{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:17:48Z","timestamp":1790741868136,"version":"4.1.0"},"reference-count":234,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 EY005722"],"award-info":[{"award-number":["P30 EY005722"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY026161"],"award-info":[{"award-number":["EY026161"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM007171"],"award-info":[{"award-number":["T32 GM007171"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001116","name":"Foundation Fighting Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015382","name":"Centre for Blood Research, University of British Columbia","doi-asserted-by":"publisher","award":["BR-CMM-0615-0681-DUKE"],"award-info":[{"award-number":["BR-CMM-0615-0681-DUKE"]}],"id":[{"id":"10.13039\/100015382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Retinal and Eye Research"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.preteyeres.2017.09.001","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T01:16:45Z","timestamp":1505783805000},"page":"38-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":160,"special_numbering":"C","title":["Complement factor H in AMD: Bridging genetic associations and pathobiology"],"prefix":"10.1016","volume":"62","author":[{"given":"Christopher B.","family":"Toomey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincoln V.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Bowes Rickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preteyeres.2017.09.001_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1086\/381713","article-title":"Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1","volume":"74","author":"Abecasis","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib2","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1001\/jama.2013.4997","article-title":"Lutein\u00a0+\u00a0zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial","volume":"309","author":"Age-Related Eye Disease Study 2 Research, G","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib3","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/archopht.119.10.1417","article-title":"A\u00a0randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8","volume":"119","author":"Age-Related Eye Disease Study Research, G","year":"2001","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9394(02)01624-0","article-title":"A\u00a0role for local inflammation in the formation of drusen in the aging eye","volume":"134","author":"Anderson","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.preteyeres.2009.11.003","article-title":"The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited","volume":"29","author":"Anderson","year":"2010","journal-title":"Prog. Retin. eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib6","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1093\/hmg\/ddt336","article-title":"Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration","volume":"22","author":"Ansari","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib7","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1167\/iovs.14-16089","article-title":"A\u00a0chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice","volume":"56","author":"Aredo","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib8","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/archopht.124.4.529","article-title":"Prevalence of age-related maculopathy in older Europeans: the European eye study (EUREYE)","volume":"124","author":"Augood","year":"2006","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0039-6257(00)00140-5","article-title":"The role of oxidative stress in the pathogenesis of age-related macular degeneration","volume":"45","author":"Beatty","year":"2000","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0039-6257(05)80092-X","article-title":"An international classification and grading system for age-related maculopathy and age-related macular degeneration","volume":"39","author":"Bird","year":"1995","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/gim.2015.70","article-title":"Age-related macular degeneration: genome-wide association studies to translation","volume":"18","author":"Black","year":"2016","journal-title":"Genet. Med."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib12","doi-asserted-by":"crossref","first-page":"48487","DOI":"10.1074\/jbc.R400025200","article-title":"C-reactive protein","volume":"279","author":"Black","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nchembio.1696","article-title":"Structural basis for sialic acid-mediated self-recognition by complement factor H","volume":"11","author":"Blaum","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib14","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.4049\/jimmunol.177.3.1872","article-title":"Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H","volume":"177","author":"Bora","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.4049\/jimmunol.174.1.491","article-title":"Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization","volume":"174","author":"Bora","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.exer.2008.08.010","article-title":"Lipid and fatty acid profile of the retina, retinal pigment epithelium\/choroid, and the lacrimal gland, and associations with adipose tissue fatty acids in human subjects","volume":"87","author":"Bretillon","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib17","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1086\/302877","article-title":"Complement factor H gene mutation associated with autosomal recessive atypical hemolytic uremic syndrome","volume":"66","author":"Buddles","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib18","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/ki.1989.110","article-title":"Basement membrane collagen in the kidney: regional localization of novel chains related to collagen IV","volume":"35","author":"Butkowski","year":"1989","journal-title":"Kidney Int."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.immuni.2017.01.006","article-title":"Complement factor H inhibits CD47-mediated resolution of inflammation","volume":"46","author":"Calippe","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib20","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1093\/hmg\/ddg363","article-title":"Complement factor H mutations and gene polymorphisms in haemolytic uraemic syndrome: the C-257T, the A2089G and the G2881T polymorphisms are strongly associated with the disease","volume":"12","author":"Caprioli","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/bjo.87.2.212","article-title":"Distribution of the collagen IV isoforms in human Bruch's membrane","volume":"87","author":"Chen","year":"2003","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib22","doi-asserted-by":"crossref","first-page":"7401","DOI":"10.1073\/pnas.0912702107","article-title":"Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/path.4766","article-title":"Monomeric C-reactive protein and inflammation in age-related macular degeneration","volume":"240","author":"Chirco","year":"2016","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib24","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1001\/jama.1996.03540140035023","article-title":"A\u00a0prospective study of cigarette smoking and risk of age-related macular degeneration in men","volume":"276","author":"Christen","year":"1996","journal-title":"Jama"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1289\/ehp.8564111","article-title":"Free-radical chemistry of cigarette smoke and its toxicological implications","volume":"64","author":"Church","year":"1985","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib26","doi-asserted-by":"crossref","first-page":"24713","DOI":"10.1074\/jbc.M605083200","article-title":"His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form","volume":"281","author":"Clark","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib27","doi-asserted-by":"crossref","first-page":"30192","DOI":"10.1074\/jbc.M110.103986","article-title":"Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina","volume":"285","author":"Clark","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib28","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.4049\/jimmunol.1201751","article-title":"Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions","volume":"190","author":"Clark","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib29","doi-asserted-by":"crossref","first-page":"16651","DOI":"10.1073\/pnas.0705079104","article-title":"Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction","volume":"104","author":"Coffey","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib30","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.1016\/S0272-6386(03)00665-6","article-title":"Visual impairment caused by retinal abnormalities in mesangiocapillary (membranoproliferative) glomerulonephritis type II (\u201cdense deposit disease\u201d)","volume":"42","author":"Colville","year":"2003","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib31","doi-asserted-by":"crossref","first-page":"23794","DOI":"10.1038\/srep23794","article-title":"Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and gammadeltaT-cells","volume":"6","author":"Coughlin","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib32","doi-asserted-by":"crossref","first-page":"14682","DOI":"10.1073\/pnas.222551899","article-title":"Drusen proteome analysis: an approach to the etiology of age-related macular degeneration","volume":"99","author":"Crabb","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib33","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1136\/bjophthalmol-2011-300344","article-title":"The oil spill in ageing Bruch membrane","volume":"95","author":"Curcio","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib34","series-title":"Retina","first-page":"465","article-title":"Structure, function, and pathology of Bruch's membrane","author":"Curcio","year":"2013"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib35","first-page":"265","article-title":"Accumulation of cholesterol with age in human Bruch's membrane","volume":"42","author":"Curcio","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib36","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.exer.2005.04.012","article-title":"Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy","volume":"81","author":"Curcio","year":"2005","journal-title":"Exp. eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.preteyeres.2017.03.002","article-title":"The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD","volume":"60","author":"Datta","year":"2017","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib39","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1167\/iovs.10-6235","article-title":"Associations of complement factor H and smoking with early age-related macular degeneration: the ALIENOR study","volume":"52","author":"Delcourt","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib40","first-page":"184","article-title":"Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas","volume":"9","author":"Dentchev","year":"2003","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib41","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.yjmcc.2003.12.005","article-title":"Effect of C-reactive protein on chemokine expression in human aortic endothelial cells","volume":"36","author":"Devaraj","year":"2004","journal-title":"J.\u00a0Mol. Cell Cardiol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib42","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00417-014-2690-7","article-title":"The contribution of genetic factors to phenotype and progression of drusen in early age-related macular degeneration","volume":"252","author":"Dietzel","year":"2014","journal-title":"Graefe's Archive Clin. Exp. Ophthalmol.\u00a0= Albrecht von Graefes Archiv fur klinische und Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ajpath.2014.08.026","article-title":"Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice","volume":"185","author":"Ding","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib44","first-page":"139","article-title":"Beitraege zur pathologischen Anatomie des Auges","volume":"1","author":"Donders","year":"1855","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib45","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1110189","article-title":"Complement factor H polymorphism and age-related macular degeneration","volume":"308","author":"Edwards","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib46","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/CIRCRESAHA.108.190611","article-title":"Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques","volume":"105","author":"Eisenhardt","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib47","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.tcm.2010.02.002","article-title":"Monomeric C-reactive protein generation on activated platelets: the missing link between inflammation and atherothrombotic risk","volume":"19","author":"Eisenhardt","year":"2009","journal-title":"Trends Cardiovasc Med."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib48","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1136\/bjo.2007.114090","article-title":"Fine-scale linkage disequilibrium mapping of age-related macular degeneration in the complement factor H gene region","volume":"91","author":"Ennis","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib49","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev.bioeng.6.040803.140055","article-title":"Ocular biomechanics and biotransport","volume":"6","author":"Ethier","year":"2004","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/ejhg.2008.140","article-title":"Variation near complement factor I is associated with risk of advanced AMD","author":"Fagerness","year":"2009","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib52","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1073\/pnas.75.4.1971","article-title":"Regulation by membrane sialic acid of beta1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway","volume":"75","author":"Fearon","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib53","doi-asserted-by":"crossref","first-page":"e73715","DOI":"10.1371\/journal.pone.0073715","article-title":"The interaction between factor H and Von Willebrand factor","volume":"8","author":"Feng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib54","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1093\/hmg\/ddv287","article-title":"A\u00a0local complement response by RPE causes early-stage macular degeneration","volume":"24","author":"Fernandez-Godino","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib55","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1001\/jamaophthalmol.2015.0814","article-title":"Phenotypic characterization of complement factor H R1210C rare genetic variant in age-related macular degeneration","volume":"133","author":"Ferrara","year":"2015","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib56","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ophtha.2012.10.036","article-title":"Clinical classification of age-related macular degeneration","volume":"120","author":"Ferris","year":"2013","journal-title":"Ophthalmology"},{"issue":"Pt 2","key":"10.1016\/j.preteyeres.2017.09.001_bib57","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/eye.1987.35","article-title":"The influence of age on some ocular basement membranes","volume":"1","author":"Fisher","year":"1987","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib58","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/014107680609900417","article-title":"Genetics of inherited retinal disease","volume":"99","author":"Francis","year":"2006","journal-title":"J.\u00a0R. Soc. Med."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib59","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/ng.2578","article-title":"Seven new loci associated with age-related macular degeneration","volume":"45","author":"Fritsche","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib60","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ng.3448","article-title":"A\u00a0large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants","volume":"48","author":"Fritsche","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib61","doi-asserted-by":"crossref","first-page":"e3119","DOI":"10.1371\/journal.pone.0003119","article-title":"Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice","volume":"3","author":"Fujihara","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib62","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1001\/archophthalmol.2012.693","article-title":"Effect of the Y402H variant in the complement factor H gene on the incidence and progression of age-related macular degeneration: results from multistate models applied to the Beaver Dam Eye Study","volume":"130","author":"Gangnon","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib63","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/hmg\/ddt395","article-title":"Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD\/ML, an inherited macular degeneration","volume":"23","author":"Garland","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib64","first-page":"409","article-title":"Drusen and disciform macular detachment and degeneration","volume":"70","author":"Gass","year":"1972","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib65","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ng1750","article-title":"Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration","volume":"38","author":"Gold","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib66","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ng1750","article-title":"Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration","volume":"38","author":"Gold","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib67","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.preteyeres.2010.05.003","article-title":"Animal models of choroidal and retinal neovascularization","volume":"29","author":"Grossniklaus","year":"2010","journal-title":"Prog. Retin. eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib68","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1350-9462(98)00012-3","article-title":"Changes in Bruch's membrane and related structures with age","volume":"18","author":"Guymer","year":"1999","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib69","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1073\/pnas.0501536102","article-title":"A\u00a0common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration","volume":"102","author":"Hageman","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib70","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1350-9462(01)00010-6","article-title":"An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration","volume":"20","author":"Hageman","year":"2001","journal-title":"Prog. Retin. eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib71","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1096\/fasebj.13.3.477","article-title":"Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells","volume":"13","author":"Hageman","year":"1999","journal-title":"Faseb J."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib72","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1126\/science.1110359","article-title":"Complement factor H variant increases the risk of age-related macular degeneration","volume":"308","author":"Haines","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib73","doi-asserted-by":"crossref","first-page":"30451","DOI":"10.1074\/jbc.M803648200","article-title":"Complement factor H binds to denatured rather than to native pentameric C-reactive protein","volume":"283","author":"Hakobyan","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib74","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/0005-2795(71)90226-1","article-title":"Evidence for progressive, age-related structural changes in post-mature human collagen","volume":"236","author":"Hamlin","year":"1971","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib75","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0161-6420(01)01049-1","article-title":"Genetic influence on early age-related maculopathy: a twin study","volume":"109","author":"Hammond","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib76","first-page":"775","article-title":"Increase in the advanced glycation end product pentosidine in Bruch's membrane with age","volume":"40","author":"Handa","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib77","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.molimm.2009.09.005","article-title":"The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification","volume":"47","author":"Harboe","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib78","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2249.2004.02627.x","article-title":"The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation","volume":"138","author":"Harboe","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib79","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1046\/j.1523-1755.1998.00188.x","article-title":"Role of distinct type IV collagen networks in glomerular development and function","volume":"54","author":"Harvey","year":"1998","journal-title":"Kidney Int."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib80","first-page":"515","article-title":"Identification and functional clustering of global gene expression differences between human age-related cataract and clear lenses","volume":"9","author":"Hawse","year":"2003","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib81","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/hmg\/ddp472","article-title":"Genetic control of the alternative pathway of complement in humans and age-related macular degeneration","volume":"19","author":"Hecker","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib82","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.ophtha.2012.09.006","article-title":"Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration","volume":"119","author":"Heier","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib83","doi-asserted-by":"crossref","first-page":"8761","DOI":"10.1073\/pnas.1019338108","article-title":"Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk","volume":"108","author":"Heurich","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib84","series-title":"Histology of the Human Eye: an Atlas and Textbook","author":"Hogan","year":"1971"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib85","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ajpath.2013.04.008","article-title":"Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration","volume":"183","author":"Hoh Kam","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib86","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.exer.2016.07.002","article-title":"Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology","volume":"149","author":"Hoh Kam","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib87","doi-asserted-by":"crossref","first-page":"e53830","DOI":"10.1371\/journal.pone.0053830","article-title":"Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis","volume":"8","author":"Holliday","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib88","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nm1709","article-title":"Oxidative damage-induced inflammation initiates age-related macular degeneration","volume":"14","author":"Hollyfield","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib89","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1001\/archopht.1994.01090150132035","article-title":"Analysis of lipid deposits extracted from human macular and peripheral Bruch's membrane","volume":"112","author":"Holz","year":"1994","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib90","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.exer.2007.03.011","article-title":"Age-related changes in human macular Bruch's membrane as seen by quick-freeze\/deep-etch","volume":"85","author":"Huang","year":"2007","journal-title":"Exp. eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib91","doi-asserted-by":"crossref","first-page":"8068","DOI":"10.4049\/jimmunol.181.11.8068","article-title":"A\u00a0novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia\/reperfusion injury","volume":"181","author":"Huang","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib92","first-page":"1116","article-title":"Morphologic observations on experimental subretinal neovascularization in the monkey","volume":"28","author":"Ishibashi","year":"1987","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib93","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1001\/archopht.116.12.1629","article-title":"Advanced glycation end products in age-related macular degeneration","volume":"116","author":"Ishibashi","year":"1998","journal-title":"Archives Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib94","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1086\/380912","article-title":"Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration","volume":"74","author":"Iyengar","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib95","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1056\/NEJMra0801537","article-title":"Age-related macular degeneration","volume":"358","author":"Jager","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib96","doi-asserted-by":"crossref","first-page":"11030","DOI":"10.1016\/S0021-9258(18)99123-4","article-title":"Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma","volume":"266","author":"Jenne","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib97","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1096\/fj.06-6722com","article-title":"Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRP(m)","volume":"21","author":"Ji","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib98","doi-asserted-by":"crossref","first-page":"18277","DOI":"10.1073\/pnas.1109703108","article-title":"Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration","volume":"108","author":"Johnson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib99","doi-asserted-by":"crossref","first-page":"11830","DOI":"10.1073\/pnas.192203399","article-title":"The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration","volume":"99","author":"Johnson","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib100","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1006\/exer.2001.1094","article-title":"Complement activation and inflammatory processes in Drusen formation and age related macular degeneration","volume":"73","author":"Johnson","year":"2001","journal-title":"Exp. eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib101","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1006\/exer.1999.0798","article-title":"A\u00a0potential role for immune complex pathogenesis in drusen formation","volume":"70","author":"Johnson","year":"2000","journal-title":"Exp. eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib102","doi-asserted-by":"crossref","first-page":"17456","DOI":"10.1073\/pnas.0606234103","article-title":"Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid","volume":"103","author":"Johnson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib103","first-page":"3861","article-title":"Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels","volume":"24","author":"Kavanagh","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib104","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1167\/iovs.14-14126","article-title":"Age-dependent changes in heparan sulfate in human Bruch's membrane: implications for age-related macular degeneration","volume":"55","author":"Keenan","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib105","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.4049\/jimmunol.0903596","article-title":"Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration","volume":"185","author":"Kelly","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib106","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1172\/JCI111760","article-title":"Cigarette smoke can activate the alternative pathway of complement in\u00a0vitro by modifying the third component of complement","volume":"75","author":"Kew","year":"1985","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib107","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1086\/301901","article-title":"Genetic association of apolipoprotein E with age-related macular degeneration","volume":"63","author":"Klaver","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib108","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/S0161-6420(02)01249-6","article-title":"Incidence of age-related cataract over a 10-year interval: the Beaver dam eye study","volume":"109","author":"Klein","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib109","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/aje\/154.3.207","article-title":"Risk of incident age-related eye diseases in people with an affected sibling : the Beaver Dam Eye Study","volume":"154","author":"Klein","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib110","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1001\/archopht.1994.01090190080025","article-title":"Heredity and age-related macular degeneration. Observations in monozygotic twins","volume":"112","author":"Klein","year":"1994","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib111","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1001\/archopht.116.8.1082","article-title":"Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q","volume":"116","author":"Klein","year":"1998","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib112","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/oxfordjournals.aje.a116659","article-title":"The Beaver Dam Eye Study: the relation of age-related maculopathy to smoking","volume":"137","author":"Klein","year":"1993","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib113","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/jamaophthalmol.2013.713","article-title":"Risk alleles in CFH and ARMS2 and the long-term natural history of age-related macular degeneration: the Beaver Dam Eye Study","volume":"131","author":"Klein","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib114","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib115","doi-asserted-by":"crossref","first-page":"14534","DOI":"10.1074\/jbc.M114.564674","article-title":"Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation","volume":"289","author":"Kunchithapautham","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib116","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14319","article-title":"Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration","volume":"5","author":"Kurihara","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib117","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.4049\/jimmunol.178.6.3831","article-title":"Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein","volume":"178","author":"Laine","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib118","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1038\/nprot.2013.135","article-title":"Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice","volume":"8","author":"Lambert","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib119","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.4049\/jimmunol.1002488","article-title":"Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant","volume":"187","author":"Lauer","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib120","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1148\/rg.286085515","article-title":"Nontraumatic orbital conditions: diagnosis with CT and MR imaging in the emergent setting","volume":"28","author":"LeBedis","year":"2008","journal-title":"Radiographics"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib121","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archopht.1994.01090180121046","article-title":"The Barbados Eye Study. Prevalence of open angle glaucoma","volume":"112","author":"Leske","year":"1994","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib122","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1167\/iovs.05-0034","article-title":"Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization","volume":"46","author":"Li","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib123","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.exer.2007.04.002","article-title":"Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen","volume":"85","author":"Li","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib124","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1136\/bjo.85.3.287","article-title":"Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration","volume":"85","author":"Li","year":"2001","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib125","first-page":"24","article-title":"Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina","volume":"36","author":"Loffler","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib126","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00417-007-0749-4","article-title":"Are low inflammatory reactions involved in exudative age-related macular degeneration? Morphological and immunhistochemical analysis of AMD associated with basal deposits","volume":"246","author":"Lommatzsch","year":"2008","journal-title":"Graefe's Archive Clin. Exp. Ophthalmol.\u00a0= Albrecht von Graefes Archiv fur klinische und Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib127","doi-asserted-by":"crossref","first-page":"6628","DOI":"10.1167\/iovs.12-9587","article-title":"Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration","volume":"53","author":"Loyet","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib128","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2353\/ajpath.2009.080927","article-title":"Complement factor h is critical in the maintenance of retinal perfusion","volume":"175","author":"Lundh von Leithner","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib129","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.2353\/ajpath.2010.091168","article-title":"Role of ocular complement factor H in a murine model of choroidal neovascularization","volume":"177","author":"Lyzogubov","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib130","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1371\/journal.pmed.0030005","article-title":"CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD","volume":"3","author":"Magnusson","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib131","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1086\/377701","article-title":"Age-related macular degeneration\u2013a genome scan in extended families","volume":"73","author":"Majewski","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib132","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ng1873","article-title":"Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration","volume":"38","author":"Maller","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib133","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/ng2131","article-title":"Variation in complement factor 3 is associated with risk of age-related macular degeneration","volume":"39","author":"Maller","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib134","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0002-9394(14)72729-1","article-title":"A\u00a0twin study of age-related macular degeneration","volume":"120","author":"Meyers","year":"1995","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib135","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1365-2249.1993.tb05956.x","article-title":"Vitronectin-mediated inhibition of complement: evidence for different binding sites for C5b-7 and C9","volume":"92","author":"Milis","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib136","doi-asserted-by":"crossref","first-page":"882","DOI":"10.4049\/jimmunol.133.2.882","article-title":"C-reactive protein inhibits pneumococcal activation of the alternative pathway by increasing the interaction between factor H and C3b","volume":"133","author":"Mold","year":"1984","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib137","doi-asserted-by":"crossref","first-page":"22889","DOI":"10.1038\/srep22889","article-title":"Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants","volume":"6","author":"Molins","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib138","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/eye.2001.142","article-title":"Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis","volume":"15","author":"Mullins","year":"2001","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib139","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.exer.2011.06.015","article-title":"Elevated membrane attack complex in human choroid with high risk complement factor H genotypes","volume":"93","author":"Mullins","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib140","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1096\/fasebj.14.7.835","article-title":"Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease","volume":"14","author":"Mullins","year":"2000","journal-title":"Faseb J."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib141","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1016\/j.ajpath.2014.07.017","article-title":"The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning","volume":"184","author":"Mullins","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib142","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.ophtha.2014.04.040","article-title":"Cigarette smoking and the natural history of age-related macular degeneration: the Beaver Dam Eye Study","volume":"121","author":"Myers","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib143","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1073\/pnas.0912019107","article-title":"Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)","volume":"107","author":"Neale","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib144","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1097\/01.ASN.0000022006.49966.F8","article-title":"Linkage of a gene causing familial membranoproliferative glomerulonephritis type III to chromosome 1","volume":"13","author":"Neary","year":"2002","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib145","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1161\/ATVBAHA.113.302280","article-title":"Human complement factor H is a reductase for large soluble von Willebrand factor multimers\u2013brief report","volume":"33","author":"Nolasco","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib146","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1073\/pnas.0408835103","article-title":"Drusen complement components C3a and C5a promote choroidal neovascularization","volume":"103","author":"Nozaki","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib147","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1136\/bjo.77.12.778","article-title":"Electrophysiology of type II mesangiocapillary glomerulonephritis with associated fundus abnormalities","volume":"77","author":"O'Brien","year":"1993","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib148","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1074\/jbc.M109.044529","article-title":"Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations","volume":"285","author":"Okemefuna","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib149","first-page":"443","article-title":"The relationships of age changes in retinal pigment epithelium and Bruch's membrane","volume":"40","author":"Okubo","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib150","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1167\/iovs.07-1297","article-title":"Functional and structural implications of the complement factor H Y402H polymorphism associated with age-related macular degeneration","volume":"49","author":"Ormsby","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib151","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3109\/02713683.2015.1011282","article-title":"Comparison of visual function in older eyes in the earliest stages of age-related macular degeneration to those in normal macular health","volume":"41","author":"Owsley","year":"2016","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib152","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0161-6420(01)00580-2","article-title":"Delays in rod-mediated dark adaptation in early age-related maculopathy","volume":"108","author":"Owsley","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib153","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ophtha.2015.09.041","article-title":"Delayed rod-mediated dark adaptation is a functional biomarker for incident early age-related macular degeneration","volume":"123","author":"Owsley","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib154","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1749-6632.1983.tb18116.x","article-title":"Initiation of the alternative complement pathway due to spontaneous hydrolysis of the thioester of C3","volume":"421","author":"Pangburn","year":"1983","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib155","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/01.CIR.102.18.2165","article-title":"Direct proinflammatory effect of C-reactive protein on human endothelial cells","volume":"102","author":"Pasceri","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib156","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0161-6420(90)32619-2","article-title":"Aging changes in Bruch's membrane. A histochemical and morphologic study","volume":"97","author":"Pauleikhoff","year":"1990","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib157","first-page":"730","article-title":"Biochemical and histochemical analysis of age related lipid deposits in Bruch's membrane","volume":"91","author":"Pauleikhoff","year":"1994","journal-title":"Ophthalmol. Z. Dtsch. Ophthalmol. Ges."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib158","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000090268","article-title":"Inhibition of lysosomal degradation in retinal pigment epithelium cells induces exocytosis of phagocytic residual material at the basolateral plasma membrane","volume":"38","author":"Peters","year":"2006","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib159","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/ng912","article-title":"Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H","volume":"31","author":"Pickering","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib160","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1084\/jem.20070301","article-title":"Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains","volume":"204","author":"Pickering","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib161","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1167\/iovs.16-21060","article-title":"Subretinal pigment epithelial deposition of drusen components including hydroxyapatite in a primary cell culture model","volume":"58","author":"Pilgrim","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib162","doi-asserted-by":"crossref","first-page":"6525","DOI":"10.1167\/iovs.14-15067","article-title":"Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation","volume":"55","author":"Poor","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib163","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1084\/jem.20071069","article-title":"Structural basis for complement factor H linked age-related macular degeneration","volume":"204","author":"Prosser","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib164","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cell.2011.09.011","article-title":"Mapping rare and common causal alleles for complex human diseases","volume":"147","author":"Raychaudhuri","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib165","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/ng.976","article-title":"A\u00a0rare penetrant mutation in CFH confers high risk of age-related macular degeneration","volume":"43","author":"Raychaudhuri","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib166","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1681\/ASN.2015050580","article-title":"Molecular basis of factor H R1210C association with ocular and renal diseases","volume":"27","author":"Recalde","year":"2016","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib167","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1182\/blood-2001-12-0166","article-title":"Von Willebrand factor cleaving protease (ADAMTS13) is deficient in recurrent and familial thrombotic thrombocytopenic purpura and hemolytic uremic syndrome","volume":"100","author":"Remuzzi","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib168","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1167\/iovs.09-3928","article-title":"Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes","volume":"50","author":"Reynolds","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib169","doi-asserted-by":"crossref","first-page":"e93459","DOI":"10.1371\/journal.pone.0093459","article-title":"Impact of the common genetic associations of age-related macular degeneration upon systemic complement component C3d levels","volume":"9","author":"Ristau","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib170","first-page":"L254","article-title":"Complement activation by cigarette smoke","volume":"260","author":"Robbins","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib171","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molimm.2004.02.005","article-title":"The human complement factor H: functional roles, genetic variations and disease associations","volume":"41","author":"Rodriguez de Cordoba","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib172","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1089\/jop.2011.0212","article-title":"Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization","volume":"28","author":"Rohrer","year":"2012","journal-title":"J.\u00a0Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib173","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.molimm.2010.12.016","article-title":"The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization","volume":"48","author":"Rohrer","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib174","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1167\/iovs.08-2222","article-title":"A\u00a0targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration","volume":"50","author":"Rohrer","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib175","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1056\/NEJMe1103334","article-title":"Bevacizumab versus ranibizumab for AMD","volume":"364","author":"Rosenfeld","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib176","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJMoa054481","article-title":"Ranibizumab for neovascular age-related macular degeneration","volume":"355","author":"Rosenfeld","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib177","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1167\/iovs.07-1466","article-title":"Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathy","volume":"49","author":"Rudolf","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib178","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.exer.2008.07.010","article-title":"Sub-retinal drusenoid deposits in human retina: organization and composition","volume":"87","author":"Rudolf","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib179","first-page":"2026","article-title":"Exocytic clearing of degraded membrane material from pigment epithelial cells in frog retina","volume":"28","author":"Rungger-Brandle","year":"1987","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib180","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1001\/archopht.125.5.671","article-title":"The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS report no. 20","volume":"125","author":"SanGiovanni","year":"2007","journal-title":"Arch. Ophthalmol."},{"issue":"Pt 5","key":"10.1016\/j.preteyeres.2017.09.001_bib181","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/eye.1988.106","article-title":"Evolution of geographic atrophy of the retinal pigment epithelium","volume":"2","author":"Sarks","year":"1988","journal-title":"Eye (Lond)"},{"issue":"Pt 3","key":"10.1016\/j.preteyeres.2017.09.001_bib182","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/eye.1994.57","article-title":"Evolution of soft drusen in age-related macular degeneration","volume":"8","author":"Sarks","year":"1994","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib183","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1167\/iovs.06-0443","article-title":"Relationship of Basal laminar deposit and membranous debris to the clinical presentation of early age-related macular degeneration","volume":"48","author":"Sarks","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib184","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1136\/bjo.60.5.324","article-title":"Ageing and degeneration in the macular region: a clinico-pathological study","volume":"60","author":"Sarks","year":"1976","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib185","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00441-010-1034-0","article-title":"The complement system","volume":"343","author":"Sarma","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib186","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.4049\/jimmunol.181.4.2610","article-title":"A\u00a0new map of glycosaminoglycan and C3b binding sites on factor H","volume":"181","author":"Schmidt","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib187","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jmb.2009.10.010","article-title":"The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module","volume":"395","author":"Schmidt","year":"2010","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib188","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1167\/iovs.14-15910","article-title":"Local production of the alternative pathway component factor B is sufficient to promote laser-induced choroidal neovascularization","volume":"56","author":"Schnabolk","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib189","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0002-9394(14)71036-0","article-title":"Familial aggregation of age-related maculopathy","volume":"123","author":"Seddon","year":"1997","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib190","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1001\/jama.1994.03520180037032","article-title":"Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration","volume":"272","author":"Seddon","year":"1994","journal-title":"Jama"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib191","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/archopht.123.3.321","article-title":"The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences","volume":"123","author":"Seddon","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib192","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1001\/jama.291.6.704","article-title":"Association between C-reactive protein and age-related macular degeneration","volume":"291","author":"Seddon","year":"2004","journal-title":"Jama"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib193","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1001\/archopht.124.7.995","article-title":"Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration","volume":"124","author":"Seddon","year":"2006","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib194","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1001\/archopht.119.8.1191","article-title":"Dietary fat and risk for advanced age-related macular degeneration","volume":"119","author":"Seddon","year":"2001","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib195","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1086\/378505","article-title":"A\u00a0genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions","volume":"73","author":"Seddon","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib196","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1001\/jama.1996.03540140029022","article-title":"A\u00a0prospective study of cigarette smoking and age-related macular degeneration in women","volume":"276","author":"Seddon","year":"1996","journal-title":"Jama"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib197","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ng.2741","article-title":"Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration","volume":"45","author":"Seddon","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib198","doi-asserted-by":"crossref","first-page":"13757","DOI":"10.1073\/pnas.1121309109","article-title":"Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids","volume":"109","author":"Shaw","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib199","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4103\/0377-4929.64316","article-title":"Large drusen following long-standing retinal detachment","volume":"53","author":"Shenoy","year":"2010","journal-title":"Indian J. Pathol. Microbiol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib200","first-page":"2288","article-title":"Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr(4)(0)(2)His polymorphism","volume":"18","author":"Silva","year":"2012","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib201","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1161\/01.ATV.0000241572.05292.fb","article-title":"C-reactive protein decreases interleukin-10 secretion in activated human monocyte-derived macrophages via inhibition of cyclic AMP production","volume":"26","author":"Singh","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib202","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1167\/iovs.10-5322","article-title":"Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells","volume":"51","author":"Skeie","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib203","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ophtha.2011.07.056","article-title":"Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration","volume":"119","author":"Smailhodzic","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib204","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0002-9394(99)80146-9","article-title":"The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration","volume":"125","author":"Souied","year":"1998","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib205","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1097\/IAE.0b013e31829c3765","article-title":"Outer retinal atrophy after regression of subretinal drusenoid deposits as a newly recognized form of late age-related macular degeneration","volume":"33","author":"Spaide","year":"2013","journal-title":"Retina"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib206","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1093\/hmg\/ddn075","article-title":"C3 R102G polymorphism increases risk of age-related macular degeneration","volume":"17","author":"Spencer","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib207","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000310612","article-title":"Contrast sensitivity evaluation in eyes predisposed to age-related macular degeneration and presenting normal visual acuity","volume":"209","author":"Stangos","year":"1995","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib208","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/CIRCULATIONAHA.113.007124","article-title":"Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in\u00a0vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy","volume":"130","author":"Thiele","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib209","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1172\/JCI65861","article-title":"Detection of complement activation using monoclonal antibodies against C3d","volume":"123","author":"Thurman","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib210","doi-asserted-by":"crossref","first-page":"E3040","DOI":"10.1073\/pnas.1424391112","article-title":"Regulation of age-related macular degeneration-like pathology by complement factor H","volume":"112","author":"Toomey","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib211","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1167\/iovs.15-17432","article-title":"Rare variants in the functional domains of complement factor H are associated with age-related macular degeneration","volume":"56","author":"Triebwasser","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib212","first-page":"1319","article-title":"Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors","volume":"12","author":"Tserentsoodol","year":"2006","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib213","first-page":"1306","article-title":"Uptake of cholesterol by the retina occurs primarily via a low density lipoprotein receptor-mediated process","volume":"12","author":"Tserentsoodol","year":"2006","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib214","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1167\/iovs.09-4457","article-title":"Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings","volume":"51","author":"Ufret-Vincenty","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib215","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.ophtha.2004.01.023","article-title":"Prevalence of age-related macular degeneration in Latinos: the Los Angeles Latino eye study","volume":"111","author":"Varma","year":"2004","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib216","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1042\/bj1810639","article-title":"Native cross-links in collagen fibrils induce resistance to human synovial collagenase","volume":"181","author":"Vater","year":"1979","journal-title":"Biochem. J."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib217","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1067\/mpd.2003.79","article-title":"Severe deficiency of the specific von Willebrand factor-cleaving protease (ADAMTS 13) activity in a subgroup of children with atypical hemolytic uremic syndrome","volume":"142","author":"Veyradier","year":"2003","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib218","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1001\/archopht.1996.01100140393005","article-title":"Age-related macular degeneration and smoking. The Rotterdam Study","volume":"114","author":"Vingerling","year":"1996","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib219","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0161-5890(01)00042-6","article-title":"Human C-reactive protein: expression, structure, and function","volume":"38","author":"Volanakis","year":"2001","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib220","doi-asserted-by":"crossref","first-page":"e5304","DOI":"10.1371\/journal.pone.0005304","article-title":"Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degeneration","volume":"4","author":"Wang","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib221","doi-asserted-by":"crossref","first-page":"e10329","DOI":"10.1371\/journal.pone.0010329","article-title":"Abundant lipid and protein components of drusen","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib222","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1167\/iovs.08-2376","article-title":"Lipoprotein particles of intraocular origin in human Bruch membrane: an unusual lipid profile","volume":"50","author":"Wang","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib223","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1086\/422476","article-title":"Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions","volume":"75","author":"Weeks","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib224","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature10449","article-title":"Complement factor H binds malondialdehyde epitopes and protects from oxidative stress","volume":"478","author":"Weismann","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2014.11.005","article-title":"Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy","volume":"45","author":"Whitmore","year":"2015","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib226","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1001\/archopht.1962.00960030223013","article-title":"Bilateral confluent drusen","volume":"68","author":"Wolter","year":"1962","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib227","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib228","doi-asserted-by":"crossref","first-page":"e67894","DOI":"10.1371\/journal.pone.0067894","article-title":"Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury","volume":"8","author":"Woodell","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2017.09.001_bib229","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1167\/iovs.15-18471","article-title":"A\u00a0targeted inhibitor of the alternative complement pathway accelerates recovery from smoke-induced ocular injury","volume":"57","author":"Woodell","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib230","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1167\/iovs.08-3202","article-title":"Expression and modulation of RPE cell membrane complement regulatory proteins","volume":"50","author":"Yang","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib231","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1056\/NEJMoa072618","article-title":"Complement C3 variant and the risk of age-related macular degeneration","volume":"357","author":"Yates","year":"2007","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib232","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1086\/302673","article-title":"Complement factor H gene mutation associated with autosomal recessive atypical hemolytic uremic syndrome","volume":"65","author":"Ying","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib233","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.1093\/hmg\/ddu226","article-title":"Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration","volume":"23","author":"Yu","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib234","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1471-4906(01)01972-X","article-title":"Hemolytic uremic syndrome: how do factor H mutants mediate endothelial damage?","volume":"22","author":"Zipfel","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib235","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nri2620","article-title":"Complement regulators and inhibitory proteins","volume":"9","author":"Zipfel","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.preteyeres.2017.09.001_bib236","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1567-5769(00)00047-3","article-title":"Complement factor H and hemolytic uremic syndrome","volume":"1","author":"Zipfel","year":"2001","journal-title":"Int. Immunopharmacol."}],"container-title":["Progress in Retinal and Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946217300381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946217300381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T22:28:16Z","timestamp":1761172096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350946217300381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":234,"alternative-id":["S1350946217300381"],"URL":"https:\/\/doi.org\/10.1016\/j.preteyeres.2017.09.001","relation":{},"ISSN":["1350-9462"],"issn-type":[{"value":"1350-9462","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement factor H in AMD: Bridging genetic associations and pathobiology","name":"articletitle","label":"Article Title"},{"value":"Progress in Retinal and Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preteyeres.2017.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}