{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:39:24Z","timestamp":1790127564877,"version":"4.0.1"},"reference-count":180,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Retinal and Eye Research"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.preteyeres.2022.101149","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T12:40:49Z","timestamp":1669380049000},"page":"101149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Non-canonical Wnt signaling in the eye"],"prefix":"10.1016","volume":"95","author":[{"given":"Ruchi","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Amador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Ghiam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnoosh","family":"Saghizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei A.","family":"Kramerov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V.","family":"Ljubimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preteyeres.2022.101149_bib1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.yexcr.2017.05.009","article-title":"Small-molecule inhibition of Wnt signaling abrogates dexamethasone-induced phenotype of primary human trabecular meshwork cells","volume":"357","author":"Ahadome","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.preteyeres.2022.101149_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc3419","article-title":"WNT signalling pathways as therapeutic targets in cancer","volume":"13","author":"Anastas","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.preteyeres.2022.101149_bib3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.modgep.2003.11.002","article-title":"Spatial and temporal expression of Wnt and Dickkopf genes during murine lens development","volume":"4","author":"Ang","year":"2004","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.preteyeres.2022.101149_bib4","series-title":"Keratoconus. [Updated 2022 May 30]. in: StatPearls [Internet]. Treasure Island (FL)","author":"Asimellis","year":"2022"},{"key":"10.1016\/j.preteyeres.2022.101149_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1755-3768.2009.01603.x","article-title":"Immunohistochemical expression of epithelial cell markers in corneas with congenital aniridia and ocular cicatrizing pemphigoid","volume":"89","author":"Auw-Haedrich","year":"2011","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.631623","article-title":"Regulation of Wnt signaling pathways at the plasma membrane and their misregulation in cancer","volume":"9","author":"Azbazdar","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib7","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/j.1460-2075.1987.tb02429.x","article-title":"Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos","volume":"6","author":"Baker","year":"1987","journal-title":"EMBO J."},{"key":"10.1016\/j.preteyeres.2022.101149_bib8","doi-asserted-by":"crossref","first-page":"20664","DOI":"10.1074\/jbc.M114.586099","article-title":"Ror2 receptor mediates Wnt11 ligand signaling and affects convergence and extension movements in zebrafish","volume":"289","author":"Bai","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2022.101149_bib9","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cell.2006.02.049","article-title":"Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells","volume":"125","author":"B\u00e4nziger","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2022.101149_bib10","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000444930","article-title":"Histopathology findings of corneal buttons in congenital aniridia patients","volume":"56","author":"Bausili","year":"2016","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.preteyeres.2022.101149_bib11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/dvdy.43","article-title":"Transcriptomic analysis of differential gene expression during chick periocular neural crest differentiation into corneal cells","volume":"248","author":"Bi","year":"2019","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.preteyeres.2022.101149_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00273-y","article-title":"Wnt6 plays a complex role in maintaining human limbal stem\/progenitor cells","volume":"11","author":"Bonnet","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2022.101149_bib13","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/1471-2407-13-316","article-title":"Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer","volume":"13","author":"Bravo","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.preteyeres.2022.101149_bib182","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ydbio.2011.01.033","article-title":"Calcium\/NFAT signalling promotes early nephrogenesis","volume":"352","author":"Burn","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40942-017-0084-9","article-title":"Retinal and choroidal angiogenesis: a review of new targets","volume":"3","author":"Cabral","year":"2017","journal-title":"Int J Retina Vitreous"},{"key":"10.1016\/j.preteyeres.2022.101149_bib15","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45853","article-title":"Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration","volume":"8","author":"Carvalho","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.preteyeres.2022.101149_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuron.2005.05.026","article-title":"Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt\/\u03b2-catenin pathway","volume":"47","author":"Cavodeassi","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.preteyeres.2022.101149_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cellsig.2018.08.020","article-title":"Wnt5a contributes to dectin-1 and LOX-1 induced host inflammatory response signature in Aspergillus fumigatus keratitis","volume":"52","author":"Che","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.preteyeres.2022.101149_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110946","article-title":"The involvement of noncanonical Wnt signaling in cancers","volume":"133","author":"Chen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.preteyeres.2022.101149_bib19","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.semcdb.2006.11.005","article-title":"A role for Wnt\/planar cell polarity signaling during lens fiber cell differentiation?","volume":"17","author":"Chen","year":"2006","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ydbio.2008.09.002","article-title":"Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture","volume":"324","author":"Chen","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib21","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202113977","article-title":"A Norrin\/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy","volume":"13","author":"Chidiac","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.preteyeres.2022.101149_bib22","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2022.101149_bib23","doi-asserted-by":"crossref","first-page":"a015081","DOI":"10.1101\/cshperspect.a015081","article-title":"Secreted and transmembrane wnt inhibitors and activators","volume":"5","author":"Cruciat","year":"2013","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib24","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1093\/hmg\/ddv211","article-title":"WNT10A exonic variant increases the risk of keratoconus by decreasing corneal thickness","volume":"24","author":"Cuellar-Partida","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2022.101149_bib25","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1167\/iovs.10-6726","article-title":"Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation","volume":"52","author":"Davis","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ydbio.2013.10.030","article-title":"Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism","volume":"385","author":"Dawes","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib27","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1167\/iovs.12-11357","article-title":"Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation","volume":"54","author":"Dawes","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib28","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1113\/jphysiol.2012.235382","article-title":"Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential","volume":"591","author":"Dawson","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib29","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1128\/MCB.02354-05","article-title":"Wnt-5a\/Ca2+-induced NFAT activity is counteracted by Wnt-5a\/Yes-Cdc42-casein kinase 1\u03b1 signaling in human mammary epithelial cells","volume":"26","author":"Dejmek","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib30","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1074\/jbc.RA119.011273","article-title":"Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability","volume":"295","author":"D\u00edaz-Cor\u00e1nguez","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2022.101149_bib31","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/bph.12364","article-title":"WNT\/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3","volume":"171","author":"Dijksterhuis","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2147\/EB.S94452","article-title":"Wnt signaling pathway in retinal vascularization","volume":"8","author":"Drenser","year":"2016","journal-title":"Eye Brain"},{"key":"10.1016\/j.preteyeres.2022.101149_bib33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.critrevonc.2015.12.005","article-title":"The Wnt signaling pathway in cancer","volume":"99","author":"Duchartre","year":"2016","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/bs.ircmb.2014.10.003","article-title":"Insight into the role of Wnt5a-induced signaling in normal and cancer cells","volume":"314","author":"Endo","year":"2015","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.preteyeres.2022.101149_bib35","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.mod.2004.03.003","article-title":"SFRP1 is required for the proper establishment of the eye field in the medaka fish","volume":"121","author":"Esteve","year":"2004","journal-title":"Mech. Dev."},{"key":"10.1016\/j.preteyeres.2022.101149_bib36","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0960-9822(00)00645-X","article-title":"Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye","volume":"10","author":"Fanto","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib37","doi-asserted-by":"crossref","first-page":"jcs216101","DOI":"10.1242\/jcs.216101","article-title":"Wnt7b signalling through Frizzled-7 receptor promotes dendrite development by coactivating CaMKII and JNK","volume":"131","author":"Ferrari","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib38","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1167\/iovs.06-0346","article-title":"The phenotype of limbal epithelial stem cells","volume":"48","author":"Figueira","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/iovs.62.6.16","article-title":"Transcriptomic and immunohistochemical analysis of progressive keratoconus reveal altered WNT10A in epithelium and Bowman's layer","volume":"62","author":"Foster","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib40","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1124\/pr.117.013896","article-title":"WNT signaling in cardiac and vascular disease","volume":"70","author":"Foulquier","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.preteyeres.2022.101149_bib41","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.07727","article-title":"Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling","volume":"5","author":"Franco","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.preteyeres.2022.101149_bib42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4161\/org.4.2.5850","article-title":"Wnt signaling in eye organogenesis","volume":"4","author":"Fuhrmann","year":"2008","journal-title":"Organogenesis"},{"key":"10.1016\/j.preteyeres.2022.101149_bib43","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fcell.2016.00138","article-title":"WNT\/\u03b2-catenin signaling in vertebrate eye development","volume":"4","author":"Fujimura","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib44","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1242\/dev.02881","article-title":"Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube","volume":"134","author":"Galli","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.preteyeres.2022.101149_bib45","first-page":"5035","article-title":"Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos","volume":"25","author":"Gao","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2022.101149_bib46","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/MOL.0000000000000445","article-title":"Wnt signaling in cardiovascular disease: opportunities and challenges","volume":"28","author":"Gay","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib47","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1038\/sj.onc.1202985","article-title":"Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response","volume":"18","author":"Gazit","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.preteyeres.2022.101149_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/795738","article-title":"The genetic and environmental factors for keratoconus","volume":"2015","author":"Gordon-Shaag","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.preteyeres.2022.101149_bib49","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0070-2153(10)90010-0","volume":"90","author":"Graw","year":"2010","journal-title":"Eye dev. Curr. Top Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib50","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1093\/hmg\/ddv298","article-title":"Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization","volume":"24","author":"Greenlees","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2022.101149_bib51","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0092-8674(01)00614-6","article-title":"Wnt\/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1","volume":"107","author":"Habas","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2022.101149_bib52","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/15216540500137586","article-title":"The Wnt signaling pathway in retinal degenerations","volume":"57","author":"Hackam","year":"2005","journal-title":"IUBMB Life"},{"key":"10.1016\/j.preteyeres.2022.101149_bib53","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1167\/iovs.18-23902","article-title":"Wnt5a contributes to the differentiation of human embryonic stem cells into lentoid bodies through the noncanonical Wnt\/JNK signaling pathway","volume":"59","author":"Han","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib54","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/ICO.0000000000002150","article-title":"The prevalence and risk factors for keratoconus: a systematic review and meta-analysis","volume":"39","author":"Hashemi","year":"2020","journal-title":"Cornea"},{"key":"10.1016\/j.preteyeres.2022.101149_bib55","doi-asserted-by":"crossref","first-page":"C48","DOI":"10.1152\/ajpcell.00091.2019","article-title":"Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4","volume":"318","author":"He","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib56","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1167\/iovs.12-10281","article-title":"Pathogenic role of the Wnt signaling pathway activation in laser-induced choroidal neovascularization","volume":"54","author":"Hu","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib58","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jtos.2015.10.003","article-title":"Congenital aniridia and the ocular surface","volume":"14","author":"Ihnatko","year":"2016","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.preteyeres.2022.101149_bib59","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/(SICI)1097-0177(199907)215:3<215::AID-AJA4>3.0.CO;2-W","article-title":"Analysis of chicken Wnt-13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction","volume":"215","author":"Jasoni","year":"1999","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.preteyeres.2022.101149_bib60","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s13287-018-1091-y","article-title":"The combination of bFGF and CHIR99021 maintains stable self-renewal of mouse adult retinal progenitor cells","volume":"9","author":"Jin","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.preteyeres.2022.101149_bib61","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1167\/iovs.18-25916","article-title":"Multiple differentially methylated regions specific to keratoconus explain known keratoconus linkage loci","volume":"60","author":"Kabza","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101016","article-title":"Anterior pituitary, sex hormones, and keratoconus: beyond traditional targets","volume":"88","author":"Karamichos","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2022.101149_bib63","doi-asserted-by":"crossref","first-page":"37479","DOI":"10.1074\/jbc.M205658200","article-title":"Frizzled-9 is activated by Wnt-2 and functions in Wnt\/\u03b2-catenin signaling","volume":"277","author":"Karasawa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2022.101149_bib64","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2762","article-title":"Quantitative live-cell reporter assay for noncanonical Wnt activity","volume":"8","author":"Karuna","year":"2018","journal-title":"Bio Protoc."},{"key":"10.1016\/j.preteyeres.2022.101149_bib183","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1038\/s41388-018-0670-9","article-title":"Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting","volume":"38","author":"Karvonen","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.preteyeres.2022.101149_bib65","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.4103\/1673-5374.303010","article-title":"The neuroprotective role of Wnt signaling in the retina","volume":"16","author":"Kassumeh","year":"2021","journal-title":"Neural Regen Res."},{"key":"10.1016\/j.preteyeres.2022.101149_bib66","first-page":"1411","article-title":"Transcriptional regulation of WNT2B based on the balance of Hedgehog, Notch, BMP and WNT signals","volume":"34","author":"Katoh","year":"2009","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib67","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3892\/ijo.2017.4129","article-title":"Canonical and non-canonical WNT signaling in cancer stem cells and their niches: cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)","volume":"51","author":"Katoh","year":"2017","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib68","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1167\/iovs.18-24267","article-title":"Differential expression of coding and long noncoding RNAs in keratoconus-affected corneas","volume":"59","author":"Khaled","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib69","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1748-1716.2011.02294.x","article-title":"Wnt5a: its signalling, functions and implication in diseases","volume":"204","author":"Kikuchi","year":"2012","journal-title":"Acta Physiol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib70","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1083\/jcb.200710188","article-title":"Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements","volume":"182","author":"Kim","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib71","doi-asserted-by":"crossref","first-page":"525","DOI":"10.5483\/BMBRep.2015.48.9.140","article-title":"Wnt5a attenuates the pathogenic effects of the Wnt\/\u03b2-catenin pathway in human retinal pigment epithelial cells via down-regulating \u03b2-catenin and Snail","volume":"48","author":"Kim","year":"2015","journal-title":"BMB Rep"},{"key":"10.1016\/j.preteyeres.2022.101149_bib72","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ceca.2005.06.022","article-title":"Wnt and calcium signaling: \u03b2-catenin-independent pathways","volume":"38","author":"Kohn","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.preteyeres.2022.101149_bib73","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/org.4.2.5851","article-title":"Wnt signal transduction pathways","volume":"4","author":"Komiya","year":"2008","journal-title":"Organogenesis"},{"key":"10.1016\/j.preteyeres.2022.101149_bib74","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1242\/dev.104422","article-title":"Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis","volume":"141","author":"Korn","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.preteyeres.2022.101149_bib75","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/CIRCRESAHA.107.151381","article-title":"Notch signaling contributes to the expression of cardiac markers in human circulating progenitor cells","volume":"101","author":"Koyanagi","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.preteyeres.2022.101149_bib76","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1021\/acsptsci.1c00084","article-title":"Quantitative profiling of WNT-3A binding to all human Frizzled paralogues in HEK293 cells by NanoBiT\/BRET assessments","volume":"4","author":"Kozielewicz","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib77","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1242\/dev.00244","article-title":"Wnt2b controls retinal cell differentiation at the ciliary marginal zone","volume":"130","author":"Kubo","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.preteyeres.2022.101149_bib78","doi-asserted-by":"crossref","first-page":"12701","DOI":"10.1074\/jbc.275.17.12701","article-title":"Ca2+\/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus","volume":"275","author":"K\u00fchl","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2022.101149_bib79","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00018-015-2076-y","article-title":"WNT-5A: signaling and functions in health and disease","volume":"73","author":"Kumawat","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib80","doi-asserted-by":"crossref","first-page":"12769","DOI":"10.1073\/pnas.0601990103","article-title":"Efficient generation of retinal progenitor cells from human embryonic stem cells","volume":"103","author":"Lamba","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2022.101149_bib81","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.3389\/fonc.2019.01248","article-title":"Multiple targets of the canonical WNT\/\u03b2-Catenin signaling in cancers","volume":"9","author":"Lecarpentier","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib82","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ncb1344","article-title":"Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway","volume":"8","author":"Lee","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib83","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1128\/MCB.01572-13","article-title":"Interleukin-1\u03b2-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA","volume":"34","author":"Lee","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib84","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/s41598-017-01585-8","article-title":"Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2022.101149_bib85","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/ICU.0000000000000405","article-title":"PAX6 aniridia syndrome: clinics, genetics, and therapeutics","volume":"28","author":"Lim","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib86","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/dvdy.10315","article-title":"Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina","volume":"227","author":"Liu","year":"2003","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.preteyeres.2022.101149_bib87","first-page":"205","article-title":"Understanding trabecular meshwork physiology: a key to the control of intraocular pressure?","volume":"18","author":"Llobet","year":"2003","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib88","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","article-title":"The Wnt signaling pathway in development and disease","volume":"20","author":"Logan","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib89","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cell.2004.09.019","article-title":"Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth","volume":"119","author":"Lu","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2022.101149_bib91","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1242\/dev.01060","article-title":"Wnt signaling enhances FGF2-triggered lens fiber cell differentiation","volume":"131","author":"Lyu","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.preteyeres.2022.101149_bib92","doi-asserted-by":"crossref","first-page":"21653","DOI":"10.1074\/jbc.M500374200","article-title":"Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing","volume":"280","author":"Lyu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2022.101149_bib93","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007880","article-title":"Frizzled and LRP5\/6 receptors for Wnt\/\u03b2-catenin signaling","volume":"4","author":"MacDonald","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib94","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1001\/archopht.1990.01070060082054","article-title":"Development of keratoconus after contact lens wear. Patient characteristics","volume":"108","author":"Macsai","year":"1990","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib95","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/j.ajpath.2019.05.016","article-title":"M\u00fcller cell-localized G-protein-coupled receptor 81 (hydroxycarboxylic acid receptor 1) regulates inner retinal vasculature via Norrin\/Wnt pathways","volume":"189","author":"Madaan","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib96","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0070-2153(05)72002-0","article-title":"Dishevelled: a mobile scaffold catalyzing development","volume":"72","author":"Malbon","year":"2006","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib97","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1167\/iovs.08-2734","article-title":"Glycogene expression in conjunctiva of patients with dry eye: downregulation of Notch signaling","volume":"50","author":"Mantelli","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib98","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1097-2765(01)00224-6","article-title":"Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway","volume":"7","author":"Mao","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.preteyeres.2022.101149_bib99","doi-asserted-by":"crossref","first-page":"dev168799","DOI":"10.1242\/dev.168799","article-title":"A biphasic role of non-canonical Wnt16 signaling during early anterior-posterior patterning and morphogenesis of the sea urchin embryo","volume":"146","author":"Mart\u00ednez-Bartolom\u00e9","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.preteyeres.2022.101149_bib100","doi-asserted-by":"crossref","first-page":"30562","DOI":"10.1074\/jbc.M115.697615","article-title":"The PTK7 and ROR2 protein receptors interact in the vertebrate WNT\/Planar Cell Polarity (PCP) Pathway","volume":"290","author":"Martinez","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2022.101149_bib101","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.3389\/fimmu.2019.02854","article-title":"WNT signaling in tumors: the way to evade drugs and immunity","volume":"10","author":"Martin-Orozco","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib102","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuint.2017.11.004","article-title":"Mechanisms of RhoA inactivation and CDC42 and Rac1 activation during zebrafish optic nerve regeneration","volume":"112","author":"Matsukawa","year":"2018","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.preteyeres.2022.101149_bib103","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/sj.emboj.7600603","article-title":"Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis","volume":"24","author":"Maurus","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.preteyeres.2022.101149_bib104","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/eye.1999.117","article-title":"Lens development","volume":"13","author":"McAvoy","year":"1999","journal-title":"Eye (Lond)."},{"key":"10.1016\/j.preteyeres.2022.101149_bib105","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1167\/iovs.09-4386","article-title":"Transforming growth factor-\u03b1 enhances corneal epithelial cell migration by promoting EGFR recycling","volume":"51","author":"McClintock","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib106","first-page":"1984","article-title":"Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas","volume":"13","author":"McGowan","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2022.101149_bib107","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/ICL.0b013e31814fb64b","article-title":"Abnormal rubbing and keratectasia","volume":"33","author":"McMonnies","year":"2007","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.preteyeres.2022.101149_bib108","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/stem.1582","article-title":"Frizzled 7 maintains the undifferentiated state of human limbal stem\/progenitor cells","volume":"32","author":"Mei","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.preteyeres.2022.101149_bib109","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2001-3-1-reviews3001","article-title":"The Wnts","volume":"3","author":"Miller","year":"2001","journal-title":"Genome Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib110","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","article-title":"Age-related macular degeneration","volume":"392","author":"Mitchell","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.preteyeres.2022.101149_bib111","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz8797","article-title":"A Zic2-regulated switch in a noncanonical Wnt\/\u03b2catenin pathway is essential for the formation of bilateral circuits","volume":"6","author":"Morenilla-Palao","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.preteyeres.2022.101149_bib112","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/20732","article-title":"Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK","volume":"399","author":"Mott","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2022.101149_bib113","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1038\/s41467-018-04042-w","article-title":"Frizzled-8 integrates Wnt-11 and transforming growth factor-\u03b2 signaling in prostate cancer","volume":"9","author":"Murillo-Garz\u00f3n","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.preteyeres.2022.101149_bib114","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0182-22.2022","article-title":"Identification of a novel axon regeneration role for non-canonical Wnt signaling in the adult retina after injury","author":"Musada","year":"2022","journal-title":"eNeuro"},{"key":"10.1016\/j.preteyeres.2022.101149_bib115","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/dneu.22741","article-title":"The effect of extrinsic Wnt\/\u03b2-catenin signaling in Muller glia on retinal ganglion cell neurite growth","volume":"80","author":"Musada","year":"2020","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib116","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0012-1606(03)00320-8","article-title":"Identification of the laminar-inducing factor: wnt-signal from the anterior rim induces correct laminar formation of the neural retina in vitro","volume":"260","author":"Nakagawa","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib117","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1167\/iovs.10-6486","article-title":"Wnt\/\u03b2-catenin signaling regulates proliferation of human cornea epithelial stem\/progenitor cells","volume":"52","author":"Nakatsu","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib118","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222112057","article-title":"Immunocytochemical analysis of endogenous Frizzled-(Co-)receptor interactions and rapid Wnt pathway activation in mammalian cells","volume":"22","author":"Neuhaus","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib119","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrm3470","article-title":"The complex world of WNT receptor signalling","volume":"13","author":"Niehrs","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.preteyeres.2022.101149_bib120","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0092-8674(91)90633-A","article-title":"A new nomenclature for int-1 and related genes: the Wnt gene family","volume":"64","author":"Nusse","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2022.101149_bib121","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2022.101149_bib122","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/dvdy.22500","article-title":"An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos","volume":"240","author":"Ohkawara","year":"2011","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.preteyeres.2022.101149_bib123","doi-asserted-by":"crossref","first-page":"14962","DOI":"10.1073\/pnas.1100513108","article-title":"Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4","volume":"108","author":"Ohta","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2022.101149_bib124","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature13465","article-title":"WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis","volume":"511","author":"Ouyang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2022.101149_bib125","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.670960","article-title":"LRP5 and LRP6 in Wnt signaling: similarity and divergence","volume":"9","author":"Ren","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib126","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0092-8674(87)90038-9","article-title":"The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless","volume":"50","author":"Rijsewijk","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2022.101149_bib127","doi-asserted-by":"crossref","first-page":"17009","DOI":"10.1074\/jbc.M114.561209","article-title":"Identification of key residues and regions important for porcupine-mediated Wnt acylation","volume":"289","author":"Rios-Esteves","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2022.101149_bib128","first-page":"3283","article-title":"Wnt signaling crosstalk via Wnt16b improves human limbal epithelial stem\/progenitor cell maintenance","volume":"61","author":"Robertson","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib129","first-page":"3631","article-title":"Non-canonical Wnt signaling via Wnt16b improves human limbal epithelial stem\/progenitor cell maintenance","volume":"63","author":"Robertson","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib130","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.semcdb.2006.10.002","article-title":"An essential role for FGF receptor signaling in lens development","volume":"17","author":"Robinson","year":"2006","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib131","first-page":"321","article-title":"An Epha4\/Sipa1l3\/Wnt pathway regulates eye development and lens maturation","volume":"144","author":"Rothe","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.preteyeres.2022.101149_bib132","doi-asserted-by":"crossref","first-page":"dev176073","DOI":"10.1242\/dev.176073","article-title":"Mechanisms of intercellular Wnt transport","volume":"146","author":"Routledge","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.preteyeres.2022.101149_bib133","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neuron.2018.03.004","article-title":"Role for Wnt Signaling in retinal neuropil development: analysis via RNA-seq and in vivo somatic CRISPR mutagenesis","volume":"98","author":"Sarin","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.preteyeres.2022.101149_bib134","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/term.1599","article-title":"Wnt signalling in an in vitro niche model for conjunctival progenitor cells","volume":"8","author":"Schrader","year":"2014","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.preteyeres.2022.101149_bib135","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1755-3768.1992.tb02170.x","article-title":"Effects of growth factors on corneal wound healing","volume":"202","author":"Schultz","year":"1992","journal-title":"Acta Ophthalmol. Suppl."},{"key":"10.1016\/j.preteyeres.2022.101149_bib136","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188264","article-title":"Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts","volume":"12","author":"Sebastian","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2022.101149_bib137","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3390\/cancers8090080","article-title":"Wnt signaling in cell motility and invasion: drawing parallels between development and cancer","volume":"8","author":"Sedgwick","year":"2016","journal-title":"Cancers"},{"key":"10.1016\/j.preteyeres.2022.101149_bib138","first-page":"847","article-title":"Wnt5a promotes diabetic corneal epithelial wound healing and limbal stem cell expression","volume":"62","author":"Shah","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib139","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.preteyeres.2018.05.002","article-title":"Pathogenesis of keratoconus: the intriguing therapeutic potential of prolactin-inducible protein","volume":"67","author":"Sharif","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2022.101149_bib140","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4103\/0301-4738.116063","article-title":"Ocular allergy and keratoconus","volume":"61","author":"Sharma","year":"2013","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib141","first-page":"134","article-title":"Wingless, a new mutant in D. melanogaster","volume":"50","author":"Sharma","year":"1973","journal-title":"Drosoph. Inf. Serv."},{"key":"10.1016\/j.preteyeres.2022.101149_bib142","series-title":"StatPearls [Internet]. Treasure Island (FL)","article-title":"Anatomy, head and neck, eye conjunctiva. 2021 jul 26","author":"Shumway","year":"2022"},{"key":"10.1016\/j.preteyeres.2022.101149_bib143","first-page":"122","article-title":"Wnt gene expression in human trabecular meshwork cells","volume":"16","author":"Shyam","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2022.101149_bib144","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/dbio.1996.8463","article-title":"Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A","volume":"182","author":"Slusarski","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib145","series-title":"StatPearls [Internet]","article-title":"Neuroanatomy, cranial nerve 2 (optic). 2021 nov 14","author":"Smith","year":"2022"},{"key":"10.1016\/j.preteyeres.2022.101149_bib146","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4103\/ijo.IJO_646_17","article-title":"Anatomy of cornea and ocular surface","volume":"66","author":"Sridhar","year":"2018","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib147","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature10085","article-title":"Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells","volume":"474","author":"Stefater","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2022.101149_bib148","doi-asserted-by":"crossref","first-page":"dev146589","DOI":"10.1242\/dev.146589","article-title":"Wnt signaling in development and tissue homeostasis","volume":"145","author":"Steinhart","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.preteyeres.2022.101149_bib149","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1167\/iovs.14-16266","article-title":"Human conjunctival stem cells are predominantly located in the medial canthal and inferior forniceal areas","volume":"56","author":"Stewart","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib150","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/387292a0","article-title":"The role of RhoA in tissue polarity and Frizzled signalling","volume":"387","author":"Strutt","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.preteyeres.2022.101149_bib151","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4161\/org.7.3.18421","article-title":"Planar cell polarity in the mammalian eye lens","volume":"7","author":"Sugiyama","year":"2011","journal-title":"Organogenesis"},{"key":"10.1016\/j.preteyeres.2022.101149_bib152","article-title":"WNT5B in physiology and disease","volume":"9","author":"Suthon","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib153","first-page":"185","article-title":"Wnt signaling pathway in development and cancer","volume":"69","author":"Taciak","year":"2018","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib154","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41597-020-00754-1","article-title":"Transcriptome dataset of human corneal endothelium based on ribosomal RNA-depleted RNA-Seq data","volume":"7","author":"Tokuda","year":"2020","journal-title":"Sci. Data"},{"key":"10.1016\/j.preteyeres.2022.101149_bib155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018992","article-title":"Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice","volume":"6","author":"Tucker","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2022.101149_bib156","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000082277","article-title":"Wnt\/frizzled signaling during vertebrate retinal development","volume":"26","author":"Van Raay","year":"2004","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib158","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1096\/fj.201700144R","article-title":"Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families","volume":"31","author":"Voloshanenko","year":"2017","journal-title":"Faseb. J."},{"key":"10.1016\/j.preteyeres.2022.101149_bib159","article-title":"Critical in vivo roles of WNT10A in wound healing by regulating collagen expression\/synthesis in WNT10A-deficient mice","volume":"13","author":"Wang","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2022.101149_bib160","article-title":"A novel role for Wnt\/Ca2+ signaling in actin cytoskeleton remodeling and cell motility in prostate cancer","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2022.101149_bib161","doi-asserted-by":"crossref","first-page":"E11827","DOI":"10.1073\/pnas.1813217115","article-title":"Interplay of the Norrin and Wnt7a\/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance","volume":"115","author":"Wang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.preteyeres.2022.101149_bib162","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2012.10.042","article-title":"Norrin\/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity","volume":"151","author":"Wang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2022.101149_bib163","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.preteyeres.2018.11.008","article-title":"Wnt signaling in vascular eye diseases","volume":"70","author":"Wang","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2022.101149_bib164","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1128\/MCB.25.12.5022-5030.2005","article-title":"Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5","volume":"25","author":"Wang","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib165","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3109\/02713683.2013.780625","article-title":"Limbal dermoid epithelium shares phenotypic characteristics common to both hair epidermal and limbal epithelial stem cells","volume":"38","author":"Watson","year":"2013","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2022.101149_bib166","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.558155","article-title":"Expression and function of WNT6: from development to disease","volume":"8","author":"Wei","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib167","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1083\/jcb.200303107","article-title":"Wnt-5\/pipetail functions in vertebrate axis formation as a negative regulator of Wnt\/\u03b2-catenin activity","volume":"162","author":"Westfall","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib168","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0092-8674(01)00298-7","article-title":"Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton","volume":"105","author":"Winter","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2022.101149_bib169","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.biopha.2017.06.061","article-title":"The many postures of noncanonical Wnt signaling in development and diseases","volume":"93","author":"Xiao","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.preteyeres.2022.101149_bib170","article-title":"Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain","volume":"8","author":"Xie","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2022.101149_bib171","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1007\/s11427-021-1941-7","article-title":"The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4\/WNT signaling axis","volume":"64","author":"Yang","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib172","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2045-3701-2-14","article-title":"Wnt signaling in development and disease","volume":"2","author":"Yang","year":"2012","journal-title":"Cell Biosci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib173","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2009.07.047","article-title":"Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization","volume":"139","author":"Ye","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.preteyeres.2022.101149_bib174","doi-asserted-by":"crossref","first-page":"42211","DOI":"10.1074\/jbc.M408223200","article-title":"Altered expression of genes of the Bmp\/Smad and Wnt\/calcium signaling pathways in the cone-only Nrl-\/- mouse retina, revealed by gene profiling using custom cDNA microarrays","volume":"279","author":"Yu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.preteyeres.2022.101149_bib175","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1167\/iovs.13-12447","article-title":"Dexamethasone induces cross-linked actin networks in trabecular meshwork cells through noncanonical Wnt signaling","volume":"54","author":"Yuan","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib176","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1167\/iovs.12-11477","article-title":"Targeted overexpression of TGF-\u03b1 in the corneal epithelium of adult transgenic mice induces changes in anterior segment morphology and activates noncanonical Wnt signaling","volume":"54","author":"Yuan","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2022.101149_bib177","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41420-021-00668-w","article-title":"Roles and action mechanisms of WNT4 in cell differentiation and human diseases: a review","volume":"7","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.preteyeres.2022.101149_bib178","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ydbio.2008.03.028","article-title":"Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation","volume":"318","author":"Zhao","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.preteyeres.2022.101149_bib179","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.stemcr.2022.03.001","article-title":"WNT16B enhances the proliferation and self-renewal of limbal epithelial cells via CXCR4\/MEK\/ERK signaling","volume":"17","author":"Zhao","year":"2022","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.preteyeres.2022.101149_bib180","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.05.021","article-title":"Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11\/Fzd7\/ROCK non-canonical Wnt pathway","volume":"185","author":"Zheng","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2022.101149_bib181","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1167\/iovs.09-4278","article-title":"The pathogenic role of the canonical Wnt pathway in age-related macular degeneration","volume":"51","author":"Zhou","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Progress in Retinal and Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946222001094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946222001094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T11:22:52Z","timestamp":1728472972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350946222001094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":180,"alternative-id":["S1350946222001094"],"URL":"https:\/\/doi.org\/10.1016\/j.preteyeres.2022.101149","relation":{},"ISSN":["1350-9462"],"issn-type":[{"value":"1350-9462","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-canonical Wnt signaling in the eye","name":"articletitle","label":"Article Title"},{"value":"Progress in Retinal and Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preteyeres.2022.101149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101149"}}