{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:43:32Z","timestamp":1785343412790,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Preventive Veterinary Medicine"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.prevetmed.2016.08.006","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T12:49:41Z","timestamp":1472474981000},"page":"83-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Correlations between peripheral parasite load and common clinical and laboratory alterations in dogs with visceral leishmaniasis"],"prefix":"10.1016","volume":"132","author":[{"given":"R.B.P.","family":"Torrecilha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.T.","family":"Utsunomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Bosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.F.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.P.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.G.","family":"Narciso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.C.M.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Baptistiolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Calvo-Bado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Courtenay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.M.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.C.","family":"Ciarlini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prevetmed.2016.08.006_bib0005","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/hep.23717","article-title":"Association between serum uric acid level and chronic liver disease in the United States","volume":"52","author":"Afzali","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0010","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.vetpar.2013.02.016","article-title":"Neutrophil dysfunction varies with the stage of canine visceral leishmaniosis","volume":"196","author":"Almeida","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0015","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.tvjl.2013.08.024","article-title":"Leishmaniasis causes oxidative stress and alteration of oxidative metabolism and viability of neutrophils in dogs","volume":"198","author":"Almeida","year":"2013","journal-title":"Vet. J."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0020","first-page":"147","article-title":"Distribution and relationships between clinical and biopathological parameters in","author":"Amusategui","year":"2003","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.freeradbiomed.2011.05.011","article-title":"Leishmania?macrophage interactions: insights into the redox biology","volume":"51","author":"Assche","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0030","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1442-200x.2005.02137.x","article-title":"Decreased total antioxidant capacity and increased oxidative stress in passive smoker infants and their mothers","volume":"47","author":"Aycicek","year":"2005","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0035","doi-asserted-by":"crossref","first-page":"e1596","DOI":"10.1371\/journal.pntd.0001596","article-title":"Canine skin and conjunctival swab samples for the detection and quantification of Leishmania infantum DNA in an endemic urban area in Brazil","volume":"6","author":"de Almeida Ferreira","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0040","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","article-title":"A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation","volume":"37","author":"Erel","year":"2004","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0045","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A new automated colorimetric method for measuring total oxidant status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2013.07.018","article-title":"Pathways of iron acquisition and utilization in Leishmania","author":"Flannery","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0055","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.vetpar.2006.01.011","article-title":"Advantages of real-time PCR assay for diagnosis and monitoring of canine leishmaniosis","volume":"137","author":"Francino","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0060","doi-asserted-by":"crossref","unstructured":"Giunchetti R.C., Mayrink W., Martins-filho O.A., Jose M., Corre R., Tafuri W.L., Reis A.B., 2008. Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis, \u0301 84, 269\u2013277. 10.1016\/j.rvsc.2007.04.020.","DOI":"10.1016\/j.rvsc.2007.04.020"},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0065","article-title":"Nonregenerative anemia: mechanisms of decreased or ineffective erythropoiesis","volume":"52","author":"Grimes","year":"2014","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0070","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/BF00988606","article-title":"Lipid peroxidation products and antioxidant proteins in plasma and cerebrospinal fluid from multiple sclerosis patients","volume":"10","author":"Hunter","year":"1985","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0075","series-title":"Schalm\u2019s Veterinary Hematology","author":"Jain","year":"1986"},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0080","series-title":"Clinical Biochemistry of Domestic Animals","author":"Kaneko","year":"1997"},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0085","doi-asserted-by":"crossref","first-page":"e59509","DOI":"10.1371\/journal.pone.0059509","article-title":"Leishmania donovani infection induces anemia in hamsters by differentially altering erythropoiesis in bone marrow and spleen","volume":"8","author":"Lafuse","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0090","first-page":"36","article-title":"Anti-Leishmania antibodies in cerebrospinal fluid from dogs with visceral leishmaniasis","author":"Lima","year":"2003","journal-title":"Med. Biol."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0095","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.vetpar.2011.08.010","article-title":"Detection of Leishmania infantum DNA by real-time PCR in canine oral and conjunctival swabs and comparison with other diagnostic techniques","volume":"184","author":"Lombardo","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0100","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.rvsc.2008.12.009","article-title":"Evidence for a relationship between Leishmania load and clinical manifestations","volume":"87","author":"Manna","year":"2009","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0105","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1365-2613.2009.00681.x","article-title":"Hepatic extracellular matrix alterations in dogs naturally infected with Leishmania (Leishmania) chagasi","volume":"90","author":"Melo","year":"2009","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0110","unstructured":"Mogami, S.R., 2008. Hematological evaluation of dogs naturally infected by 68\u201374."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082947","article-title":"Clinical forms of canine visceral leishmaniasis in naturally Leishmania infantum-infected dogs and related myelogram and hemogram changes","volume":"8","author":"Nicolato","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0120","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.freeradbiomed.2009.05.032","article-title":"Lipid peroxidation: physiological levels and dual biological effects","volume":"47","author":"Niki","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0125","first-page":"2931","article-title":"Detection of Leishmania infantum in dogs by PCR with lymph node aspirates and blood","volume":"37","author":"Reale","year":"1999","journal-title":"J. Clin."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0130","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.rvsc.2005.09.011","article-title":"Parasite density and impaired biochemical\/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis","volume":"81","author":"Reis","year":"2006","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2009.05.022","article-title":"Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis","volume":"165","author":"Solano-Gallego","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0140","first-page":"4","article-title":"LeishVet guidelines for the practical management of canine leishmaniosis","author":"Solano-Gallego","year":"2011","journal-title":"Parasite & Vectors"},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0145","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.vetpar.2011.08.026","article-title":"Qualitative and quantitative polymerase chain reaction (PCR) for detection of Leishmania in spleen samples from naturally infected dogs","volume":"184","author":"Solc\u00e0","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0150","unstructured":"Tryphonas, L., Zawidzka, Z., Bernard, M.A., Janzen, E.A., 1977. Visceral Leishmaniasis in a Dog: Clinical Hematological and Pathological Observations, 41 1\u201312."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0155","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF02869152","article-title":"Biochemical diagnosis of liver disease","volume":"14","author":"Wolf","year":"1999","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.prevetmed.2016.08.006_bib0160","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.4049\/jimmunol.173.11.6521","article-title":"Cutting edge: neutrophil granulocyte serves as a vector for leishmania entry into macrophages","volume":"173","author":"Zandbergen","year":"2004","journal-title":"J. Immunol."}],"container-title":["Preventive Veterinary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167587716302847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167587716302847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T05:40:37Z","timestamp":1566452437000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167587716302847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":32,"alternative-id":["S0167587716302847"],"URL":"https:\/\/doi.org\/10.1016\/j.prevetmed.2016.08.006","relation":{},"ISSN":["0167-5877"],"issn-type":[{"value":"0167-5877","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correlations between peripheral parasite load and common clinical and laboratory alterations in dogs with visceral leishmaniasis","name":"articletitle","label":"Article Title"},{"value":"Preventive Veterinary Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prevetmed.2016.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}