{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:20:03Z","timestamp":1791278403618,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Preventive Veterinary Medicine"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.prevetmed.2006.05.015","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T12:45:50Z","timestamp":1163767550000},"page":"97-117","source":"Crossref","is-referenced-by-count":69,"title":["A stochastic model simulating paratuberculosis in a dairy herd"],"prefix":"10.1016","volume":"78","author":[{"given":"Anne Braad","family":"Kudahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"\u00d8stergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Tind","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Saxmose","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prevetmed.2006.05.015_bib1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/vr.121.7.142","article-title":"Economic losses due to paratuberculosis in dairy cattle","volume":"121","author":"Benedictus","year":"1987","journal-title":"Vet. Rec."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib2","series-title":"Proc. 102nd Annual Meeting of the United States Animal Health Association","first-page":"420","article-title":"U.S. voluntary johne's disease herd status program for cattle","author":"Bulaga","year":"1998"},{"key":"10.1016\/j.prevetmed.2006.05.015_bib3","first-page":"218","article-title":"Ruminant paratuberculosis (Johne's disease): the current status and future prospects","volume":"74","author":"Chiodini","year":"1984","journal-title":"Cornell Vet."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0882-4010(92)90012-D","article-title":"The cellular immunology of bovine paratuberculosis: the predominant response is mediated by cytotoxic gamma\/delta T lymphocytes which prevent CD4+ activity","volume":"13","author":"Chiodini","year":"1992","journal-title":"Microb. Pathogenesis"},{"key":"10.1016\/j.prevetmed.2006.05.015_bib5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/mpat.1993.1035","article-title":"The cellular immunology of bovine paratuberculosis: immunity may be regulated by CD4+ helper and CD8+ immunoregulatory T lymphocytes which down regulate gamma\/delta T-cell cytotoxicity","volume":"14","author":"Chiodini","year":"1993","journal-title":"Microb. Pathogenesis"},{"key":"10.1016\/j.prevetmed.2006.05.015_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0167-5877(05)80035-2","article-title":"Epidemiological model of paratuberculosis in dairy cattle","volume":"11","author":"Collins","year":"1991","journal-title":"Prev. Vet. Med."},{"issue":"12","key":"10.1016\/j.prevetmed.2006.05.015_bib7","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.2460\/javma.1991.199.12.1724","article-title":"Economic decision analysis model of a paratuberculosis test-and-cull program","volume":"199","author":"Collins","year":"1991","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0167-5877(92)90081-P","article-title":"Simulation model of paratuberculosis control in a dairy herd","volume":"14","author":"Collins","year":"1992","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib9","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1128\/JCM.38.12.4373-4381.2000","article-title":"Results of multiple diagnostic tests for Mycobacterium avium subsp. paratuberculosis in patients with inflammatory bowel disease and controls","volume":"38","author":"Collins","year":"2000","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib10","first-page":"238","article-title":"Fetal infection in Johne's disease","volume":"70","author":"Doyle","year":"1958","journal-title":"Vet. Rec."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib11","unstructured":"Groenendaal, H., Galligan, D.T., 1999. Economical consequences of Johne's disease control programs. Center of Animal Health and Productivity. Technical Report. School of Veterinary Medicine, University of Pennsylvania. http:\/\/cahpwww.vet.upenn.edu\/field\/johne_report.pdf"},{"key":"10.1016\/j.prevetmed.2006.05.015_bib12","doi-asserted-by":"crossref","unstructured":"Groenendaal, H., Galligan, D.T., 2003. Economical consequences of Johne's disease control programs on mid-size dairy farms in the US. JAVMA, 15 December.","DOI":"10.2460\/javma.2003.223.1757"},{"key":"10.1016\/j.prevetmed.2006.05.015_bib13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0167-5877(02)00027-2","article-title":"A simulation of Johne's disease control","volume":"54","author":"Groenendaal","year":"2002","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0167-5877(03)00083-7","article-title":"Development of the Dutch Johne's disease control program supported by a simulation model","volume":"60","author":"Groenendaal","year":"2003","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib15","first-page":"1","article-title":"Milk fever and subclinical hypocalcemia. An evaluation of parameters on risk, diagnosis, risk factors, and biological effects as input for a decision support system for disease control","volume":"42","author":"Houe","year":"2001","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0749-0720(15)30412-6","article-title":"Economic impact of paratuberculosis","volume":"12","author":"Hutchinson","year":"1996","journal-title":"Vet. Clin. N. Am. Food Anim. Pract."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0167-5877(00)00145-8","article-title":"The effect of subclinical Mycobacterium paratuberculosis infection on days open in Michigan, USA, dairy cows","volume":"46","author":"Johnson-Ifearulundu","year":"2000","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib18","first-page":"18","article-title":"On farm management of paratuberculosis (Johne's disease) in dairy herds","volume":"362","author":"Kennedy","year":"2001","journal-title":"Bull. Int. Dairy Federation"},{"key":"10.1016\/j.prevetmed.2006.05.015_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.prevetmed.2003.11.008","article-title":"Relationship between antibodies against Mycobacterium avium subsp. paratuberculosis in milk and shape of lactation curves","volume":"62","author":"Kudahl","year":"2004","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib20","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.3168\/jds.S0022-0302(04)70029-6","article-title":"Genetic variation and heritability of the antibody response to Mycobacterium avium subsp. paratuberculosis in Danish Holstein Cows","volume":"87","author":"Mortensen","year":"2004","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0167-5877(01)00280-X","article-title":"Maximum-likelihood estimation of sensitivity and specificity of ELISAs and faecal culture for diagnosis of paratuberculosis","volume":"53","author":"Nielsen","year":"2002","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib22","series-title":"Proceedings of the Seventh International Colloquium on Paratuberculosis","first-page":"400","article-title":"Optimisation of the validity of ELISA and faecal culture test for paratuberculosis: selection of population or correction by population characteristics?","author":"Nielsen","year":"2002"},{"key":"10.1016\/j.prevetmed.2006.05.015_bib23","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3168\/jds.S0022-0302(06)72120-8","article-title":"Age-specific characteristics of ELISA and fecal culture for purposive testing for paratuberculosis","volume":"89","author":"Nielsen","year":"2006","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib24","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.2460\/javma.1996.208.11.1872","article-title":"Association between subclinical paratuberculosis and milk production, milk components and somatic cell count in dairy herds","volume":"208","author":"Nordlund","year":"1996","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib25","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3168\/jds.S0022-0302(00)74934-4","article-title":"A stochastic model simulating the feeding-health-production complex in a dairy herd","volume":"83","author":"\u00d8stergaard","year":"2000","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0167-5877(03)00049-7","article-title":"A stochastic model simulating milk fever in a dairy herd","volume":"58","author":"\u00d8stergaard","year":"2003","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib27","unstructured":"\u00d8stergaard S., S\u00f8rensen, J.T., Enevoldsen, C., 2004. Simherd III: User's Manual. PC Programmes for simulation and analysis of production and health in the dairy herd. Internal Report no. 209. October 2004. Danish Institute of Agricultural sciences, PO Box 50, DK-8830 Tjele, Denmark. www.agrsci.dk"},{"key":"10.1016\/j.prevetmed.2006.05.015_bib28","first-page":"1423","article-title":"Bovine fetal infection with Mycobacterium paratuberculosis","volume":"194","author":"Seitz","year":"1989","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib29","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0378-1135(00)00331-X","article-title":"Transitions in immune response to Mycobacterium paratuberculsosis","volume":"77","author":"Stabel","year":"2000","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib30","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.2460\/ajvr.1995.56.10.1322","article-title":"Isolation of Mycobacterium avium subsp. paratuberculosis from colostrums and milk of subclinically infected cows","volume":"56","author":"Streeter","year":"1995","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2460\/ajvr.1991.53.04.477","article-title":"Mycobacterium paratuberculosis isolated from foetuses of infected cows not manifesting signs of the disease","volume":"53","author":"Sweeney","year":"1992","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib32","series-title":"Proc. 4th Int. Colloquium on PTB","first-page":"133","article-title":"Effect of Mycobacterium paratuberculosis infection on milk production in dairy cattle","author":"Sweeney","year":"1994"},{"key":"10.1016\/j.prevetmed.2006.05.015_bib33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0167-5877(94)00436-M","article-title":"A stochastic model for simulation of the economic consequences of bovine virus diarrhroea virus infection in a dairy herd","volume":"23","author":"S\u00f8rensen","year":"1995","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0308-521X(92)90107-Y","article-title":"A stochastic model simulating the dairy herd on a PC","volume":"39","author":"S\u00f8rensen","year":"1992","journal-title":"Agric. Syst."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib35","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0368-1742(53)80037-8","article-title":"Experimental Johne's disease in cattle","volume":"63","author":"Taylor","year":"1953","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib36","unstructured":"Walker, K., French, J.J., Kliebenstein, J., McCamley, F., Headley, J.C., Belyea, R., 1988. An Economic and Epidemiologic Simulation Model of Paratuberculosis (Johne's Disease) in Dairy Herds. Part I. The Analytical Model. Columbia, Department of Agricultural Economics, University of Missouri-Columbia, MO, pp. 1\u2013137."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prevetmed.2003.11.006","article-title":"Simulation of alternatives for the Dutch Johne's disease certification-and-monitoring program","volume":"62","author":"Weber","year":"2004","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib38","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-0720(15)30410-2","article-title":"Preclinical and clinical manifastation of paratuberculosis (including pathology)","volume":"12","author":"Whitlock","year":"1996","journal-title":"Vet. Clin. N. Am. Food. Anim. pract."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib39","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0378-1135(00)00324-2","article-title":"ELISA and faecal culture for paratuberculosis (Johne's disease): sensitivity and specificity of each method","volume":"77","author":"Whitlock","year":"2000","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib40","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.2460\/ajvr.1993.54.11.1851","article-title":"Association of Mycobacterium paratuberculosis infection with reduced mastitis, but with decreased milk production and increased cull rate in clinically normal dairy cows","volume":"54","author":"Wilson","year":"1993","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.prevetmed.2006.05.015_bib41","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.dci.2004.10.004","article-title":"Kinetics and distribution of bovine **T-lymphocyte in the intestine: **T cells accumulate in the dome region of Peyer's patch during prenatal development","volume":"29","author":"Yasuda","year":"2005","journal-title":"Dev. Comp. Imm."}],"container-title":["Preventive Veterinary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167587706002212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167587706002212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T09:49:25Z","timestamp":1707385765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167587706002212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0167587706002212"],"URL":"https:\/\/doi.org\/10.1016\/j.prevetmed.2006.05.015","relation":{},"ISSN":["0167-5877"],"issn-type":[{"value":"0167-5877","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}