{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:53:35Z","timestamp":1792976015094,"version":"4.5.0"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Retinal and Eye Research"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.preteyeres.2015.06.002","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T05:56:05Z","timestamp":1435038965000},"page":"67-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":516,"special_numbering":"C","title":["Molecular pathogenesis of retinal and choroidal vascular diseases"],"prefix":"10.1016","volume":"49","author":[{"given":"Peter A.","family":"Campochiaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.preteyeres.2015.06.002_bib1","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/archopht.119.10.1417","article-title":"A\u00a0randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss","volume":"119","author":"Age-Related Eye Disease Study Research Group","year":"2001","journal-title":"Arch. Ophthalmol."},{"issue":"23","key":"10.1016\/j.preteyeres.2015.06.002_bib2","doi-asserted-by":"crossref","first-page":"10457","DOI":"10.1073\/pnas.92.23.10457","article-title":"Suppression of retinal neovascularization in\u00a0vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins","volume":"92","author":"Aiello","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.preteyeres.2015.06.002_bib3","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/nm1095-1024","article-title":"Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity","volume":"1","author":"Alon","year":"1995","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.preteyeres.2015.06.002_bib4","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1006\/mthe.2002.0702","article-title":"Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents","volume":"6","author":"Auricchio","year":"2002","journal-title":"Mol. Ther."},{"issue":"12","key":"10.1016\/j.preteyeres.2015.06.002_bib5","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1136\/bjophthalmol-2014-305252","article-title":"Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD","volume":"98","author":"Avery","year":"2014","journal-title":"Br. J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.preteyeres.2015.06.002_bib6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/sj.gt.3301680","article-title":"Inhibition of retinal neovascularization by gene transfer of soluble VEGF receptor sFlt-1","volume":"9","author":"Bainbridge","year":"2002","journal-title":"Gene Ther."},{"issue":"15","key":"10.1016\/j.preteyeres.2015.06.002_bib7","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/sj.gt.3302769","article-title":"EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV","volume":"13","author":"Balaggan","year":"2006","journal-title":"Gene Ther."},{"issue":"8","key":"10.1016\/j.preteyeres.2015.06.002_bib8","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1182\/blood.V87.8.3336.bloodjournal8783336","article-title":"Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1","volume":"87","author":"Barleon","year":"1996","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.preteyeres.2015.06.002_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cytogfr.2004.03.005","article-title":"Insight into the physiological functions of PDGF through genetic studies in mice","volume":"15","author":"Betsholtz","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"issue":"5","key":"10.1016\/j.preteyeres.2015.06.002_bib10","article-title":"Combined inhibition of platelet-derived (PDGF) and vascular endothelial (VEGF) growth factors for the treatment of neovascular age-related macular degeneration (NV-AMD). Results of a phase 1 study","volume":"50","author":"Boyer","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"14","key":"10.1016\/j.preteyeres.2015.06.002_bib11","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1056\/NEJMoa062655","article-title":"Ranibizumab versus verteporfin for neovascular age-related macular degeneration","volume":"355","author":"Brown","year":"2006","journal-title":"N.\u00a0Eng. J. Med."},{"issue":"6","key":"10.1016\/j.preteyeres.2015.06.002_bib12","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.ophtha.2010.02.022","article-title":"Efficacy and safety of ranibizumab in the treatment of macular edema secondary to central retinal vein occlusion:6-month results of the phase III CRUISE study","volume":"117","author":"Brown","year":"2010","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.preteyeres.2015.06.002_bib13","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.ophtha.2011.02.022","article-title":"Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study","volume":"118","author":"Brown","year":"2011","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib14","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1167\/iovs.03-0955","article-title":"Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412","volume":"45","author":"Campochiaro","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib15","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1167\/iovs.05-1494","article-title":"Ocular versus extraocular neovascularization: mirror images or vague resemblances","volume":"47","author":"Campochiaro","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.preteyeres.2015.06.002_bib16","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1006\/exer.1993.1158","article-title":"Corneal endothelial cell matrix promotes expression of differentiated features of retinal pigmented epithelial cells: implication of laminin and basic fibroblast growth factor as active components","volume":"57","author":"Campochiaro","year":"1993","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/hum.2006.17.167","article-title":"Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial","volume":"17","author":"Campochiaro","year":"2006","journal-title":"Hum. Gene Ther."},{"issue":"4","key":"10.1016\/j.preteyeres.2015.06.002_bib18","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/mt.2008.10","article-title":"Ranibizumab for macular edema due to retinal vein occlusions; implication of VEGF as a critical stimulator","volume":"16","author":"Campochiaro","year":"2008","journal-title":"Molec. Ther."},{"issue":"6","key":"10.1016\/j.preteyeres.2015.06.002_bib19","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.ophtha.2010.02.021","article-title":"Ranibizumab for macular edema following branch retinal vein occlusion: 6-month primary endpoint results of a phase III study","volume":"117","author":"Campochiaro","year":"2010","journal-title":"Ophthalmology"},{"issue":"10","key":"10.1016\/j.preteyeres.2015.06.002_bib20","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.ophtha.2011.02.038","article-title":"Sustained benefits from ranibizumab for macular edema following central retinal vein occlusion: 12-month outcomes of a phase III study","volume":"118","author":"Campochiaro","year":"2011","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.preteyeres.2015.06.002_bib21","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ophtha.2010.12.028","article-title":"Long-term benefit of sustained-delivery fluocinolone acetonide vitreous inserts for diabetic macular edema","volume":"118","author":"Campochiaro","year":"2011","journal-title":"Ophthalmology"},{"issue":"10","key":"10.1016\/j.preteyeres.2015.06.002_bib22","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.ophtha.2012.04.030","article-title":"Sustained delivery fluocinolone acetonide vitreous inserts provide benefit for at least 3 years in patients with diabetic macular edema","volume":"119","author":"Campochiaro","year":"2012","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.preteyeres.2015.06.002_bib23","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ophtha.2012.09.032","article-title":"Vascular endothelial growth factor promotes progressive retinal nonperfusion in patients with retinal vein occlusion","volume":"120","author":"Campochiaro","year":"2013","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.preteyeres.2015.06.002_bib24","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.ophtha.2014.03.021","article-title":"Neutralization of vascular endothelial growth factor slows progression of retinal nonperfusion in patients iwth diabetic macular edema","volume":"121","author":"Campochiaro","year":"2014","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ophtha.2014.09.023","article-title":"Treatment of diabetic macular edema with an inhibitor of vascular endothelial-protein tyrosine phosphatase that activates Tie2","volume":"122","author":"Campochiaro","year":"2015","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ajo.2014.09.012","article-title":"Regression of choroidal neovascularization results in macular atrophy in anti-vascular endothelial growth factor-treated eyes","volume":"159","author":"Channa","year":"2015","journal-title":"Am. J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.preteyeres.2015.06.002_bib27","first-page":"955","article-title":"A\u00a0human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture","volume":"36","author":"Davis","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.preteyeres.2015.06.002_bib28","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0092-8674(00)81812-7","article-title":"Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning","volume":"87","author":"Davis","year":"1996","journal-title":"Cell"},{"issue":"5425","key":"10.1016\/j.preteyeres.2015.06.002_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.285.5425.245","article-title":"Pigment epithelium-derived factor: a potent inhibitor of angiogenesis","volume":"285","author":"Dawson","year":"1999","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib30","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1001\/archopht.1989.01070010270035","article-title":"A\u00a0new model of choroidal neovascularization in the rat","volume":"107","author":"Dobi","year":"1989","journal-title":"Arch. Ophthalmol."},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib31","first-page":"553","article-title":"Antagonism of PDGF-BB suppresses subretinal neovascularization and enhances the effects of blocking VEGF-A","volume":"17","author":"Dong","year":"2014","journal-title":"Angiogenesis"},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.beha.2009.01.001","article-title":"Thrombosis associated with angiogenesis inhibitors","volume":"22","author":"Elice","year":"2009","journal-title":"Best. Pract. Res. Clin. Haematol."},{"issue":"11","key":"10.1016\/j.preteyeres.2015.06.002_bib33","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1056\/NEJMoa0707330","article-title":"VEGF inhibition and renal thrombotic microangiopathy","volume":"358","author":"Eremina","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"43","key":"10.1016\/j.preteyeres.2015.06.002_bib34","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.1038\/sj.onc.1202992","article-title":"Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2","volume":"18","author":"Fachinger","year":"1999","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.preteyeres.2015.06.002_bib119","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/emboj\/21.7.1535","article-title":"Lack of collagen XVIII\/endostatin results in eye abnormalities","volume":"21","author":"Fukai","year":"2002","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib35","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1534-5807(02)00217-4","article-title":"Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-1","volume":"3","author":"Gale","year":"2002","journal-title":"Devel. Cell."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib36","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ophtha.2013.08.015","article-title":"Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials","volume":"121","author":"Grunwald","year":"2012","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib37","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/1097-4652(200009)184:3<275::AID-JCP1>3.0.CO;2-7","article-title":"Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization","volume":"184","author":"Hackett","year":"2000","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib38","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jcp.10128","article-title":"Angiopoietin-2 plays an important role in retinal angiogenesis","volume":"192","author":"Hackett","year":"2002","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"12","key":"10.1016\/j.preteyeres.2015.06.002_bib39","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.ophtha.2012.09.006","article-title":"Intravitreal aflibercept (VEGF Trap-Eye) in wet age-related macular degeneration","volume":"119","author":"Heier","year":"2012","journal-title":"Ophthalmology"},{"issue":"11","key":"10.1016\/j.preteyeres.2015.06.002_bib40","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/sj.gt.3301203","article-title":"Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF.flt-1 receptor gene transfection: a role of VEGF and possible treatment for SRN in age-related macular degeneration","volume":"7","author":"Honda","year":"2000","journal-title":"Gene Ther."},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/sj.gt.3301878","article-title":"Lentivirus-mediated expression of angiostatin efficiently inhibits neovascularization in a murine proliferative retinopathy model","volume":"10","author":"Igarashi","year":"2003","journal-title":"Gene Ther."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0002-9440(10)63273-7","article-title":"Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts","volume":"165","author":"Inai","year":"2004","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib43","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jconrel.2013.10.008","article-title":"Sustained delivery of a HIF-1 antagonist for ocular neovascularization","volume":"172","author":"Iwase","year":"2013","journal-title":"J.\u00a0Control. Release"},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1089\/hum.2008.046","article-title":"EIAV vector-mediated co-delivery of endostatin and angiostatin driven by the RPE-specific VMD2 promoter inhibits choroidal neovascularization","volume":"20","author":"Kachi","year":"2008","journal-title":"Hum. Gene Ther."},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib44","doi-asserted-by":"crossref","first-page":"H560","DOI":"10.1152\/ajpheart.00133.2005","article-title":"VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature","volume":"290","author":"Kamba","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"11","key":"10.1016\/j.preteyeres.2015.06.002_bib45","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1161\/01.RES.0000102937.50486.1B","article-title":"Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1","volume":"93","author":"Kelly","year":"2003","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/01.RES.86.1.24","article-title":"Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-kinase\/Akt signal transduction pathway","volume":"86","author":"Kim","year":"2000","journal-title":"Circ. Res."},{"issue":"39","key":"10.1016\/j.preteyeres.2015.06.002_bib47","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1038\/sj.onc.1203800","article-title":"Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase\/Akt signal transduction pathway","volume":"19","author":"Kim","year":"2000","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.preteyeres.2015.06.002_bib48","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.ophtha.2007.08.030","article-title":"Retinal precursors and the development of geographic atrophy in age-related macular degeneration","volume":"115","author":"Klein","year":"2008","journal-title":"Ophthalmology"},{"issue":"10","key":"10.1016\/j.preteyeres.2015.06.002_bib49","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1002\/j.1460-2075.1990.tb07523.x","article-title":"Structural diversity and evolution of human receptor-like protein tyrosine phosphatases","volume":"9","author":"Krueger","year":"1990","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib50","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1001\/archopht.120.3.338","article-title":"Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment","volume":"120","author":"Kryzstolik","year":"2002","journal-title":"Arch. Ophthalmol."},{"issue":"11","key":"10.1016\/j.preteyeres.2015.06.002_bib51","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1172\/JCI65157","article-title":"Targeted deletion of Vegfa in adult mice induces vision loss","volume":"122","author":"Kurihara","year":"2012","journal-title":"J.\u00a0Clin. Invest"},{"issue":"10","key":"10.1016\/j.preteyeres.2015.06.002_bib52","first-page":"3158","article-title":"VEGF is an important stimulator in a model of choroidal neovascularization","volume":"41","author":"Kwak","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"10","key":"10.1016\/j.preteyeres.2015.06.002_bib53","first-page":"2401","article-title":"Suppression of choroidal neovascularization by adeno-associated virus vector expressing angiostatin","volume":"42","author":"Lai","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"12","key":"10.1016\/j.preteyeres.2015.06.002_bib54","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/sj.gt.3301695","article-title":"Potential long-term inhibition of ocular neovascularization by recombinant adeno-associated virus-mediated secretion gene therapy","volume":"9","author":"Lai","year":"2002","journal-title":"Gene Ther."},{"issue":"4","key":"10.1016\/j.preteyeres.2015.06.002_bib55","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.ymthe.2005.04.022","article-title":"Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys","volume":"12","author":"Lai","year":"2005","journal-title":"Mol. Ther."},{"issue":"7","key":"10.1016\/j.preteyeres.2015.06.002_bib56","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1073\/pnas.0812801106","article-title":"Antracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor induced mobilizatio of circulating angiogenic cells","volume":"106","author":"Lee","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.preteyeres.2015.06.002_bib57","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1096\/fj.06-7359com","article-title":"The SDF-1\/CXCR4 ligand\/receptor pair is an important contributor to several types of ocular neovascularization","volume":"21","author":"Lima e Silva","year":"2007","journal-title":"FASEB J."},{"issue":"5323","key":"10.1016\/j.preteyeres.2015.06.002_bib58","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.277.5323.242","article-title":"Pericyte loss and microaneurysm formation in PDGF-B-deficient mice","volume":"277","author":"Lindahl","year":"1997","journal-title":"Science"},{"issue":"15","key":"10.1016\/j.preteyeres.2015.06.002_bib59","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1101\/gad.266803","article-title":"Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall","volume":"17","author":"Lindblom","year":"2003","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib60","first-page":"260","article-title":"Inhibition of choroidal neovascularization in a nonhuman primate model by intravitreal administration of an AAV2 vector expressing a novel anti-VEGF molecule","volume":"19","author":"Lukason","year":"2011"},{"issue":"5322","key":"10.1016\/j.preteyeres.2015.06.002_bib61","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.277.5322.55","article-title":"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in\u00a0vivo angiogenesis","volume":"277","author":"Maisonpierre","year":"1997","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.preteyeres.2015.06.002_bib62","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0002-9440(10)61231-X","article-title":"Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function","volume":"167","author":"Mameros","year":"2005","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib63","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0002-9440(10)61697-5","article-title":"Inhibition of choroidal neovascularization by intravenous injection of adenoviral vectors expressing secretable endostatin","volume":"159","author":"Mori","year":"2001","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib64","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/jcp.1114","article-title":"Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization","volume":"188","author":"Mori","year":"2001","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"7","key":"10.1016\/j.preteyeres.2015.06.002_bib65","first-page":"2428","article-title":"Regression of ocular neovascularization by increased expression of pigment epithelium-derived factor","volume":"43","author":"Mori","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.preteyeres.2015.06.002_bib66","first-page":"2001","article-title":"Retina-specific expression of PDGF-B versus PDGF-A: vascular versus nonvascular proliferative retinopathy","volume":"43","author":"Mori","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.preteyeres.2015.06.002_bib67","first-page":"1994","article-title":"AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization","volume":"43","author":"Mori","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib68","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/(SICI)1097-4644(19990701)74:1<135::AID-JCB15>3.0.CO;2-#","article-title":"Extracellular matrix-integrin binding modulates secretion of angiogenic growth factors by retinal pigmented epithelial cells","volume":"74","author":"Mousa","year":"1999","journal-title":"J.\u00a0Cell. Biochem."},{"issue":"10","key":"10.1016\/j.preteyeres.2015.06.002_bib69","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/sj.gt.3302230","article-title":"Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier","volume":"11","author":"Nambu","year":"2004","journal-title":"Gene Ther."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib70","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/jcp.20292","article-title":"Angiopoietin 1 prevents retinal detachment in an aggressive model of proliferative retinopathy, but has no effect on established neovascularization","volume":"204","author":"Nambu","year":"2005","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib71","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1167\/iovs.03-0557","article-title":"Supplemental inspired oxygen improves diabetic macular edema; a pilot study","volume":"45","author":"Nguyen","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.preteyeres.2015.06.002_bib72","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.ajo.2006.06.068","article-title":"Vascular endothelial growth factor is a critical stimulus for diabetic macular edema","volume":"142","author":"Nguyen","year":"2006","journal-title":"Am. J. Ophthalmol."},{"issue":"11","key":"10.1016\/j.preteyeres.2015.06.002_bib73","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/j.ophtha.2009.04.023","article-title":"Primary end point (six months) results of the ranibizumab for edema of the macula in diabetes (READ-2) study","volume":"116","author":"Nguyen","year":"2009","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.preteyeres.2015.06.002_bib74","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.ophtha.2011.12.039","article-title":"Ranibizumab for diabetic macular edema. Results from 2 phase III randomized Trials: RISE and RIDE","volume":"119","author":"Nguyen","year":"2012","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib75","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0092-8674(94)90200-3","article-title":"Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma","volume":"79","author":"O'Reilly","year":"1994","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib76","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0092-8674(00)81848-6","article-title":"Endostatin: an endogenous inhibitor of angiogenesis and tumor growth","volume":"88","author":"O'Reilly","year":"1997","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib77","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0002-9440(10)64891-2","article-title":"Inducible expression of vascular endothelial growth factor in photoreceptors of adult mice causes severe proliferative retinopathy and retinal detachment","volume":"160","author":"Ohno-Matsui","year":"2002","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib78","first-page":"281","article-title":"Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization","volume":"151","author":"Okamoto","year":"1997","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib79","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/jcp.10442","article-title":"Angiopoietin-2 enhances retinal vessel sensitivity to vascular endothelial growth factor","volume":"199","author":"Oshima","year":"2004","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib80","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/jcp.20110","article-title":"Increased expression of VEGF in retinal pigmented epithelial cells is not sufficient to cause choroidal neovascularization","volume":"201","author":"Oshima","year":"2004","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib81","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/jcp.10441","article-title":"Intraocular gutless adenoviral vectored VEGF stimulates anterior segment but not retinal neovascularization","volume":"199","author":"Oshima","year":"2004","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"8","key":"10.1016\/j.preteyeres.2015.06.002_bib82","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1096\/fj.04-2209fje","article-title":"Different effects of angiopoietin 2 in different vascular beds in the eye; new vessels are most sensitive","volume":"19","author":"Oshima","year":"2005","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.preteyeres.2015.06.002_bib83","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1006\/exer.1996.0239","article-title":"Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates","volume":"64","author":"Ozaki","year":"1997","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib84","first-page":"182","article-title":"Hypoxia inducible factor-1a is increased in ischemic retina: temporal and spatial correlation with VEGF expression","volume":"40","author":"Ozaki","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib85","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0002-9440(10)64773-6","article-title":"Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization","volume":"156","author":"Ozaki","year":"2000","journal-title":"Am. J. Pathol."},{"issue":"41","key":"10.1016\/j.preteyeres.2015.06.002_bib86","doi-asserted-by":"crossref","first-page":"25646","DOI":"10.1016\/S0021-9258(18)47298-5","article-title":"Placenta growth factor: potentiation of vascular endothelial growth factor bioactivity, in\u00a0vitro and in\u00a0vivo, and high affinity binding to Flt-1 but not to Flk-1\/KDR","volume":"269","author":"Park","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"issue":"11","key":"10.1016\/j.preteyeres.2015.06.002_bib87","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/0002-9394(53)91779-6","article-title":"Oxygen studies in retrolental fibroplasia: production of the microscopic changes of retrolental fibroplasia in experimental animals","volume":"36","author":"Patz","year":"1953","journal-title":"Am. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib88","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/gt.2008.115","article-title":"Novel anit-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization","volume":"16","author":"Pechan","year":"2009","journal-title":"Gene Ther."},{"issue":"11","key":"10.1016\/j.preteyeres.2015.06.002_bib89","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1074\/jbc.275.11.8051","article-title":"New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in\u00a0vivo","volume":"275","author":"Petitclerc","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"issue":"10","key":"10.1016\/j.preteyeres.2015.06.002_bib90","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1001\/archopht.1996.01100140419009","article-title":"Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity","volume":"114","author":"Pierce","year":"1996","journal-title":"Arch. Ophthalmol."},{"issue":"13","key":"10.1016\/j.preteyeres.2015.06.002_bib91","doi-asserted-by":"crossref","first-page":"8909","DOI":"10.1073\/pnas.122247299","article-title":"Adeno-associated virus type 2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization","volume":"99","author":"Raisler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"14","key":"10.1016\/j.preteyeres.2015.06.002_bib92","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJMoa054481","article-title":"Ranibizumab for neovascular age-related macular degeneration","volume":"355","author":"Rosenfeld","year":"2006","journal-title":"N.\u00a0Eng. J. Med."},{"issue":"9","key":"10.1016\/j.preteyeres.2015.06.002_bib93","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/jgm.586","article-title":"Marked inhibition of retinal neovascularization in rats following soluble-flt-1 gene transfer","volume":"6","author":"Rota","year":"2004","journal-title":"J.\u00a0Gene Med."},{"issue":"11","key":"10.1016\/j.preteyeres.2015.06.002_bib94","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1001\/archopht.1982.01030040784015","article-title":"Subretinal neovascularization: natural history of an experimental model","volume":"100","author":"Ryan","year":"1982","journal-title":"Arch. Ophthalmol."},{"issue":"44","key":"10.1016\/j.preteyeres.2015.06.002_bib95","doi-asserted-by":"crossref","first-page":"18751","DOI":"10.1073\/pnas.0905010106","article-title":"An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris","volume":"106","author":"Saint-Geniez","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib96","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/jcp.10246","article-title":"VEGF-TRAPR1R2 suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier","volume":"195","author":"Saishin","year":"2003","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"6535","key":"10.1016\/j.preteyeres.2015.06.002_bib97","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/376070a0","article-title":"Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation","volume":"376","author":"Sato","year":"1995","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.preteyeres.2015.06.002_bib98","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1152\/jappl.2000.88.4.1474","article-title":"HIF-1: mediator of physiological and pathophysiological responses to hypoxia","volume":"88","author":"Semenza","year":"2000","journal-title":"J.\u00a0Appl. Physiol."},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib99","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0002-9440(10)64612-3","article-title":"Photoreceptor-specific expression of PDGF-B results in traction retinal detachment","volume":"157","author":"Seo","year":"2000","journal-title":"Am. J. Pathol."},{"issue":"9","key":"10.1016\/j.preteyeres.2015.06.002_bib100","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1167\/iovs.07-0113","article-title":"In\u00a0vivo immunostaining demonstrates macrophages associate with growing and regressing vessels","volume":"48","author":"Shen","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"10","key":"10.1016\/j.preteyeres.2015.06.002_bib101","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1172\/JCI74527","article-title":"Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature","volume":"124","author":"Shen","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib102","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7 pt 1","key":"10.1016\/j.preteyeres.2015.06.002_bib103","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1523\/JNEUROSCI.15-07-04738.1995","article-title":"Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia","volume":"15","author":"Stone","year":"1995","journal-title":"J.\u00a0Neurosci."},{"issue":"8","key":"10.1016\/j.preteyeres.2015.06.002_bib121","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1096\/fj.02-0824fje","article-title":"Intraocular expression of endostatin reduces VEGF-induced retinal vascular permeability, neovascularization, and retinal detachment","volume":"17","author":"Takahashi","year":"2003","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.preteyeres.2015.06.002_bib104","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.ophtha.2010.02.031","article-title":"Randomized trial evaluating ranibzumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema","volume":"117","author":"The Diabetic Retinopathy Clinical Research Network","year":"2010","journal-title":"Ophthalmolgy"},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib105","first-page":"180","article-title":"Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors","volume":"39","author":"Tobe","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.preteyeres.2015.06.002_bib106","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0002-9440(10)65753-7","article-title":"Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model","volume":"153","author":"Tobe","year":"1998","journal-title":"Am. J. Pathol."},{"issue":"8","key":"10.1016\/j.preteyeres.2015.06.002_bib107","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1001\/archopht.1996.01100140172010","article-title":"Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate","volume":"114","author":"Tolentino","year":"1996","journal-title":"Arch. Ophthalmol."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib108","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/jcp.21445","article-title":"Prolonged blockade of VEGF family members does not cause identifiable damage to retinal neurons or vessels","volume":"217","author":"Ueno","year":"2008","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"6","key":"10.1016\/j.preteyeres.2015.06.002_bib109","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1124\/mol.105.020941","article-title":"Suppression and regression of choroidal neovascularization by systemic administration of an Alpha5Beta1 integrin antagonist","volume":"69","author":"Umeda","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.preteyeres.2015.06.002_bib110","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/jcp.20525","article-title":"Implication of the hypoxia response element of the VEGF promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development","volume":"206","author":"Vinores","year":"2006","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"4","key":"10.1016\/j.preteyeres.2015.06.002_bib111","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ng1294-352","article-title":"Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy","volume":"8","author":"Weber","year":"1994","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.preteyeres.2015.06.002_bib112","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10456-008-9126-0","article-title":"Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells","volume":"12","author":"Yacyshyn","year":"2009","journal-title":"Angiogenesis"},{"issue":"2","key":"10.1016\/j.preteyeres.2015.06.002_bib113","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1097-4652(199905)179:2<149::AID-JCP5>3.0.CO;2-2","article-title":"Hyperoxia causes decreased expression of vascular endothelial growth factor and endothelial cell apoptosis in adult retina","volume":"179","author":"Yamada","year":"1999","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"5","key":"10.1016\/j.preteyeres.2015.06.002_bib114","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00006982-200110000-00003","article-title":"Retinal angiomatous proliferation in age-related macular degeneration","volume":"21","author":"Yannuzzi","year":"2001","journal-title":"Retina"},{"issue":"6","key":"10.1016\/j.preteyeres.2015.06.002_bib115","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1096\/fj.09-145664","article-title":"Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization","volume":"24","author":"Yoshida","year":"2010","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.preteyeres.2015.06.002_bib116","first-page":"3999","article-title":"Intraretinal oxygen levels before and after photoreceptor loss in the RCS rat","volume":"41","author":"Yu","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"10.1016\/j.preteyeres.2015.06.002_bib117","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1128\/MCB.01472-08","article-title":"Angiopoietin 2 is a partial agonist\/antagonist of Tie2 signaling in the endothelium","volume":"29","author":"Yuan","year":"2009","journal-title":"Molec. Cell. Biol."},{"issue":"50","key":"10.1016\/j.preteyeres.2015.06.002_bib118","doi-asserted-by":"crossref","first-page":"19579","DOI":"10.1073\/pnas.0809763105","article-title":"Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Progress in Retinal and Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946215000440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946215000440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T19:40:09Z","timestamp":1652557209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350946215000440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":121,"alternative-id":["S1350946215000440"],"URL":"https:\/\/doi.org\/10.1016\/j.preteyeres.2015.06.002","relation":{},"ISSN":["1350-9462"],"issn-type":[{"value":"1350-9462","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular pathogenesis of retinal and choroidal vascular diseases","name":"articletitle","label":"Article Title"},{"value":"Progress in Retinal and Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preteyeres.2015.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}