{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:58:01Z","timestamp":1793051881261,"version":"4.5.0"},"reference-count":247,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"TM"},{"name":"TM"},{"name":"TM"},{"name":"TM"},{"name":"SC"},{"name":"SC"},{"name":"TM"},{"name":"Public Health Service Center Grant","award":["PO1-EY000292"],"award-info":[{"award-number":["PO1-EY000292"]}]},{"name":"Public Health Service Center Grant","award":["TO1-EY-00018"],"award-info":[{"award-number":["TO1-EY-00018"]}]},{"name":"Public Health Service Center Grant","award":["RO1EY00002"],"award-info":[{"award-number":["RO1EY00002"]}]},{"name":"Public Health Service Center Grant","award":["R01EY0190601"],"award-info":[{"award-number":["R01EY0190601"]}]},{"name":"Public Health Service Center Grant","award":["R01EY024158"],"award-info":[{"award-number":["R01EY024158"]}]},{"name":"Public Health Service Center Grant","award":["R01EY028753"],"award-info":[{"award-number":["R01EY028753"]}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P51OD010425"],"award-info":[{"award-number":["P51OD010425"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Retinal and Eye Research"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.preteyeres.2020.100917","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T02:23:28Z","timestamp":1605579808000},"page":"100917","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"special_numbering":"C","title":["Aqueous outflow regulation \u2013 21st century concepts"],"prefix":"10.1016","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2136-2433","authenticated-orcid":false,"given":"Murray","family":"Johnstone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruikang K.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preteyeres.2020.100917_bib1","first-page":"100897","article-title":"Normal and glaucomatous outflow regulation","author":"Acott","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib2","series-title":"Molecular Biology of the Cell","article-title":"The cytoskeleton","author":"Alberts","year":"2002"},{"key":"10.1016\/j.preteyeres.2020.100917_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/stke.2002.119.pe6","article-title":"Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins","author":"Alenghat","year":"2002","journal-title":"Sci. STKE"},{"key":"10.1016\/j.preteyeres.2020.100917_bib4","series-title":"Shields Textbook of Glaucoma","author":"Allingham","year":"2012"},{"key":"10.1016\/j.preteyeres.2020.100917_bib5","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s11999-008-0264-x","article-title":"Loss of homeostatic strain alters mechanostat \u201cset point\u201d of tendon cells in vitro","volume":"466","author":"Arnoczky","year":"2008","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/archopht.1949.00900050069006","article-title":"Aqueous veins and their significance for pathogenesis of glaucoma","volume":"42","author":"Ascher","year":"1949","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib7","series-title":"The Aqueous Veins: Biomicroscopic Study of the Aqueous Humor Elimination","author":"Ascher","year":"1961"},{"key":"10.1016\/j.preteyeres.2020.100917_bib8","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0002-9394(42)93294-X","article-title":"Glaucoma and the aqueous veins","volume":"25","author":"Ascher","year":"1942","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib9","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0002-9394(42)90325-8","article-title":"Physiologic importance of the visible elimination of intraocular fluid","volume":"25","author":"Ascher","year":"1942","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib10","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/S0002-9394(44)90116-9","article-title":"Backflow phenomena in aqueous veins","volume":"27","author":"Ascher","year":"1944","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0002-9394(14)78379-5","article-title":"Compression tests on aqueous veins of glaucomatous eyes; application of hydrodynamic principles to the problem of intraocular-fluid elimination","volume":"32","author":"Ascher","year":"1949","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib12","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1172\/JCI75395","article-title":"The schlemm's canal is a vegf-c\/vegfr-3-responsive lymphatic-like vessel","volume":"124","author":"Aspelund","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2020.100917_bib13","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1167\/iovs.15-17753","article-title":"Anatomical variation of human collector channel orifices","volume":"57","author":"Bentley","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib14","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0014-4835(70)80030-6","article-title":"Scanning electron microscopy studies of the canal of schlemm","volume":"10","author":"Bill","year":"1970","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1755-3768.1972.tb05954.x","article-title":"Scanning electron microscopic studies of the trabecular meshwork and the canal of schlemm--an attempt to localize the main resistance to outflow of aqueous humor in man","volume":"50","author":"Bill","year":"1972","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.preteyeres.2020.100917_bib16","first-page":"12","article-title":"Shrinkage during fixation and embedding of histological specimens","volume":"1","author":"Bloom","year":"1956","journal-title":"Acta Morphol. Neerl-Scand"},{"key":"10.1016\/j.preteyeres.2020.100917_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1161\/01.CIR.78.1.81","article-title":"Human right ventricular end-systolic pressure-volume relation defined by maximal elastance","volume":"78","author":"Brown","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.preteyeres.2020.100917_bib18","first-page":"1","article-title":"Effeto della jaluronidasi sulla pressone intraocular e sull\u2019asetto della vene dell\u2019accqueo","volume":"34","author":"Cambiaggi","year":"1958","journal-title":"Boll. Soc. di Biologia Sperimentale"},{"key":"10.1016\/j.preteyeres.2020.100917_bib19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.preteyeres.2016.12.004","article-title":"Aqueous outflow - a continuum from trabecular meshwork to episcleral veins","volume":"57","author":"Carreon","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0002-9394(57)92910-0","article-title":"Primary degeneration in the vicinity of the chamber angle; as an etiologic factor in wide-angle glaucoma. Ii","volume":"43","author":"Chi","year":"1957","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib21","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/archopht.1969.00990020633011","article-title":"Direct-recorded intraocular pressure variations in a human subject","volume":"82","author":"Coleman","year":"1969","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF00921119","article-title":"Histochemical survey of the anterior segment of the normal human foetal and adult eye","volume":"231","author":"Coupland","year":"1993","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib23","first-page":"4667","article-title":"New insights into schlemm's canal (sc) structural relationships using multiple imaging modalities and 3d reconstructions","volume":"52","author":"Curtiss","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib24","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/CIRCRESAHA.108.173989","article-title":"Nuclear shape, mechanics, and mechanotransduction","volume":"102","author":"Dahl","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib25","first-page":"424","article-title":"Localization of smooth muscle and nonmuscle actin isoforms in the human aqueous outflow pathway","volume":"33","author":"De Kater","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib26","series-title":"De Zichtbare Afvoer Van Het Kamerwater","author":"De Vries","year":"1947"},{"key":"10.1016\/j.preteyeres.2020.100917_bib27","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1242\/jcs.037457","article-title":"Desmosomes at a glance","volume":"122","author":"Desai","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0002-9394(56)91458-1","article-title":"Aqueous pathways in some cases of glaucoma","volume":"41","author":"Dvorak-Theobald","year":"1956","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib29","first-page":"705","article-title":"Influence of intraocular pressure and trabeculotomy on aqueous outflow in enucleated monkey eyes","volume":"10","author":"Ellingsen","year":"1971","journal-title":"Invest. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib30","first-page":"430","article-title":"The relationship of pressure and aqueous outflow in enucleated human eyes","volume":"10","author":"Ellingsen","year":"1971","journal-title":"Invest. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib31","first-page":"21","article-title":"Trabeculotomy and sinusotomy in enucleated human eyes","volume":"11","author":"Ellingsen","year":"1972","journal-title":"Invest. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/exer.2002.1144","article-title":"The inner wall of schlemm's canal","volume":"74","author":"Ethier","year":"2002","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib33","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1529\/biophysj.103.038133","article-title":"Biomechanics of schlemm's canal endothelial cells: influence on f-actin architecture","volume":"87","author":"Ethier","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.preteyeres.2020.100917_bib34","series-title":"Episcleral Venous Fluid Wave: Intraoperative Evidence for Patency of the Conventional Outflow System","first-page":"347","author":"Fellman","year":"2014"},{"key":"10.1016\/j.preteyeres.2020.100917_bib35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.exer.2017.08.017","article-title":"Disruption of fibronectin matrix affects type iv collagen, fibrillin and laminin deposition into extracellular matrix of human trabecular meshwork (htm) cells","volume":"165","author":"Filla","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib36","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1001\/archopht.1956.00930040716010","article-title":"The anatomy of the trabecular meshwork as seen in tangential section","volume":"56","author":"Flocks","year":"1957","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib37","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1167\/iovs.09-3783","article-title":"Morphologic indication for proprioception in the human ciliary muscle","volume":"50","author":"Fl\u00fcgel-Koch","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0014-4835(90)90234-L","article-title":"Histochemical differences within the ciliary muscle and its function in accommodation","volume":"50","author":"Fl\u00fcgel","year":"1990","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib39","first-page":"384","article-title":"[structural differences in the structure of the ciliary muscles in eyes of primates. A histochemical and morphological study]","volume":"87","author":"Fl\u00fcgel","year":"1990","journal-title":"Fortschr. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF00315900","article-title":"Rod-shaped bodies and crystalloid inclusions in ocular vascular endothelia of adult and developing macaca mulatta","volume":"158","author":"Freddo","year":"1980","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib41","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1167\/iovs.05-0292","article-title":"Biochemical and morphological analysis of basement membrane component expression in corneoscleral and cribriform human trabecular meshwork cells","volume":"47","author":"Fuchshofer","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib42","series-title":"Biomechanics Mechanical Structure of Living Cells","author":"Fung","year":"1993"},{"key":"10.1016\/j.preteyeres.2020.100917_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1115\/1.2895465","article-title":"Elementary mechanics of the endothelium of blood vessels","volume":"115","author":"Fung","year":"1993","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.preteyeres.2020.100917_bib44","series-title":"Biomechanics: Circulation","author":"Fung","year":"1996"},{"key":"10.1016\/j.preteyeres.2020.100917_bib45","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.preteyeres.2004.10.003","article-title":"Changes in aqueous humor dynamics with age and glaucoma","volume":"24","author":"Gabelt","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib46","first-page":"4824","article-title":"Trabecular meshwork motion in normal compared with glaucoma eyes","volume":"60","author":"Gao","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0002-9394(58)90031-X","article-title":"Electron microscopic studies of the human eye","volume":"46","author":"Garron","year":"1958","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib48","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/cc2854","article-title":"Bench-to-bedside review: chest wall elastance in acute lung injury\/acute respiratory distress syndrome patients","volume":"8","author":"Gattinoni","year":"2004","journal-title":"Crit. Care"},{"key":"10.1016\/j.preteyeres.2020.100917_bib49","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/35099066","article-title":"Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk","volume":"2","author":"Geiger","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib50","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000300317","article-title":"Abfluss des kammerwassers beim menschen","volume":"111","author":"Goldmann","year":"1946","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.preteyeres.2020.100917_bib51","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1159\/000300402","article-title":"Weitere mitteilung \u00fcber den abfluss des kammerwassers beim menschen","volume":"112","author":"Goldmann","year":"1946","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.preteyeres.2020.100917_bib52","first-page":"193","article-title":"Uber abflussdruck und glasstab-phanomen. Pathogenese des einfachen glaukoms","volume":"116","author":"Goldmann","year":"1948","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.preteyeres.2020.100917_bib53","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/ceo.12255","article-title":"Observing live actin in the human trabecular meshwork","volume":"42","author":"Gonzalez","year":"2014","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib54","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1167\/iovs.11-8570","article-title":"Two-photon immunofluorescence characterization of the trabecular meshwork in situ","volume":"53","author":"Gonzalez","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib55","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1167\/iovs.12-10479","article-title":"Analyzing live cellularity in the human trabecular meshwork","volume":"54","author":"Gonzalez","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib56","doi-asserted-by":"crossref","first-page":"17071","DOI":"10.1038\/s41598-017-16897-y","article-title":"Deep tissue analysis of distal aqueous drainage structures and contractile features","volume":"7","author":"Gonzalez","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2020.100917_bib57","doi-asserted-by":"crossref","first-page":"21315","DOI":"10.1038\/srep21315","article-title":"Tissue-based multiphoton analysis of actomyosin and structural responses in human trabecular meshwork","volume":"6","author":"Gonzalez","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2020.100917_bib58","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1001\/archopht.1958.00940080541001","article-title":"Further studies on facility of flow through the trabecular meshwork","volume":"60","author":"Grant","year":"1958","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib59","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/archopht.1963.00960040789022","article-title":"Experimental aqueous perfusion in enucleated human eyes","volume":"69","author":"Grant","year":"1963","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib60","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-4835(74)90068-2","article-title":"Changes in the monkey outflow apparatus at graded levels of intraocular pressure: a qualitative analysis by light microscopy and scanning electron microscopy","volume":"19","author":"Grierson","year":"1974","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00410696","article-title":"Junctions between the cells of the trabecular meshwork","volume":"192","author":"Grierson","year":"1974","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib62","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0014-4835(75)90218-3","article-title":"The fine structure of the trabecular meshwork at graded levels of intraocular pressure. (1) pressure effects within the near-physiological range (8-30 mmhg)","volume":"20","author":"Grierson","year":"1975","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib63","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0014-4835(75)90219-5","article-title":"The fine structure of the trabecular meshwork at graded levels of intraocular pressure. (2) pressures outside the physiological range (0 and 50 mmhg)","volume":"20","author":"Grierson","year":"1975","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib64","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00406980","article-title":"Associations between the cells of the walls of schlemm's canal","volume":"208","author":"Grierson","year":"1978","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib65","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/aos.12513","article-title":"Long-term results of up to 12 years of over 700 cases of viscocanalostomy for open-angle glaucoma","volume":"93","author":"Grieshaber","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib66","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1136\/bjo.2009.163170","article-title":"Canaloplasty for primary open-angle glaucoma: long-term outcome","volume":"94","author":"Grieshaber","year":"2010","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib67","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/IJG.0000000000000325","article-title":"Gonioscopy-assisted transluminal trabeculotomy (gatt): thermal suture modification with a dye-stained rounded tip","volume":"25","author":"Grover","year":"2016","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.preteyeres.2020.100917_bib68","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0014-4835(92)90121-8","article-title":"Aspects of the development of schlemm's canal","volume":"55","author":"Hamanaka","year":"1992","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib69","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0021-5155(97)00031-2","article-title":"Cytoskeleton and tissue origin in the anterior cynomolgus monkey eye","volume":"41","author":"Hamanaka","year":"1997","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib70","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1167\/iovs.08-2375","article-title":"Preferential fluid flow in the human trabecular meshwork near collector channels","volume":"50","author":"Hann","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib71","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1167\/iovs.10-5620","article-title":"The elastin fiber system between and adjacent to collector channels in the human juxtacanalicular tissue","volume":"52","author":"Hann","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib72","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.exer.2010.12.010","article-title":"Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3d micro-ct)","volume":"92","author":"Hann","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib73","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.1167\/iovs.14-14128","article-title":"Anatomic changes in schlemm's canal and collector channels in normal and primary open-angle glaucoma eyes using low and high perfusion pressures","volume":"55","author":"Hann","year":"2014","journal-title":"Invest. Opthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib74","doi-asserted-by":"crossref","first-page":"106013 1","DOI":"10.1117\/1.JBO.19.10.106013","article-title":"Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography","volume":"19","author":"Hariri","year":"2014","journal-title":"J. Biomed. Optic."},{"key":"10.1016\/j.preteyeres.2020.100917_bib75","series-title":"Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus","author":"Harvey","year":"1970"},{"key":"10.1016\/j.preteyeres.2020.100917_bib76","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/j.ophtha.2009.06.042","article-title":"Natural history of open-angle glaucoma","volume":"116","author":"Heijl","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2020.100917_bib77","series-title":"The Glaucomas","first-page":"213","article-title":"Extracellular matrix of the trabecular meshwork and optic nerve head","author":"Hernandez","year":"1996"},{"key":"10.1016\/j.preteyeres.2020.100917_bib78","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1136\/bjo.38.5.266","article-title":"Slitlamp studies on the flow of aqueous humor","volume":"38","author":"Hodgson","year":"1954","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib79","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000264541","article-title":"Schlemm's canal under the scanning electron microscope","volume":"2","author":"Hoffmann","year":"1971","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib80","series-title":"Histology of the Human Eye, and Atlas and Textbook","author":"Hogan","year":"1971"},{"key":"10.1016\/j.preteyeres.2020.100917_bib81","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1001\/archopht.1959.04220060028005","article-title":"The fine structure of the inner wall of schlemm's canal","volume":"62","author":"Holmberg","year":"1959","journal-title":"Arch. Ophtalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib82","first-page":"339","article-title":"Schlemm's canal and the trabecular meshwork. An electron microscopic study of the normal structure in man and monkey (cercopithecus ethiops)","volume":"29","author":"Holmberg","year":"1965","journal-title":"Documentia Ophthalmolgoica"},{"key":"10.1016\/j.preteyeres.2020.100917_bib83","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00180-012-0324-2","article-title":"Attractors in boolean networks: a tutorial","volume":"28","author":"Hopfensitz","year":"2013","journal-title":"Comput. Stat."},{"key":"10.1016\/j.preteyeres.2020.100917_bib84","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.bbrc.2005.02.026","article-title":"Prestress mediates force propagation into the nucleus","volume":"329","author":"Hu","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.preteyeres.2020.100917_bib85","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.ophtha.2017.03.058","article-title":"Aqueous angiography: aqueous humor outflow imaging in live human subjects","volume":"124","author":"Huang","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2020.100917_bib86","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ophtha.2017.01.030","article-title":"Aqueous angiography in living nonhuman primates shows segmental, pulsatile, and dynamic angiographic aqueous humor outflow","volume":"124","author":"Huang","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2020.100917_bib87","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/tvst.5.6.5","article-title":"Aqueous angiography with fluorescein and indocyanine green in bovine eyes","volume":"5","author":"Huang","year":"2016","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.preteyeres.2020.100917_bib88","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1167\/iovs.16-19644","article-title":"Aqueous angiography-mediated guidance of trabecular bypass improves angiographic outflow in human enucleated eyes","volume":"57","author":"Huang","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib89","doi-asserted-by":"crossref","first-page":"128701","DOI":"10.1103\/PhysRevLett.94.128701","article-title":"Cell fates as high-dimensional attractor states of a complex gene regulatory network","volume":"94","author":"Huang","year":"2005","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.preteyeres.2020.100917_bib90","series-title":"Cardiovascular Solid Mechanics: Cells, Tissues, and Organs","author":"Humphrey","year":"2002"},{"key":"10.1016\/j.preteyeres.2020.100917_bib91","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1242\/jcs.104.3.613","article-title":"Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton","volume":"104","author":"Ingber","year":"1993","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib92","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1242\/jcs.00359","article-title":"Tensegrity I. Cell structure and hierarchical systems biology","volume":"116","author":"Ingber","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib93","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/01.RES.0000039537.73816.E5","article-title":"Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology","volume":"91","author":"Ingber","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib94","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1073\/pnas.0530201100","article-title":"Mechanosensation through integrins: cells act locally but think globally","volume":"100","author":"Ingber","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2020.100917_bib95","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/0002-9394(72)90394-7","article-title":"Aqueous humor pathways through the trabecular meshwork and into schlemm's canal in the cynomolgus monkey (macaca irus). An electron microscopic study","volume":"73","author":"Inomata","year":"1972","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib96","first-page":"3214","article-title":"Transparent cylindrical structures spanning schlemm's canal: examination by oblique light, phase contrast, differential interference contrast (nomarski) and fluorescence microscopy","volume":"52","author":"Jamil","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib97","first-page":"2950","article-title":"The pore density in the inner wall endothelium of schlemm's canal of glaucomatous eyes","volume":"43","author":"Johnson","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib99","series-title":"Glaucoma Research and Clinical Advances: 2016 to 2018","article-title":"Intraocular pressure control through linked trabecular meshwork and collector channel motion","author":"Johnstone","year":"2016"},{"key":"10.1016\/j.preteyeres.2020.100917_bib100","series-title":"New imaging techniques to study transparent tubules spanning schlemm's canal, structures subject to disruption by schlemm's canal surgery","first-page":"103","author":"Johnstone","year":"2011"},{"key":"10.1016\/j.preteyeres.2020.100917_bib101","series-title":"Endothelial-lined Aqueous Conduits Span Schlemm's Canal (SC) to Attach to Collector Channel Ostia: Identification by 3D Reconstruction of Histologic Sections","first-page":"47","author":"Johnstone","year":"2011"},{"key":"10.1016\/j.preteyeres.2020.100917_bib102","series-title":"The Glaucoma Book","first-page":"65","article-title":"Aqueous veins and open angle glaucoma","author":"Johnstone","year":"2010"},{"key":"10.1016\/j.preteyeres.2020.100917_bib103","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.exer.2011.03.011","article-title":"Pulsatile flow into the aqueous veins: manifestations in normal and glaucomatous eyes","volume":"92","author":"Johnstone","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib104","first-page":"76","article-title":"Latanoprost instillation results in a rapid directly measurable increase in conventional aqueous outflow","volume":"48S","author":"Johnstone","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib105","first-page":"2169","article-title":"Pulse-dependent trabecular meshwork motion: direct microscope observation and measurement in radial limbal segments of non-human primate eyes","volume":"55","author":"Johnstone","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib106","first-page":"56","article-title":"The slit lamp, the ophthalmoscope and the genome: clinically visible parallels of mechanotransduction in the aqueous outflow and vascular circulatory systems","volume":"13","author":"Johnstone","year":"2004","journal-title":"Am. Glaucoma Soc."},{"key":"10.1016\/j.preteyeres.2020.100917_bib107","first-page":"4639","article-title":"New noninvasive techniques to characterize schlemm's canal endothelial cell (sce) topography and relationships: adjunct to scanning electron microscopy (sem)","volume":"52","author":"Johnstone","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib108","first-page":"28","article-title":"Pulsatile circumferential aqueous flow into schlemm's canal is synchronous with the cardiac pulse","volume":"50","author":"Johnstone","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib109","series-title":"Diagnosis and Therapy of the Glaucomas","first-page":"22","article-title":"Aqueous humor outflow","author":"Johnstone","year":"2009"},{"key":"10.1016\/j.preteyeres.2020.100917_bib110","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0002-9394(14)76301-9","article-title":"Pressure-dependent changes in configuration of the endothelial tubules of schlemm's canal","volume":"78","author":"Johnstone","year":"1974","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib111","first-page":"44","article-title":"Pressure-dependent changes in nuclei and the process origins of the endothelial cells lining schlemm's canal","volume":"18","author":"Johnstone","year":"1979","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib112","series-title":"Essentials in Ophthalmology: Glaucoma II","doi-asserted-by":"crossref","DOI":"10.1007\/3-540-34773-9_1","article-title":"A new model describes an aqueous outflow pump and explores causes of pump failure in glaucoma","author":"Johnstone","year":"2006"},{"key":"10.1016\/j.preteyeres.2020.100917_bib113","series-title":"Glaucoma: Applied Pharmacology in Medical Treatment","first-page":"87","article-title":"The morphology of the aqueous outflow channels","author":"Johnstone","year":"1984"},{"key":"10.1016\/j.preteyeres.2020.100917_bib114","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0002-9394(73)91145-8","article-title":"Pressure-dependent changes in structure of the aqueous outflow system in human and monkey eyes","volume":"75","author":"Johnstone","year":"1973","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib115","first-page":"835","article-title":"Concentration-dependent morphologic effects of cytochalasin b in the aqueous outflow system","volume":"19","author":"Johnstone","year":"1980","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib116","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/01.ijg.0000131757.63542.24","article-title":"The aqueous outflow system as a mechanical pump: evidence from examination of tissue and aqueous movement in human and non-human primates","volume":"13","author":"Johnstone","year":"2004","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.preteyeres.2020.100917_bib117","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1089\/jop.2013.0224","article-title":"Intraocular pressure regulation: findings of pulse-dependent trabecular meshwork motion lead to unifying concepts of intraocular pressure homeostasis","volume":"30","author":"Johnstone","year":"2014","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"key":"10.1016\/j.preteyeres.2020.100917_bib118","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/0002-9394(73)90080-9","article-title":"Microsurgery of schlemm's canal and the human aqueous outflow system","volume":"76","author":"Johnstone","year":"1973","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib119","article-title":"Travoprost instillation results in a rapid directly observable increase in conventional aqueous outflow in normal subjects","volume":"49S","author":"Johnstone","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib120","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.exer.2013.12.011","article-title":"Effects of a schlemm canal scaffold on collector channel ostia in human anterior segments","volume":"119","author":"Johnstone","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib121","first-page":"5907","article-title":"Collector channel dynamics: oct capture of real-time pressure-dependent changes in lumen area in ex vivo normal and glaucomatous eyes","volume":"59","author":"Johnstone","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib122","first-page":"4704","article-title":"Aqueous outflow pathways that may be specially organized to sense flow and pressure","volume":"57","author":"Johnstone","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib123","first-page":"2825","article-title":"Microscope real-time video high- resolution oct & histopathology to assess how transcleral micropulse laser affects the sclera, ciliary body muscle, secretory epithelium, suprachoroidal space & aqueous outflow system","volume":"60","author":"Johnstone","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib124","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/224177a0","article-title":"Homeostasis and differentiation in random genetic control networks","volume":"224","author":"Kauffman","year":"1969","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2020.100917_bib125","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0022-5193(69)90015-0","article-title":"Metabolic stability and epigenesis in randomly constructed genetic nets","volume":"22","author":"Kauffman","year":"1969","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib126","series-title":"The Origins of Order: Self-Organization and Selection in Evolution","author":"Kauffman","year":"1993"},{"key":"10.1016\/j.preteyeres.2020.100917_bib127","doi-asserted-by":"crossref","first-page":"108105","DOI":"10.1016\/j.exer.2020.108105","article-title":"Deconstructing aqueous humor outflow\u2013the last 50 years","author":"Kaufman","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib128","first-page":"793","article-title":"Loss of acute pilocarpine effect on outflow facility following surgical disinsertion and retrodisplacement of the ciliary muscle from the scleral spur in the cynomolgus monkey","volume":"15","author":"Kaufman","year":"1976","journal-title":"Invest. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib129","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ogla.2019.04.001","article-title":"Hemoglobin video imaging provides novel in vivo high-resolution imaging and quantification of human aqueous outflow in patients with glaucoma","volume":"2","author":"Khatib","year":"2019","journal-title":"Ophthalmol. Glaucoma"},{"key":"10.1016\/j.preteyeres.2020.100917_bib130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001912","article-title":"Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process","volume":"12","author":"Kizhatil","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib131","first-page":"726","article-title":"Das durch druck auf das auge erzielte ruckflussphanomen in den kammerwasservenen","volume":"122","author":"Kleinert","year":"1951","journal-title":"Klin. Monatsbl\u00e4tter Augenheilkd."},{"key":"10.1016\/j.preteyeres.2020.100917_bib132","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/BF00680828","article-title":"Der sichtbare abfluss des kammerwassers in den epibulb\u00e4ren venen","volume":"152","author":"Kleinert","year":"1951","journal-title":"von Graefes Arch. Ophth."},{"key":"10.1016\/j.preteyeres.2020.100917_bib133","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/archopht.1951.01700020632002","article-title":"The compensation maximum: a new glaucoma sign in aqueous veins","volume":"46","author":"Kleinert","year":"1951","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib134","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1113\/jphysiol.1912.sp001511","article-title":"The influence of variations in temperature and blood-pressure on the performance of the isolated mammalian heart","volume":"44","author":"Knowlton","year":"1912","journal-title":"J. Physiol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib135","first-page":"37","article-title":"[sinusotomy in glaucoma]","volume":"77","author":"Krasnov","year":"1964","journal-title":"Vestn. Oftalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib136","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0002-9394(69)90079-8","article-title":"Microsurgery of glaucoma: indications and choice of techniques","volume":"67","author":"Krasnov","year":"1969","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib137","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1034\/j.1600-0420.1999.770102.x","article-title":"Expression of factor viii-related antigen in human aqueous drainage channels","volume":"77","author":"Krohn","year":"1999","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1016\/j.preteyeres.2020.100917_bib138","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1001\/archopht.1949.00900040403001","article-title":"Further gonioscopic studies on the canal of schlemm","volume":"41","author":"Kronfeld","year":"1949","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib139","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/ajmg.a.35838","article-title":"Marfan syndrome caused by a novel fbn1 mutation with associated pigmentary glaucoma","volume":"161A","author":"Kuchtey","year":"2013","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.preteyeres.2020.100917_bib140","first-page":"87","article-title":"Studien \u00fcber den fl\u00fcssigkeitswechsel im auge","volume":"19","author":"Leber","year":"1873","journal-title":"Albr. v. Gr. Arch. Ophthal"},{"key":"10.1016\/j.preteyeres.2020.100917_bib141","first-page":"430","article-title":"Relationships between intraocular pressure and the morphology of the outflow apparatus","volume":"94","author":"Lee","year":"1974","journal-title":"Trans. Ophthalmol. Soc. U. K."},{"key":"10.1016\/j.preteyeres.2020.100917_bib142","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF00410037","article-title":"Pressure effects on the endothelium of the trabecular wall of schlemm's canal: a study by scanning electron microscopy","volume":"196","author":"Lee","year":"1975","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib143","series-title":"Cardiovascular Physiology","author":"Levick","year":"2000"},{"key":"10.1016\/j.preteyeres.2020.100917_bib144","series-title":"Introduction to Cardiovascular Physiology","author":"Levick","year":"2010"},{"key":"10.1016\/j.preteyeres.2020.100917_bib145","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.17.7.076026","article-title":"Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement in ex vivo nonhuman primate eyes","volume":"17","author":"Li","year":"2012","journal-title":"J. Biomed. Optic."},{"key":"10.1016\/j.preteyeres.2020.100917_bib146","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1364\/BOE.4.002051","article-title":"Pulsatile motion of the trabecular meshwork in healthy human subjects quantified by phase-sensitive optical coherence tomography","volume":"4","author":"Li","year":"2013","journal-title":"Biomed. Optic Express"},{"key":"10.1016\/j.preteyeres.2020.100917_bib147","first-page":"25","article-title":"[morphological principles of the aqueous humor secretory system and its changes induced by antiglaucoma drugs]","volume":"85","author":"L\u00fctjen-Drecoll","year":"1988","journal-title":"Fortschr. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib148","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0014-4835(86)90005-9","article-title":"Quantitative analysis of \u2018plaque material\u2019 between ciliary muscle tips in normal- and glaucomatous eyes","volume":"42","author":"L\u00fctjen-Drecoll","year":"1986","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib149","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0014-4835(88)90070-X","article-title":"Age changes in rhesus monkey ciliary muscle: light and electron microscopy","volume":"47","author":"L\u00fctjen-Drecoll","year":"1988","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib150","series-title":"The Glaucomas","first-page":"89","article-title":"Morphology of aqueous outflow in normal and glaucomatous eyes","author":"Lutjen-Drecoll","year":"1996"},{"key":"10.1016\/j.preteyeres.2020.100917_bib151","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1083\/jcb.42.3.647","article-title":"Endothelial contraction induced by histamine-type mediators, an electron microscopic study","volume":"42","author":"Majno","year":"1969","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib152","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1073\/pnas.94.3.849","article-title":"Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure","volume":"94","author":"Maniotis","year":"1997","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.preteyeres.2020.100917_bib153","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.ophtha.2012.02.050","article-title":"Reduction in intraocular pressure after cataract extraction: the ocular hypertension treatment study","volume":"119","author":"Mansberger","year":"2012","journal-title":"Ophthalmology"},{"issue":"13","key":"10.1016\/j.preteyeres.2020.100917_bib154","first-page":"A5683","article-title":"Schlemm's canal (SC) and distal aqueous outflow pathways: new scanning em (SEM) preparation technique permits identifying unique structural relationships","volume":"55","author":"Martin","year":"2014","journal-title":"Invest Ophthalmol Vis"},{"key":"10.1016\/j.preteyeres.2020.100917_bib155","first-page":"3259","article-title":"Scanning electron microscopy to characterize collector channel anatomic relationships in a non-glaucomatous human eye","volume":"56","author":"Martin","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib156","first-page":"47","article-title":"Aqueous outflow increase resulting from transient blink-induced IOP elevation","volume":"51","author":"Martin","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib157","first-page":"3534","article-title":"Microspheres (ms) perfused into the anterior chamber (ac) enter the lumen of cylindrical structures spanning schlemm's canal (sc)","volume":"54","author":"Martin","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib158","first-page":"3261","article-title":"Schlemm's canal (sc) and distal outflow system relationships revealed by immunohistochemistry (ihc) and confocal microscopy (cfm) following clarification","volume":"53","author":"Martin","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib159","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.preteyeres.2018.01.003","article-title":"Cataract, phacoemulsification and intraocular pressure: is the anterior segment anatomy the missing piece of the puzzle","volume":"64","author":"Masis Solano","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib160","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1529\/biophysj.108.132274","article-title":"Dynamics of chromatin decondensation reveals the structural integrity of a mechanically prestressed nucleus","volume":"95","author":"Mazumder","year":"2008","journal-title":"Biophys. J."},{"key":"10.1016\/j.preteyeres.2020.100917_bib161","doi-asserted-by":"crossref","first-page":"S321","DOI":"10.1098\/rsif.2010.0039.focus","article-title":"Emergence of a prestressed eukaryotic nucleus during cellular differentiation and development","volume":"7","author":"Mazumder","year":"2010","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.preteyeres.2020.100917_bib162","doi-asserted-by":"crossref","first-page":"C44","DOI":"10.1152\/ajpcell.00024.2018","article-title":"Pharmacological regulation of outflow resistance distal to schlemm's canal","volume":"315","author":"Mcdonnell","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib163","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1038\/s41598-020-62730-4","article-title":"Shear stress in schlemm's canal as a sensor of intraocular pressure","volume":"10","author":"Mcdonnell","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2020.100917_bib164","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1083\/jcb.32.3.757","article-title":"Loss of lipid during fixation for electron microscopy","volume":"32","author":"Morgan","year":"1967","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib165","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.preteyeres.2016.06.003","article-title":"Retinal venous pulsation: expanding our understanding and use of this enigmatic phenomenon","volume":"55","author":"Morgan","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib166","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0002-9394(70)90484-8","article-title":"Role of the blockade of schlemm's canal in pathogenesis of primary open-angle glaucoma","volume":"70","author":"Nesterov","year":"1970","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib167","series-title":"Mosby's Medical Dictionary","author":"O'Toole","year":"2013"},{"key":"10.1016\/j.preteyeres.2020.100917_bib168","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1080\/02713683.2016.1257726","article-title":"Immunohistochemical profiles of loxl-1, fbn1, tgf-\u03b21, and cox-2 in pseudoexfoliation syndrome","volume":"42","author":"Papadopoulou","year":"2017","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib169","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149384","article-title":"Coarsened exact matching of phaco-trabectome to trabectome in phakic patients: lack of additional pressure reduction from phacoemulsification","volume":"11","author":"Parikh","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2020.100917_bib170","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1172\/JCI75392","article-title":"Lymphatic regulator prox1 determines schlemm canal integrity and identity","volume":"124","author":"Park","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2020.100917_bib171","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1113\/jphysiol.1914.sp001676","article-title":"The regulation of the heart beat","volume":"48","author":"Patterson","year":"1914","journal-title":"J. Physiol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib172","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1001\/archopht.1972.01000030627011","article-title":"Blood reflux into schlemm's canal","volume":"88","author":"Phelps","year":"1972","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib173","series-title":"Phiillip's Current Online Version","article-title":"Oxford world encyclopedia","author":"Phillips","year":"2004"},{"key":"10.1016\/j.preteyeres.2020.100917_bib174","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1159\/000267190","article-title":"Ocular pulsation correlates with ocular tension: the choroid as piston for an aqueous pump?","volume":"24","author":"Phillips","year":"1992","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib175","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.preteyeres.2007.06.002","article-title":"Cochlin in the eye: functional implications","volume":"26","author":"Picciani","year":"2007","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib176","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/j.jcrs.2009.05.061","article-title":"Intraocular pressure reduction after phacoemulsification with intraocular lens implantation in glaucomatous and nonglaucomatous eyes: evaluation of a causal relationship between the natural lens and open-angle glaucoma","volume":"35","author":"Poley","year":"2009","journal-title":"J. Cataract Refract. Surg."},{"key":"10.1016\/j.preteyeres.2020.100917_bib177","doi-asserted-by":"crossref","first-page":"8209","DOI":"10.1073\/pnas.0900142106","article-title":"The effect of network topology on the stability of discrete state models of genetic control","volume":"106","author":"Pomerance","year":"2009","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.preteyeres.2020.100917_bib178","doi-asserted-by":"crossref","first-page":"H662","DOI":"10.1152\/ajpheart.00322.2008","article-title":"Lymphatic pump-conduit duality: contraction of postnodal lymphatic vessels inhibits passive flow","volume":"296","author":"Quick","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib179","doi-asserted-by":"crossref","first-page":"H2144","DOI":"10.1152\/ajpheart.00781.2007","article-title":"First-order approximation for the pressure-flow relationship of spontaneously contracting lymphangions","volume":"294","author":"Quick","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib180","doi-asserted-by":"crossref","first-page":"R1510","DOI":"10.1152\/ajpregu.00258.2006","article-title":"Intrinsic pump-conduit behavior of lymphangions","volume":"292","author":"Quick","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib181","first-page":"52","article-title":"Paracellular route of aqueous outflow in the trabecular meshwork and canal of schlemm. A freeze-fracture study of the endothelial junctions in the sclerocorneal angel of the macaque monkey eye","volume":"21","author":"Raviola","year":"1981","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib182","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1755-3768.1978.tb01347.x","article-title":"Actin filaments in trabecular endothelial cells in eyes of the vervet monkey. (cercopithecus aethiops)","volume":"56","author":"Ringvold","year":"1978","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.preteyeres.2020.100917_bib183","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000169701","article-title":"Vascular caliber","volume":"60","author":"Rodbard","year":"1975","journal-title":"Cardiology"},{"key":"10.1016\/j.preteyeres.2020.100917_bib184","first-page":"574","article-title":"The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections","volume":"21","author":"Rohen","year":"1981","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00577152","article-title":"The relation between the ciliary muscle and the trabecular meshwork and its importance for the effect of miotics on aqueous outflow resistance. A study in two contrasting monkey species, macaca irus and cercopithecus aethiops","volume":"172","author":"Rohen","year":"1967","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib186","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.90.098701","article-title":"Superpolynomial growth in the number of attractors in kauffman networks","volume":"90","author":"Samuelsson","year":"2003","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.preteyeres.2020.100917_bib187","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147176","article-title":"Aqueous angiography: real-time and physiologic aqueous humor outflow imaging","volume":"11","author":"Saraswathy","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2020.100917_bib188","first-page":"183","article-title":"Loss of absorbed lipid during fixation and dehydration of jejunal mucosa","volume":"32","author":"Saunders","year":"1967","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.preteyeres.2020.100917_bib189","first-page":"40","article-title":"Reflux of blood in the canal of schlemm quantitated","volume":"4","author":"Schirmer","year":"1969","journal-title":"Can. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib190","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1001\/archopht.1971.00990050265001","article-title":"Gonioscopic assessment of blood in schlemm's canal. Correlation with glaucoma tests","volume":"85","author":"Schirmer","year":"1971","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib191","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF02955984","article-title":"Untersuchungen \u00fcber die lymphbahnen des auges und ihre begrenzungen","volume":"6","author":"Schwalbe","year":"1870","journal-title":"Arch. Mikrosk. Anat."},{"key":"10.1016\/j.preteyeres.2020.100917_bib192","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12551-015-0184-4","article-title":"Historical perspective on heart function: the frank-starling law","volume":"7","author":"Sequeira","year":"2015","journal-title":"Biophys Rev"},{"key":"10.1016\/j.preteyeres.2020.100917_bib193","first-page":"883","article-title":"Physiological and medical aspects of flow in collapsible tubes","volume":"vol. 2","author":"Shapiro","year":"1977"},{"key":"10.1016\/j.preteyeres.2020.100917_bib194","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1115\/1.3426281","article-title":"Steady flow in collapsible tubes","volume":"99","author":"Shapiro","year":"1977","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.preteyeres.2020.100917_bib195","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1242\/jcs.103.4.1215","article-title":"Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape","volume":"103","author":"Sims","year":"1992","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib196","first-page":"S578","article-title":"Effects of viscocanalostomy on the histology of schlemm's canal in primate eyes","volume":"41","author":"Smit","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib197","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0161-6420(01)01006-5","article-title":"Effects of viscoelastic injection into schlemm's canal in primate and human eyes: potential relevance to viscocanalostomy","volume":"109","author":"Smit","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2020.100917_bib198","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/bjo.40.6.358","article-title":"Blood in the canal of schlemm","volume":"40","author":"Smith","year":"1956","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib199","doi-asserted-by":"crossref","DOI":"10.1038\/bonekey.2014.57","article-title":"The nuclear envelope as a mechanostat: a central cog in the machinery of cell and tissue regulation","volume":"3","author":"Snedeker","year":"2014","journal-title":"BoneKEy Rep."},{"key":"10.1016\/j.preteyeres.2020.100917_bib200","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1001\/archopht.1954.00920040026004","article-title":"Study of the compensation-maximum test on aqueous veins","volume":"51","author":"Stambaugh","year":"1954","journal-title":"A. M. A. Arch. Ophth."},{"key":"10.1016\/j.preteyeres.2020.100917_bib201","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.preteyeres.2014.08.002","article-title":"Biomechanics of schlemm's canal endothelium and intraocular pressure reduction","volume":"44","author":"Stamer","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib202","doi-asserted-by":"crossref","first-page":"9438","DOI":"10.1167\/iovs.11-7839","article-title":"Enos, a pressure-dependent regulator of intraocular pressure","volume":"52","author":"Stamer","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib203","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/0002-9394(54)91933-9","article-title":"Measuring velocity of flow in aqueous veins","volume":"37","author":"Stepanik","year":"1954","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib204","first-page":"208","article-title":"Der sichtbare kammerwasserabfluss. Eine kinematographische studie","volume":"130","author":"Stepanik","year":"1957","journal-title":"Klin. Monatsbl\u00e4tter Augenheilkd."},{"key":"10.1016\/j.preteyeres.2020.100917_bib205","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1001\/archopht.1954.00920040681011","article-title":"Outflow of aqueous humor. Biomicroscopic estimation compared with tonographic measurement","volume":"57","author":"Stepanik","year":"1954","journal-title":"A.M.A. Arch. Ophthal."},{"key":"10.1016\/j.preteyeres.2020.100917_bib206","article-title":"The force of lens growth on the uvea","volume":"59","author":"Strenk","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib207","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jcrs.2009.08.029","article-title":"Magnetic resonance imaging of the anteroposterior position and thickness of the aging, accommodating, phakic, and pseudophakic ciliary muscle","volume":"36","author":"Strenk","year":"2010","journal-title":"J. Cataract Refract. Surg."},{"key":"10.1016\/j.preteyeres.2020.100917_bib208","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1152\/japplphysiol.01087.2004","article-title":"Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces","volume":"98","author":"Suki","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib209","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/tvst.4.2.1","article-title":"Why do people (still) go blind from glaucoma","volume":"4","author":"Susanna","year":"2015","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.preteyeres.2020.100917_bib210","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1001\/archopht.1969.00990010810010","article-title":"Blood in schlemm's canal in glaucoma suspects. A study of the relationship between blood-filling pattern and outflow facility in ocular hypertension","volume":"81","author":"Suson","year":"1969","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib211","first-page":"1678","article-title":"Posterior attachment of ciliary muscle in young, accommodating old, presbyopic monkeys","volume":"32","author":"Tamm","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib212","first-page":"1157","article-title":"Nerve endings with structural characteristics of mechanoreceptors in the human scleral spur","volume":"35","author":"Tamm","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib213","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1350-9462(02)00010-1","article-title":"Myocilin and glaucoma: facts and ideas","volume":"21","author":"Tamm","year":"2002","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib214","first-page":"414","article-title":"Nerve cells in the human ciliary muscle: ultrastructural and immunocytochemical characterization","volume":"36","author":"Tamm","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib215","first-page":"1633","article-title":"Innervation of myofibroblast-like scleral spur cells in human monkey eyes","volume":"36","author":"Tamm","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib216","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000310789","article-title":"Nitrergic nerve cells in the primate ciliary muscle are only present in species with a fovea centralis","volume":"211","author":"Tamm","year":"1997","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.preteyeres.2020.100917_bib217","first-page":"2636","article-title":"Tissue distribution of type viii collagen in human adult and fetal eyes","volume":"32","author":"Tamura","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib218","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0002-9394(55)91489-6","article-title":"Primary degeneration in the vicinity of the chamber angle; as an etiologic factor in wide-angle glaucoma","volume":"40","author":"Teng","year":"1955","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib219","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00177651","article-title":"Integrins in human anterior chamber angle","volume":"233","author":"Tervo","year":"1995","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib220","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1136\/bjo.34.4.221","article-title":"Aqueous veins in glaucomatous eyes","volume":"34","author":"Thomassen","year":"1950","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib221","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1755-3768.1947.tb07574.x","article-title":"On aqueous veins","volume":"25","author":"Thomassen","year":"1947","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib222","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1755-3768.1947.tb07561.x","article-title":"The venous tension of eyes suffering from simple glaucoma","volume":"25","author":"Thomassen","year":"1947","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib223","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1172\/JCI77162","article-title":"A lymphatic defect causes ocular hypertension and glaucoma in mice","volume":"124","author":"Thomson","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2020.100917_bib224","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1167\/iovs.02-1099","article-title":"Gene expression profile of the human trabecular meshwork: Neibank sequence tag analysis","volume":"44","author":"Tomarev","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib225","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0002-9394(25)90063-3","article-title":"Gonioscopy and its clinical applications","volume":"8","author":"Troncoso","year":"1925","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib226","doi-asserted-by":"crossref","first-page":"26555","DOI":"10.1073\/pnas.1911837116","article-title":"Increased stiffness and flow resistance of the inner wall of schlemm\u2019s canal in glaucomatous human eyes","volume":"116","author":"Vahabikashi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2020.100917_bib227","doi-asserted-by":"crossref","DOI":"10.1016\/0002-9394(76)90011-8","article-title":"Changes in facility of aqueous outflow induced by lens depression and intraocular pressure in excised human eyes","volume":"82","author":"Van Buskirk","year":"1976","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib228","first-page":"625","article-title":"Anatomic correlates of changing aqueous outflow facility in excised human eyes","volume":"22","author":"Van Buskirk","year":"1982","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib229","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/0002-9394(73)90555-2","article-title":"Lens depression and aqueous outflow in enucleated primate eyes","volume":"76","author":"Van Buskirk","year":"1973","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib230","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0002-9394(74)90472-3","article-title":"Influence of temperature and the question of involvement of cellular metabolism in aqueous outflow","volume":"77","author":"Van Buskirk","year":"1974","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2020.100917_bib231","doi-asserted-by":"crossref","first-page":"10339","DOI":"10.1073\/pnas.2001250117","article-title":"Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis","volume":"117","author":"Van Zyl","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2020.100917_bib232","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.exer.2014.07.014","article-title":"Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma","volume":"133","author":"Vranka","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib233","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1167\/iovs.17-22175","article-title":"Estimating human trabecular meshwork stiffness by numerical modeling and advanced oct imaging","volume":"58","author":"Wang","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib234","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.7684161","article-title":"Mechanotransduction across the cell surface and through the cytoskeleton","volume":"260","author":"Wang","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2020.100917_bib235","doi-asserted-by":"crossref","DOI":"10.1117\/1.3486543","article-title":"Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of corti at a subnanometer scale: a preliminary study","volume":"15","author":"Wang","year":"2010","journal-title":"J. Biomed. Optic."},{"key":"10.1016\/j.preteyeres.2020.100917_bib236","doi-asserted-by":"crossref","first-page":"164105","DOI":"10.1063\/1.2724920","article-title":"Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time","volume":"90","author":"Wang","year":"2007","journal-title":"Appl. Phys. Lett."},{"key":"10.1016\/j.preteyeres.2020.100917_bib237","doi-asserted-by":"crossref","first-page":"144103","DOI":"10.1063\/1.2357854","article-title":"Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue","volume":"89","author":"Wang","year":"2006","journal-title":"Appl. Phys. Lett."},{"key":"10.1016\/j.preteyeres.2020.100917_bib238","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1167\/iovs.17-23075","article-title":"High-resolution, three-dimensional reconstruction of the outflow tract demonstrates segmental differences in cleared eyes","volume":"59","author":"Waxman","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib239","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1167\/iovs.18-24943","article-title":"Structure-function changes of the porcine distal outflow tract in response to nitric oxide","volume":"59","author":"Waxman","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib240","first-page":"1839","article-title":"In situ localization of cytoskeletal elements in the human trabecular meshwork and cornea","volume":"31","author":"Weinreb","year":"1990","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib241","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1350-9462(99)00015-4","article-title":"The regulation of trabecular meshwork and ciliary muscle contractility","volume":"19","author":"Wiederholt","year":"2000","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib242","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162048","article-title":"Oct study of mechanical properties associated with trabecular meshwork and collector channel motion in human eyes","volume":"11","author":"Xin","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2020.100917_bib243","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1167\/iovs.17-23579","article-title":"Quantification of pulse-dependent trabecular meshwork motion in normal humans using phase-sensitive oct","volume":"59","author":"Xin","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib244","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.exer.2016.06.007","article-title":"Aqueous outflow regulation: optical coherence tomography implicates pressure-dependent tissue motion","volume":"158","author":"Xin","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib245","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1167\/iovs.16-20583","article-title":"Schlemm's canal expansion after uncomplicated phacoemulsification surgery: an optical coherence tomography study","volume":"57","author":"Zhao","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib246","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1076\/ceyr.19.5.395.5297","article-title":"Expression of integrin receptors in the human trabecular meshwork","volume":"19","author":"Zhou","year":"1999","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2020.100917_bib247","first-page":"104","article-title":"Adhesion of human trabecular meshwork cells to extracellular matrix proteins. Roles and distribution of integrin receptors","volume":"37","author":"Zhou","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2020.100917_bib248","first-page":"3259","article-title":"Systematic intraluminal disruption of schlemm's canal structural features alters pressure-dependent changes in sc and collector channel lumen dimensions","volume":"56","author":"Zhou","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Progress in Retinal and Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946220300896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946220300896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T22:47:53Z","timestamp":1761173273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350946220300896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":247,"alternative-id":["S1350946220300896"],"URL":"https:\/\/doi.org\/10.1016\/j.preteyeres.2020.100917","relation":{},"ISSN":["1350-9462"],"issn-type":[{"value":"1350-9462","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aqueous outflow regulation \u2013 21st century concepts","name":"articletitle","label":"Article Title"},{"value":"Progress in Retinal and Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preteyeres.2020.100917","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100917"}}