{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:09:15Z","timestamp":1791871755887,"version":"4.3.4"},"reference-count":149,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Combined Ophthalmic Research Rotterdam, The Netherlands","award":["CORR 4.2.0"],"award-info":[{"award-number":["CORR 4.2.0"]}]},{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","award":["EMCR 2014-6905"],"award-info":[{"award-number":["EMCR 2014-6905"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Retinal and Eye Research"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.preteyeres.2019.100800","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T19:34:14Z","timestamp":1569526454000},"page":"100800","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":252,"special_numbering":"C","title":["Uveal melanoma: Towards a molecular understanding"],"prefix":"10.1016","volume":"75","author":[{"given":"Kyra N.","family":"Smit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine J.","family":"Jager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"de Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Kili\u04ab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preteyeres.2019.100800_bib2","doi-asserted-by":"crossref","first-page":"10615","DOI":"10.1038\/ncomms10615","article-title":"Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage","volume":"7","author":"Alsafadi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.preteyeres.2019.100800_bib3","doi-asserted-by":"crossref","first-page":"49623","DOI":"10.18632\/oncotarget.10418","article-title":"In-depth proteomic profiling of the uveal melanoma secretome","volume":"7","author":"Angi","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.preteyeres.2019.100800_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40644-019-0218-4","article-title":"Chemosaturation with percutaneous hepatic perfusion of melphalan for liver-dominant metastatic uveal melanoma: a single center experience","volume":"19","author":"Artzner","year":"2019","journal-title":"Cancer Image"},{"key":"10.1016\/j.preteyeres.2019.100800_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ajo.2009.01.023","article-title":"Effectiveness of treatments for metastatic uveal melanoma","volume":"148","author":"Augsburger","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature16965","article-title":"Genomic analyses identify molecular subtypes of pancreatic cancer","volume":"531","author":"Bailey","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2019.100800_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00279","article-title":"Clinical application of circulating tumor cells and circulating tumor DNA in uveal melanoma","author":"Beasley","year":"2018","journal-title":"JCO Precis. Oncol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib8","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/ijc.28436","article-title":"Detection rate and prognostic value of circulating tumor cells and circulating tumor DNA in metastatic uveal melanoma","volume":"134","author":"Bidard","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.preteyeres.2019.100800_bib9","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1016\/j.ophtha.2016.06.027","article-title":"Adjuvant dendritic cell vaccination in high-risk uveal melanoma","volume":"123","author":"Bol","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2019.100800_bib10","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.4161\/cc.9.13.12147","article-title":"The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors","volume":"9","author":"Bommi","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.preteyeres.2019.100800_bib11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature22798","article-title":"BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation","volume":"546","author":"Bononi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2019.100800_bib12","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1167\/iovs.10-5979","article-title":"Detection of M2-macrophages in uveal melanoma and relation with survival","volume":"52","author":"Bronkhorst","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2019.100800_bib13","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1167\/iovs.11-9280","article-title":"Different subsets of tumor-infiltrating lymphocytes correlate with macrophage influx and monosomy 3 in uveal melanoma","volume":"53","author":"Bronkhorst","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2019.100800_bib14","article-title":"Tumour angiogenesis in uveal melanoma is related to genetic evolution","volume":"vol 11","author":"Brouwer","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.preteyeres.2019.100800_bib15","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.cell.2017.05.046","article-title":"Comprehensive and integrative genomic characterization of hepatocellular carcinoma","volume":"169","author":"Cancer Genome Atlas Research Network Electronic address, w.b.e., Cancer Genome Atlas Research, N.","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib16","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1200\/JCO.2017.74.1090","article-title":"Selumetinib in combination with dacarbazine in patients with metastatic uveal melanoma: a phase III, multicenter, randomized trial (SUMIT)","volume":"36","author":"Carvajal","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib17","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1001\/jama.2014.6096","article-title":"Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial","volume":"311","author":"Carvajal","year":"2014","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.preteyeres.2019.100800_bib18","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.ejca.2014.03.289","article-title":"A phase 2 randomised study of ramucirumab (IMC-1121B) with or without dacarbazine in patients with metastatic melanoma","volume":"50","author":"Carvajal","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.preteyeres.2019.100800_bib19","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/bjophthalmol-2013-303867","article-title":"Genome-wide profiling is a clinically relevant and affordable prognostic test in posterior uveal melanoma","volume":"98","author":"Cassoux","year":"2014","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib20","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1002\/cncr.29727","article-title":"Uveal melanoma: from diagnosis to treatment and the science in between","volume":"122","author":"Chattopadhyay","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.preteyeres.2019.100800_bib21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ccell.2017.04.002","article-title":"RasGRP3 mediates MAPK pathway activation in GNAQ mutant uveal melanoma","volume":"31","author":"Chen","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/BST20160173","article-title":"Molecular architecture of polycomb repressive complexes","volume":"45","author":"Chittock","year":"2017","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.preteyeres.2019.100800_bib23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.cell.2015.09.033","article-title":"Comprehensive molecular portraits of invasive lobular breast cancer","volume":"163","author":"Ciriello","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib24","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1001\/archopht.1996.01100130743022","article-title":"Metastatic choroidal melanoma to the contralateral orbit 40 years after enucleation","volume":"114","author":"Coupland","year":"1996","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.preteyeres.2018.03.004","article-title":"Ocular treatment of choroidal melanoma in relation to the prevention of metastatic death - a personal view","volume":"66","author":"Damato","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.preteyeres.2011.05.003","article-title":"Estimating prognosis for survival after treatment of choroidal melanoma","volume":"30","author":"Damato","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11070971","article-title":"Tebentafusp: T cell redirection for the treatment of metastatic uveal melanoma","volume":"11","author":"Damato","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.preteyeres.2019.100800_bib28","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.celrep.2015.09.053","article-title":"Cancer-associated SF3B1 hotspot mutations induce cryptic 3' splice site selection through use of a different branch point","volume":"13","author":"Darman","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.preteyeres.2019.100800_bib29","doi-asserted-by":"crossref","first-page":"37824","DOI":"10.18632\/oncotarget.5637","article-title":"Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma","volume":"6","author":"de Lange","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.preteyeres.2019.100800_bib30","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1126\/science.1221711","article-title":"Loss of the tumor suppressor BAP1 causes myeloid transformation","volume":"337","author":"Dey","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2019.100800_bib31","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1167\/iovs.16-20212","article-title":"The prognostic value of AJCC staging in uveal melanoma is enhanced by adding chromosome 3 and 8q status","volume":"58","author":"Dogrusoz","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2019.100800_bib32","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/bjc.2013.804","article-title":"Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma","volume":"110","author":"Dono","year":"2014","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.preteyeres.2019.100800_bib33","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1167\/iovs.18-24818","article-title":"Multi-modality analysis improves survival prediction in enucleated uveal melanoma patients","volume":"60","author":"Drabarek","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2019.100800_bib34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1504\/IJBET.2012.045355","article-title":"Enhancing survival prognostication in patients with choroidal melanoma by integrating pathologic clinical and genetic predictors of metastases","author":"Eleuteri","year":"2012","journal-title":"Int. J. Biomed. Eng. Technol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib35","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0161-6420(00)00182-2","article-title":"Tumor doubling times in metastatic malignant melanoma of the uvea: tumor progression before and after treatment","volume":"107","author":"Eskelin","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2019.100800_bib36","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1158\/1078-0432.CCR-13-0485","article-title":"Phase I pharmacokinetic and pharmacodynamic study of the first-in-class spliceosome inhibitor E7107 in patients with advanced solid tumors","volume":"19","author":"Eskens","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib37","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1167\/iovs.14-14550","article-title":"Chromosome 3 status combined with BAP1 and EIF1AX mutation profiles are associated with metastasis in uveal melanoma","volume":"55","author":"Ewens","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2019.100800_bib38","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1021\/cb100356k","article-title":"Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing","volume":"6","author":"Fan","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib39","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/cjp2.86","article-title":"Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma","volume":"4","author":"Farquhar","year":"2018","journal-title":"J. Pathol. Clin. Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib40","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.ccr.2014.04.016","article-title":"Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry","volume":"25","author":"Feng","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41467-017-02428-w","article-title":"Punctuated evolution of canonical genomic aberrations in uveal melanoma","volume":"9","author":"Field","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.preteyeres.2019.100800_bib42","doi-asserted-by":"crossref","first-page":"59209","DOI":"10.18632\/oncotarget.10962","article-title":"Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in Class 1 and Class 2 uveal melanomas","volume":"7","author":"Field","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.preteyeres.2019.100800_bib43","article-title":"Das Sarkom des Uvealtractus","volume":"233","author":"Fuchs","year":"1882","journal-title":"Graefe's Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib44","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1158\/2159-8290.CD-13-0330","article-title":"SF3B1 mutations are associated with alternative splicing in uveal melanoma","volume":"3","author":"Furney","year":"2013","journal-title":"Cancer Discov."},{"key":"10.1016\/j.preteyeres.2019.100800_bib45","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s00262-017-1991-1","article-title":"Genetic evolution of uveal melanoma guides the development of an inflammatory microenvironment","volume":"66","author":"Gezgin","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.preteyeres.2019.100800_bib46","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/modpathol.2013.138","article-title":"Genetic and clinico-pathologic analysis of metastatic uveal melanoma","volume":"27","author":"Griewank","year":"2014","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib47","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrc2110","article-title":"Protein kinase C and other diacylglycerol effectors in cancer","volume":"7","author":"Griner","year":"2007","journal-title":"Nat. Rev. Cancer"},{"issue":"265","key":"10.1016\/j.preteyeres.2019.100800_bib149","doi-asserted-by":"crossref","first-page":"ra14","DOI":"10.1126\/scisignal.2003398","article-title":"The small GTPase ARF6 stimulates beta-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis","volume":"6","author":"Grossmann","year":"2013","journal-title":"Sci Signal"},{"key":"10.1016\/j.preteyeres.2019.100800_bib48","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/pros.20022","article-title":"Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer","volume":"59","author":"Halkidou","year":"2004","journal-title":"The Prostate"},{"key":"10.1016\/j.preteyeres.2019.100800_bib49","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1126\/science.1194472","article-title":"Frequent mutation of BAP1 in metastasizing uveal melanomas","volume":"330","author":"Harbour","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2019.100800_bib50","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/ng.2523","article-title":"Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma","volume":"45","author":"Harbour","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2019.100800_bib51","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s10637-013-0046-5","article-title":"A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors","volume":"32","author":"Hong","year":"2014","journal-title":"Investig. New Drugs"},{"key":"10.1016\/j.preteyeres.2019.100800_bib52","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Hoshino","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2019.100800_bib53","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature14985","article-title":"The spliceosome is a therapeutic vulnerability in MYC-driven cancer","volume":"525","author":"Hsu","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2019.100800_bib54","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.ophtha.2018.03.011","article-title":"The cancer genome Atlas project: an integrated molecular view of uveal melanoma","volume":"125","author":"Jager","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2019.100800_bib55","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.preteyeres.2010.11.004","article-title":"Macrophages in uveal melanoma and in experimental ocular tumor models: friends or foes?","volume":"30","author":"Jager","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib56","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1093\/nar\/gku274","article-title":"The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex","volume":"42","author":"Ji","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib57","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.18632\/oncotarget.6614","article-title":"Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4","volume":"7","author":"Johansson","year":"2016","journal-title":"Oncotarget"},{"issue":"5\u20136","key":"10.1016\/j.preteyeres.2019.100800_bib58","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00251-019-01108-x","article-title":"Prolonged stable disease in a uveal melanoma patient with germline MBD4 nonsense mutation treated with pembrolizumab and ipilimumab","volume":"71","author":"Johansson","year":"2019","journal-title":"Immunogenetics"},{"key":"10.1016\/j.preteyeres.2019.100800_bib59","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nchembio.2007.18","article-title":"Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA","volume":"3","author":"Kaida","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib60","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/bjc.2014.417","article-title":"Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing","volume":"111","author":"Kalirai","year":"2014","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.preteyeres.2019.100800_bib61","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1167\/iovs.04-1460","article-title":"Concurrent loss of chromosome arm 1p and chromosome 3 predicts a decreased disease-free survival in uveal melanoma patients","volume":"46","author":"Kilic","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2019.100800_bib62","doi-asserted-by":"crossref","first-page":"28903","DOI":"10.18632\/oncotarget.25627","article-title":"Real world experience in low-dose ipilimumab in combination with PD-1 blockade in advanced melanoma patients","volume":"9","author":"Kirchberger","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.preteyeres.2019.100800_bib63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11912-017-0606-5","article-title":"Immunotherapy for the treatment of uveal melanoma: current status and emerging therapies","volume":"19","author":"Komatsubara","year":"2017","journal-title":"Curr. Oncol. Rep."},{"key":"10.1016\/j.preteyeres.2019.100800_bib64","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/modpathol.2014.43","article-title":"Clinical significance of immunohistochemistry for detection of BAP1 mutations in uveal melanoma","volume":"27","author":"Koopmans","year":"2014","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib65","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/nchembio.2007.16","article-title":"Splicing factor SF3b as a target of the antitumor natural product pladienolide","volume":"3","author":"Kotake","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib66","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cell.2016.11.037","article-title":"Emerging biological principles of metastasis","volume":"168","author":"Lambert","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib67","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1158\/1078-0432.CCR-11-0946","article-title":"Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma","volume":"18","author":"Landreville","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib68","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nm.4097","article-title":"Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins","volume":"22","author":"Lee","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.preteyeres.2019.100800_bib69","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.molcel.2010.01.042","article-title":"Highly compacted chromatin formed in vitro reflects the dynamics of transcription activation in vivo","volume":"38","author":"Li","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib70","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/cr.2015.153","article-title":"Organotropic metastasis: role of tumor exosomes","volume":"26","author":"Liu","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib71","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.4049\/jimmunol.0903479","article-title":"In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages","volume":"185","author":"Ly","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib72","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1167\/iovs.07-0786","article-title":"Monosomy of chromosome 3 and an inflammatory phenotype occur together in uveal melanoma","volume":"49","author":"Maat","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2019.100800_bib73","doi-asserted-by":"crossref","first-page":"34179","DOI":"10.1074\/jbc.M109.046755","article-title":"The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1","volume":"284","author":"Machida","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2019.100800_bib74","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","article-title":"The epithelial-mesenchymal transition generates cells with properties of stem cells","volume":"133","author":"Mani","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib75","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31250","article-title":"eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast","volume":"6","author":"Martin-Marcos","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.preteyeres.2019.100800_bib76","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/ng.2674","article-title":"Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3","volume":"45","author":"Martin","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2019.100800_bib77","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.molcel.2014.03.002","article-title":"Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O","volume":"54","author":"Mashtalir","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib78","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/1471-2407-13-371","article-title":"BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma","volume":"13","author":"Matatall","year":"2013","journal-title":"BMC Canc."},{"key":"10.1016\/j.preteyeres.2019.100800_bib79","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/pcmr.12433","article-title":"Insights into genetic alterations of liver metastases from uveal melanoma","volume":"29","author":"McCarthy","year":"2016","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib80","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.coph.2015.07.005","article-title":"An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies","volume":"24","author":"McClorey","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib81","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0046-8177(82)80116-0","article-title":"Uveal melanoma: location, size, cell type, and enucleation as risk factors in metastasis","volume":"13","author":"McLean","year":"1982","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib82","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00270-019-02177-x","article-title":"Safety of percutaneous hepatic perfusion with melphalan in patients with unresectable liver metastases from ocular melanoma using the delcath systems' second-generation hemofiltration system: a prospective non-randomized phase II trial","volume":"42","author":"Meijer","year":"2019","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib83","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/cam4.61","article-title":"Ultradeep sequencing detects GNAQ and GNA11 mutations in cell\u2010free DNA from plasma of patients with uveal melanoma","volume":"2","author":"Metz","year":"2013","journal-title":"Canc. Med."},{"key":"10.1016\/j.preteyeres.2019.100800_bib84","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/ng.3549","article-title":"Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma","volume":"48","author":"Moore","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2019.100800_bib85","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.celrep.2018.01.081","article-title":"GNA11 Q209L mouse model reveals RasGRP3 as an essential signaling node in uveal melanoma","volume":"22","author":"Moore","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.preteyeres.2019.100800_bib86","doi-asserted-by":"crossref","first-page":"39654","DOI":"10.18632\/oncotarget.9207","article-title":"Minimal contribution of ERK1\/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish","volume":"7","author":"Mouti","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.preteyeres.2019.100800_bib87","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature09626","article-title":"Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation","volume":"468","author":"Nazarian","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2019.100800_bib88","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.preteyeres.2009.06.002","article-title":"Immune escape mechanisms of intraocular tumors","volume":"28","author":"Niederkorn","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib89","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrc3521","article-title":"The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer","volume":"13","author":"O'Hayre","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.preteyeres.2019.100800_bib90","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/1745-6215-15-317","article-title":"Isolated hepatic perfusion as a treatment for uveal melanoma liver metastases (the SCANDIUM trial): study protocol for a randomized controlled trial","volume":"15","author":"Olofsson","year":"2014","journal-title":"Trials"},{"key":"10.1016\/j.preteyeres.2019.100800_bib91","doi-asserted-by":"crossref","first-page":"7205","DOI":"10.1158\/0008-5472.CAN-04-1750","article-title":"Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death","volume":"64","author":"Onken","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib92","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(00)49915-0","article-title":"The distribution of secondary growths in cancer of the breast","volume":"133","author":"Paget","year":"1889","journal-title":"The Lancet"},{"key":"10.1016\/j.preteyeres.2019.100800_bib93","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23268","article-title":"Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability","volume":"6","author":"Paolella","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.preteyeres.2019.100800_bib94","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1158\/0008-5472.CAN-17-2876","article-title":"Familial and somatic BAP1 mutations inactivate ASXL1\/2-mediated allosteric regulation of BAP1 deubiquitinase by targeting multiple independent domains","volume":"78","author":"Peng","year":"2018","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.preteyeres.2019.100800_bib95","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/pcmr.12700","article-title":"Uveal melanoma driver mutations in GNAQ\/11 yield numerous changes in melanocyte biology","volume":"31","author":"Perez","year":"2018","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib96","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0140-6736(96)90736-9","article-title":"Prognostic implications of monosomy 3 in uveal melanoma","volume":"347","author":"Prescher","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.preteyeres.2019.100800_bib97","doi-asserted-by":"crossref","DOI":"10.1097\/CMR.0000000000000575","article-title":"Overall survival after treatment for metastatic uveal melanoma: a systematic review and meta-analysis","author":"Rantala","year":"2019","journal-title":"Melanoma Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib98","first-page":"5712","article-title":"Lack of BRAF mutations in uveal melanoma","volume":"63","author":"Rimoldi","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib99","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ccell.2017.07.003","article-title":"Integrative analysis identifies four molecular and clinical subsets in uveal melanoma","volume":"32","author":"Robertson","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib100","doi-asserted-by":"crossref","DOI":"10.1158\/1078-0432.CCR-19-1215","article-title":"Evolutionary routes in metastatic uveal melanomas depend on MBD4 alterations","author":"Rodrigues","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib101","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1038\/s41467-018-04322-5","article-title":"Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors","volume":"9","author":"Rodrigues","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.preteyeres.2019.100800_bib102","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature08966","article-title":"Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB","volume":"465","author":"Scheuermann","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2019.100800_bib103","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.celrep.2018.01.088","article-title":"Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types","volume":"23","author":"Seiler","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.preteyeres.2019.100800_bib104","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nm.4493","article-title":"H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers","volume":"24","author":"Seiler","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.preteyeres.2019.100800_bib105","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/PAT.0000000000000002","article-title":"BAP1 protein loss by immunohistochemistry: a potentially useful tool for prognostic prediction in patients with uveal melanoma","volume":"45","author":"Shah","year":"2013","journal-title":"Pathology"},{"key":"10.1016\/j.preteyeres.2019.100800_bib106","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/s41588-019-0440-9","article-title":"The genetic evolution of metastatic uveal melanoma","volume":"51","author":"Shain","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2019.100800_bib107","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/archophthalmol.2009.208","article-title":"Metastasis of uveal melanoma millimeter-by-millimeter in 8033 consecutive eyes","volume":"127","author":"Shields","year":"2009","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib1","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2016.34.15_suppl.9511","article-title":"A randomized phase 2 study of trametinib with or without GSK2141795 in patients with advanced uveal melanoma","volume":"34","author":"Shoushtari","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib108","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1136\/bjo.2003.029058","article-title":"The Zimmerman-McLean-Foster hypothesis: 25 years later","volume":"88","author":"Singh","year":"2004","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib109","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.ophtha.2011.01.040","article-title":"Uveal melanoma: trends in incidence, treatment, and survival","volume":"118","author":"Singh","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2019.100800_bib110","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/modpathol.2017.187","article-title":"Combined mutation and copy-number variation detection by targeted next-generation sequencing in uveal melanoma","volume":"31","author":"Smit","year":"2018","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib111","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1600-0463.2005.apm_04.x","article-title":"Increased expression of histone deacetylase 2 is found in human gastric cancer","volume":"113","author":"Song","year":"2005","journal-title":"APMIS"},{"key":"10.1016\/j.preteyeres.2019.100800_bib112","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cell.2009.04.042","article-title":"Defining the human deubiquitinating enzyme interaction landscape","volume":"138","author":"Sowa","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib113","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1167\/tvst.8.3.11","article-title":"Digital image analysis of BAP-1 accurately predicts uveal melanoma metastasis","volume":"8","author":"Stalhammar","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib114","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1002\/cam4.2167","article-title":"Expression of immune checkpoint receptors Indoleamine 2,3-dioxygenase and T cell Ig and ITIM domain in metastatic versus nonmetastatic choroidal melanoma","volume":"8","author":"Stalhammar","year":"2019","journal-title":"Canc. Med."},{"key":"10.1016\/j.preteyeres.2019.100800_bib115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ophtha.2017.07.018","article-title":"Uveal melanoma nuclear BRCA1-associated protein-1 immunoreactivity is an indicator of metastasis","volume":"125","author":"Szalai","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2019.100800_bib116","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: the catalogue of somatic mutations in cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib117","first-page":"2578","article-title":"Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities","volume":"63","author":"Tschentscher","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.preteyeres.2019.100800_bib118","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/bjc.2017.259","article-title":"GNAQ and GNA11 mutations and downstream YAP activation in choroidal nevi","volume":"117","author":"Vader","year":"2017","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.preteyeres.2019.100800_bib119","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1167\/iovs.11-8697","article-title":"Higher percentage of FISH-determined monosomy 3 and 8q amplification in uveal melanoma cells relate to poor patient prognosis","volume":"53","author":"van den Bosch","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2019.100800_bib120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/0284186X.2016.1260773","article-title":"Anti-PD1 treatment in metastatic uveal melanoma in The Netherlands","volume":"56","author":"van der Kooij","year":"2017","journal-title":"Acta Oncol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib121","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1136\/bjophthalmol-2014-305047","article-title":"Prognostic parameters in uveal melanoma and their association with BAP1 expression","volume":"98","author":"van Essen","year":"2014","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib122","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1167\/iovs.08-2033","article-title":"Gene expression profiling in uveal melanoma: two regions on 3p related to prognosis","volume":"49","author":"van Gils","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2019.100800_bib123","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/gb-2005-6-6-113","article-title":"Histone modifications: from genome-wide maps to functional insights","volume":"6","author":"van Leeuwen","year":"2005","journal-title":"Genome Biol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib124","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11081200","article-title":"SRSF2 mutations in uveal melanoma: a preference for in-frame deletions?","volume":"11","author":"van Poppelen","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.preteyeres.2019.100800_bib125","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.ophtha.2017.12.022","article-title":"Genetic background of Iris melanomas and Iris melanocytic tumors of uncertain malignant potential","volume":"125","author":"van Poppelen","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2019.100800_bib126","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature07586","article-title":"Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi","volume":"457","author":"Van Raamsdonk","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2019.100800_bib127","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1056\/NEJMoa1000584","article-title":"Mutations in GNA11 in uveal melanoma","volume":"363","author":"Van Raamsdonk","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.preteyeres.2019.100800_bib128","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1167\/iovs.17-22255","article-title":"PRiMeUM: a model for predicting risk of metastasis in uveal melanoma","volume":"58","author":"Vaquero-Garcia","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2019.100800_bib129","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116371","article-title":"Digital PCR validates 8q dosage as prognostic tool in uveal melanoma","volume":"10","author":"Versluis","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2019.100800_bib130","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1007\/s12325-016-0424-4","article-title":"Chemosaturation percutaneous hepatic perfusion: a systematic review","volume":"33","author":"Vogel","year":"2017","journal-title":"Adv. Ther."},{"key":"10.1016\/j.preteyeres.2019.100800_bib131","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/jnci\/djy171","article-title":"Comprehensive study of the clinical phenotype of germline BAP1 variant-carrying families worldwide","volume":"110","author":"Walpole","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.preteyeres.2019.100800_bib132","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1109016","article-title":"SF3B1 and other novel cancer genes in chronic lymphocytic leukemia","volume":"365","author":"Wang","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.preteyeres.2019.100800_bib133","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/IIO.0000000000000263","article-title":"Immune checkpoint inhibitors in uveal and conjunctival melanoma","volume":"59","author":"Wierenga","year":"2019","journal-title":"Int. Ophthalmol. Clin."},{"key":"10.1016\/j.preteyeres.2019.100800_bib134","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ophtha.2016.10.039","article-title":"Correlation of gene mutation status with copy number profile in uveal melanoma","volume":"124","author":"Yavuzyigitoglu","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2019.100800_bib135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000440981","article-title":"Lipomatous change in uveal melanoma: histopathological, immunohistochemical and cytogenetic analysis","volume":"2","author":"Yavuzyigitoglu","year":"2016","journal-title":"Ocul. Oncol. Pathol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib136","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.ophtha.2016.01.023","article-title":"Uveal melanomas with SF3B1 mutations: a distinct subclass Associated with late-onset metastases","volume":"123","author":"Yavuzyigitoglu","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2019.100800_bib137","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1111\/j.1742-4658.2011.08387.x","article-title":"Biological validation that SF3b is a target of the antitumor macrolide pladienolide","volume":"278","author":"Yokoi","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.preteyeres.2019.100800_bib138","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.ccell.2016.04.015","article-title":"ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma","volume":"29","author":"Yoo","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib139","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ccr.2014.04.017","article-title":"Mutant Gq\/11 promote uveal melanoma tumorigenesis by activating YAP","volume":"25","author":"Yu","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib140","doi-asserted-by":"crossref","first-page":"480","DOI":"10.18632\/oncoscience.57","article-title":"YAP as oncotarget in uveal melanoma","volume":"1","author":"Yu","year":"2014","journal-title":"Oncoscience"},{"key":"10.1016\/j.preteyeres.2019.100800_bib141","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1128\/MCB.00396-10","article-title":"The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression","volume":"30","author":"Yu","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib142","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1073\/pnas.1309085110","article-title":"Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair","volume":"111","author":"Yu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2019.100800_bib143","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10549-005-6001-1","article-title":"Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*","volume":"94","author":"Zhang","year":"2005","journal-title":"Breast Canc. Res. Treat."},{"key":"10.1016\/j.preteyeres.2019.100800_bib144","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.molcel.2007.07.024","article-title":"A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation","volume":"27","author":"Zhu","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.preteyeres.2019.100800_bib145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0118564","article-title":"Phase II DeCOG-study of ipilimumab in pretreated and treatment-naive patients with metastatic uveal melanoma","volume":"10","author":"Zimmer","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2019.100800_bib146","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/bjo.62.6.420","article-title":"Does enucleation of the eye containing a malignant melanoma prevent or accelerate the dissemination of tumour cells","volume":"62","author":"Zimmerman","year":"1978","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib147","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/s41379-018-0043-5","article-title":"Programmed cell death ligand-1 expression in tumor and immune cells is associated with better patient outcome and decreased tumor-infiltrating lymphocytes in uveal melanoma","volume":"31","author":"Zoroquiain","year":"2018","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.preteyeres.2019.100800_bib148","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1038\/sj.bjc.6601374","article-title":"Gene expression profiling identifies tumour markers potentially playing a role in uveal melanoma development","volume":"89","author":"Zuidervaart","year":"2003","journal-title":"Br. J. Canc."}],"container-title":["Progress in Retinal and Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946219300874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946219300874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T22:34:01Z","timestamp":1761172441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350946219300874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":149,"alternative-id":["S1350946219300874"],"URL":"https:\/\/doi.org\/10.1016\/j.preteyeres.2019.100800","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736701897.793585166","asserted-by":"object"}]},"ISSN":["1350-9462"],"issn-type":[{"value":"1350-9462","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uveal melanoma: Towards a molecular understanding","name":"articletitle","label":"Article Title"},{"value":"Progress in Retinal and Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preteyeres.2019.100800","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100800"}}