{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:59:05Z","timestamp":1790233145405,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Prostate International"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.prnil.2026.04.005","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:50:03Z","timestamp":1777942203000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathologic profile of Filipino men with low-risk prostate cancer and predictors of unfavorable pathology at radical prostatectomy"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4407-2108","authenticated-orcid":false,"given":"Pia N.A.","family":"Duque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prnil.2026.04.005_bib1","unstructured":"International Agency for Research on Cancer. Cancer over time [Internet]. Lyon (FR): International Agency for Research on Cancer; [cited 2024 Feb 20]. Available from: https:\/\/qco.iarc.who.int\/today."},{"key":"10.1016\/j.prnil.2026.04.005_bib2","series-title":"Philippines fact sheet: cancer today (GLOBOCAN 2020)","year":"2020"},{"key":"10.1016\/j.prnil.2026.04.005_bib3","series-title":"NCCN clinical practice guidelines in oncology: prostate cancer. Version 4.2026","year":"2026"},{"issue":"3","key":"10.1016\/j.prnil.2026.04.005_bib4","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.eururo.2015.06.046","article-title":"A contemporary prostate cancer grading system: a validated alternative to the gleason score","volume":"69","author":"Epstein","year":"2016","journal-title":"Eur Urol"},{"issue":"3","key":"10.1016\/j.prnil.2026.04.005_bib5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.eururo.2016.11.028","article-title":"Extraprostatic extension is extremely rare for contemporary gleason score 6 prostate cancer","volume":"72","author":"Anderson","year":"2017","journal-title":"Eur Urol"},{"issue":"9","key":"10.1016\/j.prnil.2026.04.005_bib6","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1097\/PAS.0b013e3182556dcd","article-title":"Do adenocarcinomas of the prostate with Gleason score \u22646 have the potential to metastasize to lymph nodes?","volume":"36","author":"Ross","year":"2012","journal-title":"Am J Surg Pathol"},{"issue":"30","key":"10.1016\/j.prnil.2026.04.005_bib7","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1200\/JCO.2015.62.5764","article-title":"Intermediate and longer-term outcomes from a prospective active-surveillance program for favorable-risk prostate cancer","volume":"33","author":"Tosoian","year":"2015","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.prnil.2026.04.005_bib8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJMoa1209978","article-title":"Long-term functional outcomes after treatment for localized prostate cancer","volume":"368","author":"Resnick","year":"2013","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.prnil.2026.04.005_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/JU.0000000000003454","article-title":"Risk stratification of low-risk prostate cancer: individualizing care in the era of active surveillance","volume":"210","author":"Ho","year":"2023","journal-title":"J Urol"},{"issue":"2","key":"10.1016\/j.prnil.2026.04.005_bib10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.21037\/tau.2018.03.02","article-title":"Active surveillance review: contemporary selection criteria, follow-up, compliance and outcomes","volume":"7","author":"Komisarenko","year":"2018","journal-title":"Transl Androl Urol"},{"issue":"2","key":"10.1016\/j.prnil.2026.04.005_bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.prnil.2025.12.004","article-title":"Active surveillance could apply to one-quarter of Korean prostate cancer cases: insights from a 27,075-patient cohort","volume":"14","author":"Ko","year":"2026","journal-title":"Prostate Int"},{"key":"10.1016\/j.prnil.2026.04.005_bib12","series-title":"Protocol for the examination of radical prostatectomy specimens from patients with carcinoma of the prostate gland","year":"2023"},{"issue":"5","key":"10.1016\/j.prnil.2026.04.005_bib13","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.urology.2008.10.048","article-title":"Biopsy core number represents one of the foremost predictors of clinically significant Gleason sum upgrading in patients with low-risk prostate cancer","volume":"73","author":"Capitanio","year":"2009","journal-title":"Urology"},{"issue":"5","key":"10.1016\/j.prnil.2026.04.005_bib14","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.eururo.2012.01.050","article-title":"Upgrading and downgrading of prostate cancer from biopsy to radical prostatectomy: incidence and predictive factors using the modified Gleason grading system and factoring in tertiary grades","volume":"61","author":"Epstein","year":"2012","journal-title":"Eur Urol"},{"issue":"2","key":"10.1016\/j.prnil.2026.04.005_bib15","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.juro.2015.02.015","article-title":"Incidence and predictors of upgrading and up staging among 10,000 contemporary patients with low risk prostate cancer","volume":"194","author":"Dinh","year":"2015","journal-title":"J Urol"},{"issue":"10","key":"10.1016\/j.prnil.2026.04.005_bib16","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1007\/s11255-022-03250-0","article-title":"Adverse upgrading and\/or upstaging in contemporary low-risk prostate cancer patients","volume":"54","author":"Flammia","year":"2022","journal-title":"Int Urol Nephrol"},{"issue":"2","key":"10.1016\/j.prnil.2026.04.005_bib17","first-page":"11059","article-title":"Increasing rate of pathologic upgrading in low risk prostate cancer patients in the active surveillance era","volume":"29","author":"Davaro","year":"2022","journal-title":"Can J Urol"},{"issue":"1","key":"10.1016\/j.prnil.2026.04.005_bib18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/JU.0000000000002956","article-title":"Gleason grade 1 prostate cancer volume at biopsy is associated with upgrading but not adverse pathology or recurrence after radical prostatectomy","volume":"209","author":"Shee","year":"2023","journal-title":"J Urol"},{"issue":"1","key":"10.1016\/j.prnil.2026.04.005_bib19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000445034","article-title":"Low-risk prostate cancer and tumor upgrading to higher patterns in the surgical specimen","volume":"97","author":"Porcaro","year":"2016","journal-title":"Urol Int"},{"issue":"6","key":"10.1016\/j.prnil.2026.04.005_bib20","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4103\/aja.aja_29_19","article-title":"Prostate cancer upgrading or downgrading of biopsy Gleason scores at radical prostatectomy","volume":"21","author":"Altok","year":"2019","journal-title":"Asian J Androl"},{"issue":"2","key":"10.1016\/j.prnil.2026.04.005_bib21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00345-008-0343-3","article-title":"Prediction of Gleason score upgrading in low-risk prostate cancers diagnosed via multi (\u226512)-core prostate biopsy","volume":"27","author":"Hong","year":"2009","journal-title":"World J Urol"},{"issue":"7","key":"10.1016\/j.prnil.2026.04.005_bib22","doi-asserted-by":"crossref","first-page":"932","DOI":"10.3346\/jkms.2015.30.7.932","article-title":"Pathologic outcomes in men with low-risk prostate cancer who are potential candidates for contemporary active surveillance protocols","volume":"30","author":"Kang","year":"2015","journal-title":"J Kor Med Sci"},{"issue":"4","key":"10.1016\/j.prnil.2026.04.005_bib23","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jcma.2017.07.008","article-title":"Pathological outcomes in men with prostate cancer who are eligible for active surveillance","volume":"81","author":"Wang","year":"2018","journal-title":"J Chin Med Assoc"},{"issue":"2","key":"10.1016\/j.prnil.2026.04.005_bib24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1177\/03915603221118457","article-title":"Concordance between Gleason score of prostate biopsies and radical prostatectomy specimens and its predictive factors","volume":"90","author":"Ariafar","year":"2023","journal-title":"Urologia"},{"key":"10.1016\/j.prnil.2026.04.005_bib25","article-title":"Predictors of Gleason grading group upgrading in low-risk prostate cancer patients from transperineal biopsy after radical prostatectomy","author":"Zhou","year":"2024","journal-title":"Acad Radiol"},{"key":"10.1016\/j.prnil.2026.04.005_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.urology.2015.08.026","article-title":"Occult high-risk disease in clinically low-risk prostate cancer with \u226550% positive biopsy cores","volume":"87","author":"Dinh","year":"2016","journal-title":"Urology"},{"issue":"1","key":"10.1016\/j.prnil.2026.04.005_bib27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4143\/crt.2016.477","article-title":"Selection criteria for active surveillance of patients with prostate cancer in Korea: a multicenter analysis of pathology after radical prostatectomy","volume":"50","author":"Jeong","year":"2018","journal-title":"Cancer Res Treat"},{"key":"10.1016\/j.prnil.2026.04.005_bib28","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3332\/ecancer.2019.971","article-title":"Pathological upgrading and upstaging at radical prostatectomy in Jamaican men with low-risk prostate cancer","volume":"13","author":"Morrison","year":"2019","journal-title":"Ecancermedicalscience"},{"issue":"5","key":"10.1016\/j.prnil.2026.04.005_bib29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/bju.14554","article-title":"Pathological upgrading at radical prostatectomy for patients with Grade Group 1 prostate cancer","volume":"123","author":"Kaye","year":"2019","journal-title":"BJU Int"},{"issue":"5","key":"10.1016\/j.prnil.2026.04.005_bib30","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1097\/JU.0000000000001937","article-title":"Factors associated with time to conversion from active surveillance to treatment for prostate cancer","volume":"206","author":"Cooley","year":"2021","journal-title":"J Urol"},{"issue":"6","key":"10.1016\/j.prnil.2026.04.005_bib31","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/sim.6003","article-title":"Modeling grade progression in an active surveillance study","volume":"33","author":"Inoue","year":"2014","journal-title":"Stat Med"},{"issue":"2","key":"10.1016\/j.prnil.2026.04.005_bib32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4111\/icu.20250460","article-title":"Does protocol heterogeneity in active surveillance influence clinical outcomes? Insights from a multicenter prostate cancer cohort","volume":"67","author":"Ko","year":"2026","journal-title":"Investig Clin Urol"},{"issue":"4","key":"10.1016\/j.prnil.2026.04.005_bib33","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.juro.2017.10.010","article-title":"Biopsy core features are poor predictors of adverse pathology in men with grade group 1 prostate cancer","volume":"199","author":"Audenet","year":"2018","journal-title":"J Urol"},{"issue":"5","key":"10.1016\/j.prnil.2026.04.005_bib34","doi-asserted-by":"crossref","first-page":"516","DOI":"10.4103\/aja.aja_9_21","article-title":"Prostate cancer: a presentation of clinicopathologic prognosticators among Filipino and American men at radical prostatectomy","volume":"23","author":"Grageda","year":"2021","journal-title":"Asian J Androl"}],"container-title":["Prostate International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2287888226000322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2287888226000322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:02:19Z","timestamp":1790229739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2287888226000322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2287888226000322"],"URL":"https:\/\/doi.org\/10.1016\/j.prnil.2026.04.005","relation":{},"ISSN":["2287-8882"],"issn-type":[{"value":"2287-8882","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathologic profile of Filipino men with low-risk prostate cancer and predictors of unfavorable pathology at radical prostatectomy","name":"articletitle","label":"Article Title"},{"value":"Prostate International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prnil.2026.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Asian Pacific Prostate Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}