{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:26:13Z","timestamp":1793384773350,"version":"4.5.0"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Retinal and Eye Research"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.preteyeres.2017.08.004","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T02:16:43Z","timestamp":1506565003000},"page":"24-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":306,"special_numbering":"C","title":["The mechanism of cone cell death in Retinitis Pigmentosa"],"prefix":"10.1016","volume":"62","author":[{"given":"Peter A.","family":"Campochiaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahreem A.","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preteyeres.2017.08.004_bib1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.cell.2015.03.023","article-title":"Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis","volume":"161","author":"Ait-Ali","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0022-510X(98)00042-2","article-title":"Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid","volume":"156","author":"Ando","year":"1998","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1073\/pnas.022630199","article-title":"Reactive oxygen generated by Nox1 triggers the angiogenic switch","volume":"99","author":"Arbiser","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib4","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/ptr.1749","article-title":"Radical scavenging activity of Crocus sativusL. extract and its bioactive constituents","volume":"19","author":"Assimopoulou","year":"2005","journal-title":"Phytother. Res."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib5","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/abbi.2001.2642","article-title":"The neutrophil NADPH oxidase","volume":"397","author":"Babior","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib6","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1073\/pnas.87.4.1620","article-title":"Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide","volume":"87","author":"Beckman","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.preteyeres.2017.08.004_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1515\/bchm3.1994.375.2.81","article-title":"Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry","volume":"375","author":"Beckmann","year":"1994","journal-title":"Biol. Chem. Hoppe Seyler"},{"issue":"6","key":"10.1016\/j.preteyeres.2017.08.004_bib8","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1073\/pnas.1118847109","article-title":"Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa","volume":"109","author":"Beltran","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0005-2760(80)90209-X","article-title":"Indentification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids","volume":"620","author":"Benedetti","year":"1980","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib10","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0002-9394(14)73708-0","article-title":"Ocular findings in patients with autosomal dominant retinitis pigmentosa and rhodopsin, proline-347-leucine","volume":"111","author":"Berson","year":"1991","journal-title":"Am. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.preteyeres.2017.08.004_bib11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/09286586.2014.929710","article-title":"Prevalence of generalized retinal dystrophy in Denmark","volume":"21","author":"Bertelsen","year":"2014","journal-title":"Ophthalmic Epidemiol."},{"issue":"9","key":"10.1016\/j.preteyeres.2017.08.004_bib12","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1001\/jamaophthalmol.2013.4160","article-title":"Spectral-domain optical coherence tomography measures of outer segment layer progression in patients with X-linked retinitis pigmentosa","volume":"131","author":"Birch","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib13","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0022-3565(25)24517-7","article-title":"Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection","volume":"272","author":"Botla","year":"1995","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"issue":"10","key":"10.1016\/j.preteyeres.2017.08.004_bib14","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1136\/bjo.22.10.608","article-title":"Cataract associated with an hereditary retinal lesion in rats","volume":"22","author":"Bourne","year":"1938","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/347677a0","article-title":"Retinal degeneration in the rd mouse caused by a defect in the beta subunit of rod cGMP-phosphodiesterase","volume":"347","author":"Bowes","year":"1990","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.preteyeres.2017.08.004_bib16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1172\/JCI65654","article-title":"Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration","volume":"125","author":"Byrne","year":"2015","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib17","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1046\/j.1471-4159.1999.0720751.x","article-title":"Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's Disease","volume":"72","author":"Calingasan","year":"1999","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib18","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/ars.2015.6327","article-title":"Is there excess oxidative stress and damage in eyes of patients with retinitis pigmentosa","volume":"23","author":"Campochiaro","year":"2015","journal-title":"Antioxid. Redox. Signal"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib19","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1164\/rccm.200902-0296OC","article-title":"NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice","volume":"180","author":"Carnesecchi","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib20","first-page":"489","article-title":"Differential effects of the rd mutation on rods and cones in the mouse retina","volume":"17","author":"Carter-Dawson","year":"1978","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.preteyeres.2017.08.004_bib21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/physrev.1979.59.3.527","article-title":"Hydroperoxide metabolism in mammalian organisms","volume":"59","author":"Chance","year":"1979","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0042-6989(01)00146-8","article-title":"Retinal degeneration mutants in the mouse","volume":"42","author":"Chang","year":"2002","journal-title":"Vis. Res."},{"issue":"1\u20132","key":"10.1016\/j.preteyeres.2017.08.004_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-1119(01)00449-8","article-title":"Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5","volume":"269","author":"Cheng","year":"2001","journal-title":"Gene"},{"issue":"6","key":"10.1016\/j.preteyeres.2017.08.004_bib24","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1152\/ajplegacy.1974.226.6.1401","article-title":"Superoxide dismutase and pulmonary oxygen toxicity","volume":"226","author":"Crapo","year":"1974","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib25","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/cdd.2010.2","article-title":"The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress","volume":"17","author":"Cronin","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib26","first-page":"479","article-title":"Determination of 8-hydroxydeoxyguanosine in human urine: a possible assay for in\u00a0vivo oxidative DNA damage","volume":"49","author":"Cundy","year":"1988","journal-title":"Basic Life Sci."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/hmg\/9.4.645","article-title":"Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat","volume":"9","author":"D'Cruz","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1001\/archopht.125.2.151","article-title":"Perspective on genes and mutations causing retinitis pigmentosa","volume":"125","author":"Daiger","year":"2007","journal-title":"Arch. Ophthalmol."},{"issue":"12","key":"10.1016\/j.preteyeres.2017.08.004_bib29","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.4161\/cbt.4.12.2233","article-title":"Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors","volume":"4","author":"Desouki","year":"2005","journal-title":"Canc. Biol. Ther."},{"issue":"1","key":"10.1016\/j.preteyeres.2017.08.004_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1172\/JCI109273","article-title":"Subcellular localization of the superoxide-forming enzyme in human neutrophils","volume":"63","author":"Dewald","year":"1979","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib31","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.2527\/jas.2006-835","article-title":"Oral N-acetyl-L-cysteine is a safe and effective precursor of cysteine","volume":"85","author":"Dilger","year":"2007","journal-title":"J.\u00a0Anim. Sci."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib32","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/jcp.20683","article-title":"Superoxide dismutase 1 protects retinal cells from oxidative damage","volume":"208","author":"Dong","year":"2006","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib33","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/343364a0","article-title":"A\u00a0point mutation of the rhodopsin gene in one form of retinitis pigmentosa","volume":"343","author":"Dryja","year":"1990","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.preteyeres.2017.08.004_bib34","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.freeradbiomed.2015.01.003","article-title":"Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage","volume":"2015","author":"Elachouri","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib35","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0076-6879(90)86134-H","article-title":"Determination of aldehydic lipid peroxidation products: malondialdehyde, and 4-hydroxynonenal","volume":"186","author":"Esterbauer","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.preteyeres.2017.08.004_bib37","doi-asserted-by":"crossref","first-page":"e43074","DOI":"10.1371\/journal.pone.0043074","article-title":"Safranal, a saffron constituent, attenuates retinal degeneration in P23H rats","volume":"7","author":"Fernandez-Sanchez","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.preteyeres.2017.08.004_bib38","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1167\/iovs.11-7496","article-title":"Tauroursodeoxycholic acid prevents retinal degeneration in transgenic P23H rats","volume":"52","author":"Fernandez-Sanchez","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib39","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1001\/archopht.1978.03910060019004","article-title":"Retinitis pigmentosa. Visual loss","volume":"96","author":"Fishman","year":"1978","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib40","doi-asserted-by":"crossref","first-page":"10986","DOI":"10.1016\/S0021-9258(19)68544-3","article-title":"Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria","volume":"256","author":"Freeman","year":"1981","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib41","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/81555","article-title":"Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa","volume":"26","author":"Gal","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib42","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/cne.21144","article-title":"Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study","volume":"500","author":"Gargini","year":"2007","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"12","key":"10.1016\/j.preteyeres.2017.08.004_bib43","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1167\/iovs.09-3916","article-title":"Mapping retinal degeneration and loss-of-function in Rd-FTL mice","volume":"50","author":"Greferath","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.preteyeres.2017.08.004_bib44","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0161-6420(97)30291-7","article-title":"Rate of visual field loss in retinitis pigmentosa","volume":"104","author":"Grover","year":"1997","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.preteyeres.2017.08.004_bib45","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1172\/JCI117607","article-title":"Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury","volume":"94","author":"Haddad","year":"1994","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib46","first-page":"1","article-title":"Epidemiology of retinitis pigmentosa in Denmark","volume":"233","author":"Haim","year":"2002","journal-title":"Acta Ophalmol. Scand. Suppl."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1755-3768.1992.tb04120.x","article-title":"A\u00a0population survey of retinitis pigmentosa and allied disorders in Denmark. Completeness of registration and quality of data","volume":"70","author":"Haim","year":"1992","journal-title":"Acta Ophthalmol. (Copenh)"},{"issue":"6","key":"10.1016\/j.preteyeres.2017.08.004_bib48","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1001\/jamaophthalmol.2016.0502","article-title":"Quantification of the ellipsoid zone changes in retinitis pigmentosa using en face spectral domain-optical coherence tomography","volume":"134","author":"Hariri","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib49","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/0016-5085(94)90027-2","article-title":"Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts in primary primary biliary cirrhosis","volume":"106","author":"Heuman","year":"1994","journal-title":"Gastroenterology"},{"issue":"4 Pt2","key":"10.1016\/j.preteyeres.2017.08.004_bib50","first-page":"H1626","article-title":"Expression of phagocyte NADPH oxidase components in human endothelial cells","volume":"271","author":"Jones","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib51","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1021\/jf062638l","article-title":"Crocetin, dimethylcorcetin, and safranal bind human serum albumin: stability and antioxidative properties","volume":"55","author":"Kanakis","year":"2007","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib52","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1073\/pnas.10.7.329","article-title":"The inheritance of a retinal abnormality in white mice","volume":"10","author":"Keeler","year":"1924","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib53","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/jcp.21152","article-title":"Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa","volume":"213","author":"Komeima","year":"2007","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib54","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1073\/pnas.0604056103","article-title":"Antioxidants reduce cone cell death in a model of retinitis pigmentosa","volume":"103","author":"Komeima","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib55","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.freeradbiomed.2008.06.020","article-title":"Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa","volume":"45","author":"Komeima","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.preteyeres.2017.08.004_bib56","doi-asserted-by":"crossref","first-page":"e57163","DOI":"10.1371\/journal.pone.0057163","article-title":"Testing for gap junction-meidated bystander effect in retinitis pigmentosa: secondary cone death is not altered by deletion of connexin36 from cones","volume":"8","author":"Kranz","year":"2013","journal-title":"PLoS One"},{"issue":"6117","key":"10.1016\/j.preteyeres.2017.08.004_bib57","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/327077a0","article-title":"Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues","volume":"327","author":"Kuchino","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib58","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1161\/hh0901.090299","article-title":"Novel gp91(phox) homologues in vascular smooth muscle cells: nox1 mediates angiotensin II-induced superoxide formulation and redox-sensitive signaling pathways","volume":"88","author":"Lassegue","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/exer.1997.0308","article-title":"Variability in rate of cone degeneration in the retinal degeneration (rd\/rd) mouse","volume":"65","author":"LaVail","year":"1997","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib60","first-page":"1843","volume":"vol. 226","author":"Lee","year":"2011"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib61","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/ng1386","article-title":"Identification and characterization of rod-derived viability factor","volume":"36","author":"Leveillard","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib62","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nm0898-967","article-title":"Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa","volume":"4","author":"Lewin","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib63","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1038\/mt.2008.164","article-title":"Downregulation of p22phox in retinal pigment epithelial cells inhibits choroidal neovascularization in mice","volume":"16","author":"Li","year":"2008","journal-title":"Molec. Ther."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib64","first-page":"808","article-title":"Rhodopsin transgenic pigs as a model for human retinitis pigmentosa","volume":"39","author":"Li","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.preteyeres.2017.08.004_bib65","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.exer.2008.11.022","article-title":"Remodeling of cone photoreceptor cells after rod degeneration in rd mice","volume":"88","author":"Lin","year":"2009","journal-title":"Exp. Eye Res."},{"issue":"9","key":"10.1016\/j.preteyeres.2017.08.004_bib66","doi-asserted-by":"crossref","first-page":"74221","DOI":"10.1371\/journal.pone.0074223","article-title":"Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa","volume":"8","author":"Martinez-Fernandez de la Camara","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib67","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ng0693-130","article-title":"Recessive mutations in the gene encoding the beta subunit of rod phosphodiesterase in patients with retinitis pigmenta","volume":"4","author":"McLaughlin","year":"1993","journal-title":"Nat. Genet."},{"issue":"16","key":"10.1016\/j.preteyeres.2017.08.004_bib68","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1089\/ars.2015.6509","article-title":"The thioredoxin encoded by the rod-derived cone viability factor gene protects cone photoreceptors against oxidative stress","volume":"24","author":"Mei","year":"2016","journal-title":"Antioxid. Redox. Signal."},{"issue":"Pt 1","key":"10.1016\/j.preteyeres.2017.08.004_bib69","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/bj2750241","article-title":"Identification of a superoxide-generating NADPH oxidase system in human fibroblasts","volume":"275","author":"Meier","year":"1991","journal-title":"Biochem. J."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib70","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1476-5381.1993.tb12798.x","article-title":"7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure","volume":"108","author":"Moore","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib71","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1167\/iovs.08-1722","article-title":"Expression and role of the early-response gene oxr1 in the hyperoxia-challenged mouse retina","volume":"49","author":"Natoli","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib72","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.exer.2010.12.013","article-title":"Morphological, functional and gene expression analysis of the hyperoxic mouse retina","volume":"92","author":"Natoli","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib73","first-page":"107","article-title":"Visual cell effects of high oxygen pressures","volume":"14","author":"Noell","year":"1955","journal-title":"Fed. Proc."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib74","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0896-6273(92)90236-7","article-title":"Transgenic mice with a rhodopsin muation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa","volume":"9","author":"Olsson","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib75","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1471-4159.2010.07092.x","article-title":"Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration","volume":"116","author":"Oveson","year":"2011","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib76","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1167\/iovs.05-1284","article-title":"Retinal oxygenation and oxygen metabolism in abyssinian cats with a hereditary retinal degeneration","volume":"47","author":"Padnick-Silver","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"24","key":"10.1016\/j.preteyeres.2017.08.004_bib115","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1523\/JNEUROSCI.5200-13.2014","article-title":"Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa","volume":"34","author":"Peng","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib77","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nbt1097-965","article-title":"Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa","volume":"15","author":"Petters","year":"1997","journal-title":"Nat. Biotech."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib78","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0140-6736(77)90612-2","article-title":"Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine","volume":"2","author":"Prescott","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib79","first-page":"L699","article-title":"The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide","volume":"268","author":"Pryor","year":"1995","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.preteyeres.2017.08.004_bib80","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nn.2234","article-title":"Stimulation of the insulin\/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa","volume":"12","author":"Punzo","year":"2009","journal-title":"Nat. Neurosci."},{"issue":"8","key":"10.1016\/j.preteyeres.2017.08.004_bib81","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1167\/iovs.09-4945","article-title":"A\u00a0comparison of visual field sensitivity to photoreceptor thickness in retinitis pigmentosa","volume":"51","author":"Rangaswamy","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib82","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/exer.2002.1155","article-title":"Cell death in retinitis pigmentosa: gap junctions and the 'bystander' effect","volume":"74","author":"Ripps","year":"2002","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.preteyeres.2017.08.004_bib83","first-page":"196","article-title":"Microglial cells invade the outer retina as photoreceptors degenerate n Royal College of Surgeons rats","volume":"37","author":"Roque","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.preteyeres.2017.08.004_bib84","first-page":"516","article-title":"Mitochondrial and other ultrastructural changes in great alveolar cells of oxygen-adapted and poisoned rats","volume":"20","author":"Rosenbaum","year":"1969","journal-title":"Lab. Invest."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib85","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.neuroscience.2006.12.034","article-title":"Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration","volume":"145","author":"Sanz","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib86","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/jcp.20346","article-title":"Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa","volume":"203","author":"Shen","year":"2005","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib87","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJM198812153192401","article-title":"Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976-1985)","volume":"319","author":"Smilkstein","year":"1988","journal-title":"N.\u00a0Eng. J. Med."},{"issue":"12","key":"10.1016\/j.preteyeres.2017.08.004_bib88","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1161\/01.CIR.0000012917.74432.66","article-title":"Superoxide production and expression of nox family proteins in human atherosclerosis","volume":"105","author":"Sorescu","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib89","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0006-2952(95)02099-3","article-title":"Selective pharmacological inhibition of distinct nitric oxide synthase isoforms","volume":"51","author":"Southan","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib90","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1073\/pnas.84.16.5918","article-title":"Antioxidant activity of albumin-bound bilirubin","volume":"84","author":"Stocker","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib91","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiologic importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"issue":"6748","key":"10.1016\/j.preteyeres.2017.08.004_bib92","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/43459","article-title":"Cell transformation by the superoxide-generating oxidase Mox1","volume":"401","author":"Suh","year":"1999","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.preteyeres.2017.08.004_bib93","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1167\/iovs.05-1443","article-title":"Prevalence of disease-causing mutations in families with autosomal dominant retinitis pigmentosa. A screen of known genes in 200 families","volume":"47","author":"Sullivan","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib94","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1523\/JNEUROSCI.14-10-05818.1994","article-title":"A\u00a0rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment","volume":"14","author":"Sung","year":"1994","journal-title":"J.\u00a0Neurosci."},{"issue":"1","key":"10.1016\/j.preteyeres.2017.08.004_bib95","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/hq0102.102189","article-title":"Upregulation of Nox-based NAD(P) oxidases in restenosis after carotid injury","volume":"22","author":"Szocs","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.preteyeres.2017.08.004_bib96","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/archopht.126.3.337","article-title":"Age of onset curves of retinitis pigmentosa","volume":"126","author":"Tsujikawa","year":"2008","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib97","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1073\/pnas.95.9.4882","article-title":"Protein-bound acrolein: potential markers for oxidative stress","volume":"95","author":"Uchida","year":"1998","journal-title":"Proc. Natil. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib98","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/mt.2009.47","article-title":"Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa","volume":"17","author":"Usui","year":"2009","journal-title":"Molec. Ther."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib99","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.freeradbiomed.2011.06.010","article-title":"Overexpression of SOD in retina: need for increase in H2O2-detoxifying enzyme in same cellular compartment","volume":"51","author":"Usui","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib100","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1471-4159.2009.06195.x","article-title":"NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa","volume":"110","author":"Usui","year":"2009","journal-title":"J.\u00a0Neurochem."},{"issue":"4","key":"10.1016\/j.preteyeres.2017.08.004_bib101","article-title":"Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice","volume":"124","author":"Venkatexh","year":"2015","journal-title":"J.\u00a0Clin. Invest"},{"issue":"26","key":"10.1016\/j.preteyeres.2017.08.004_bib102","doi-asserted-by":"crossref","first-page":"E3764","DOI":"10.1073\/pnas.1521749113","article-title":"Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib103","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S0952523805224112","article-title":"Photoreceptors in the rat retina are specifically vulnerable to both hypoxia and hyperoxia","volume":"22","author":"Wellard","year":"2005","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib104","doi-asserted-by":"crossref","first-page":"23937","DOI":"10.1016\/S0021-9258(18)35927-1","article-title":"Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury","volume":"267","author":"Wispe","year":"1992","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib105","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1006\/abbi.1995.1040","article-title":"Aminoguanidine is an isoform-selective, mechanism-based inactivator of nitric oxide synthase","volume":"316","author":"Wolff","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib106","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrg2717","article-title":"Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait","volume":"11","author":"Wright","year":"2010","journal-title":"Nat. Rev. Genet."},{"issue":"4","key":"10.1016\/j.preteyeres.2017.08.004_bib107","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1172\/JCI79735","article-title":"NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage","volume":"125","author":"Xiong","year":"2015","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib108","first-page":"1113","article-title":"FGF2 decreases hyperoxia-induced cell death in mice","volume":"159","author":"Yamada","year":"2001","journal-title":"J.\u00a0Am. Pathlol"},{"key":"10.1016\/j.preteyeres.2017.08.004_bib109","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1097-4652(199905)179:2<149::AID-JCP5>3.0.CO;2-2","article-title":"Hyperoxia causes decreased expression of vascular endothelial growth factor and endothelial cell apoptosis in adult retina","volume":"179","author":"Yamada","year":"1999","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"5","key":"10.1016\/j.preteyeres.2017.08.004_bib110","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/mt.2009.28","article-title":"Functional cone rescue by RdCVF protein in a dominant model of retinitis pigmentosa","volume":"17","author":"Yang","year":"2009","journal-title":"Mol. Ther."},{"issue":"4","key":"10.1016\/j.preteyeres.2017.08.004_bib111","first-page":"683","article-title":"Immunoperoxidase detection of 8-hydroxydeoxyguanosine in aflatoxin B1-treated rat liver and human oral mucosal lesions","volume":"56","author":"Yarborough","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib112","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1073\/pnas.93.7.2696","article-title":"Immunohistochemical detection of 4-hydroxynonenal-protein-adducts in Parkinson's disease","volume":"93","author":"Yoritaka","year":"1996","journal-title":"Proc. Natil. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib113","first-page":"3999","article-title":"Intraretinal oxygen levels before and after photoreceptor loss in the RCS rat","volume":"41","author":"Yu","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.08.004_bib114","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1167\/iovs.03-0845","article-title":"Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat","volume":"45","author":"Yu","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Progress in Retinal and Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135094621730071X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135094621730071X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T22:26:41Z","timestamp":1761172001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S135094621730071X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":115,"alternative-id":["S135094621730071X"],"URL":"https:\/\/doi.org\/10.1016\/j.preteyeres.2017.08.004","relation":{},"ISSN":["1350-9462"],"issn-type":[{"value":"1350-9462","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mechanism of cone cell death in Retinitis Pigmentosa","name":"articletitle","label":"Article Title"},{"value":"Progress in Retinal and Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preteyeres.2017.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}