{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:32:03Z","timestamp":1792805523517,"version":"4.5.0"},"reference-count":267,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001116","name":"Foundation Fighting Blindness Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Retinal and Eye Research"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.preteyeres.2021.100952","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T08:02:36Z","timestamp":1613894556000},"page":"100952","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Implications of genetic variation in the complement system in age-related macular degeneration"],"prefix":"10.1016","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3705-3371","authenticated-orcid":false,"given":"Sarah","family":"de Jong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8118-0629","authenticated-orcid":false,"given":"Giuliana","family":"Gagliardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Garanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"de Breuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara T.E.","family":"Lechanteur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Katti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambert P.","family":"van den Heuvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4294-8460","authenticated-orcid":false,"given":"Elena B.","family":"Volokhina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke I.","family":"den Hollander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preteyeres.2021.100952_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.addr.2018.05.005","article-title":"Stem cell-based retina models","volume":"140","author":"Achberger","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.preteyeres.2021.100952_bib2","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46188","article-title":"Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform","volume":"8","author":"Achberger","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.preteyeres.2021.100952_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.exer.2014.01.015","article-title":"Cultured primary human fetal retinal pigment epithelium (hfRPE) as a model for evaluating RPE metabolism","volume":"126","author":"Adijanto","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib4","article-title":"Predicting progression to advanced age-related macular degeneration from clinical, genetic, and lifestyle factors using machine learning","author":"Ajana","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2021.100952_bib5","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/s41433-019-0501-4","article-title":"Early local activation of complement in aqueous humour of patients with age-related macular degeneration","volume":"33","author":"Altay","year":"2019","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2021.100952_bib6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9394(02)01624-0","article-title":"A role for local inflammation in the formation of drusen in the aging eye","volume":"134","author":"Anderson","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib7","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1093\/hmg\/ddt336","article-title":"Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration","volume":"22","author":"Ansari","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib8","doi-asserted-by":"crossref","first-page":"10320","DOI":"10.1038\/s41598-020-67292-z","article-title":"Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells","volume":"10","author":"Armento","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.exer.2018.03.023","article-title":"Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration","volume":"172","author":"Arya","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12886-018-0941-9","article-title":"Quantitative proteomic analysis of aqueous humor from patients with drusen and reticular pseudodrusen in age-related macular degeneration","volume":"18","author":"Baek","year":"2018","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib11","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00018-019-03419-4","article-title":"The role of lymphocytes and phagocytes in age-related macular degeneration (AMD)","volume":"77","author":"Behnke","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12015-018-9811-3","article-title":"Genome editing in induced pluripotent stem cells using CRISPR\/Cas9","volume":"14","author":"Ben Jehuda","year":"2018","journal-title":"Stem Cell Rev Rep"},{"key":"10.1016\/j.preteyeres.2021.100952_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.preteyeres.2018.12.003","article-title":"On the origin of proteins in human drusen: the meet, greet and stick hypothesis","volume":"70","author":"Bergen","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib14","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nbt.2989","article-title":"Microfluidic organs-on-chips","volume":"32","author":"Bhatia","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2009.08.003","article-title":"The dynamic nature of Bruch's membrane","volume":"29","author":"Booij","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib16","first-page":"3579","article-title":"Differential expression of the complement regulatory proteins in the human eye","volume":"34","author":"Bora","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib17","doi-asserted-by":"crossref","first-page":"491","DOI":"10.4049\/jimmunol.174.1.491","article-title":"Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization","volume":"174","author":"Bora","year":"2005","journal-title":"Journal of immunology (Baltimore, Md. : 1950"},{"key":"10.1016\/j.preteyeres.2021.100952_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50420-9","article-title":"CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex","volume":"9","author":"Borras","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3389\/fimmu.2020.00443","article-title":"Mechanisms of FH protection against neovascular AMD","volume":"11","author":"Borras","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib20","doi-asserted-by":"crossref","first-page":"31189","DOI":"10.1074\/jbc.M115.671180","article-title":"Complement component C5a primes retinal pigment epithelial cells for inflammasome activation by lipofuscin-mediated photooxidative damage","volume":"290","author":"Brandstetter","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2021.100952_bib21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.preteyeres.2018.03.003","article-title":"CRISPR-Cas9 genome engineering: treating inherited retinal degeneration","volume":"65","author":"Burnight","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib22","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3389\/fimmu.2017.00703","article-title":"Anaphylatoxins activate Ca(2+), Akt\/PI3-Kinase, and FOXO1\/FoxP3 in the retinal pigment epithelium","volume":"8","author":"Busch","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib23","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/j.neurobiolaging.2015.06.010","article-title":"Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light","volume":"36","author":"Calaza","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.preteyeres.2021.100952_bib24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.immuni.2017.01.006","article-title":"Complement factor H inhibits CD47-mediated resolution of inflammation","volume":"46","author":"Calippe","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.preteyeres.2021.100952_bib25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2249.2011.04400.x","article-title":"CD46 in innate and adaptive immunity: an update","volume":"164","author":"Cardone","year":"2011","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib26","article-title":"Ethical and scientific pitfalls concerning laboratory research with non-human primates, and possible solutions","volume":"9","author":"Carvalho","year":"2018","journal-title":"Animals (Basel"},{"key":"10.1016\/j.preteyeres.2021.100952_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/ICL.0b013e31821fbd3e","article-title":"A review: role of ultraviolet radiation in age-related macular degeneration","volume":"37","author":"Chalam","year":"2011","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.preteyeres.2021.100952_bib28","article-title":"Lampalizumab inhibits ocular alternative complement activity in patients with geographic atrophy secondary to age-related macular degeneration","volume":"61","author":"Chang","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fnagi.2014.00191","article-title":"The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress","volume":"6","author":"Chang","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib30","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1038\/s41598-017-03788-5","article-title":"Microfluidic co-cultures of retinal pigment epithelial cells and vascular endothelial cells to investigate choroidal angiogenesis","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.preteyeres.2018.10.003","article-title":"Immune regulation in the aging retina","volume":"69","author":"Chen","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib32","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1586\/17469899.2014.939171","article-title":"Animal models of age-related macular degeneration and their translatability into the clinic","volume":"9","author":"Chen","year":"2014","journal-title":"Expet Rev. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib33","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/bjo.2009.165563","article-title":"Bruch's membrane and choroidal macrophages in early and advanced age-related macular degeneration","volume":"94","author":"Cherepanoff","year":"2010","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.exer.2015.09.003","article-title":"Selective accumulation of the complement membrane attack complex in aging choriocapillaris","volume":"146","author":"Chirco","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib35","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1021\/acs.chemrestox.9b00363","article-title":"Stem cell-derived endothelial cell model that responds to tobacco smoke like primary endothelial cells","volume":"33","author":"Chu","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib36","article-title":"Wet-AMD on a chip: modeling outer blood-retinal barrier in vitro","volume":"7","author":"Chung","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.preteyeres.2021.100952_bib37","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41467-020-14499-3","article-title":"Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration","volume":"11","author":"Cipriani","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.preteyeres.2021.100952_bib38","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41467-020-14499-3","article-title":"Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration","volume":"11","author":"Cipriani","year":"2020","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.preteyeres.2021.100952_bib39","doi-asserted-by":"crossref","first-page":"13546","DOI":"10.1111\/jcmm.16000","article-title":"Treatment with interleukin-33 is non-toxic and protects retinal pigment epithelium in an ageing model of outer retinal degeneration","volume":"24","author":"Clare","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.preteyeres.2021.100952_bib40","doi-asserted-by":"crossref","first-page":"24713","DOI":"10.1074\/jbc.M605083200","article-title":"His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form","volume":"281","author":"Clark","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2021.100952_bib41","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.3389\/fimmu.2017.01778","article-title":"Bruch's membrane compartmentalizes complement regulation in the eye with implications for therapeutic design in age-related macular degeneration","volume":"8","author":"Clark","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib42","doi-asserted-by":"crossref","first-page":"30192","DOI":"10.1074\/jbc.M110.103986","article-title":"Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina","volume":"285","author":"Clark","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2021.100952_bib43","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.4049\/jimmunol.1401613","article-title":"Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration","volume":"193","author":"Clark","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib44","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.2174\/138945009789753264","article-title":"Targeting matrix metalloproteinases in inflammatory conditions","volume":"10","author":"Clutterbuck","year":"2009","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.preteyeres.2021.100952_bib45","doi-asserted-by":"crossref","first-page":"16651","DOI":"10.1073\/pnas.0705079104","article-title":"Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction","volume":"104","author":"Coffey","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib46","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.cell.2020.08.013","article-title":"Cell types of the human retina and its organoids at single-cell resolution","volume":"182","author":"Cowan","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2021.100952_bib47","doi-asserted-by":"crossref","first-page":"14682","DOI":"10.1073\/pnas.222551899","article-title":"Drusen proteome analysis: an approach to the etiology of age-related macular degeneration","volume":"99","author":"Crabb","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.101341","article-title":"Regulation of regulators: role of the complement factor H-related proteins","volume":"45","author":"Cserhalmi","year":"2019","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib49","article-title":"Development of a genotype Assay for age-related macular degeneration: the EYE-RISK consortium","author":"de Breuk","year":"2020","journal-title":"Ophthalmology"},{"issue":"14","key":"10.1016\/j.preteyeres.2021.100952_bib50","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/hmg\/ddaa114","article-title":"Effect of rare coding variants in the CFI gene on factor I expression levels","volume":"29","author":"de Jong","year":"2020","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.preteyeres.2021.100952_bib51","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.1133807","article-title":"HTRA1 promoter polymorphism in wet age-related macular degeneration","volume":"314","author":"Dewan","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2021.100952_bib52","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.1248943","article-title":"Complement is activated by IgG hexamers assembled at the cell surface","volume":"343","author":"Diebolder","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2021.100952_bib53","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ajpath.2014.08.026","article-title":"Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh Knockout mice","volume":"185","author":"Ding","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib54","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/exer.1996.0020","article-title":"ARPE-19, a human retinal pigment epithelial cell line with differentiated properties","volume":"62","author":"Dunn","year":"1996","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094165","article-title":"Analysis of rare variants in the C3 gene in patients with age-related macular degeneration","volume":"9","author":"Duvvari","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.preteyeres.2021.100952_bib56","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1210\/me.2010-0392","article-title":"Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration","volume":"25","author":"Dwyer","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib57","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1110189","article-title":"Complement factor H polymorphism and age-related macular degeneration","volume":"308","author":"Edwards","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2021.100952_bib58","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.3389\/fimmu.2018.02237","article-title":"Interpretation of serological complement biomarkers in disease","volume":"9","author":"Ekdahl","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib59","article-title":"GT005, a gene therapy for the treatment of dry age-related macular degeneration (AMD)","volume":"61","author":"Ellis","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/nu12103051","article-title":"A multi-omics approach identifies key regulatory pathways induced by long-term zinc supplementation in human primary retinal pigment epithelium","volume":"12","author":"Emri","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.preteyeres.2021.100952_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15212-z","article-title":"Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress","volume":"7","author":"Fanelli","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib62","doi-asserted-by":"crossref","first-page":"24022","DOI":"10.1073\/pnas.2006515117","article-title":"Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research","volume":"117","author":"Feng","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib63","doi-asserted-by":"crossref","first-page":"9679","DOI":"10.1038\/s41598-018-28143-0","article-title":"C3a triggers formation of sub-retinal pigment epithelium deposits via the ubiquitin proteasome pathway","volume":"8","author":"Fernandez-Godino","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib64","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.4049\/jimmunol.0804031","article-title":"The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome","volume":"182","author":"Ferreira","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib65","first-page":"357","article-title":"Immunohistochemical localization of complement regulatory proteins in the human retina","volume":"27","author":"Fett","year":"2012","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177763","article-title":"Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cells","volume":"12","author":"Fields","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.preteyeres.2021.100952_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.100803","article-title":"Interactions of the choroid, Bruch's membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier","volume":"76","author":"Fields","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib68","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev-genom-090413-025610","article-title":"Age-related macular degeneration: genetics and biology coming together","volume":"15","author":"Fritsche","year":"2014","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib69","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ng.3448","article-title":"A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants","volume":"48","author":"Fritsche","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib70","article-title":"A proof of concept study of intravitreal (IVT) LFG316 in patients with neovascular age realted macular degeneration (nAMD)","volume":"57","author":"Gallemore","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib71","doi-asserted-by":"crossref","first-page":"E8214","DOI":"10.1073\/pnas.1710430114","article-title":"Drusen in patient-derived hiPSC-RPE models of macular dystrophies","volume":"114","author":"Galloway","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib72","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3928\/23258160-20131217-01","article-title":"Change in drusen volume as a novel clinical trial endpoint for the study of complement inhibition in age-related macular degeneration","volume":"45","author":"Garcia Filho","year":"2014","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"10.1016\/j.preteyeres.2021.100952_bib73","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molimm.2016.11.016","article-title":"The complement system in age-related macular degeneration: a review of rare genetic variants and implications for personalized treatment","volume":"84","author":"Geerlings","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib74","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jamaophthalmol.2016.4604","article-title":"The functional effect of rare variants in complement genes on C3b degradation in patients with age-related macular degeneration","volume":"135","author":"Geerlings","year":"2017","journal-title":"JAMA ophthalmology"},{"key":"10.1016\/j.preteyeres.2021.100952_bib75","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/cge.13392","article-title":"Genotype-phenotype correlations of low-frequency variants in the complement system in renal disease and age-related macular degeneration","volume":"94","author":"Geerlings","year":"2018","journal-title":"Clin. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib76","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/1874364101004010052","article-title":"Aqueous humor dynamics: a review","volume":"4","author":"Goel","year":"2010","journal-title":"Open Ophthalmol. J."},{"key":"10.1016\/j.preteyeres.2021.100952_bib77","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ng1750","article-title":"Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration","volume":"38","author":"Gold","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib78","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s12967-016-1101-8","article-title":"Repressed SIRT1\/PGC-1alpha pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration","volume":"14","author":"Golestaneh","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.preteyeres.2021.100952_bib79","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/sctm.19-0321","article-title":"Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions","volume":"9","author":"Gong","year":"2020","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.preteyeres.2021.100952_bib80","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00417-015-2970-x","article-title":"Plasma levels of amyloid beta and other proinflammatory mediators in patients with age-related macular degeneration","volume":"253","author":"Guymer","year":"2015","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib81","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1073\/pnas.0501536102","article-title":"A common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration","volume":"102","author":"Hageman","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib82","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1350-9462(01)00010-6","article-title":"An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration","volume":"20","author":"Hageman","year":"2001","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib83","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1096\/fasebj.13.3.477","article-title":"Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells","volume":"13","author":"Hageman","year":"1999","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.preteyeres.2021.100952_bib84","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1126\/science.1110359","article-title":"Complement factor H variant increases the risk of age-related macular degeneration","volume":"308","author":"Haines","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2021.100952_bib85","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1167\/iovs.07-1523","article-title":"Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration","volume":"49","author":"Hakobyan","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib86","doi-asserted-by":"crossref","first-page":"30451","DOI":"10.1074\/jbc.M803648200","article-title":"Complement factor H binds to denatured rather than to native pentameric C-reactive protein","volume":"283","author":"Hakobyan","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2021.100952_bib87","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1002\/stem.2708","article-title":"An induced pluripotent stem cell patient specific model of complement factor H (Y402H) polymorphism displays characteristic features of age-related macular degeneration and indicates a beneficial role for UV light exposure","volume":"35","author":"Hallam","year":"2017","journal-title":"Stem Cell."},{"key":"10.1016\/j.preteyeres.2021.100952_bib88","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/iovs.61.6.18","article-title":"Rare genetic variants in complement factor I lead to low FI plasma levels resulting in increased risk of age-related macular degeneration","volume":"61","author":"Hallam","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib89","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/j.1582-4934.2008.00350.x","article-title":"The alternative complement pathway revisited","volume":"12","author":"Harboe","year":"2008","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.preteyeres.2021.100952_bib90","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.addr.2011.05.010","article-title":"Advances in assay of complement function and activation","volume":"63","author":"Harboe","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.preteyeres.2021.100952_bib91","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.it.2012.06.001","article-title":"The complotype: dictating risk for inflammation and infection","volume":"33","author":"Harris","year":"2012","journal-title":"Trends Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib92","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/hmg\/ddp472","article-title":"Genetic control of the alternative pathway of complement in humans and age-related macular degeneration","volume":"19","author":"Hecker","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib93","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/iovs.61.3.18","article-title":"Complement activation levels are related to disease stage in AMD","volume":"61","author":"Heesterbeek","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib94","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/opo.12675","article-title":"Risk factors for progression of age-related macular degeneration","volume":"40","author":"Heesterbeek","year":"2020","journal-title":"Ophthalmic Physiol. Optic."},{"key":"10.1016\/j.preteyeres.2021.100952_bib95","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.oret.2020.01.019","article-title":"Visual function decline resulting from geographic atrophy: results from the chroma and spectri phase 3 trials","volume":"4","author":"Heier","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.preteyeres.2021.100952_bib96","doi-asserted-by":"crossref","first-page":"8761","DOI":"10.1073\/pnas.1019338108","article-title":"Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk","volume":"108","author":"Heurich","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib97","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.stem.2016.04.013","article-title":"Induced pluripotent stem cells meet genome editing","volume":"18","author":"Hockemeyer","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.preteyeres.2021.100952_bib98","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/jamaophthalmol.2018.1544","article-title":"Efficacy and safety of lampalizumab for geographic atrophy due to age-related macular degeneration: chroma and spectri phase 3 randomized clinical trials","volume":"136","author":"Holz","year":"2018","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.preteyeres.2021.100952_bib99","first-page":"2583","article-title":"Matrix metalloproteases as a pharmacological target in cardiovascular diseases","volume":"19","author":"Hopps","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib100","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1167\/iovs.15-18744","article-title":"Sequence and expression of complement factor H gene cluster variants and their roles in age-related macular degeneration risk","volume":"57","author":"Hughes","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib101","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/ng1890","article-title":"A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration","volume":"38","author":"Hughes","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib102","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800226","article-title":"The application of biomaterials to tissue engineering neural retina and retinal pigment epithelium","volume":"7","author":"Hunt","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.preteyeres.2021.100952_bib103","article-title":"C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration: a randomized pivotal phase 2\/3 trial","author":"Jaffe","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2021.100952_bib104","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/ckj\/sfs190","article-title":"Complement factor H mutation associated with membranoproliferative glomerulonephritis with transformation to atypical haemolytic uraemic syndrome","volume":"6","author":"Janssen van Doorn","year":"2013","journal-title":"Clinical kidney journal"},{"key":"10.1016\/j.preteyeres.2021.100952_bib105","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1167\/tvst.9.9.37","article-title":"Functional analysis of rare genetic variants in complement factor I (CFI) using a serum-based assay in advanced age-related macular degeneration","volume":"9","author":"Java","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.preteyeres.2021.100952_bib106","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ekir.2019.04.003","article-title":"A multimodality approach to assessing factor I genetic variants in atypical hemolytic uremic syndrome","volume":"4","author":"Java","year":"2019","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.preteyeres.2021.100952_bib107","first-page":"679","article-title":"Ablation of C3 modulates macrophage reactivity in the outer retina during photo-oxidative damage","volume":"26","author":"Jiao","year":"2020","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2021.100952_bib108","doi-asserted-by":"crossref","first-page":"18277","DOI":"10.1073\/pnas.1109703108","article-title":"Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration","volume":"108","author":"Johnson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib109","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1006\/exer.2001.1094","article-title":"Complement activation and inflammatory processes in Drusen formation and age related macular degeneration","volume":"73","author":"Johnson","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib110","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1006\/exer.1999.0798","article-title":"A potential role for immune complex pathogenesis in drusen formation","volume":"70","author":"Johnson","year":"2000","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib111","doi-asserted-by":"crossref","first-page":"17456","DOI":"10.1073\/pnas.0606234103","article-title":"Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid","volume":"103","author":"Johnson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib112","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1681\/ASN.2005080868","article-title":"Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions","volume":"17","author":"J\u00f3zsi","year":"2006","journal-title":"J. Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"key":"10.1016\/j.preteyeres.2021.100952_bib113","doi-asserted-by":"crossref","first-page":"7348","DOI":"10.1038\/s41598-018-25557-8","article-title":"Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy","volume":"8","author":"Katschke","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib114","article-title":"Complement C3 inhibitor POT-4: clinical safety of intravitreal administration","volume":"50","author":"Kaushal","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molimm.2007.05.004","article-title":"Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome","volume":"45","author":"Kavanagh","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib116","first-page":"3861","article-title":"Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels","volume":"24","author":"Kavanagh","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib117","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1172\/JCI86418","article-title":"VEGF regulates local inhibitory complement proteins in the eye and kidney","volume":"127","author":"Keir","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2021.100952_bib118","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.4049\/jimmunol.0903596","article-title":"Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration","volume":"185","author":"Kelly","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib119","series-title":"A Phase 1, Single Ascending Dose Study of GEM103 (Recombinant Human CFH) in Patients with GA","author":"Khanani","year":"2020"},{"key":"10.1016\/j.preteyeres.2021.100952_bib120","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2021.100952_bib121","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096895","article-title":"Proteomics of vitreous humor of patients with exudative age-related macular degeneration","volume":"9","author":"Koss","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.preteyeres.2021.100952_bib122","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1093\/hmg\/ddy178","article-title":"Functional analyses of rare genetic variants in complement component C9 identified in patients with age-related macular degeneration","volume":"27","author":"Kremlitzka","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100846","article-title":"The cell biology of the retinal pigment epithelium","author":"Lakkaraju","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib124","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1073\/pnas.1814014116","article-title":"Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice","volume":"116","author":"Landowski","year":"2019","journal-title":"P Natl Acad Sci USA"},{"key":"10.1016\/j.preteyeres.2021.100952_bib125","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1182\/blood-2010-01-261503","article-title":"Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis","volume":"116","author":"Langer","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2021.100952_bib126","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195751","article-title":"A monoclonal antibody targeting amyloid \u03b2 (A\u03b2) restores complement factor I bioactivity: potential implications in age-related macular degeneration and Alzheimer's disease","volume":"13","author":"Lashkari","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.preteyeres.2021.100952_bib127","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/eye.2008.21","article-title":"Adult vitreous structure and postnatal changes","volume":"22","author":"Le Goff","year":"2008","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2021.100952_bib128","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1038\/s41467-019-12917-9","article-title":"Single-nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling","volume":"10","author":"Liang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.preteyeres.2021.100952_bib129","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ophtha.2019.07.011","article-title":"Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial","volume":"127","author":"Liao","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2021.100952_bib130","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ab76a1","article-title":"A biofabricated vascularized skin model of atopic dermatitis for preclinical studies","volume":"12","author":"Liu","year":"2020","journal-title":"Biofabrication"},{"key":"10.1016\/j.preteyeres.2021.100952_bib131","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6958752","article-title":"C3a increases VEGF and decreases PEDF mRNA levels in human retinal pigment epithelial cells","volume":"2016","author":"Long","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.preteyeres.2021.100952_bib132","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.ophtha.2017.12.023","article-title":"Genome-wide association study reveals variants in CFH and CFHR4 associated with systemic complement activation: implications in age-related macular degeneration","volume":"125","author":"Lor\u00e9s-Motta","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2021.100952_bib133","doi-asserted-by":"crossref","first-page":"6628","DOI":"10.1167\/iovs.12-9587","article-title":"Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration","volume":"53","author":"Loyet","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib134","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/eye.2011.109","article-title":"Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration","volume":"25","author":"Lueck","year":"2011","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2021.100952_bib135","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100811","article-title":"A single-cell transcriptome atlas of the adult human retina","volume":"38","author":"Lukowski","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.preteyeres.2021.100952_bib136","first-page":"150","article-title":"Application of stem cell-derived retinal pigmented epithelium in retinal degenerative diseases: present and future","volume":"11","author":"Luo","year":"2018","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib137","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.ajpath.2014.06.001","article-title":"Complement regulatory protein CD46 protects against choroidal neovascularization in mice","volume":"184","author":"Lyzogubov","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib138","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.ajpath.2016.03.021","article-title":"The complement regulatory protein CD46 deficient mouse spontaneously develops dry-type Age-related macular degeneration-like phenotype","volume":"186","author":"Lyzogubov","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib139","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1021\/bi4003452","article-title":"Functional anatomy of complement factor H","volume":"52","author":"Makou","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.preteyeres.2021.100952_bib140","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/ng2131","article-title":"Variation in complement factor 3 is associated with risk of age-related macular degeneration","volume":"39","author":"Maller","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib141","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.596415","article-title":"Tuning the functionality by splicing: factor H and its alternative splice variant FHL-1 share a gene but not all functions","volume":"11","author":"Mannes","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib142","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1172\/JCI16651","article-title":"Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome","volume":"111","author":"Manuelian","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2021.100952_bib143","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.celrep.2017.12.038","article-title":"Primary cilium-mediated retinal pigment epithelium maturation is disrupted in ciliopathy patient cells","volume":"22","author":"May-Simera","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib144","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1167\/iovs.02-0813","article-title":"Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesion","volume":"44","author":"McLaughlin","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib145","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1167\/iovs.16-20049","article-title":"Distribution and quantification of choroidal macrophages in human eyes with age-related macular degeneration","volume":"57","author":"McLeod","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib146","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1038\/s41467-019-12780-8","article-title":"Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration","volume":"10","author":"Menon","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.preteyeres.2021.100952_bib147","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.kint.2017.07.015","article-title":"Complete functional characterization of disease-associated genetic variants in the complement factor H gene","volume":"93","author":"Merinero","year":"2018","journal-title":"Kidney Int."},{"key":"10.1016\/j.preteyeres.2021.100952_bib148","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fimmu.2015.00262","article-title":"Complement system Part I - molecular mechanisms of activation and regulation","volume":"6","author":"Merle","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib149","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fimmu.2015.00257","article-title":"Complement system Part II: role in immunity","volume":"6","author":"Merle","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib150","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","article-title":"Age-related macular degeneration","volume":"392","author":"Mitchell","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.preteyeres.2021.100952_bib151","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/03009734.2018.1431744","article-title":"A model to study complement involvement in experimental retinal degeneration","volume":"123","author":"Mohlin","year":"2018","journal-title":"Ups. J. Med. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib152","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.3389\/fimmu.2018.01813","article-title":"Analysis of C3 gene variants in patients with idiopathic recurrent spontaneous pregnancy loss","volume":"9","author":"Mohlin","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib153","doi-asserted-by":"crossref","DOI":"10.1038\/srep22889","article-title":"Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants","volume":"6","author":"Molins","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib154","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1073\/pnas.0812584106","article-title":"Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B","volume":"106","author":"Montes","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib155","first-page":"2970","article-title":"The effect of age on the macromolecular permeability of human Bruch's membrane","volume":"42","author":"Moore","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib156","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.imbio.2015.04.006","article-title":"The membrane attack complex as an inflammatory trigger","volume":"221","author":"Morgan","year":"2016","journal-title":"Immunobiology"},{"key":"10.1016\/j.preteyeres.2021.100952_bib157","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/imr.12461","article-title":"Terminal complexes of the complement system: new structural insights and their relevance to function","volume":"274","author":"Morgan","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.preteyeres.2021.100952_bib158","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.exer.2011.06.015","article-title":"Elevated membrane attack complex in human choroid with high risk complement factor H genotypes","volume":"93","author":"Mullins","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib159","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1096\/fasebj.14.7.835","article-title":"Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease","volume":"14","author":"Mullins","year":"2000","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.preteyeres.2021.100952_bib160","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1016\/j.ajpath.2014.07.017","article-title":"The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning","volume":"184","author":"Mullins","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib161","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ng.3314","article-title":"The support of human genetic evidence for approved drug indications","volume":"47","author":"Nelson","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib162","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/eji.200939280","article-title":"Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead to either altered secretion or altered function of factor I","volume":"40","author":"Nilsson","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib163","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.molimm.2006.10.005","article-title":"A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation","volume":"44","author":"Nilsson","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib164","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1074\/jbc.M109.097212","article-title":"Analysis of binding sites on complement factor I that are required for its activity","volume":"285","author":"Nilsson","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2021.100952_bib165","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/eji.200838702","article-title":"Genetic, molecular and functional analyses of complement factor I deficiency","volume":"39","author":"Nilsson","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib166","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1167\/iovs.11-8425","article-title":"C9-R95X polymorphism in patients with neovascular age-related macular degeneration","volume":"53","author":"Nishiguchi","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib167","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1073\/pnas.0408835103","article-title":"Drusen complement components C3a and C5a promote choroidal neovascularization","volume":"103","author":"Nozaki","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib168","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1074\/jbc.M109.044529","article-title":"Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations","volume":"285","author":"Okemefuna","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2021.100952_bib169","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.celrep.2019.12.082","article-title":"Integration of eQTL and a single-cell atlas in the human eye identifies causal genes for age-related macular degeneration","volume":"30","author":"Orozco","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib170","doi-asserted-by":"crossref","first-page":"7627","DOI":"10.1021\/acsnano.9b00686","article-title":"Microphysiological engineering of self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues","volume":"13","author":"Paek","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.preteyeres.2021.100952_bib171","doi-asserted-by":"crossref","DOI":"10.1002\/ajp.22931","article-title":"Generation of genetically engineered non-human primate models of brain function and neurological disorders","volume":"81","author":"Park","year":"2019","journal-title":"Am. J. Primatol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib172","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.scr.2018.01.014","article-title":"A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells","volume":"27","author":"Parmar","year":"2018","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib173","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1016\/j.celrep.2019.10.084","article-title":"Cell-type-specific complement expression in the healthy and diseased retina","volume":"29","author":"Pauly","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib174","doi-asserted-by":"crossref","first-page":"26568","DOI":"10.1038\/srep26568","article-title":"A novel complotype combination associates with age-related macular degeneration and high complement activation levels in vivo","volume":"6","author":"Paun","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib175","doi-asserted-by":"crossref","first-page":"11082","DOI":"10.1074\/jbc.M110.211839","article-title":"Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities","volume":"286","author":"Pechtl","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2021.100952_bib176","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/ng912","article-title":"Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H","volume":"31","author":"Pickering","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib177","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.61.5.19","article-title":"Functional evaluation of AMD-associated risk variants of complement factor B","volume":"61","author":"Pilotti","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib178","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1016\/j.molimm.2008.02.008","article-title":"Molecular characterization of Complement Factor I deficiency in two Spanish families","volume":"45","author":"Ponce-Castro","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib179","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.molimm.2015.03.011","article-title":"Of mice and men: the factor H protein family and complement regulation","volume":"67","author":"Pouw","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib180","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.imbio.2016.06.008","article-title":"Complement analysis 2016: clinical indications, laboratory diagnostics and quality control","volume":"221","author":"Proh\u00e1szka","year":"2016","journal-title":"Immunobiology"},{"key":"10.1016\/j.preteyeres.2021.100952_bib181","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/s41588-019-0351-9","article-title":"Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration","volume":"51","author":"Ratnapriya","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib182","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/ng.976","article-title":"A rare penetrant mutation in CFH confers high risk of age-related macular degeneration","volume":"43","author":"Raychaudhuri","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib183","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1681\/ASN.2015050580","article-title":"Molecular basis of factor H R1210C association with ocular and renal diseases","volume":"27","author":"Recalde","year":"2016","journal-title":"J. Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"key":"10.1016\/j.preteyeres.2021.100952_bib184","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.exer.2016.02.004","article-title":"IBI302, a promising candidate for AMD treatment, targeting both the VEGF and complement system with high binding affinity in vitro and effective targeting of the ocular tissue in healthy rhesus monkeys","volume":"145","author":"Ren","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib185","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1167\/iovs.09-3928","article-title":"Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes","volume":"50","author":"Reynolds","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib186","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093459","article-title":"Impact of the common genetic associations of age-related macular degeneration upon systemic complement component C3d levels","volume":"9","author":"Ristau","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.preteyeres.2021.100952_bib187","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/hmg\/ddi353","article-title":"Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk","volume":"14","author":"Rivera","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib188","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20140117","article-title":"New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3","volume":"34","author":"Rodriguez","year":"2014","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib189","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/ni.1756","article-title":"Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor","volume":"10","author":"Rooijakkers","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib190","first-page":"608","article-title":"Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice","volume":"118","author":"Rose","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2021.100952_bib191","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1182\/blood-2011-10-383281","article-title":"A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function","volume":"119","author":"Roumenina","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2021.100952_bib192","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.stem.2016.12.015","article-title":"Nicotinamide ameliorates disease phenotypes in a human iPSC model of age-related macular degeneration","volume":"20","author":"Saini","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.preteyeres.2021.100952_bib193","first-page":"60","article-title":"Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells","volume":"23","author":"Samuel","year":"2017","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2021.100952_bib194","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1086\/344515","article-title":"Structural and functional characterization of factor H mutations associated with atypical hemolytic uremic syndrome","volume":"71","author":"S\u00e1nchez-Corral","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib195","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9090793","article-title":"Properdin modulates complement component production in stressed human primary retinal pigment epithelium cells","volume":"9","author":"Sch\u00e4fer","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.preteyeres.2021.100952_bib196","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/eye.2016.328","article-title":"Local complement activation in aqueous humor in patients with age-related macular degeneration","volume":"31","author":"Schick","year":"2017","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2021.100952_bib197","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/32b9bc31-ed6d-4d31-9ce0-480407017bad","article-title":"Systemic complement activation in age-related macular degeneration","volume":"3","author":"Scholl","year":"2008","journal-title":"PloS One"},{"key":"10.1016\/j.preteyeres.2021.100952_bib198","doi-asserted-by":"crossref","first-page":"Amd31","DOI":"10.1167\/iovs.18-24122","article-title":"The proteomic landscape in the vitreous of patients with age-related and diabetic retinal disease","volume":"59","author":"Schori","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib199","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1182\/blood-2014-10-609073","article-title":"Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome","volume":"125","author":"Schramm","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.preteyeres.2021.100952_bib200","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1167\/iovs.61.14.32","article-title":"Rare and common genetic variants, smoking, and body mass index: progression and earlier age of developing advanced age-related macular degeneration","volume":"61","author":"Seddon","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib201","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ng.2741","article-title":"Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration","volume":"45","author":"Seddon","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib202","doi-asserted-by":"crossref","first-page":"10587","DOI":"10.1038\/ncomms10587","article-title":"Structural basis of complement membrane attack complex formation","volume":"7","author":"Serna","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.preteyeres.2021.100952_bib203","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1167\/iovs.07-1072","article-title":"Complement-associated deposits in the human retina","volume":"49","author":"Seth","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib204","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1089\/dna.2013.2072","article-title":"Predictive model for earlier diagnosis of suspected age-related macular degeneration patients","volume":"32","author":"Sharma","year":"2013","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib205","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat5580","article-title":"Clinical-grade stem cell-derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs","volume":"11","author":"Sharma","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.preteyeres.2021.100952_bib206","doi-asserted-by":"crossref","first-page":"13757","DOI":"10.1073\/pnas.1121309109","article-title":"Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids","volume":"109","author":"Shaw","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib207","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrd.2016.245","article-title":"Induced pluripotent stem cell technology: a decade of progress","volume":"16","author":"Shi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.preteyeres.2021.100952_bib208","first-page":"2288","article-title":"Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr(4)(0)(2)His polymorphism","volume":"18","author":"Silva","year":"2012","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2021.100952_bib209","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-3-030-27378-1_6","article-title":"Adaptive and maladaptive complement activation in the retina","volume":"1185","author":"Silverman","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib210","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/s41598-018-37673-6","article-title":"Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration","volume":"9","author":"Sivapathasuntharam","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib211","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1001\/archopht.125.4.515","article-title":"Estimation of systemic complement C3 activity in age-related macular degeneration","volume":"125","author":"Sivaprasad","year":"2007","journal-title":"Archives of ophthalmology (Chicago, Ill. : 1960"},{"key":"10.1016\/j.preteyeres.2021.100952_bib212","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1001\/jamaophthalmol.2014.2065","article-title":"Proteomic landscape of the human choroid-retinal pigment epithelial complex","volume":"132","author":"Skeie","year":"2014","journal-title":"JAMA ophthalmology"},{"key":"10.1016\/j.preteyeres.2021.100952_bib213","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127567","article-title":"Proteomic insight into the molecular function of the vitreous","volume":"10","author":"Skeie","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.preteyeres.2021.100952_bib214","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ophtha.2011.07.056","article-title":"Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration","volume":"119","author":"Smailhodzic","year":"2012","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.preteyeres.2021.100952_bib267","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.stemcr.2019.04.012","article-title":"Human iPSC-Derived Retinal Pigment Epithelium: A Model System for Prioritizing and Functionally Characterizing Causal Variants at AMD Risk Loci","volume":"12","author":"Smith","year":"2019","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.preteyeres.2021.100952_bib215","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100845","article-title":"No flow through the vitreous humor: how strong is the evidence?","author":"Smith","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib216","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1167\/iovs.15-17073","article-title":"Generating iPSC-derived choroidal endothelial cells to study age-related macular degeneration","volume":"56","author":"Songstad","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib217","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/sctm.16-0399","article-title":"Connective tissue growth factor promotes efficient generation of human induced pluripotent stem cell-derived choroidal endothelium","volume":"6","author":"Songstad","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.preteyeres.2021.100952_bib218","article-title":"Progress in developing rodent models of age-related macular degeneration (AMD)","volume":"203","author":"Soundara Pandi","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib219","first-page":"2988","article-title":"A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture","volume":"40","author":"Sparrow","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib220","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1038\/s41598-018-24219-z","article-title":"A mega-analysis of expression quantitative trait loci (eQTL) provides insight into the regulatory architecture of gene expression variation in liver","volume":"8","author":"Strunz","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib221","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/s41598-020-58510-9","article-title":"A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration","volume":"10","author":"Strunz","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2021.100952_bib222","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.stem.2015.05.004","article-title":"Programming and reprogramming cellular age in the era of induced pluripotency","volume":"16","author":"Studer","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.preteyeres.2021.100952_bib223","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1167\/iovs.18-24769","article-title":"Detection of complement activators in immune attack eyes after iPS-derived retinal pigment epithelial cell transplantation","volume":"59","author":"Sugita","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib224","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1021\/acs.analchem.8b05293","article-title":"Recent advances in body-on-a-chip systems","volume":"91","author":"Sung","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.preteyeres.2021.100952_bib225","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.molimm.2016.01.003","article-title":"Genetic analysis and functional characterization of novel mutations in a series of patients with atypical hemolytic uremic syndrome","volume":"71","author":"Szarvas","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib226","article-title":"Systematic functional testing of rare variants: contributions of CFI to age-related macular degeneration","volume":"58","author":"Tan","year":"2017","journal-title":"Investigative Opthalmology & Visual Science"},{"key":"10.1016\/j.preteyeres.2021.100952_bib227","doi-asserted-by":"crossref","first-page":"16939","DOI":"10.1074\/jbc.M808166200","article-title":"Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury","volume":"284","author":"Thurman","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2021.100952_bib228","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1136\/bjo.2005.072108","article-title":"The expression of native and cultured human retinal pigment epithelial cells grown in different culture conditions","volume":"89","author":"Tian","year":"2005","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib229","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.preteyeres.2017.09.001","article-title":"Complement factor H in AMD: bridging genetic associations and pathobiology","volume":"62","author":"Toomey","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib230","doi-asserted-by":"crossref","first-page":"E3040","DOI":"10.1073\/pnas.1424391112","article-title":"Regulation of age-related macular degeneration-like pathology by complement factor H","volume":"112","author":"Toomey","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib231","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1167\/iovs.17-23134","article-title":"Effect of anti-C5a therapy in a murine model of early\/intermediate dry age-related macular degeneration","volume":"59","author":"Toomey","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib232","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1093\/hmg\/ddp289","article-title":"The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity","volume":"18","author":"Tortajada","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib233","doi-asserted-by":"crossref","DOI":"10.3390\/antiox8110548","article-title":"Oxidative stress increases endogenous complement-dependent inflammatory and angiogenic responses in retinal pigment epithelial cells independently of exogenous complement sources","volume":"8","author":"Trakkides","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.preteyeres.2021.100952_bib234","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1167\/iovs.15-17432","article-title":"Rare variants in the functional domains of complement factor H are associated with age-related macular degeneration","volume":"56","author":"Triebwasser","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib235","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1167\/iovs.09-4457","article-title":"Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings","volume":"51","author":"Ufret-Vincenty","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib236","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/ng.2640","article-title":"A functional variant in the CFI gene confers a high risk of age-related macular degeneration","volume":"45","author":"van de Ven","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib237","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/bjo.77.10.657","article-title":"Early stages of age-related macular degeneration: an immunofluorescence and electron microscopy study","volume":"77","author":"van der Schaft","year":"1993","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib238","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.preteyeres.2018.04.006","article-title":"A new perspective on lipid research in age-related macular degeneration","volume":"67","author":"van Leeuwen","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib239","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.exer.2006.04.002","article-title":"Distribution of complement anaphylatoxin receptors and membrane-bound regulators in normal human retina","volume":"83","author":"Vogt","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib240","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.exer.2011.06.002","article-title":"Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy","volume":"93","author":"Vogt","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib241","doi-asserted-by":"crossref","first-page":"24100","DOI":"10.1073\/pnas.1914143116","article-title":"Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration","volume":"116","author":"Voigt","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib242","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s00467-012-2183-z","article-title":"Novel C3 mutation p.Lys65Gln in aHUS affects complement factor H binding","volume":"27","author":"Volokhina","year":"2012","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib243","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1172\/JCI118515","article-title":"The molecular basis of hereditary complement factor I deficiency","volume":"97","author":"Vyse","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.preteyeres.2021.100952_bib244","doi-asserted-by":"crossref","first-page":"712","DOI":"10.4049\/jimmunol.181.1.712","article-title":"Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen","volume":"181","author":"Wang","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib245","first-page":"264","article-title":"CFH Y402H polymorphism is associated with elevated vitreal GM-CSF and choroidal macrophages in the postmortem human eye","volume":"21","author":"Wang","year":"2015","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2021.100952_bib246","article-title":"Abundant lipid and protein components of drusen","volume":"5","author":"Wang","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.preteyeres.2021.100952_bib247","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.3390\/jcm3041234","article-title":"Age-related macular degeneration: a disease of systemic or local complement dysregulation?","volume":"3","author":"Warwick","year":"2014","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.preteyeres.2021.100952_bib248","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000351624","article-title":"Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells","volume":"51","author":"Weinberger","year":"2014","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib249","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature10449","article-title":"Complement factor H binds malondialdehyde epitopes and protects from oxidative stress","volume":"478","author":"Weismann","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2021.100952_bib250","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature10449","article-title":"Complement factor H binds malondialdehyde epitopes and protects from oxidative stress","volume":"478","author":"Weismann","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2021.100952_bib251","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2014.11.005","article-title":"Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy","volume":"45","author":"Whitmore","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2021.100952_bib252","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.preteyeres.2021.100952_bib253","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1167\/tvst.9.7.49","article-title":"NEI-supported age-related macular degeneration research: past, present, and future","volume":"9","author":"Wright","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.preteyeres.2021.100952_bib254","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.2147\/DDDT.S206355","article-title":"Complement system and age-related macular degeneration: drugs and challenges","volume":"13","author":"Wu","year":"2019","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.preteyeres.2021.100952_bib255","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12944-017-0647-7","article-title":"Understanding AMD by analogy: systematic review of lipid-related common pathogenic mechanisms in AMD, AD, AS and GN","volume":"17","author":"Xu","year":"2018","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.preteyeres.2021.100952_bib256","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1093\/hmg\/ddu053","article-title":"Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines","volume":"23","author":"Yang","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib257","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1126\/science.1133811","article-title":"A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration","volume":"314","author":"Yang","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2021.100952_bib258","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1056\/NEJMoa072618","article-title":"Complement C3 variant and the risk of age-related macular degeneration","volume":"357","author":"Yates","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.preteyeres.2021.100952_bib259","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ophtha.2013.09.044","article-title":"Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE study","volume":"121","author":"Yehoshua","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2021.100952_bib260","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.1093\/hmg\/ddu226","article-title":"Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration","volume":"23","author":"Yu","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib261","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/ng.2758","article-title":"Identification of a rare coding variant in complement 3 associated with age-related macular degeneration","volume":"45","author":"Zhan","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.preteyeres.2021.100952_bib262","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.dci.2014.01.010","article-title":"Complement system in zebrafish","volume":"46","author":"Zhang","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.preteyeres.2021.100952_bib263","article-title":"Complement factor H expressed by retinal pigment epithelium cells can suppress neovascularization of human umbilical vein endothelial cells: an in vitro study","volume":"10","author":"Zhang","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.preteyeres.2021.100952_bib264","doi-asserted-by":"crossref","first-page":"16182","DOI":"10.1073\/pnas.0604255103","article-title":"Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium","volume":"103","author":"Zhou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.preteyeres.2021.100952_bib265","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1167\/iovs.08-2868","article-title":"Complement activation by bisretinoid constituents of RPE lipofuscin","volume":"50","author":"Zhou","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2021.100952_bib266","doi-asserted-by":"crossref","DOI":"10.3410\/B2-3","article-title":"Ocular immune privilege","volume":"2","author":"Zhou","year":"2010","journal-title":"F1000 Biol Rep"}],"container-title":["Progress in Retinal and Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946221000136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946221000136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T22:41:44Z","timestamp":1761172904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350946221000136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":267,"alternative-id":["S1350946221000136"],"URL":"https:\/\/doi.org\/10.1016\/j.preteyeres.2021.100952","relation":{},"ISSN":["1350-9462"],"issn-type":[{"value":"1350-9462","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implications of genetic variation in the complement system in age-related macular degeneration","name":"articletitle","label":"Article Title"},{"value":"Progress in Retinal and Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preteyeres.2021.100952","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100952"}}