocytes and experimental corneal vascularization","volume":"17","author":"Eliason","year":"1978","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib79","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/02713680903395273","article-title":"Efficacy of topical bevacizumab for inhibiting growth of impending recurrent pterygium","volume":"35","author":"Fallah","year":"2010","journal-title":"Current Eye Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib80","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/IOP.0b013e3182392f29","article-title":"Refractory squamous cell carcinoma of the conjunctiva treated with subconjunctival ranibizumab (Lucentis): a two-year study","volume":"28","author":"Finger","year":"2012","journal-title":"Ophthalmic Plastic and Reconstructive Surgery"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib81","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib82","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00000658-197203000-00014","article-title":"Anti-angiogenesis: new concept for therapy of solid tumors","volume":"175","author":"Folkman","year":"1972","journal-title":"Annals of Surgery"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib83","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1097\/ICO.0b013e3181d92834","article-title":"Perilimbal bevacizumab injection for interface neovascularization after deep anterior lamellar keratoplasty","volume":"29","author":"Foroutan","year":"2010","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib84","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1167\/iovs.09-4618","article-title":"Intracellular thiol redox status regulates lymphangiogenesis and dictates corneal limbal graft survival","volume":"51","author":"Fukumoto","year":"2010","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib85","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.exer.2003.09.005","article-title":"Anti-angiogenic role of angiostatin during corneal wound healing","volume":"78","author":"Gabison","year":"2004","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib86","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.ajo.2010.01.015","article-title":"Phase I study of subconjunctival ranibizumab in patients with primary pterygium undergoing pterygium surgery","volume":"149","author":"Galor","year":"2010","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib87","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000315018","article-title":"Intravital multidimensional real-time imaging of the conjunctival immune system","volume":"45","author":"Gehlsen","year":"2010","journal-title":"Developments in Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib88","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1055\/s-2006-926653","article-title":"Conjunctival chemosis resistant to therapy","volume":"223","author":"Gottschalk","year":"2006","journal-title":"Klin Monbl Augenheilkd"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib89","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/archophthalmol.2010.124","article-title":"Evidence of corneal lymphangiogenesis in dry eye disease: a potential link to adaptive immunity?","volume":"128","author":"Goyal","year":"2010","journal-title":"Archives of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib90","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/archophthalmol.2011.266","article-title":"Blockade of prolymphangiogenic vascular endothelial growth factor C in dry eye disease","volume":"130","author":"Goyal","year":"2011","journal-title":"Archives of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib91","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1126\/science.270.5239.1189","article-title":"Fas ligand-induced apoptosis as a mechanism of immune privilege","volume":"270","author":"Griffith","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib92","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.exer.2011.11.011","article-title":"Quantitative study of the topographic distribution of conjunctival lymphatic vessels in the monkey","volume":"94","author":"Guo","year":"2012","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib93","first-page":"639","article-title":"Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells","volume":"43","author":"Hamrah","year":"2002","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib94","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1167\/iovs.02-0838","article-title":"The corneal stroma is endowed with a significant number of resident dendritic cells","volume":"44","author":"Hamrah","year":"2003","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib95","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.exer.2004.06.028","article-title":"Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) on monocytic bone marrow-derived cells in the conjunctiva","volume":"79","author":"Hamrah","year":"2004","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib96","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0092-8674(00)80108-7","article-title":"Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis","volume":"86","author":"Hanahan","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib97","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib98","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/ICO.0b013e3181e291a6","article-title":"Deep intrastromal bevacizumab injection for management of corneal stromal vascularization after deep anterior lamellar keratoplasty, a novel technique","volume":"30","author":"Hashemian","year":"2011","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib99","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1167\/iovs.10-6741","article-title":"Characterization of Langerin-expressing dendritic cell subsets in the normal cornea","volume":"52","author":"Hattori","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib100","first-page":"2723","article-title":"Promotion of murine orthotopic corneal allograft survival by systemic administration of anti-CD4 monoclonal antibody","volume":"32","author":"He","year":"1991","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib101","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/jnci\/94.11.819","article-title":"Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling","volume":"94","author":"He","year":"2002","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib102","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1358\/dnp.2008.21.2.1188196","article-title":"Angiogenesis: the new potential target for the therapy of psoriasis?","volume":"21","author":"Heidenreich","year":"2008","journal-title":"Drug News and Perspectives"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib103","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1055\/s-0031-1273332","article-title":"Special topic \u201cinflammations of the eye in inflammatory systemic diseases\u201d","volume":"228","author":"Heiligenhaus","year":"2011","journal-title":"Klin Monbl Augenheilkd"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib104","doi-asserted-by":"crossref","DOI":"10.1007\/s00347-009-2100-4","article-title":"Pterygium. Etiology, clinical aspects and novel adjuvant therapies","volume":"107","author":"Heindl","year":"2010","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00347-009-2011-4","article-title":"Retained Descemet's membrane after penetrating keratoplasty for macular corneal dystrophy","volume":"107","author":"Heindl","year":"2010","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib106","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1167\/iovs.08-2935","article-title":"Intraocular lymphangiogenesis in malignant melanomas of the ciliary body with extraocular extension","volume":"50","author":"Heindl","year":"2009","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib107","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ophtha.2010.01.032","article-title":"Tumor-associated lymphangiogenesis in the development of conjunctival squamous cell carcinoma","volume":"117","author":"Heindl","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib108","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ophtha.2009.06.057","article-title":"Intraocular tumor-associated lymphangiogenesis a novel prognostic factor for ciliary body melanomas with extraocular extension?","volume":"117","author":"Heindl","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib109","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/archophthalmol.2010.143","article-title":"Intraocular lymphatics in ciliary body melanomas with extraocular extension: functional for lymphatic spread?","volume":"128","author":"Heindl","year":"2010","journal-title":"Archives of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib110","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/j.ophtha.2011.05.025","article-title":"Prognostic significance of tumor-associated lymphangiogenesis in malignant melanomas of the conjunctiva","volume":"118","author":"Heindl","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib111","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1167\/iovs.11-7902","article-title":"Tumor-associated lymphangiogenesis in the development of conjunctival melanoma","volume":"52","author":"Heindl","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib112","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ophtha.2010.05.025","article-title":"Split cornea transplantation for 2 recipients: a new strategy to reduce corneal tissue cost and shortage","volume":"118","author":"Heindl","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib113","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ajo.2011.03.021","article-title":"Split cornea transplantation for 2 recipients \u2013 review of the first 100 consecutive patients","volume":"152","author":"Heindl","year":"2011","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib114","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.exer.2008.07.013","article-title":"Age-related changes in murine limbal lymphatic vessels and corneal lymphangiogenesis","volume":"87","author":"Hos","year":"2008","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib115","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1167\/iovs.07-1314","article-title":"Inflammatory corneal (lymph)angiogenesis is blocked by VEGFR-tyrosine kinase inhibitor ZK 261991, resulting in improved graft survival after corneal transplantation","volume":"49","author":"Hos","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib116","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1167\/iovs.10-6816","article-title":"Blockade of insulin receptor substrate-1 inhibits corneal lymphangiogenesis","volume":"52","author":"Hos","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib117","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/archophthalmol.2011.42","article-title":"Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids","volume":"129","author":"Hos","year":"2011","journal-title":"Archives of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib118","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1167\/iovs.09-3949","article-title":"Combined treatment with bevacizumab and 5-fluorouracil attenuates the postoperative scarring response after experimental glaucoma filtration surgery","volume":"51","author":"How","year":"2010","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"Suppl. 5","key":"10.1016\/j.preteyeres.2013.01.001_bib119","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1097\/00005344-198900135-00067","article-title":"Human vascular responses to endothelin-1: observations in\u00a0vivo and in\u00a0vitro","volume":"13","author":"Hughes","year":"1989","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib120","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1073\/pnas.84.24.9265","article-title":"Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide","volume":"84","author":"Ignarro","year":"1987","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib121","doi-asserted-by":"crossref","first-page":"10181","DOI":"10.1158\/0008-5472.CAN-07-2366","article-title":"Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis","volume":"67","author":"Iwata","year":"2007","journal-title":"Cancer Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib122","first-page":"186","article-title":"Corneal Langerhans cells and ocular immunology","volume":"4","author":"Jager","year":"1992","journal-title":"Regional Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib123","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/ICO.0b013e31820ca19e","article-title":"Efficacy of bevacizumab against interface neovascularization after deep anterior lamellar keratoplasty","volume":"31","author":"Jarrin","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib124","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1126\/science.276.5317.1423","article-title":"Hyperplasia of lymphatic vessels in VEGF-C transgenic mice","volume":"276","author":"Jeltsch","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib125","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/71517","article-title":"Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1","volume":"6","author":"Jimenez","year":"2000","journal-title":"Nature Medicine"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib126","doi-asserted-by":"crossref","first-page":"33671","DOI":"10.1074\/jbc.M702889200","article-title":"Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1","volume":"282","author":"Johnson","year":"2007","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib127","first-page":"1079","article-title":"Inhibition of lymphocyte-induced angiogenesis by enzymatically isolated rabbit cornea cells","volume":"26","author":"Kaminski","year":"1978","journal-title":"Archivum Immunologiae et Therapiae Experimentalis (Warsz)"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib128","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1038\/sj.onc.1203855","article-title":"Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis","volume":"19","author":"Karkkainen","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib129","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0014-5793(01)02897-6","article-title":"Diminished corneal angiogenesis in gelatinase A-deficient mice","volume":"508","author":"Kato","year":"2001","journal-title":"FEBS Letters"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib130","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1167\/iovs.01-1257","article-title":"Expression of type XVIII collagen during healing of corneal incisions and keratectomy wounds","volume":"44","author":"Kato","year":"2003","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib131","first-page":"1625","article-title":"A\u00a0model of angiogenesis in the mouse cornea","volume":"37","author":"Kenyon","year":"1996","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib132","first-page":"180","article-title":"Transplantation and rejection of individual cell layers of the cornea","volume":"8","author":"Khodadoust","year":"1969","journal-title":"Investigative Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib133","doi-asserted-by":"crossref","first-page":"27872","DOI":"10.1074\/jbc.M202771200","article-title":"Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR\/Flk-1","volume":"277","author":"Kim","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib134","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1167\/iovs.08-2805","article-title":"Bevacizumab application delays epithelial healing in rabbit cornea","volume":"50","author":"Kim","year":"2009","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib135","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1007\/s00417-009-1099-1","article-title":"Short- and long-term safety profile and efficacy of topical bevacizumab (Avastin) eye drops against corneal neovascularization","volume":"247","author":"Koenig","year":"2009","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology\u00a0=\u00a0Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"issue":"8","key":"10.1016\/j.preteyeres.2013.01.001_bib136","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/ICO.0b013e31823f8f7a","article-title":"Angioregressive pretreatment of mature corneal blood vessels before keratoplasty: fine-needle vessel coagulation combined with anti-VEGFs","volume":"31","author":"Koenig","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib137","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1084\/jem.194.6.797","article-title":"Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages","volume":"194","author":"Kriehuber","year":"2001","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib138","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/01.ico.0000157400.81408.2b","article-title":"Endothelin-1 and ETA\/ETB receptor protein and mRNA: expression in normal and vascularized human corneas","volume":"24","author":"Kuhlmann","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib139","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1167\/iovs.01-1058","article-title":"Corneal neovascularization after excimer keratectomy wounds in matrilysin-deficient mice","volume":"44","author":"Kure","year":"2003","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib140","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ajo.2005.08.080","article-title":"Surgery-related factors influencing corneal neovascularization after low-risk keratoplasty","volume":"141","author":"Lam","year":"2006","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib141","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/bjo.37.4.210","article-title":"Observations on the growth of blood vessels into the cornea; application of a new experimental technique","volume":"37","author":"Langham","year":"1953","journal-title":"British Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib142","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S0955-0674(00)00143-5","article-title":"The functions of thrombospondin-1 and-2","volume":"12","author":"Lawler","year":"2000","journal-title":"Current Opinion in Cell Biology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1582-4934.2002.tb00307.x","article-title":"Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth","volume":"6","author":"Lawler","year":"2002","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib144","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0039-6257(05)80054-2","article-title":"Ocular surface squamous neoplasia","volume":"39","author":"Lee","year":"1995","journal-title":"Survey of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib145","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/ICO.0b013e3182151e0e","article-title":"Randomized controlled trial of subconjunctival bevacizumab injection in impending recurrent pterygium: a pilot study","volume":"31","author":"Lekhanont","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib146","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1001\/archopht.1963.00960050244017","article-title":"Experimental corneal vascularization","volume":"70","author":"Levene","year":"1963","journal-title":"Archives of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib147","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0014-4835(05)80056-9","article-title":"Endotoxin induced uveitis in the mouse: susceptibility and genetic control","volume":"61","author":"Li","year":"1995","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib148","first-page":"2517","article-title":"Matrilysin cleavage of corneal collagen type XVIII NC1 domain and generation of a 28-kDa fragment","volume":"42","author":"Lin","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib149","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1167\/iovs.09-4571","article-title":"The different effects of early and late bevacizumab (Avastin) injection on inhibiting corneal neovascularization and conjunctivalization in rabbit limbal insufficiency","volume":"51","author":"Lin","year":"2010","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib150","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1084\/jem.20010838","article-title":"Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts","volume":"195","author":"Liu","year":"2002","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib151","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ydbio.2010.02.003","article-title":"Genetic heterogeneity of skin microvasculature","volume":"340","author":"Liu","year":"2010","journal-title":"Developmental Biology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib152","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ygyno.2007.05.029","article-title":"Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix","volume":"107","author":"Longatto-Filho","year":"2007","journal-title":"Gynecologic Oncology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib153","first-page":"1822","article-title":"Inhibition of vascular endothelial cell morphogenesis in cultures by limbal epithelial cells","volume":"40","author":"Ma","year":"1999","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib154","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S1542-0124(12)70308-7","article-title":"Matrix revolution: molecular mechanism for inflammatory corneal neovascularization and restoration of corneal avascularity by epithelial stem cell transplantation","volume":"7","author":"Ma","year":"2009","journal-title":"The Ocular Surface"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib155","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/S0161-6420(94)31138-9","article-title":"Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies. Collaborative Corneal Transplantation Studies Research Group","volume":"101","author":"Maguire","year":"1994","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib156","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2353\/ajpath.2006.050834","article-title":"Vascular endothelial growth factor localization in the adult","volume":"168","author":"Maharaj","year":"2006","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib157","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/35107085","article-title":"Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression","volume":"414","author":"Makino","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib158","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1172\/JCI23874","article-title":"Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages","volume":"115","author":"Maruyama","year":"2005","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib159","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.2353\/ajpath.2007.060018","article-title":"Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing","volume":"170","author":"Maruyama","year":"2007","journal-title":"The American Journal of Pathology"},{"issue":"6","key":"10.1016\/j.preteyeres.2013.01.001_bib160","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1167\/iovs.11-8010","article-title":"The maintenance of lymphatic vessels in the cornea is dependent on the presence of macrophages","volume":"53","author":"Maruyama","year":"2012","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib161","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/ICO.0b013e3181a16578","article-title":"Analysis of inflammatory cytokines in the tears of dry eye patients","volume":"28","author":"Massingale","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib162","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1076\/ceyr.23.1.1.5422","article-title":"Corneal epithelial VEGF and cytochrome P450 4B1 expression in a rabbit model of closed eye contact lens wear","volume":"23","author":"Mastyugin","year":"2001","journal-title":"Current Eye Research"},{"issue":"6","key":"10.1016\/j.preteyeres.2013.01.001_bib163","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.jaci.2010.06.001","article-title":"Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis","volume":"126","author":"Matsuda","year":"2010","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib164","doi-asserted-by":"crossref","first-page":"45400","DOI":"10.1074\/jbc.M208339200","article-title":"Mapping the type I collagen-binding site on pigment epithelium-derived factor. Implications for its antiangiogenic activity","volume":"277","author":"Meyer","year":"2002","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib165","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/eye.1989.19","article-title":"The circulation of the human limbus","volume":"3","author":"Meyer","year":"1989","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib166","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/exer.2000.0925","article-title":"Expression of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in corneal lymphangiogenesis","volume":"72","author":"Mimura","year":"2001","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib167","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1097\/00007890-199906270-00020","article-title":"Angiogenesis in the huPBL-SCID model of human transplant rejection","volume":"67","author":"Moulton","year":"1999","journal-title":"Transplantation"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib168","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1182\/blood-2006-04-016030","article-title":"Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes\/macrophages","volume":"108","author":"Murakami","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib169","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1161\/ATVBAHA.107.150433","article-title":"VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment","volume":"28","author":"Murakami","year":"2008","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib170","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/intimm\/dxf031","article-title":"The conversion of redox status of peritoneal macrophages during pathological progression of spontaneous inflammatory bowel disease in Janus family tyrosine kinase 3(\u2212\/\u2212) and IL-2 receptor gamma(\u2212\/\u2212) mice","volume":"14","author":"Murata","year":"2002","journal-title":"International Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib171","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1172\/JCI23298","article-title":"Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth","volume":"115","author":"Nakao","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib172","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.2353\/ajpath.2007.070172","article-title":"Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis","volume":"171","author":"Nakao","year":"2007","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib173","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1096\/fj.09-134056","article-title":"Lymphangiogenesis and angiogenesis: concurrence and\/or dependence? Studies in inbred mouse strains","volume":"24","author":"Nakao","year":"2010","journal-title":"The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib174","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1096\/fj.11-183897","article-title":"Discontinuous LYVE-1 expression in corneal limbal lymphatics: dual function as microvalves and immunological hot spots","volume":"26","author":"Nakao","year":"2012","journal-title":"The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib175","first-page":"3050","article-title":"Formation of capillary-like tubes by vascular endothelial cells cocultivated with keratocytes","volume":"33","author":"Nakayasu","year":"1992","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib176","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/09273948.2010.486100","article-title":"Immune privilege of corneal allografts","volume":"18","author":"Niederkorn","year":"2010","journal-title":"Ocular Immunology and Inflammation"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib177","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/00007890-199508270-00009","article-title":"Alloantigens introduced into the anterior chamber of the eye induce systemic suppression of delayed hypersensitivity to third-party alloantigens through \u201clinked recognition\u201d","volume":"60","author":"Niederkorn","year":"1995","journal-title":"Transplantation"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib178","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.4049\/jimmunol.176.7.3950","article-title":"Desiccating stress induces T cell-mediated Sjogren's syndrome-like lacrimal keratoconjunctivitis","volume":"176","author":"Niederkorn","year":"2006","journal-title":"Journal of Immunology"},{"issue":"2","key":"10.1016\/j.preteyeres.2013.01.001_bib263","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ajo.2011.08.005","article-title":"Subconjunctival bevacizumab versus mitomycin C adjunctive to trabeculectomy","volume":"153","author":"Nilforushan","year":"2012","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib179","first-page":"35","article-title":"Immunohistochemical demonstration of actin and myosin in brain capillaries","volume":"20","author":"Owman","year":"1978","journal-title":"Advances in Neurology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib180","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1126\/science.1071420","article-title":"Lymphatic metastasis in the absence of functional intratumor lymphatics","volume":"296","author":"Padera","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib181","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.survophthal.2007.04.008","article-title":"Corneal graft rejection","volume":"52","author":"Panda","year":"2007","journal-title":"Survey of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib182","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1167\/iovs.09-4407","article-title":"Cellular-level characterization of lymph vessels in live, unlabeled corneas by in\u00a0vivo confocal microscopy","volume":"51","author":"Peebo","year":"2009","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib183","series-title":"Herpes Simplex Virus Disease: Anterior Segment of the Eye","author":"Pepose","year":"1996"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib184","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1167\/iovs.06-1202","article-title":"Bacterial transcytosis across conjunctival M cells","volume":"48","author":"Petris","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib185","first-page":"2148","article-title":"Fine needle diathermy occlusion of corneal vessels","volume":"41","author":"Pillai","year":"2000","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib264","unstructured":"Platonova, N., Miquel, G., Regenfuss, B., Taouji, S., Cursiefen, C., Chevet, E., Bikfalvi, A. Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1. Blood, in press."},{"key":"10.1016\/j.preteyeres.2013.01.001_bib186","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basic and therapeutic aspects of angiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib187","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0026-2862(88)90035-0","article-title":"Spontaneous cyclic contractions of the capillary wall in\u00a0vivo, impeding red cell flow: a quantitative analysis. Evidence for endothelial contractility","volume":"36","author":"Ragan","year":"1988","journal-title":"Microvascular Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib188","series-title":"Encyclopedia of the Eye","article-title":"Concept of angiogenic privilege","author":"Regenfuss","year":"2010"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib189","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/lrb.2008.6348","article-title":"Corneal (lymph)angiogenesis \u2013 from bedside to bench and back: a tribute to Judah Folkman","volume":"6","author":"Regenfuss","year":"2008","journal-title":"Lymphatic Research and Biology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib190","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2353\/ajpath.2010.090794","article-title":"Genetic heterogeneity of lymphangiogenesis in different mouse strains","volume":"177","author":"Regenfuss","year":"2010","journal-title":"The American Journal of Pathology"},{"issue":"6","key":"10.1016\/j.preteyeres.2013.01.001_bib191","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/ICO.0b013e31823f8c85","article-title":"Pentacam-based big bubble deep anterior lamellar keratoplasty in patients with keratoconus","volume":"31","author":"Riss","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib192","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1161\/01.CIR.99.1.111","article-title":"Age-dependent impairment of angiogenesis","volume":"99","author":"Rivard","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib193","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1096\/fj.03-0246fje","article-title":"Genetic loci that control vascular endothelial growth factor-induced angiogenesis","volume":"17","author":"Rogers","year":"2003","journal-title":"The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib194","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1096\/fj.03-1241com","article-title":"Genetic loci that control the angiogenic response to basic fibroblast growth factor","volume":"18","author":"Rogers","year":"2004","journal-title":"The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib195","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1096\/fasebj.14.7.871","article-title":"Genetic heterogeneity of angiogenesis in mice","volume":"14","author":"Rohan","year":"2000","journal-title":"The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib196","first-page":"762","article-title":"Lymphatic vessels: structure and function","volume":"13","author":"Rovenska","year":"2011","journal-title":"The Israel Medical Association Journal: IMAJ"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib197","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2567.2008.02846.x","article-title":"Widespread natural variation in murine natural killer T-cell number and function","volume":"125","author":"Rymarchyk","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib198","first-page":"2435","article-title":"The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens","volume":"14","author":"Saban","year":"2008","journal-title":"Molecular Vision"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib199","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.4049\/jimmunol.1001133","article-title":"Thrombospondin-1 derived from APCs regulates their capacity for allosensitization","volume":"185","author":"Saban","year":"2010","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib200","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1177\/002215540305100902","article-title":"Impaired angiogenesis in aging is associated with alterations in vessel density, matrix composition, inflammatory response, and growth factor expression","volume":"51","author":"Sadoun","year":"2003","journal-title":"Journal of Histochemistry & Cytochemistry"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib201","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1182\/blood-2002-03-0755","article-title":"VEGFR-3 and CD133 identify a population of CD34+ lymphatic\/vascular endothelial precursor cells","volume":"101","author":"Salven","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib202","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1177\/112067210901900530","article-title":"Topical bevacizumab for corneal neovascularization after penetrating keratoplasty","volume":"19","author":"Saxena","year":"2009","journal-title":"European Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib203","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.4049\/jimmunol.1101442","article-title":"Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis","volume":"187","author":"Schaumburg","year":"2011","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib204","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.exer.2005.02.016","article-title":"Identification and characterization of limbal stem cells","volume":"81","author":"Schloetzer-Schrehardt","year":"2005","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib205","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0002-9440(10)64255-1","article-title":"Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis","volume":"161","author":"Schoppmann","year":"2002","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib206","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1167\/iovs.08-1721","article-title":"The normal human choroid is endowed with a significant number of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)-positive macrophages","volume":"49","author":"Schroedl","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib207","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3109\/02713683.2011.601840","article-title":"The impact of subconjuctivally injected EGF and VEGF inhibitors on experimental corneal neovascularization in rat model","volume":"36","author":"Sener","year":"2011","journal-title":"Current Eye Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib208","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.4049\/jimmunol.1000680","article-title":"Eye mucosa: an efficient vaccine delivery route for inducing protective immunity","volume":"185","author":"Seo","year":"2010","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib209","doi-asserted-by":"crossref","DOI":"10.1016\/j.ophtha.2010.06.021","article-title":"Conjunctival melanoma: outcomes based on tumor origin in 382 consecutive cases","volume":"118","author":"Shields","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib210","doi-asserted-by":"crossref","first-page":"44965","DOI":"10.1074\/jbc.M111.294967","article-title":"Pharmacologic uncoupling of angiogenesis and inflammation during initiation of pathological corneal neovascularization","volume":"286","author":"Sivak","year":"2011","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib211","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0002-9440(10)61765-8","article-title":"Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma","volume":"159","author":"Skobe","year":"2001","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib212","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.4049\/jimmunol.150.5.1727","article-title":"Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts","volume":"150","author":"Sonoda","year":"1993","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib213","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc863","article-title":"Lymphangiogenesis and cancer metastasis","volume":"2","author":"Stacker","year":"2002","journal-title":"Nature Reviews. Cancer"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib214","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.atherosclerosis.2006.01.019","article-title":"Lower macrophage recruitment and atherosclerosis resistance in FVB mice","volume":"189","author":"Stein","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib215","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/01.all.0000182547.60595.64","article-title":"The Th1\/Th2 paradigm in ocular allergy","volume":"5","author":"Stern","year":"2005","journal-title":"Current Opinion in Allergy & Clinical Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib216","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000219678","article-title":"Conjunctiva-associated lymphoid tissue \u2013 current knowledge, animal models and experimental prospects","volume":"42","author":"Steven","year":"2009","journal-title":"Ophthalmic Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib217","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1167\/iovs.07-0809","article-title":"Experimental induction and three-dimensional two-photon imaging of conjunctiva-associated lymphoid tissue","volume":"49","author":"Steven","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib218","doi-asserted-by":"crossref","first-page":"064040","DOI":"10.1117\/1.3275475","article-title":"Comparison of Cornea Module and DermaInspect for noninvasive imaging of ocular surface pathologies","volume":"14","author":"Steven","year":"2009","journal-title":"J\u00a0Biomed Opt"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib219","doi-asserted-by":"crossref","first-page":"e26253","DOI":"10.1371\/journal.pone.0026253","article-title":"Intravital two-photon microscopy of immune cell dynamics in corneal lymphatic vessels","volume":"6","author":"Steven","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib220","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/S0041-1345(99)00010-X","article-title":"Anterior chamber-associated immune deviation, ocular immune privilege, and orthotopic corneal allografts","volume":"31","author":"Streilein","year":"1999","journal-title":"Transplantation Proceedings"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib221","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nri1224","article-title":"Ocular immune privilege: therapeutic opportunities from an experiment of nature","volume":"3","author":"Streilein","year":"2003","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib222","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1038\/sj.onc.1206457","article-title":"Angiogenesis, lymphangiogenesis, and melanoma metastasis","volume":"22","author":"Streit","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib223","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1600-6143.2006.01638.x","article-title":"Lymphatic neoangiogenesis in human renal allografts: results from sequential protocol biopsies","volume":"7","author":"Stuht","year":"2007","journal-title":"American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib224","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/ICO.0b013e3181ba0ae2","article-title":"Corneal graft surgery combined with subconjunctival bevacizumab (avastin)","volume":"29","author":"Symes","year":"2010","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib225","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1136\/bjo.2008.156489","article-title":"Subconjunctival ranibizumab for squamous cell carcinoma of the conjunctiva with corneal extension","volume":"93","author":"Teng","year":"2009","journal-title":"British Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib226","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jbiotec.2006.01.007","article-title":"Tumor-induced lymphangiogenesis: a target for cancer therapy?","volume":"124","author":"Thiele","year":"2006","journal-title":"Journal of Biotechnology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib227","doi-asserted-by":"crossref","first-page":"e21918","DOI":"10.1371\/journal.pone.0021918","article-title":"Novel characterization of lymphatic valve formation during corneal inflammation","volume":"6","author":"Truong","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib228","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/sj.bjc.6603445","article-title":"First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours","volume":"95","author":"Van der Auwera","year":"2006","journal-title":"British Journal of Cancer"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib229","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00217308","article-title":"Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. An enzyme-histochemical study","volume":"238","author":"van Rooijen","year":"1984","journal-title":"Cell and Tissue Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib230","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s00417-009-1170-y","article-title":"Avastin use in high risk corneal transplantation","volume":"247","author":"Vassileva","year":"2009","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology\u00a0=\u00a0Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib231","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1534-5807(02)00231-9","article-title":"Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis","volume":"3","author":"Veikkola","year":"2002","journal-title":"Developmental Cell"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib232","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1369\/jhc.2010.956672","article-title":"Proinflammatory signals and the loss of lymphatic vessel hyaluronan receptor-1 (LYVE-1) in the early pathogenesis of laminin alpha2-deficient skeletal muscle","volume":"59","author":"Wardrop","year":"2011","journal-title":"Journal of Histochemistry & Cytochemistry"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib233","first-page":"85","article-title":"Fine structure and function of ocular tissues. The conjunctiva","volume":"13","author":"Weingeist","year":"1973","journal-title":"International Ophthalmology Clinics"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib234","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1432-1327.1998.2530771.x","article-title":"Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site","volume":"253","author":"Wenger","year":"1998","journal-title":"European Journal of Biochemistry\/FEBS"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib235","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1167\/iovs.12-9507","article-title":"Invasion of lymphatic vessels into the eye after open globe injuries","volume":"53","author":"Wessel","year":"2012","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib236","first-page":"214","article-title":"Corneal blindness: a global perspective","volume":"79","author":"Whitcher","year":"2001","journal-title":"Bulletin of the World Health Organization"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib237","first-page":"725","article-title":"Some actions of prostacyclin (PGI2) on the cardiovascular system and the gastric microcirculation","volume":"37","author":"Whittle","year":"1978","journal-title":"Acta biologica et medica Germanica"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib238","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(00)81511-1","article-title":"Prox1 function is required for the development of the murine lymphatic system","volume":"98","author":"Wigle","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib239","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/01.tp.0000285489.91595.13","article-title":"The immunobiology of corneal transplantation","volume":"84","author":"Williams","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib240","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/ICO.0b013e3181822615","article-title":"Topical bevacizumab eyedrops for limbal-conjunctival neovascularization in impending recurrent pterygium","volume":"28","author":"Wu","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib241","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1084\/jem.20091385","article-title":"VEGF-A expression by HSV-1-infected cells drives corneal lymphangiogenesis","volume":"207","author":"Wuest","year":"2010","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib242","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1167\/iovs.06-0783","article-title":"LYVE-1-positive macrophages are present in normal murine eyes","volume":"48","author":"Xu","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib243","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0966-3274(98)80041-5","article-title":"Fate of orthotopic corneal allografts in C57BL\/6 mice","volume":"6","author":"Yamada","year":"1998","journal-title":"Transplant Immunology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib244","first-page":"2614","article-title":"Role of CD4+ T cells in immunobiology of orthotopic corneal transplants in mice","volume":"40","author":"Yamada","year":"1999","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib245","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1167\/iovs.08-2993","article-title":"MHC-matched corneal allograft rejection in an IFN-gamma\/IL-17-independent manner in C57BL\/6 mice","volume":"50","author":"Yamada","year":"2009","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib246","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/00003226-200205000-00014","article-title":"Draining lymph nodes play an essential role in alloimmunity generated in response to high-risk corneal transplantation","volume":"21","author":"Yamagami","year":"2002","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib247","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/35040568","article-title":"Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors","volume":"408","author":"Yamashita","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib248","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1172\/JCI11317","article-title":"Control of hair growth and follicle size by VEGF-mediated angiogenesis","volume":"107","author":"Yano","year":"2001","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib249","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/ICO.0b013e3181dc81a0","article-title":"Photodynamic therapy with verteporfin combined with subconjunctival injection of bevacizumab for corneal neovascularization","volume":"30","author":"You","year":"2011","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib250","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1167\/iovs.07-1418","article-title":"Vascular endothelial growth factor mediates corneal nerve repair","volume":"49","author":"Yu","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib251","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.exer.2009.08.010","article-title":"Identification of lymphatics in the ciliary body of the human eye: a novel \u201cuveolymphatic\u201d outflow pathway","volume":"89","author":"Yucel","year":"2009","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib252","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1158\/0008-5472.CAN-09-3488","article-title":"Suppression of tumor growth and metastasis by simultaneously blocking vascular endothelial growth factor (VEGF)-A and VEGF-C with a receptor-immunoglobulin fusion protein","volume":"70","author":"Zhang","year":"2010","journal-title":"Cancer Research"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib253","doi-asserted-by":"crossref","first-page":"9828","DOI":"10.1128\/JVI.75.20.9828-9835.2001","article-title":"Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis","volume":"75","author":"Zheng","year":"2001","journal-title":"Journal of Virology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib254","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0002-9440(10)61777-4","article-title":"Control of stromal keratitis by inhibition of neovascularization","volume":"159","author":"Zheng","year":"2001","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib255","first-page":"1427","article-title":"Expression of cell adhesion molecules on limbal and neovascular endothelium in corneal inflammatory neovascularization","volume":"40","author":"Zhu","year":"1999","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib256","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00251-008-0353-8","article-title":"Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen","volume":"61","author":"Zhu","year":"2009","journal-title":"Immunogenetics"},{"issue":"Pt 2","key":"10.1016\/j.preteyeres.2013.01.001_bib257","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/eye.1994.41","article-title":"Perpetuation of stem cells in the eye","volume":"8","author":"Zieske","year":"1994","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib258","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1136\/bjo.2008.147355","article-title":"Tumour-associated lymphangiogenesis in conjunctival malignant melanoma","volume":"93","author":"Zimmermann","year":"2009","journal-title":"British Journal of Ophthalmology"},{"key":"10.1016\/j.preteyeres.2013.01.001_bib259","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3928\/1081-597X-19890701-12","article-title":"Eine erfolgreiche totale Keratoplastik","volume":"5","author":"Zirm","year":"1989","journal-title":"Refractive & Corneal Surgery"}],"container-title":["Progress in Retinal and Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946213000037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946213000037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T17:23:16Z","timestamp":1687972996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350946213000037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":263,"alternative-id":["S1350946213000037"],"URL":"https:\/\/doi.org\/10.1016\/j.preteyeres.2013.01.001","relation":{},"ISSN":["1350-9462"],"issn-type":[{"value":"1350-9462","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}