{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:17:43Z","timestamp":1790741863261,"version":"4.1.0"},"reference-count":324,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2014862"],"award-info":[{"award-number":["2014862"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["11174385"],"award-info":[{"award-number":["11174385"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1186915"],"award-info":[{"award-number":["1186915"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Retinal and Eye Research"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.preteyeres.2026.101463","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T16:28:57Z","timestamp":1774110537000},"page":"101463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Inner-retinal changes in AMD: Evidence, mechanisms, and future perspectives"],"prefix":"10.1016","volume":"112","author":[{"given":"Matt","family":"Trinh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kalloniatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan William","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn C.","family":"Yiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Borrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-1949","authenticated-orcid":false,"given":"Lisa","family":"Nivison-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.preteyeres.2026.101463_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/tvst.8.4.6","article-title":"Automatic characterization of retinal blood flow using OCT angiograms","volume":"8","author":"Aharony","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/01913123.2020.1731039","article-title":"Retinal and choroidal capillaries contribution to age-related macular degeneration (AMD) phenotypes in murine models of the disease","volume":"44","author":"Ahsan","year":"2020","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib3","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/ejn.13904","article-title":"Contrast gain control and retinogeniculate communication","volume":"49","author":"Alitto","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib4","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.15252\/emmm.201606531","article-title":"Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization","volume":"8","author":"Andriessen","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.preteyeres.2026.101463_bib5","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1007\/s00018-021-03796-9","article-title":"The complement system in age-related macular degeneration","volume":"78","author":"Armento","year":"2021","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"10.1016\/j.preteyeres.2026.101463_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ajo.2018.08.001","article-title":"Advanced optical coherence tomography angiography analysis of age-related macular degeneration complicated by onset of unilateral choroidal neovascularization","volume":"195","author":"Arrigo","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib7","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/s41433-022-02139-7","article-title":"Morphological and functional involvement of the inner retina in retinitis pigmentosa","volume":"37","author":"Arrigo","year":"2023","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.oret.2020.06.024","article-title":"Analyzing relative flow speeds in diabetic retinopathy using variable interscan time analysis optical coherence tomography angiography","volume":"5","author":"Arya","year":"2021","journal-title":"Ophthalmol. Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib9","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1177\/11206721231199126","article-title":"Understanding and interpreting CNN's decision in optical coherence tomography-based AMD detection","volume":"34","author":"Azoad Ahnaf","year":"2024","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib10","first-page":"5397","article-title":"Intravitreal anti-VEGF injections for treating wet age-related macular degeneration: a systematic review and meta-analysis","volume":"9","author":"Ba","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.preteyeres.2026.101463_bib11","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1001\/jamaophthalmol.2019.3509","article-title":"Association between cilioretinal arteries and advanced age-related macular degeneration: secondary analysis of the comparison of age-related macular degeneration treatment trials (CATT)","volume":"137","author":"Bavinger","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib12","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.ajpath.2013.05.031","article-title":"VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro","volume":"183","author":"Beazley-Long","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib13","article-title":"Ciliary neurotrophic factor mediated growth of retinal ganglion cell axons on PGS\/PCL scaffolds","volume":"19","author":"Behtaj","year":"2024","journal-title":"Biomed. Mater. Bristol Engl"},{"key":"10.1016\/j.preteyeres.2026.101463_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2024.101260","article-title":"Glycative stress as a cause of macular degeneration","volume":"101","author":"Bejarano","year":"2024","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib15","series-title":"Neural Stem Cells - New Perspectives","article-title":"Reactive Muller glia as potential retinal progenitors","author":"Belecky-Adams","year":"2013"},{"key":"10.1016\/j.preteyeres.2026.101463_bib16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.neuron.2010.09.043","article-title":"Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging","volume":"68","author":"Bell","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.preteyeres.2026.101463_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2023.100280","article-title":"Histology of type 3 macular neovascularization and microvascular anomalies in treated age-related macular degeneration","volume":"3","author":"Berlin","year":"2023","journal-title":"Ophthalmol. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12974-024-03045-3","article-title":"Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury","volume":"21","author":"Biber","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.preteyeres.2026.101463_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/768026","article-title":"Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration","volume":"2014","author":"Blasiak","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.preteyeres.2026.101463_bib20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0306-3623(97)00359-5","article-title":"The b-wave of the electroretinogram as an index of retinal ischemia","volume":"30","author":"Block","year":"1998","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib21","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3390\/life12050638","article-title":"Retinal glutamate neurotransmission: from physiology to pathophysiological mechanisms of retinal ganglion cell degeneration","volume":"12","author":"Boccuni","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.preteyeres.2026.101463_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajo.2017.06.005","article-title":"Postreceptor neuronal loss in intermediate age-related macular degeneration","volume":"181","author":"Borrelli","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1167\/iovs.64.4.21","article-title":"Capturing the transition from intermediate to neovascular AMD: longitudinal inner retinal thinning and factors associated with neuronal loss","volume":"64","author":"Borrelli","year":"2023","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib24","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1038\/s41433-020-0804-5","article-title":"Widefield topographical analysis of the retinal perfusion and neuroretinal thickness in healthy eyes: a pilot study","volume":"34","author":"Borrelli","year":"2020","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib25","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/eye.2001.141","article-title":"The role of the retinal pigment epithelium: topographical variation and ageing changes","volume":"15","author":"Boulton","year":"2001","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib26","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1167\/iovs.18-25332","article-title":"Retinal layer thicknesses in early age-related macular degeneration: results from the German AUGUR study","volume":"60","author":"Brandl","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12974-024-03055-1","article-title":"The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome","volume":"21","author":"Brandli","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.preteyeres.2026.101463_bib28","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.amjmed.2015.10.015","article-title":"Mining retrospective data for virtual prospective drug repurposing: L-DOPA and age-related macular degeneration","volume":"129","author":"Brilliant","year":"2016","journal-title":"Am. J. Med."},{"key":"10.1016\/j.preteyeres.2026.101463_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2013.00048","article-title":"GABA and glutamate uptake and metabolism in retinal glial (M\u00fcller) cells","volume":"4","author":"Bringmann","year":"2013","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1167\/tvst.13.11.4","article-title":"Impairment of neurovascular function in intermediate age-related macular degeneration","volume":"13","author":"Bui","year":"2024","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib31","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3109\/02713683.2013.840384","article-title":"Retinal blood flow velocity in patients with age-related macular degeneration","volume":"39","author":"Burgansky-Eliash","year":"2014","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib32","author":"Burke"},{"key":"10.1016\/j.preteyeres.2026.101463_bib33","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1167\/tvst.13.11.7","article-title":"SLOctolyzer: fully automatic analysis toolkit for segmentation and feature extracting in scanning laser ophthalmoscopy images","volume":"13","author":"Burke","year":"2024","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2018.08.002","article-title":"Adaptive optics imaging of the human retina","volume":"68","author":"Burns","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib35","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1177\/11206721221149065","article-title":"Relationship between ganglion cell complex thickness and vision in age-related macular degeneration treated with aflibercept","volume":"33","author":"Buyukavsar","year":"2023","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000468965","article-title":"Ganglion cell complex in early and intermediate age-related macular degeneration: evidence by SD-OCT manual segmentation","volume":"238","author":"Camacho","year":"2017","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.preteyeres.2026.101463_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/srep42201","article-title":"Detailed vascular anatomy of the human retina by projection-resolved optical coherence tomography angiography","volume":"7","author":"Campbell","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2026.101463_bib38","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1113\/JP274177","article-title":"How do horizontal cells \u2018talk\u2019 to cone photoreceptors? Different levels of complexity at the cone\u2013horizontal cell synapse","volume":"595","author":"Chapot","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1167\/iovs.62.1.33","article-title":"Biometrics, impact, and significance of basal linear deposit and subretinal drusenoid deposit in age-related macular degeneration","volume":"62","author":"Chen","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1076\/ocii.10.1.27.10328","article-title":"Distribution, markers, and functions of retinal microglia","volume":"10","author":"Chen","year":"2002","journal-title":"Ocul. Immunol. Inflamm."},{"key":"10.1016\/j.preteyeres.2026.101463_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214104","article-title":"An altered neurovascular system in aging-related eye diseases","volume":"23","author":"Choi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101130","article-title":"Potential therapeutic targets for age-related macular degeneration: the nuclear option","volume":"94","author":"Choudhary","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib43","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/HJH.0000000000001916","article-title":"Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography","volume":"37","author":"Chua","year":"2019","journal-title":"J. Hypertens."},{"key":"10.1016\/j.preteyeres.2026.101463_bib44","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/cne.22029","article-title":"Functional remodeling of glutamate receptors by inner retinal neurons occurs from an early stage of retinal degeneration","volume":"514","author":"Chua","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib45","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1167\/iovs.61.5.32","article-title":"Ambient air pollution associations with retinal morphology in the UK biobank","volume":"61","author":"Chua","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib46","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1136\/bjophthalmol-2017-311317","article-title":"Retinal vascular alterations in reticular pseudodrusen with and without outer retinal atrophy assessed by optical coherence tomography angiography","volume":"102","author":"Cicinelli","year":"2018","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0002-9394(99)00061-6","article-title":"Color doppler imaging discloses reduced ocular blood flow velocities in nonexudative age-related macular degeneration","volume":"128","author":"Ciulla","year":"1999","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib48","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/bjo.86.2.209","article-title":"Choroidal perfusion perturbations in non-neovascular age related macular degeneration","volume":"86","author":"Ciulla","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib49","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1177\/1120672120968758","article-title":"Quantitative deep vascular complex analysis of different AMD stages on optical coherence tomography angiography","volume":"31","author":"Colantuono","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib50","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1172\/JCI31692","article-title":"CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration","volume":"117","author":"Combadi\u00e8re","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.preteyeres.2026.101463_bib51","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/IAE.0000000000002990","article-title":"Choriocapillaris flow deficits as a risk factor for progression of age-related macular degeneration","volume":"41","author":"Corvi","year":"2021","journal-title":"Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib52","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12886-024-03381-1","article-title":"Artificial intelligence in age-related macular degeneration: state of the art and recent updates","volume":"24","author":"Crincoli","year":"2024","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib53","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1460-9568.2005.04300.x","article-title":"Early changes in synaptic connectivity following progressive photoreceptor degeneration in RCS rats","volume":"22","author":"Cuenca","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.107961","article-title":"Oral administration of the iron chelator deferiprone protects against loss of retinal ganglion cells in a mouse model of glaucoma","volume":"193","author":"Cui","year":"2020","journal-title":"Exp. Eye Res."},{"issue":"Suppl. 6","key":"10.1016\/j.preteyeres.2026.101463_bib55","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.5301\/EJO.2010.6049","article-title":"Blood-retinal barrier","volume":"21","author":"Cunha-Vaz","year":"2011","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib56","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/eye.2001.140","article-title":"Photoreceptor topography in ageing and age-related maculopathy","volume":"15","author":"Curcio","year":"2001","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib57","first-page":"1236","article-title":"Photoreceptor loss in age-related macular degeneration","volume":"37","author":"Curcio","year":"1996","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib58","article-title":"Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images","volume":"17","author":"Currant","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.preteyeres.2026.101463_bib59","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1001\/archopht.123.11.1484","article-title":"The age-related eye disease study severity scale for age-related macular degeneration: AREDS report no. 17","volume":"123","author":"Davis","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib60","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/15569527.2021.1919136","article-title":"Anatomical effects of intravitreal anti-vascular endothelial growth factor injections on inner layers of the lesion-free retina","volume":"40","author":"Demir","year":"2021","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib61","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.132114","article-title":"Local photoreceptor degeneration causes local pathophysiological remodeling of retinal neurons","volume":"5","author":"Denlinger","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.preteyeres.2026.101463_bib62","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3109\/15569527.2014.975240","article-title":"Effect of smoking on retina nerve fiber layer and ganglion cell-inner plexiform layer complex","volume":"34","author":"Dervi\u015fo\u011fullar\u0131","year":"2015","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2024.1335176","article-title":"Evaluation of the neuroprotective efficacy of the gramine derivative ITH12657 against NMDA-induced excitotoxicity in the rat retina","volume":"18","author":"Di Pierdomenico","year":"2024","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.preteyeres.2026.101463_bib64","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/sj.eye.6700161","article-title":"Retrobulbar circulation in patients with age-related maculopathy","volume":"16","author":"Dimitrova","year":"2002","journal-title":"Eye Lond"},{"key":"10.1016\/j.preteyeres.2026.101463_bib65","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1038\/s41467-022-34443-x","article-title":"Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas","volume":"13","author":"Do Rhee","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.preteyeres.2026.101463_bib66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00417-019-04533-6","article-title":"The flicker response of venous oxygen saturation is significantly reduced in the early and late stages of age-related macular degeneration","volume":"258","author":"Donicova","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib67","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12974-020-02010-0","article-title":"Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization","volume":"17","author":"Droho","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.preteyeres.2026.101463_bib68","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/archopht.1986.01050170102031","article-title":"Scotopic sensitivity loss in glaucoma","volume":"104","author":"Drum","year":"1986","journal-title":"Arch. Ophthalmol. Chic. Ill"},{"key":"10.1016\/j.preteyeres.2026.101463_bib69","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1167\/iovs.11-9130","article-title":"Thickness, phase retardation, birefringence, and reflectance of the retinal nerve fiber layer in normal and glaucomatous non-human primates","volume":"53","author":"Dwelle","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib70","first-page":"334","article-title":"Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin","volume":"23","author":"Eleftheriou","year":"2017","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2026.101463_bib71","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.redox.2016.10.017","article-title":"The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients","volume":"10","author":"Escribano-Lopez","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib72","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/imm.13479","article-title":"Retinal microglia: functions and diseases","volume":"166","author":"Fan","year":"2022","journal-title":"Immunology"},{"key":"10.1016\/j.preteyeres.2026.101463_bib73","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1007\/s00417-021-05140-0","article-title":"Retinal layer thicknesses and neurodegeneration in early age-related macular degeneration: insights from the Coimbra eye study","volume":"259","author":"Farinha","year":"2021","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib74","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0002-9394(99)00401-8","article-title":"Abnormalities in rod photoreceptors, amacrine cells, and horizontal cells in human retinas with retinitis pigmentosa","volume":"129","author":"Fariss","year":"2000","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib75","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1444-0938.2007.00152.x","article-title":"Age\u2010related maculopathy in the light of ischaemia","volume":"90","author":"Feigl","year":"2007","journal-title":"Clin. Exp. Optom."},{"key":"10.1016\/j.preteyeres.2026.101463_bib76","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10633-005-5319-7","article-title":"Dynamics of retinal function after multiple photodynamic therapies in age-related macular degeneration: a report of cases","volume":"111","author":"Feigl","year":"2005","journal-title":"Doc. Ophthalmol. Adv. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib77","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/sj.eye.6702389","article-title":"Functional loss in early age-related maculopathy: the ischaemia postreceptoral hypothesis","volume":"21","author":"Feigl","year":"2007","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib78","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1017\/S0952523806230190","article-title":"Postreceptoral adaptation abnormalities in early age-related maculopathy","volume":"23","author":"Feigl","year":"2006","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib79","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1167\/iovs.05-0795","article-title":"Adaptation responses in early age-related maculopathy","volume":"46","author":"Feigl","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib80","first-page":"167","article-title":"Functional outcomes after multiple treatments with ranibizumab in neovascular age-related macular degeneration beyond visual acuity","volume":"1","author":"Feigl","year":"2007","journal-title":"Clin. Ophthalmol. Auckl. NZ"},{"key":"10.1016\/j.preteyeres.2026.101463_bib81","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1479","article-title":"Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non-infectious uveitis","volume":"12","author":"Ferreira","year":"2023","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib82","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/(SICI)1096-9861(19961216)376:3<343::AID-CNE1>3.0.CO;2-2","article-title":"Neurochemical architecture of the normal and degenerating rat retina","volume":"376","author":"Fletcher","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib83","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0161-6420(95)30974-8","article-title":"Ocular blood flow velocity in age-related macular degeneration","volume":"102","author":"Friedman","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2026.101463_bib84","doi-asserted-by":"crossref","DOI":"10.1194\/jlr.TR120000618","article-title":"Fatty acid oxidation and photoreceptor metabolic needs","volume":"62","author":"Fu","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib85","article-title":"Reduction of retinal vessel density in non-exudative macular neovascularization: a retrospective study","volume":"10","author":"Gao","year":"2023","journal-title":"Front. Med."},{"key":"10.1016\/j.preteyeres.2026.101463_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/tvst.10.2.5","article-title":"Advances in retinal oximetry","volume":"10","author":"Garg","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib87","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1001\/archopht.121.10.1404","article-title":"Assessment of multifocal electroretinogram abnormalities and their relation to morphologic characteristics in patients with large drusen","volume":"121","author":"Gerth","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib88","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/iovs.63.1.18","article-title":"In vivo sublayer analysis of human retinal inner plexiform layer obtained by visible-light optical coherence tomography","volume":"63","author":"Ghassabi","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib89","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/cne.23284","article-title":"Functional and neurochemical development in the normal and degenerating mouse retina","volume":"521","author":"Gibson","year":"2013","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib90","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1167\/iovs.08-1724","article-title":"Advanced glycation end product (AGE) accumulation on Bruch's membrane: links to age-related RPE dysfunction","volume":"50","author":"Glenn","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib91","doi-asserted-by":"crossref","DOI":"10.4161\/tisb.24782","article-title":"Regulation of claudins in blood-tissue barriers under physiological and pathological states","volume":"1","author":"Gon\u00e7alves","year":"2013","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.preteyeres.2026.101463_bib92","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fncel.2015.00293","article-title":"Inner retinal change in a novel rd1-FTL mouse model of retinal degeneration","volume":"9","author":"Greferath","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib93","series-title":"Encyclopedia of Neuroscience","first-page":"3492","article-title":"Retinal bipolar cells","author":"Gr\u00fcnert","year":"2009"},{"key":"10.1016\/j.preteyeres.2026.101463_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108257","article-title":"The role of TRPV4 channels in ocular function and pathologies","volume":"201","author":"Guarino","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib95","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.804782","article-title":"Microglia: key players in retinal ageing and neurodegeneration","volume":"16","author":"Guo","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib96","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.bbadis.2014.05.026","article-title":"BDNF impairment is associated with age-related changes in the inner retina and exacerbates experimental glaucoma","volume":"1842","author":"Gupta","year":"2014","journal-title":"Biochim. Biophys. Acta BBA - Mol. Basis Dis."},{"key":"10.1016\/j.preteyeres.2026.101463_bib97","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.3390\/jcm12082870","article-title":"Bruch's membrane: a key consideration with complement-based therapies for age-related macular degeneration","volume":"12","author":"Hammadi","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.preteyeres.2026.101463_bib98","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddz193","article-title":"Genome-wide association analysis of 95 549 individuals identifies novel loci and genes influencing optic disc morphology","volume":"28","author":"Han","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.preteyeres.2026.101463_bib99","article-title":"Gene therapy for glaucoma: targeting key mechanisms","volume":"225","author":"Henderson","year":"2024","journal-title":"Vis. Resour."},{"key":"10.1016\/j.preteyeres.2026.101463_bib100","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.preteyeres.2005.11.002","article-title":"Visual function and dysfunction in early and late age-related maculopathy","volume":"25","author":"Hogg","year":"2006","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.100965","article-title":"Artificial intelligence in OCT angiography","volume":"85","author":"Hormel","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib102","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/112067219800800406","article-title":"Color Doppler imaging of the retrobulbar circulation in age-related macular degeneration","volume":"8","author":"Hosal","year":"1998","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib103","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-4614-4711-5_4","article-title":"The inner blood-retinal barrier: molecular structure and transport biology","volume":"763","author":"Hosoya","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib104","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1167\/iovs.05-0532","article-title":"Microtubules contribute to the birefringence of the retinal nerve fiber layer","volume":"46","author":"Huang","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib105","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1167\/iovs.06-0451","article-title":"Microtubule contribution to the reflectance of the retinal nerve fiber layer","volume":"47","author":"Huang","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib106","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.1167\/iovs.11-7665","article-title":"Reflectance decreases before thickness changes in the retinal nerve fiber layer in glaucomatous retinas","volume":"52","author":"Huang","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib107","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.130273","article-title":"Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy","volume":"4","author":"Hudson","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.preteyeres.2026.101463_bib108","article-title":"The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective","volume":"2","author":"Hugh Perry","year":"2010","journal-title":"ASN Neuro"},{"key":"10.1016\/j.preteyeres.2026.101463_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2025.100741","article-title":"Potential efficacy of metformin for age-related macular degeneration: a systematic review and meta-analysis","volume":"5","author":"Huh","year":"2025","journal-title":"Ophthalmol. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib110","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/ceo.13818","article-title":"Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: a crossover randomized clinical trial","volume":"48","author":"Hui","year":"2020","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib111","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrn3320","article-title":"Synaptic circuit remodelling by matrix metalloproteinases in health and disease","volume":"13","author":"Huntley","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib112","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/jnr.23583","article-title":"Glucose, lactate, and shuttling of metabolites in vertebrate retinas","volume":"93","author":"Hurley","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib113","first-page":"244","article-title":"Virtual reality and augmented reality in ophthalmology: a contemporary prospective. Asia-Pac","volume":"10","author":"Iskander","year":"2021","journal-title":"J. Ophthalmol. Phila. Pa"},{"key":"10.1016\/j.preteyeres.2026.101463_bib114","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/s41467-024-55635-7","article-title":"Multi-omic spatial effects on high-resolution AI-derived retinal thickness","volume":"16","author":"Jackson","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.preteyeres.2026.101463_bib115","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/IAE.0000000000002528","article-title":"Morphologic features of the retinal pigment epithelium and associated chorioretinal characteristics in eyes with early age-related macular degeneration and subretinal drusenoid deposits","volume":"40","author":"Jang","year":"2020","journal-title":"Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib116","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.ajo.2008.07.006","article-title":"Retinal vascular caliber and age-related macular degeneration: the Singapore Malay eye study","volume":"146","author":"Jeganathan","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib117","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1167\/iovs.03-0436","article-title":"Drusen-associated degeneration in the retina","volume":"44","author":"Johnson","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib118","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2016.00103","article-title":"Retinal remodeling and metabolic alterations in human AMD","volume":"10","author":"Jones","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100858","article-title":"Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration","volume":"79","author":"Kaarniranta","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib120","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.exer.2015.10.019","article-title":"Using the rd1 mouse to understand functional and anatomical retinal remodelling and treatment implications in retinitis pigmentosa: a review","volume":"150","author":"Kalloniatis","year":"2016","journal-title":"Exp. Eye Res., Special Issue: Cellular Remodel. Retina Optic Nerve Injury Dis."},{"key":"10.1016\/j.preteyeres.2026.101463_bib121","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12886-022-02518-4","article-title":"Chorioretinal thickness and retinal pigment epithelial degeneration of fellow eyes in patients with unilateral neovascular age-related macular degeneration with subretinal drusenoid deposits","volume":"22","author":"Kang","year":"2022","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omtm.2023.05.011","article-title":"Starburst amacrine cells amplify optogenetic visual restoration through gap junctions","volume":"30","author":"Katada","year":"2023","journal-title":"Mol. Ther., Methods Clin. Dev."},{"key":"10.1016\/j.preteyeres.2026.101463_bib123","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.2147\/OPTH.S204344","article-title":"Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography","volume":"13","author":"Keiner","year":"2019","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib124","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ajo.2021.10.033","article-title":"Unilateral cilioretinal artery and advanced age-related macular degeneration: a retrospective cross-sectional study","volume":"237","author":"Kim","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib125","doi-asserted-by":"crossref","first-page":"e1056","DOI":"10.1111\/aos.14784","article-title":"Longitudinal changes in the ganglion cell-inner plexiform layer thickness of age-related macular degeneration","volume":"99","author":"Kim","year":"2021","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib126","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/ceo.14165","article-title":"Retinal microvasculature and choriocapillaris impairments according to the stage of dry age-related macular degeneration","volume":"51","author":"Kim","year":"2023","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib127","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00006982-200208000-00012","article-title":"Morphometric analysis of the macula in eyes with disciform age-related macular degeneration","volume":"22","author":"Kim","year":"2002","journal-title":"Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib128","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.661938","article-title":"Retinal ganglion cells-diversity of cell types and clinical relevance","volume":"12","author":"Kim","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib129","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ajo.2003.10.020","article-title":"The relation of retinal microvascular characteristics to age-related eye disease: the beaver dam eye study","volume":"137","author":"Klein","year":"2004","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib130","series-title":"Webvision: the Organization of the Retina and Visual System","article-title":"Morphology and circuitry of ganglion cells","author":"Kolb","year":"1995"},{"key":"10.1016\/j.preteyeres.2026.101463_bib131","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1126\/science.186.4158.47","article-title":"Rod and cone pathways in the inner plexiform layer of cat retina","volume":"186","author":"Kolb","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.preteyeres.2026.101463_bib132","article-title":"Webvision: the organization of the retina and visual system","author":"Kolb","year":"2020","journal-title":"WordPress"},{"key":"10.1016\/j.preteyeres.2026.101463_bib133","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/archopht.1966.00970050328005","article-title":"The retinal vasculature in macular degeneration","volume":"75","author":"Kornzweig","year":"1966","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-022-04016-1","article-title":"Bipolar cell targeted optogenetic gene therapy restores parallel retinal signaling and high-level vision in the degenerated retina","volume":"5","author":"Kralik","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib135","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41433-018-0234-9","article-title":"Changes in volume of various retinal layers over time in early and intermediate age-related macular degeneration","volume":"33","author":"Lamin","year":"2019","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib136","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1167\/iovs.17-23600","article-title":"Variation of retinal and choroidal vasculatures in patients with age-related macular degeneration","volume":"59","author":"Lee","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib137","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1167\/iovs.15-17013","article-title":"Ganglion cell-inner plexiform layer and peripapillary retinal nerve fiber layer thicknesses in age-related macular degeneration","volume":"56","author":"Lee","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib138","doi-asserted-by":"crossref","first-page":"352","DOI":"10.21037\/atm-22-5634","article-title":"Nitric oxide: an old drug but with new horizons in ophthalmology\u2014a narrative review","volume":"11","author":"Lee","year":"2023","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.preteyeres.2026.101463_bib139","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3928\/23258160-20220919-01","article-title":"Long-term retinal vascular changes in age-related macular degeneration measured using optical coherence tomography angiography","volume":"53","author":"Lee","year":"2022","journal-title":"Ophthalmic Surg. Lasers Imag. Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib140","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajo.2019.11.031","article-title":"Retinal vessel density in exudative and nonexudative age-related macular degeneration on optical coherence tomography angiography","volume":"212","author":"Lee","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib141","article-title":"Changes in inner retinal layer thickness in patients with exudative age-related macular degeneration during treatment with anti-vascular endothelial growth factor","volume":"99","author":"Lee","year":"2020","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.preteyeres.2026.101463_bib142","article-title":"Retinal microvascular change in hypertension as measured by optical coherence tomography angiography","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2026.101463_bib143","series-title":"Adler's Physiology of the Eye","author":"Levin","year":"2011"},{"key":"10.1016\/j.preteyeres.2026.101463_bib144","first-page":"17","article-title":"Sigma-1R protects retinal ganglion cells in optic nerve crush model for glaucoma","volume":"62","author":"Li","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib145","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1523\/JNEUROSCI.15-08-05429.1995","article-title":"Rod photoreceptor neurite sprouting in retinitis pigmentosa","volume":"15","author":"Li","year":"1995","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib146","doi-asserted-by":"crossref","DOI":"10.3389\/fnetp.2023.1162757","article-title":"Two decades of astrocytes in neurovascular coupling","volume":"3","author":"Lia","year":"2023","journal-title":"Front. Netw. Physiol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib147","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s12964-024-01761-0","article-title":"Axonal mitophagy in retinal ganglion cells","volume":"22","author":"Liang","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.preteyeres.2026.101463_bib148","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.ophtha.2006.03.051","article-title":"Retinal vessel signs and 10-year incident age-related maculopathy: the Blue Mountains eye study","volume":"113","author":"Liew","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2026.101463_bib149","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.3390\/jcm10102072","article-title":"A review of the role of the intestinal microbiota in age-related macular degeneration","volume":"10","author":"Lin","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.preteyeres.2026.101463_bib150","first-page":"81","article-title":"Retinoid receptors trigger neuritogenesis in retinal degenerations","volume":"26","author":"Lin","year":"2012","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib151","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s11357-019-00138-3","article-title":"Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions","volume":"41","author":"Lipecz","year":"2019","journal-title":"GeroScience"},{"key":"10.1016\/j.preteyeres.2026.101463_bib152","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.3390\/ijms22073689","article-title":"Energy metabolism in the inner retina in health and glaucoma","volume":"22","author":"Liu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib153","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/864871","article-title":"Ocular blood flow autoregulation mechanisms and methods","volume":"2015","author":"Luo","year":"2015","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib154","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-3-319-17121-0_11","article-title":"Aging changes in retinal microglia and their relevance to age-related retinal disease","volume":"854","author":"Ma","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib155","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1167\/iovs.10-5756","article-title":"Different populations of circulating endothelial cells in patients with age-related macular degeneration: a novel insight into pathogenesis","volume":"52","author":"Machalinska","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib156","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00006982-199401000-00014","article-title":"Intermediate filament expression in human retinal macroglia. histopathologic changes associated with age-related macular degeneration","volume":"14","author":"Madigan","year":"1994","journal-title":"Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib157","series-title":"StatPearls","article-title":"Neuroanatomy, retina","author":"Mahabadi","year":"2025"},{"key":"10.1016\/j.preteyeres.2026.101463_bib158","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/cells13010050","article-title":"Choroidal mast cells and pathophysiology of age-related macular degeneration","volume":"13","author":"Malih","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.preteyeres.2026.101463_bib159","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/bjophthalmol-2011-301087","article-title":"Macular ischaemia: a contraindication for anti-VEGF treatment in retinal vascular disease?","volume":"96","author":"Manousaridis","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib160","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1097\/IAE.0000000000002054","article-title":"Macular atrophy incidence in anti-vascular endothelial growth factor-treated neovascular age-related macular degeneration: risk factor evaluation for individualized treatment need of Ranibizumab or Aflibercept according to an observe-and-plan regimen","volume":"39","author":"Mantel","year":"2019","journal-title":"Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib161","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1350-9462(03)00039-9","article-title":"Neural remodeling in retinal degeneration","volume":"22","author":"Marc","year":"2003","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib162","first-page":"782","article-title":"Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration","volume":"14","author":"Marc","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.preteyeres.2026.101463_bib163","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40942-024-00549-1","article-title":"AI-based support for optical coherence tomography in age-related macular degeneration","volume":"10","author":"Mares","year":"2024","journal-title":"Int. J. Retina Vitr."},{"key":"10.1016\/j.preteyeres.2026.101463_bib164","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.661477","article-title":"Cross-modal interaction between auditory and visual input impacts memory retrieval","volume":"15","author":"Marian","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib165","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/iovs.62.9.22","article-title":"Composition of the inner nuclear layer in human retina","volume":"62","author":"Masri","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib166","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cmet.2023.12.022","article-title":"The hormesis principle of neuroplasticity and neuroprotection","volume":"36","author":"Mattson","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.preteyeres.2026.101463_bib167","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/exer.1996.0089","article-title":"Morphological and physiological consequences of the selective elimination of rod photoreceptors in transgenic mice","volume":"63","author":"McCall","year":"1996","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib168","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/eye.1997.49","article-title":"The distribution of immune cells in the uveal tract of the normal eye","volume":"11","author":"McMenamin","year":"1997","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib169","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.preteyeres.2018.12.002","article-title":"Immune cells in the retina and choroid: two different tissue environments that require different defenses and surveillance","volume":"70","author":"McMenamin","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib170","first-page":"795","article-title":"Preservation of ganglion cell layer neurons in age-related macular degeneration","volume":"42","author":"Medeiros","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib171","doi-asserted-by":"crossref","DOI":"10.3389\/fgeed.2021.644319","article-title":"Delivery platforms for CRISPR\/cas9 genome editing of glial cells in the central nervous system","volume":"3","author":"Meneghini","year":"2021","journal-title":"Front. Genome Ed."},{"key":"10.1016\/j.preteyeres.2026.101463_bib172","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1038\/s41467-019-12780-8","article-title":"Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration","volume":"10","author":"Menon","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.preteyeres.2026.101463_bib173","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1113\/JP270979","article-title":"Binaural blood flow control by astrocytes: listening to synapses and the vasculature","volume":"595","author":"Mishra","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib174","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1177\/15353702231181188","article-title":"Repurposing medications for treatment of age-related macular degeneration: insights from novel approaches to data mining","volume":"248","author":"Moir","year":"2023","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.preteyeres.2026.101463_bib175","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.102094","article-title":"The role of optical coherence tomography angiography in reticular pseudodrusen","volume":"33","author":"Montorio","year":"2021","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.preteyeres.2026.101463_bib176","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.3390\/cells10071593","article-title":"The influence of mitochondrial dynamics and function on retinal ganglion cell susceptibility in optic nerve disease","volume":"10","author":"Muench","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.preteyeres.2026.101463_bib177","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1097\/IAE.0000000000001759","article-title":"Quantitative analysis of the inner retinal layer thicknesses in age-related macular degeneration using corrected optical coherence tomography segmentation","volume":"38","author":"Muftuoglu","year":"2018","journal-title":"Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib178","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.oret.2022.02.007","article-title":"Recommendations for OCT angiography reporting in retinal vascular disease: a Delphi approach by international experts","volume":"6","author":"Munk","year":"2022","journal-title":"Ophthalmol. Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib179","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.oret.2020.12.022","article-title":"Standardization of OCT angiography nomenclature in retinal vascular diseases: first survey results","volume":"5","author":"Munk","year":"2021","journal-title":"Ophthalmol. Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib180","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.oret.2025.01.015","article-title":"Standardization of OCT angiography nomenclature in retinal vascular diseases: consensus-based recommendations","volume":"9","author":"Munk","year":"2025","journal-title":"Ophthalmol. Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib181","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.636330","article-title":"Intrinsically photosensitive retinal ganglion cells of the human retina","volume":"12","author":"Mure","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib182","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101015","article-title":"The role of dark adaptation in understanding early AMD","volume":"88","author":"Murray","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib183","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1523\/JNEUROSCI.18-07-02506.1998","article-title":"Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in m\u00fcller cells and fibrous astrocytes","volume":"18","author":"Nagelhus","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib184","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1167\/iovs.65.2.33","article-title":"Spatial analysis reveals vascular changes in retinal and choroidal vessel perfusion in intermediate AMD with reticular pseudodrusen","volume":"65","author":"Nam","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib185","series-title":"Investigative Ophthalmology & Visual Science","first-page":"PB0083","article-title":"Spatial optimisation of retinal thickness analyses for improved accuracy of diagnosing age-related macular degeneration (AMD)","author":"Nam","year":"2024"},{"key":"10.1016\/j.preteyeres.2026.101463_bib186","first-page":"2757","article-title":"Reticular pseudodrusen is associated with location-specific increased and decreased retinal vascular perfusion in intermediate AMD","volume":"64","author":"Nam","year":"2023","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib187","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jphs.2024.02.011","article-title":"Drug combination of topical ripasudil and brimonidine enhances neuroprotection in a mouse model of optic nerve injury","volume":"154","author":"Namekata","year":"2024","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib188","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1080\/07853890.2022.2066169","article-title":"New frontiers of retinal therapeutic intervention: a critical analysis of novel approaches","volume":"54","author":"Nanegrungsunk","year":"2022","journal-title":"Ann. Med."},{"key":"10.1016\/j.preteyeres.2026.101463_bib189","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1007\/s10792-023-02758-3","article-title":"Vessel density changes in choroid, chorio-capillaries, deep and superficial retinal plexuses on OCTA in normal ageing and various stages of age-related macular degeneration","volume":"43","author":"Narnaware","year":"2023","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib190","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1167\/iovs.65.2.42","article-title":"M\u00fcller glial cells in the macula: their activation and cell-cell interactions in age-related macular degeneration","volume":"65","author":"Navneet","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib191","first-page":"1183","article-title":"Synaptic patterns and response properties of bipolar and ganglion cells in the cat retina","volume":"23","author":"Nelson","year":"1983","journal-title":"Vis. Resour."},{"key":"10.1016\/j.preteyeres.2026.101463_bib192","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1167\/19.14.14","article-title":"Human visual steady-state responses to amplitude-modulated flicker: latency measurement","volume":"19","author":"Nguyen","year":"2019","journal-title":"J. Vis."},{"key":"10.1016\/j.preteyeres.2026.101463_bib193","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.preteyeres.2009.12.002","article-title":"The multifunction choroid","volume":"29","author":"Nickla","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib194","first-page":"1","article-title":"Retinal vessel diameters in intermediate age-related macular degeneration using en face optical coherence tomography","volume":"0","author":"Nivison-Smith","year":"2024","journal-title":"Clin. Exp. Optom."},{"key":"10.1016\/j.preteyeres.2026.101463_bib195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2017.10.008","article-title":"Vinpocetine protects inner retinal neurons with functional NMDA glutamate receptors against retinal ischemia","volume":"167","author":"Nivison-Smith","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib196","article-title":"Progressive vascular loss may precede neuronal thickness changes in the inner retina of intermediate AMD","author":"Nivison-Smith","year":"2025","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib197","series-title":"Investigative Ophthalmology & Visual Science","first-page":"2291","article-title":"Spatial distribution of perfusion and thickness changes of the inner retina is associated with conversion to late age-related macular degeneration","author":"Nivison-Smith","year":"2024"},{"key":"10.1016\/j.preteyeres.2026.101463_bib198","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.celrep.2019.12.082","article-title":"Integration of eQTL and a single-cell atlas in the human eye identifies causal genes for age-related macular degeneration","volume":"30","author":"Orozco","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.preteyeres.2026.101463_bib199","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3109\/02713683.2015.1011282","article-title":"Comparison of visual function in older eyes in the earliest stages of age-related macular degeneration to those in normal macular health","volume":"41","author":"Owsley","year":"2016","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.102030","article-title":"Quantitative analysis of inner retinal structural and microvascular alterations in intermediate age-related macular degeneration: a swept-source OCT angiography study","volume":"32","author":"Ozcaliskan","year":"2020","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.preteyeres.2026.101463_bib201","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.03.002","article-title":"The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: potential targets for neurotherapeutics","volume":"161","author":"Pajarillo","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.preteyeres.2026.101463_bib202","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013885","article-title":"Distinct signature of altered homeostasis in aging rod photoreceptors: implications for retinal diseases","volume":"5","author":"Parapuram","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.preteyeres.2026.101463_bib203","first-page":"A14","article-title":"Macular functional and morphological changes in intermediate age-related maculopathy","volume":"61","author":"Parisi","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib204","first-page":"527","article-title":"Artificial intelligence for early diagnosis of retinal diseases","volume":"60","author":"Parmar","year":"2024","journal-title":"Med. Kaunas Lith"},{"key":"10.1016\/j.preteyeres.2026.101463_bib205","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1469-7580.2005.00395.x","article-title":"Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures","volume":"206","author":"Patton","year":"2005","journal-title":"J. Anat."},{"key":"10.1016\/j.preteyeres.2026.101463_bib206","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.preteyeres.2008.05.001","article-title":"Vascular endothelial growth factor in eye disease","volume":"27","author":"Penn","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib207","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100907","article-title":"Fundus-controlled perimetry (microperimetry): application as outcome measure in clinical trials","volume":"82","author":"Pfau","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib208","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1167\/tvst.10.7.30","article-title":"Probabilistic forecasting of anti-VEGF treatment frequency in neovascular age-related macular degeneration","volume":"10","author":"Pfau","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib209","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108196","article-title":"A pathoconnectome of early neurodegeneration: network changes in retinal degeneration","volume":"199","author":"Pfeiffer","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib210","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.tem.2020.01.005","article-title":"M\u00fcller cell metabolic signatures: evolutionary conservation and disruption in disease","volume":"31","author":"Pfeiffer","year":"2020","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"10.1016\/j.preteyeres.2026.101463_bib211","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.07.004","article-title":"Persistent remodeling and neurodegeneration in late-stage retinal degeneration","volume":"74","author":"Pfeiffer","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib212","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exer.2016.04.022","article-title":"M\u00fcller cell metabolic chaos during retinal degeneration","volume":"150","author":"Pfeiffer","year":"2016","journal-title":"Exp. Eye Res., Special Issue: Cellular Remodel. Retina Optic Nerve Injury Dis."},{"key":"10.1016\/j.preteyeres.2026.101463_bib213","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2025.101353","article-title":"AI image generation technology in ophthalmology: use, misuse and future applications","author":"Phipps","year":"2025","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib214","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1167\/iovs.04-0253","article-title":"Flicker perimetry losses in age-related macular degeneration","volume":"45","author":"Phipps","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib215","series-title":"Webvision: the Organization of the Retina and Visual System","article-title":"Role of dopamine in retinal function","author":"Popova","year":"1995"},{"key":"10.1016\/j.preteyeres.2026.101463_bib216","series-title":"Neuroscience","article-title":"Anatomical distribution of rods and cones","author":"Purves","year":"2001"},{"key":"10.1016\/j.preteyeres.2026.101463_bib217","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/978-1-4419-1399-9_60","article-title":"Functional changes in inner retinal neurons in animal models of photoreceptor degeneration","volume":"664","author":"Puthussery","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib218","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1097\/IAE.0000000000002283","article-title":"Retinal arterial dilation is impaired in eyes with drusen and reticular pseudodrusen","volume":"39","author":"Rabiolo","year":"2019","journal-title":"Retina Phila. Pa"},{"key":"10.1016\/j.preteyeres.2026.101463_bib219","doi-asserted-by":"crossref","DOI":"10.3389\/fopht.2023.1296624","article-title":"Unlocking the role of lactate: Metabolic pathways, signaling, and gene regulation in postmitotic retinal cells","volume":"3","author":"Rajala","year":"2023","journal-title":"Front. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib220","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1006\/exer.2001.1061","article-title":"Changes of astrocytes in retinal ageing and age-related macular degeneration","volume":"73","author":"Ram\u00edrez","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib221","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.3389\/fimmu.2019.01975","article-title":"Microglia in retinal degeneration","volume":"10","author":"Rashid","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib222","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/glia.22477","article-title":"New functions of M\u00fcller cells","volume":"61","author":"Reichenbach","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.preteyeres.2026.101463_bib223","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.preteyeres.2017.12.001","article-title":"Neural control of choroidal blood flow","volume":"64","author":"Reiner","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib224","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1167\/iovs.18-26237","article-title":"Longitudinal association between drusen volume and retinal capillary perfusion in intermediate age-related macular degeneration","volume":"60","author":"Reiter","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib225","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1007\/s004170000202","article-title":"Changes of retinal capillary blood flow in age-related maculopathy","volume":"238","author":"Remsch","year":"2000","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib226","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3390\/biom11040581","article-title":"Use of gene therapy in retinal ganglion cell neuroprotection: current concepts and future directions","volume":"11","author":"Rhee","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.preteyeres.2026.101463_bib227","doi-asserted-by":"crossref","first-page":"E4520","DOI":"10.1073\/pnas.1303604110","article-title":"CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in M\u00fcller glial cells","volume":"110","author":"Rhee","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.preteyeres.2026.101463_bib228","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00417-013-2496-z","article-title":"Inner retinal layer comparisons of eyes with exudative age-related macular degeneration and eyes with age-related macular degeneration and glaucoma","volume":"252","author":"Rimayanti","year":"2014","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib229","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00154376","article-title":"Interrelationship between retinal ischaemic damage and turnover and metabolism of putative amino acid neurotransmitters, glutamate and GABA","volume":"80","author":"Robin","year":"1992","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib230","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.3390\/ijms19113688","article-title":"The question of a role for statins in age-related macular degeneration","volume":"19","author":"Roizenblatt","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib231","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jphs.2019.03.006","article-title":"Dopaminergic modulation of retinal processing from starlight to sunlight","volume":"140","author":"Roy","year":"2019","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib232","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ophtha.2017.09.028","article-title":"Consensus definition for atrophy associated with age-related macular degeneration on OCT: classification of atrophy report 3","volume":"125","author":"Sadda","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2026.101463_bib233","first-page":"667","article-title":"Hyperspectral retinal imaging biomarkers of ocular and systemic diseases","volume":"39","author":"Saeed","year":"2025","journal-title":"Eye Lond. Engl."},{"key":"10.1016\/j.preteyeres.2026.101463_bib234","doi-asserted-by":"crossref","first-page":"18751","DOI":"10.1073\/pnas.0905010106","article-title":"An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris","volume":"106","author":"Saint-Geniez","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.preteyeres.2026.101463_bib235","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.survophthal.2022.07.006","article-title":"Retinal and choroidal changes in AMD: a systematic review and meta-analysis of spectral-domain optical coherence tomography studies","volume":"68","author":"Salehi","year":"2022","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib236","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1167\/iovs.17-22712","article-title":"Structure-function analysis in patients with intermediate age-related macular degeneration","volume":"59","author":"Sassmannshausen","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib237","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/sj.eye.6701951","article-title":"Retinal haemodynamics in patients with age-related macular degeneration","volume":"20","author":"Sato","year":"2006","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib238","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1167\/iovs.13-12172","article-title":"Differential vulnerability of retinal layers to early age-related macular degeneration: evidence by SD-OCT segmentation analysis","volume":"55","author":"Savastano","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib239","series-title":"Retinal Vascular Disease","first-page":"167","article-title":"Retinal blood flow","author":"Schmetterer","year":"2007"},{"key":"10.1016\/j.preteyeres.2026.101463_bib240","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ophtha.2008.10.006","article-title":"Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography","volume":"116","author":"Schuman","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2026.101463_bib241","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.726792","article-title":"Gut microbiome in retina health: the crucial role of the gut-retina axis","volume":"12","author":"Scuderi","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib242","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/bs.ctdb.2018.02.005","article-title":"Basement membranes in development and disease","volume":"130","author":"Sekiguchi","year":"2018","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib243","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2023.100440","article-title":"Metformin for the minimization of geographic atrophy progression: a randomized trial","volume":"4","author":"Shen","year":"2024","journal-title":"Ophthalmol. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib244","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/IAE.0000000000001535","article-title":"Thickness of the macula, retinal nerve fibre layer, and ganglion cell-inner plexiform layer in age-related macular degeneration: the repeatability study of spectral domain optical coherence tomography","volume":"38","author":"Shin","year":"2018","journal-title":"Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib245","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000503295","article-title":"Characteristics of the foveal microvasculature in asian patients with dry age-related macular degeneration: an optical coherence tomography angiography study","volume":"243","author":"Shin","year":"2020","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.preteyeres.2026.101463_bib246","doi-asserted-by":"crossref","first-page":"901","DOI":"10.3390\/biom13060901","article-title":"The role of retinal pigment epithelial cells in age-related macular degeneration: phagocytosis and autophagy","volume":"13","author":"Si","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.preteyeres.2026.101463_bib247","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/eye.2008.206","article-title":"Macrophages in neovascular age-related macular degeneration: friends or foes?","volume":"23","author":"Skeie","year":"2009","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib248","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/jamaophthalmol.2018.2650","article-title":"Association between the cilioretinal artery and choroidal neovascularization in age-related macular degeneration: a secondary analysis from the age-related eye disease study","volume":"136","author":"Snyder","year":"2018","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib249","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ophtha.2019.11.004","article-title":"Consensus nomenclature for reporting neovascular age-related macular degeneration data: consensus on neovascular age-related macular degeneration nomenclature study group","volume":"127","author":"Spaide","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2026.101463_bib250","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041304","article-title":"A systematic review of optogenetic vision restoration: history, challenges, and new inventions from bench to bedside","volume":"13","author":"Stefanov","year":"2023","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.preteyeres.2026.101463_bib251","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1167\/iovs.02-0416","article-title":"Neuronal migration and glial remodeling in degenerating retinas of aged rats and in nonneovascular AMD","volume":"44","author":"Sullivan","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib252","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1167\/iovs.06-1283","article-title":"Dendritic and synaptic plasticity of neurons in the human age-related macular degeneration retina","volume":"48","author":"Sullivan","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib253","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/cne.21470","article-title":"Alterations in photoreceptor\u2010bipolar cell signaling following ischemia\/reperfusion in the rat retina","volume":"505","author":"Sun","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib254","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.22058","article-title":"The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse","volume":"516","author":"Sun","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib255","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nn.4288","article-title":"Pericytes of the neurovascular unit: key functions and signaling pathways","volume":"19","author":"Sweeney","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib256","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1364\/BOE.462568","article-title":"Optical analysis of M\u00fcller glia cells as light transporters through the retina","volume":"13","author":"Szab\u00f3","year":"2022","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.preteyeres.2026.101463_bib257","first-page":"800","article-title":"Mitoquinone intravitreal injection ameliorates retinal ischemia-reperfusion injury in rats involving SIRT1\/Notch1\/NADPH axis","volume":"83","author":"Tang","year":"2022","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib258","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.ophtha.2018.04.040","article-title":"Rho kinase inhibitors as a novel treatment for glaucoma and ocular hypertension","volume":"125","author":"Tanna","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2026.101463_bib259","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41433-023-02721-7","article-title":"The role of the retinal vasculature in age-related macular degeneration: a spotlight on OCTA","volume":"38","author":"Taylor","year":"2023","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib260","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.neuron.2019.02.015","article-title":"Retinoic acid induces hyperactivity, and blocking its receptor unmasks light responses and augments vision in retinal degeneration","volume":"102","author":"Telias","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.preteyeres.2026.101463_bib261","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.618019","article-title":"Degeneration-dependent retinal remodeling: looking for the molecular trigger","volume":"14","author":"Telias","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib262","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1097\/IAE.0000000000000603","article-title":"Effect of systemic beta-blockers, ace inhibitors, and angiotensin receptor blockers on development of choroidal neovascularization in patients with age-related macular degeneration","volume":"35","author":"Thomas","year":"2015","journal-title":"Retina Phila. Pa"},{"key":"10.1016\/j.preteyeres.2026.101463_bib263","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1038\/s41433-020-01298-9","article-title":"Progression of choriocapillaris flow deficits in clinically stable intermediate age-related macular degeneration","volume":"35","author":"Tiosano","year":"2021","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib264","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells10010064","article-title":"The impact of oxidative stress on blood-retinal barrier physiology in age-related macular degeneration","volume":"10","author":"Tisi","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.preteyeres.2026.101463_bib265","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3390\/antiox10050653","article-title":"Oxidative and nitrosative stress in age-related macular degeneration: a review of their role in different stages of disease","volume":"10","author":"Toma","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.preteyeres.2026.101463_bib266","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75599-0","article-title":"Custom extraction of macular ganglion cell-inner plexiform layer thickness more precisely co-localizes structural measurements with visual fields test grids","volume":"10","author":"Tong","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2026.101463_bib267","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/cne.25483","article-title":"Derivation of human retinal cell densities using high-density, spatially localized optical coherence tomography data from the human retina","volume":"531","author":"Tong","year":"2023","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib268","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2024.109877","article-title":"Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in choroidal neovascularization model","volume":"242","author":"Tong","year":"2024","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib269","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1097\/IAE.0000000000000962","article-title":"Retinal vascular plexuses' changes in dry age-related macular degeneration, evaluated by means of optical coherence tomography angiography","volume":"36","author":"Toto","year":"2016","journal-title":"Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib270","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8210599","article-title":"Relationship of retinal vessel caliber with age-related macular degeneration","volume":"2022","author":"Toulouie","year":"2022","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib271","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fncel.2015.00277","article-title":"Origins of spontaneous activity in the degenerating retina","volume":"9","author":"Trenholm","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib272","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1167\/iovs.67.2.34","article-title":"Inner retinal reflectivity loss and concurrent thickening predict short-term conversion to neovascular AMD","volume":"67","author":"Trinh","year":"2026","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib273","first-page":"553","article-title":"Prognostic biomarkers for progression to late age-related macular degeneration: a systematic review and meta-analysis. Ophthalmol","volume":"8","author":"Trinh","year":"2024","journal-title":"Retina"},{"key":"10.1016\/j.preteyeres.2026.101463_bib274","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/iovs.63.11.12","article-title":"Reticular pseudodrusen are associated with more advanced para-central photoreceptor degeneration in intermediate age-related macular degeneration","volume":"63","author":"Trinh","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib275","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/tvst.12.9.6","article-title":"Spatial cluster patterns of retinal sensitivity loss in intermediate age-related macular degeneration features","volume":"12","author":"Trinh","year":"2023","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib276","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1167\/iovs.63.5.36","article-title":"High-density optical coherence tomography analysis provides insights into early\/intermediate age-related macular degeneration retinal layer changes","volume":"63","author":"Trinh","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib277","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1038\/s41433-024-03033-0","article-title":"Retinal sensitivity changes in early\/intermediate AMD: a systematic review and meta-analysis of visual field testing under mesopic and scotopic lighting","volume":"38","author":"Trinh","year":"2024","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib278","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/opo.12919","article-title":"Should clinical automated perimetry be considered for routine functional assessment of early\/intermediate age-related macular degeneration (AMD)? A systematic review of current literature","volume":"42","author":"Trinh","year":"2022","journal-title":"Ophthalmic Physiol. Opt."},{"key":"10.1016\/j.preteyeres.2026.101463_bib279","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.62.4.2","article-title":"Radial peripapillary capillary plexus sparing and underlying retinal vascular impairment in intermediate age-related macular degeneration","volume":"62","author":"Trinh","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib280","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1167\/tvst.8.4.20","article-title":"Vascular changes in intermediate age-related macular degeneration quantified using optical coherence tomography angiography","volume":"8","author":"Trinh","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib281","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/iovs.62.13.13","article-title":"Location-specific thickness patterns in intermediate age-related macular degeneration reveals anatomical differences in multiple retinal layers","volume":"62","author":"Trinh","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib282","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/tvst.13.3.22","article-title":"OCTA signal quality augmentation using the isometric handgrip test to maximize vascular flow (SQUEEZE): a randomized crossover trial","volume":"13","author":"Trinh","year":"2024","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib283","article-title":"Decoupling longitudinal changes in reflectivity and thickness across retinal layers in intermediate AMD","author":"Trinh","year":"2025","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib284","doi-asserted-by":"crossref","DOI":"10.1111\/opo.13362","article-title":"Linking physiology and demographics, non-ocular pathology and pharmaceutical drug use to standard OCT measures of the inner retina: the PPP project","author":"Trinh","year":"2024","journal-title":"Ophthalmic Physiol. Opt. J. Br. Coll. Ophthalmic Opt. Optom."},{"key":"10.1016\/j.preteyeres.2026.101463_bib285","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40662-025-00459-9","article-title":"Localising OCTA changes induced by the isometric hand-grip test to the superficial retina in neovascular age-related macular degeneration","volume":"12","author":"Trinh","year":"2025","journal-title":"Eye Vis."},{"key":"10.1016\/j.preteyeres.2026.101463_bib286","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.61.3.2","article-title":"Macula ganglion cell thickness changes display location-specific variation patterns in intermediate age-related macular degeneration","volume":"61","author":"Trinh","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib287","article-title":"Peripapillary and macular microvasculature in neovascular age-related macular degeneration in long-term and recently started anti-VEGF therapy versus healthy controls","volume":"9","author":"T\u00fcrksever","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.preteyeres.2026.101463_bib288","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/APO.0000000000000278","article-title":"Quantification of optical coherence tomography angiography in age and age-related macular degeneration using vessel density analysis","volume":"9","author":"Vaghefi","year":"2020","journal-title":"Asia-Pac. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib289","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.05.001","article-title":"Voltage- and calcium-gated ion channels of neurons in the vertebrate retina","volume":"72","author":"Van Hook","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib290","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ajo.2024.04.024","article-title":"Alterations of the ganglion cell complex in age-related macular degeneration: an Amish eye study analysis","volume":"265","author":"Velaga","year":"2024","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib291","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.656000","article-title":"A metabolic landscape for maintaining retina integrity and function","volume":"14","author":"Viegas","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib292","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/aos.15767","article-title":"Epidemiology of geographic atrophy and its precursor features of intermediate age-related macular degeneration","volume":"101","author":"Vujosevic","year":"2023","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib293","article-title":"Extracting full information from OCT scans-signs of early age-related macular degeneration within inner retinal layers by local neighbourhood statistics. Part II: results","author":"Wagner","year":"2024","journal-title":"Ophthalmic Physiol. Opt. J. Br. Coll. Ophthalmic Opt. Optom."},{"key":"10.1016\/j.preteyeres.2026.101463_bib294","article-title":"Extracting full information from OCT scans-signs of early age-related macular degeneration within inner retinal layers by local neighbourhood statistics. Part I: methodology","author":"Wagner","year":"2024","journal-title":"Ophthalmic Physiol. Opt. J. Br. Coll. Ophthalmic Opt. Optom."},{"key":"10.1016\/j.preteyeres.2026.101463_bib295","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s004170050331","article-title":"Electrophysiological abnormalities in age-related macular degeneration","volume":"237","author":"Walter","year":"1999","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib296","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1136\/bjo.88.1.104","article-title":"Retinal vessel wall signs and the 5 year incidence of age related maculopathy: the Blue Mountains eye study","volume":"88","author":"Wang","year":"2004","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib297","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.preteyeres.2010.11.001","article-title":"The cone-specific visual cycle","volume":"30","author":"Wang","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib298","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jconrel.2017.10.031","article-title":"Injectable hydrogels for ophthalmic applications","volume":"268","author":"Wang","year":"2017","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.preteyeres.2026.101463_bib299","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.fmre.2023.08.011","article-title":"The retinal pigment epithelium: functions and roles in ocular diseases","volume":"4","author":"Wang","year":"2024","journal-title":"Fundam. Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib300","article-title":"Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseases","volume":"2","author":"Wang","year":"2022","journal-title":"Cell Genom."},{"key":"10.1016\/j.preteyeres.2026.101463_bib301","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1017\/S1740925X05000049","article-title":"Contribution of M\u00fcller cells toward the regulation of photoreceptor outer segment assembly","volume":"1","author":"Wang","year":"2004","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib302","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1152\/physrev.1991.71.2.447","article-title":"Functional architecture of the mammalian retina","volume":"71","author":"W\u00e4ssle","year":"1991","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.preteyeres.2026.101463_bib303","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3390\/ijms24010402","article-title":"Examination of inner retinal layers in unilateral wet age-related macular degeneration treated with anti-vegf, compared to fellow untreated eyes","volume":"24","author":"Wichrowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib304","doi-asserted-by":"crossref","DOI":"10.1172\/JCI178296","article-title":"Complement regulation in the eye: implications for age-related macular degeneration","volume":"134","author":"Wilke","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.preteyeres.2026.101463_bib305","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1009599","article-title":"Exploring the pathogenesis of age-related macular degeneration: a review of the interplay between retinal pigment epithelium dysfunction and the innate immune system","volume":"16","author":"Wong","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib306","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1136\/bjo.87.9.1159","article-title":"Differential expression of GFAP in early v late AMD: a quantitative analysis","volume":"87","author":"Wu","year":"2003","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib307","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.ajpath.2023.04.006","article-title":"The emerging role of gut microbiota in age-related macular degeneration","volume":"193","author":"Xiao","year":"2023","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib308","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00417-011-1824-4","article-title":"Association of dilated retinal arteriolar caliber with early age-related macular degeneration: the Handan eye study","volume":"250","author":"Yang","year":"2012","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib309","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.4103\/1673-5374.133169","article-title":"The development of blood-retinal barrier during the interaction of astrocytes with vascular wall cells","volume":"9","author":"Yao","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.preteyeres.2026.101463_bib310","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/eye.2015.86","article-title":"Ganglion cell complex thickness in nonexudative age-related macular degeneration","volume":"29","author":"Yenice","year":"2015","journal-title":"Eye"},{"key":"10.1016\/j.preteyeres.2026.101463_bib311","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1038\/s41598-019-41509-2","article-title":"Vascular response to sildenafil citrate in aging and age-related macular degeneration","volume":"9","author":"Yiu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2026.101463_bib312","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ajo.2019.09.004","article-title":"Detection of reduced retinal vessel density in eyes with geographic atrophy secondary to age-related macular degeneration using projection-resolved optical coherence tomography angiography","volume":"209","author":"You","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib313","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1167\/iovs.15-16431","article-title":"The project MACULA retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degeneration","volume":"56","author":"Zanzottera","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib314","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.ophtha.2022.02.001","article-title":"Photoreceptor layer thinning is an early biomarker for age-related macular degeneration: epidemiologic and genetic evidence from UK biobank OCT data","volume":"129","author":"Zekavat","year":"2022","journal-title":"Ophthalmology"},{"key":"10.1016\/j.preteyeres.2026.101463_bib315","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1073\/pnas.1018987108","article-title":"Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration","volume":"108","author":"Zhang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.preteyeres.2026.101463_bib316","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1167\/iovs.17-22953","article-title":"A novel strategy for quantifying choriocapillaris flow voids using swept-source OCT angiography","volume":"59","author":"Zhang","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib317","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.2174\/0929867324666170801100516","article-title":"Therapeutic potential of co-enzyme q10 in retinal diseases","volume":"24","author":"Zhang","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.preteyeres.2026.101463_bib318","first-page":"1132","article-title":"Crosstalk between microglia and m\u00fcller glia in the age-related macular degeneration: role and therapeutic value of neuroinflammation","volume":"15","author":"Zhao","year":"2024","journal-title":"Aging Dis."},{"key":"10.1016\/j.preteyeres.2026.101463_bib319","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1186\/s12886-023-03203-w","article-title":"Retinal layers changes in patients with age-related macular degeneration treated with intravitreal anti-VEGF agents","volume":"23","author":"Zhou","year":"2023","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib320","doi-asserted-by":"crossref","first-page":"e1479","DOI":"10.1111\/aos.15157","article-title":"Association of cigarette smoking with retinal capillary plexus: an optical coherence tomography angiography study","volume":"100","author":"Zhu","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib321","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1017\/S0952523813000047","article-title":"Mapping cation entry in photoreceptors and inner retinal neurons during early degeneration in the P23H-3 rat retina","volume":"30","author":"Zhu","year":"2013","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.preteyeres.2026.101463_bib322","doi-asserted-by":"crossref","DOI":"10.1038\/srep40826","article-title":"Association of the intestinal microbiome with the development of neovascular age-related macular degeneration","volume":"7","author":"Zinkernagel","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.preteyeres.2026.101463_bib323","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ajo.2015.05.030","article-title":"Macular ganglion cell complex and retinal nerve fiber layer comparison in different stages of age-related macular degeneration","volume":"160","author":"Zucchiatti","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.preteyeres.2026.101463_bib324","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41525-020-00141-0","article-title":"Associations of the intestinal microbiome with the complement system in neovascular age-related macular degeneration","volume":"5","author":"Zysset-Burri","year":"2020","journal-title":"NPJ Genomic Med."}],"container-title":["Progress in Retinal and Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946226000297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350946226000297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T02:44:30Z","timestamp":1779504270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350946226000297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":324,"alternative-id":["S1350946226000297"],"URL":"https:\/\/doi.org\/10.1016\/j.preteyeres.2026.101463","relation":{},"ISSN":["1350-9462"],"issn-type":[{"value":"1350-9462","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inner-retinal changes in AMD: Evidence, mechanisms, and future perspectives","name":"articletitle","label":"Article Title"},{"value":"Progress in Retinal and Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.preteyeres.2026.101463","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101463"}}